ES2187028T3 - El uso de alfa-metil-p-tirosina para inhibir la produccion de melanina en melanocitos de iris. - Google Patents

El uso de alfa-metil-p-tirosina para inhibir la produccion de melanina en melanocitos de iris.

Info

Publication number
ES2187028T3
ES2187028T3 ES98924164T ES98924164T ES2187028T3 ES 2187028 T3 ES2187028 T3 ES 2187028T3 ES 98924164 T ES98924164 T ES 98924164T ES 98924164 T ES98924164 T ES 98924164T ES 2187028 T3 ES2187028 T3 ES 2187028T3
Authority
ES
Spain
Prior art keywords
iris
melanocits
alfa
tyrosine
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98924164T
Other languages
English (en)
Inventor
Filippo Drago
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Application granted granted Critical
Publication of ES2187028T3 publication Critical patent/ES2187028T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe la utilización de agentes para bloquear la síntesis de tirosinasa para evitar la pigmentación permanente del iris causada por el depósito de melanina inducido por tratamientos farmacológicos o por un desequilibrio metabólico.
ES98924164T 1997-04-22 1998-04-21 El uso de alfa-metil-p-tirosina para inhibir la produccion de melanina en melanocitos de iris. Expired - Lifetime ES2187028T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000939A IT1291633B1 (it) 1997-04-22 1997-04-22 Uso dell'alfa-metil-p-tirosina per inibire la produzione di melanina nei melanociti dell'iride

Publications (1)

Publication Number Publication Date
ES2187028T3 true ES2187028T3 (es) 2003-05-16

Family

ID=11376994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98924164T Expired - Lifetime ES2187028T3 (es) 1997-04-22 1998-04-21 El uso de alfa-metil-p-tirosina para inhibir la produccion de melanina en melanocitos de iris.

Country Status (22)

Country Link
US (1) US6359001B1 (es)
EP (1) EP0977575B1 (es)
JP (1) JP2001521540A (es)
KR (1) KR20010020202A (es)
CN (1) CN1255064A (es)
AT (1) ATE227577T1 (es)
AU (1) AU732046B2 (es)
CA (1) CA2287887A1 (es)
DE (1) DE69809408T2 (es)
DK (1) DK0977575T3 (es)
ES (1) ES2187028T3 (es)
HU (1) HUP0002100A3 (es)
IL (1) IL132503A (es)
IT (1) IT1291633B1 (es)
NO (1) NO995122L (es)
NZ (1) NZ500435A (es)
PL (1) PL189304B1 (es)
PT (1) PT977575E (es)
RU (1) RU2218159C2 (es)
SI (1) SI0977575T1 (es)
SK (1) SK284255B6 (es)
WO (1) WO1998047515A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2232434T3 (es) 1999-03-05 2005-06-01 Duke University Analogos de prostaglandinas c-16 fp selectivas insaturadas.
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20110280909A1 (en) * 2009-01-29 2011-11-17 Kambiz Thomas Moazed Method and system for effecting changes in pigmented tissue
US9744237B2 (en) * 2009-01-29 2017-08-29 Kambiz Thomas Moazed Method and system for effecting changes in pigmented tissue
US20120076848A1 (en) * 2009-07-22 2012-03-29 Kambiz Thomas Moazed Method and system for effecting changes in pigmented tissue
US10272068B2 (en) 2012-01-17 2019-04-30 Tyme, Inc. Pharmaceutical compositions and methods
US10646552B2 (en) 2012-01-17 2020-05-12 Tyme, Inc. Pharmaceutical compositions and methods
US8481498B1 (en) 2012-01-17 2013-07-09 Steven Hoffman Pharmaceutical compositions and methods
US20130183263A1 (en) 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
NZ721280A (en) * 2012-01-17 2017-08-25 Tyme Inc Pharmaceutical compositions and methods for treating cancer
US9326962B2 (en) 2013-10-22 2016-05-03 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US9585841B2 (en) 2013-10-22 2017-03-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
US9763903B2 (en) 2013-10-22 2017-09-19 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US10751313B2 (en) 2013-10-22 2020-08-25 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US10813901B2 (en) 2013-10-22 2020-10-27 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
ES2738248B2 (es) * 2018-06-21 2023-03-10 Consejo Superior Investigacion Uso de inhibidores de la tirosina hidroxilasa para el tratamiento del aneurisma de aorta
US11534420B2 (en) 2019-05-14 2022-12-27 Tyme, Inc. Compositions and methods for treating cancer
CN116035151A (zh) * 2023-01-18 2023-05-02 云南贝泰妮生物科技集团股份有限公司 一种刺梨闪释粉及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04117313A (ja) * 1990-09-06 1992-04-17 Kanebo Ltd 美白化粧料

Also Published As

Publication number Publication date
NO995122L (no) 1999-12-21
ITMI970939A0 (es) 1997-04-22
PL336386A1 (en) 2000-06-19
KR20010020202A (ko) 2001-03-15
IL132503A0 (en) 2001-03-19
DE69809408D1 (de) 2002-12-19
PL189304B1 (pl) 2005-07-29
SK142499A3 (en) 2000-09-12
JP2001521540A (ja) 2001-11-06
CN1255064A (zh) 2000-05-31
ATE227577T1 (de) 2002-11-15
IL132503A (en) 2004-06-20
RU2218159C2 (ru) 2003-12-10
EP0977575A1 (en) 2000-02-09
IT1291633B1 (it) 1999-01-11
CA2287887A1 (en) 1998-10-29
EP0977575B1 (en) 2002-11-13
ITMI970939A1 (it) 1998-10-22
US6359001B1 (en) 2002-03-19
WO1998047515A1 (en) 1998-10-29
DK0977575T3 (da) 2003-03-10
DE69809408T2 (de) 2003-07-10
HUP0002100A3 (en) 2003-05-28
NO995122D0 (no) 1999-10-21
PT977575E (pt) 2003-03-31
AU7646298A (en) 1998-11-13
AU732046B2 (en) 2001-04-12
NZ500435A (en) 2001-09-28
SK284255B6 (sk) 2004-12-01
SI0977575T1 (en) 2003-04-30
HUP0002100A2 (hu) 2000-11-28

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