ES2183788T3 - Implante. - Google Patents
Implante.Info
- Publication number
- ES2183788T3 ES2183788T3 ES00909195T ES00909195T ES2183788T3 ES 2183788 T3 ES2183788 T3 ES 2183788T3 ES 00909195 T ES00909195 T ES 00909195T ES 00909195 T ES00909195 T ES 00909195T ES 2183788 T3 ES2183788 T3 ES 2183788T3
- Authority
- ES
- Spain
- Prior art keywords
- implant
- suggested
- diffusion
- receptacle space
- pore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Radiology & Medical Imaging (AREA)
- Prostheses (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
Abstract
Implante (1) con un espacio de alojamiento (2) para un medio terapéutico (3) y/o que contienen al menos una substancia activa, donde el espacio de alojamiento (2) presenta al menos un orificio de paso (4), en el que está insertado un elemento de paso (5), a través del cual el medio (3) puede abandonar el espacio de alojamiento (2), donde el elemento de paso (5) está configurado con poros abiertos (6) con un tamaño de los poros y/o una pared de poros (7) que permite al menos esencialmente sólo una difusión del medio (3) y/o al menos de una substancia activa del medio (3) a través del elemento de difusión, sin posibilitar una circulación libre a través del elemento de paso (5), donde el elemento de paso (5) presenta poros abiertos (6) con paredes de poros (7) que están modificadas químicamente al menos por regiones, para interactuar con el medio (3), con al menos una substancia activa del medio (3) y/o con substancias que se encuentran fuera, con preferencia de forma selectiva, con respecto al paso a través del elemento de paso (5), caracterizado porque el elemento de paso (5) está constituido al menos esencialmente por óxido de aluminio, de magnesio, de tantalio, de hierro, de volframio y/o de titanio fabricado a través de anodización.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19907006 | 1999-02-18 | ||
DE19910188A DE19910188C2 (de) | 1998-11-02 | 1999-03-09 | Implantat, Verfahren zu seiner Herstellung und seine Verwendung |
DE19948783A DE19948783C2 (de) | 1999-02-18 | 1999-10-08 | Implantat |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2183788T3 true ES2183788T3 (es) | 2003-04-01 |
Family
ID=27218985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00909195T Expired - Lifetime ES2183788T3 (es) | 1999-02-18 | 2000-02-17 | Implante. |
Country Status (20)
Country | Link |
---|---|
US (1) | US6740077B1 (es) |
EP (1) | EP1150738B1 (es) |
JP (1) | JP2002537029A (es) |
CN (1) | CN1186105C (es) |
AT (1) | ATE227597T1 (es) |
AU (1) | AU761882B2 (es) |
BR (1) | BR0008322A (es) |
CA (1) | CA2371800A1 (es) |
DE (2) | DE19948783C2 (es) |
DK (1) | DK1150738T3 (es) |
EE (1) | EE200100435A (es) |
ES (1) | ES2183788T3 (es) |
IL (1) | IL144753A0 (es) |
NO (1) | NO20013917L (es) |
NZ (1) | NZ513364A (es) |
PL (1) | PL350562A1 (es) |
PT (1) | PT1150738E (es) |
TR (1) | TR200102384T2 (es) |
WO (1) | WO2000048660A1 (es) |
YU (1) | YU58801A (es) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7713297B2 (en) | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US7018401B1 (en) | 1999-02-01 | 2006-03-28 | Board Of Regents, The University Of Texas System | Woven intravascular devices and methods for making the same and apparatus for delivery of the same |
CA2434156A1 (en) | 2000-12-29 | 2002-07-25 | Bausch & Lomb Incorporated | Sustained release drug delivery devices |
US6756058B2 (en) | 2001-01-03 | 2004-06-29 | Bausch & Lomb Incorporated | Sustained release drug delivery devices with multiple agents |
DE10123442C2 (de) * | 2001-03-23 | 2003-05-22 | Alcove Surfaces Gmbh | Operationswerkzeug |
US6697662B2 (en) | 2001-03-23 | 2004-02-24 | Alcover Surfaces Gmbh | Surgical instrument |
DE60239868D1 (de) | 2001-06-12 | 2011-06-09 | Univ Johns Hopkins Med | Reservoirvorrichtung für die intraokulare arzneimittelabgabe |
WO2003002243A2 (en) | 2001-06-27 | 2003-01-09 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
KR101191254B1 (ko) * | 2002-03-11 | 2012-10-16 | 알콘, 인코퍼레이티드 | 이식 가능한 약물 전달 시스템 |
JP2006514848A (ja) | 2002-11-13 | 2006-05-18 | セタゴン インコーポレーティッド | 多孔質層を有する医療装置およびその作製方法 |
US9770349B2 (en) | 2002-11-13 | 2017-09-26 | University Of Virginia Patent Foundation | Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation |
US20060121080A1 (en) | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
AU2003270244A1 (en) | 2002-11-14 | 2004-06-03 | Universitat Duisburg-Essen | Implant, therapeutic agent and micelle |
US7488343B2 (en) | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
US20050158365A1 (en) * | 2003-12-22 | 2005-07-21 | David Watson | Drug delivery device with mechanical locking mechanism |
US8137397B2 (en) | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
NL1025624C2 (nl) * | 2004-03-03 | 2005-09-07 | Solvist | Stroomrestrictie. |
US8348930B2 (en) * | 2005-07-01 | 2013-01-08 | Microlin, Llc | Fluid delivery device with a diffusion membrane and electrochemical pump |
GB2442396B (en) * | 2005-07-22 | 2011-05-11 | Univ Utah Res Found | Osmotically driven dispense pump and related components for use in high pressure applications |
US20070212397A1 (en) * | 2005-09-15 | 2007-09-13 | Roth Daniel B | Pharmaceutical delivery device and method for providing ocular treatment |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
JP2009540926A (ja) * | 2006-06-22 | 2009-11-26 | ウィルソン−クック・メディカル・インコーポレーテッド | 自浄式ステント |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
EP2032091A2 (en) | 2006-06-29 | 2009-03-11 | Boston Scientific Limited | Medical devices with selective coating |
JP2009545407A (ja) | 2006-08-02 | 2009-12-24 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 三次元分解制御を備えたエンドプロテーゼ |
EP1891995A1 (en) * | 2006-08-08 | 2008-02-27 | Debiotech S.A. | Drug loading of porous coating |
ATE508708T1 (de) | 2006-09-14 | 2011-05-15 | Boston Scient Ltd | Medizinprodukte mit wirkstofffreisetzender beschichtung |
EP2081616B1 (en) | 2006-09-15 | 2017-11-01 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8057534B2 (en) | 2006-09-15 | 2011-11-15 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US7955382B2 (en) | 2006-09-15 | 2011-06-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with adjustable surface features |
EP2068964B1 (en) | 2006-09-15 | 2017-11-01 | Boston Scientific Limited | Medical devices and methods of making the same |
JP2010503491A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 生物学的安定性無機層を有する生浸食性エンドプロスシーシス |
EP2068962B1 (en) | 2006-09-18 | 2013-01-30 | Boston Scientific Limited | Endoprostheses |
CN102525700B (zh) | 2006-10-22 | 2015-05-13 | Idev科技公司 | 支架推进装置 |
KR101659197B1 (ko) | 2006-10-22 | 2016-09-22 | 이데브 테크놀로지스, 아이엔씨. | 스텐트 전진을 위한 장치 및 방법 |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
ES2356274T3 (es) | 2006-12-28 | 2011-04-06 | Boston Scientific Limited | Endoprótesis biodegradables y procedimientos de fabricación de las mismas. |
US20080208308A1 (en) * | 2007-02-27 | 2008-08-28 | Medtronic Vascular, Inc. | High Temperature Oxidation-Reduction Process to Form Porous Structures on a Medical Implant |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
EP1977754A1 (en) * | 2007-04-02 | 2008-10-08 | Universität Duisburg-Essen | Treatment of diseases with nanoparticles having a size-dependent cytotoxicity |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US9284409B2 (en) | 2007-07-19 | 2016-03-15 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
WO2009018340A2 (en) | 2007-07-31 | 2009-02-05 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
EP2185103B1 (en) | 2007-08-03 | 2014-02-12 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
EP2271380B1 (en) | 2008-04-22 | 2013-03-20 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
EP2303350A2 (en) | 2008-06-18 | 2011-04-06 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
JP5670326B2 (ja) * | 2008-06-25 | 2015-02-18 | メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ | 複数の薬剤リザーバを有する電子ピル |
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US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
EP2391419B1 (en) | 2009-01-29 | 2019-06-12 | ForSight Vision4, Inc. | Posterior segment drug delivery |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
US8734829B2 (en) * | 2009-02-13 | 2014-05-27 | Boston Scientific Scimed, Inc. | Medical devices having polymeric nanoporous coatings for controlled therapeutic agent delivery and a nonpolymeric macroporous protective layer |
WO2010101901A2 (en) | 2009-03-02 | 2010-09-10 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20100256772A1 (en) * | 2009-04-02 | 2010-10-07 | Wilson-Cook Medical Inc. | System and method for maintaining patency of a stent using a magnet |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
SG177768A1 (en) * | 2009-08-25 | 2012-03-29 | Prostec Co Ltd | Medical supplies and method of producing the same |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US9023095B2 (en) | 2010-05-27 | 2015-05-05 | Idev Technologies, Inc. | Stent delivery system with pusher assembly |
CN103153316B (zh) | 2010-08-05 | 2015-08-19 | 弗赛特影像4股份有限公司 | 组合药物递送方法和设备 |
US9033911B2 (en) | 2010-08-05 | 2015-05-19 | Forsight Vision4, Inc. | Injector apparatus and method for drug delivery |
WO2012019176A2 (en) | 2010-08-05 | 2012-02-09 | Forsight Vision4 Inc. | Implantable therapeutic device |
AU2011329656B2 (en) | 2010-11-19 | 2017-01-05 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
EP2726016B1 (en) | 2011-06-28 | 2023-07-19 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
EP2739252A4 (en) | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE |
CA2848385C (en) | 2011-09-16 | 2021-10-26 | Forsight Vision4, Inc. | Methods and apparatus to exchange a fluid of an implantable device |
WO2013116061A1 (en) | 2012-02-03 | 2013-08-08 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
AU2014236455B2 (en) | 2013-03-14 | 2018-07-12 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
JP6385423B2 (ja) | 2013-03-28 | 2018-09-05 | フォーサイト・ビジョン フォー・インコーポレーテッド | 治療物質送達用の眼移植片 |
TWI551313B (zh) * | 2013-05-24 | 2016-10-01 | 中臺科技大學 | 胰島素注射裝置 |
RU2695563C2 (ru) | 2014-07-15 | 2019-07-24 | Форсайт Вижн4, Инк. | Способ и устройство для доставки глазного имплантата |
BR112017002466A2 (pt) | 2014-08-08 | 2017-12-05 | Forsight Vision4 Inc | formulações estáveis e solúveis de inibidores da tirosina cinase do receptor, e métodos para a sua preparação |
WO2016077371A1 (en) | 2014-11-10 | 2016-05-19 | Forsight Vision4, Inc. | Expandable drug delivery devices and method of use |
EP3377009B1 (en) | 2015-11-20 | 2020-10-28 | ForSight Vision4, Inc. | Porous structures for extended release drug delivery devices |
US11617680B2 (en) | 2016-04-05 | 2023-04-04 | Forsight Vision4, Inc. | Implantable ocular drug delivery devices |
CN115607358A (zh) | 2017-11-21 | 2023-01-17 | 弗赛特影像4股份有限公司 | 用于可扩展端口递送系统的流体交换装置及使用方法 |
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US3732865A (en) * | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
US3760804A (en) * | 1971-01-13 | 1973-09-25 | Alza Corp | Improved osmotic dispenser employing magnesium sulphate and magnesium chloride |
CH580961A5 (en) * | 1972-01-13 | 1976-10-29 | Alza Corp | Dispenser - functioning by osmotic pressure using active agents in solid or semi solid form |
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US4218255A (en) | 1976-08-30 | 1980-08-19 | University Of Dayton | Porous ceramic carriers for controlled release of proteins, polypeptide hormones, and other substances within human and/or other mamillian species and method |
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-
1999
- 1999-10-08 DE DE19948783A patent/DE19948783C2/de not_active Expired - Fee Related
-
2000
- 2000-02-17 AT AT00909195T patent/ATE227597T1/de not_active IP Right Cessation
- 2000-02-17 CN CNB008039240A patent/CN1186105C/zh not_active Expired - Fee Related
- 2000-02-17 BR BR0008322-4A patent/BR0008322A/pt not_active IP Right Cessation
- 2000-02-17 PL PL00350562A patent/PL350562A1/xx unknown
- 2000-02-17 TR TR2001/02384T patent/TR200102384T2/xx unknown
- 2000-02-17 EE EEP200100435A patent/EE200100435A/xx unknown
- 2000-02-17 DK DK00909195T patent/DK1150738T3/da active
- 2000-02-17 AU AU31561/00A patent/AU761882B2/en not_active Ceased
- 2000-02-17 PT PT00909195T patent/PT1150738E/pt unknown
- 2000-02-17 DE DE50000750T patent/DE50000750D1/de not_active Expired - Fee Related
- 2000-02-17 NZ NZ513364A patent/NZ513364A/en unknown
- 2000-02-17 YU YU58801A patent/YU58801A/sh unknown
- 2000-02-17 WO PCT/EP2000/001287 patent/WO2000048660A1/de active IP Right Grant
- 2000-02-17 ES ES00909195T patent/ES2183788T3/es not_active Expired - Lifetime
- 2000-02-17 EP EP00909195A patent/EP1150738B1/de not_active Expired - Lifetime
- 2000-02-17 CA CA002371800A patent/CA2371800A1/en not_active Abandoned
- 2000-02-17 JP JP2000599449A patent/JP2002537029A/ja active Pending
- 2000-02-17 IL IL14475300A patent/IL144753A0/xx unknown
-
2001
- 2001-08-10 NO NO20013917A patent/NO20013917L/no not_active Application Discontinuation
- 2001-08-20 US US09/913,942 patent/US6740077B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT1150738E (pt) | 2003-03-31 |
TR200102384T2 (tr) | 2002-01-21 |
AU761882B2 (en) | 2003-06-12 |
DK1150738T3 (da) | 2002-12-30 |
CA2371800A1 (en) | 2000-08-24 |
NO20013917D0 (no) | 2001-08-10 |
NO20013917L (no) | 2001-08-10 |
IL144753A0 (en) | 2002-06-30 |
BR0008322A (pt) | 2002-01-29 |
EP1150738B1 (de) | 2002-11-13 |
CN1339976A (zh) | 2002-03-13 |
DE19948783C2 (de) | 2001-06-13 |
YU58801A (sh) | 2004-03-12 |
EP1150738A1 (de) | 2001-11-07 |
DE19948783A1 (de) | 2000-08-24 |
ATE227597T1 (de) | 2002-11-15 |
DE50000750D1 (de) | 2002-12-19 |
US6740077B1 (en) | 2004-05-25 |
NZ513364A (en) | 2003-10-31 |
PL350562A1 (en) | 2002-12-16 |
AU3156100A (en) | 2000-09-04 |
JP2002537029A (ja) | 2002-11-05 |
EE200100435A (et) | 2002-12-16 |
WO2000048660A1 (de) | 2000-08-24 |
CN1186105C (zh) | 2005-01-26 |
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