ES2182061T3 - 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina. - Google Patents

1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina.

Info

Publication number
ES2182061T3
ES2182061T3 ES97916633T ES97916633T ES2182061T3 ES 2182061 T3 ES2182061 T3 ES 2182061T3 ES 97916633 T ES97916633 T ES 97916633T ES 97916633 T ES97916633 T ES 97916633T ES 2182061 T3 ES2182061 T3 ES 2182061T3
Authority
ES
Spain
Prior art keywords
citosine
desoxi
arabinofuranosil
fluor
tio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97916633T
Other languages
English (en)
Spanish (es)
Inventor
Yuichi Yoshimura
Kenji Kitano
Shinji Miura
Haruhiko Machida
Mikari Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Corp
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ES2182061T3 publication Critical patent/ES2182061T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES97916633T 1996-04-09 1997-04-09 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina. Expired - Lifetime ES2182061T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP21508296 1996-07-26
JP27863196 1996-09-30

Publications (1)

Publication Number Publication Date
ES2182061T3 true ES2182061T3 (es) 2003-03-01

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97916633T Expired - Lifetime ES2182061T3 (es) 1996-04-09 1997-04-09 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina.

Country Status (10)

Country Link
US (1) US6147058A (OSRAM)
EP (1) EP0841344B1 (OSRAM)
JP (1) JP3657008B2 (OSRAM)
AT (1) ATE224909T1 (OSRAM)
CA (1) CA2224155C (OSRAM)
DE (1) DE69715774T2 (OSRAM)
DK (1) DK0841344T3 (OSRAM)
ES (1) ES2182061T3 (OSRAM)
PT (1) PT841344E (OSRAM)
WO (1) WO1997038001A1 (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
EP2390257A1 (en) * 1998-02-25 2011-11-30 Emory University 2'-fluoronucleosides
WO2005027962A1 (en) * 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
EP2799432B1 (en) * 2009-12-18 2016-09-21 Libramedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses
EP2388257A1 (en) * 2010-05-20 2011-11-23 LibraMedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses
KR101770246B1 (ko) * 2012-03-28 2017-08-22 후지필름 가부시키가이샤 1-(2-디옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 염
MX2015001935A (es) * 2012-08-13 2015-06-22 Fujifilm Corp Intermediario para sintesis de 1-(2-desoxi-2-fluoro-4-tio-beta-d-a rabinofuranosil) citosina, intermediario para sintesis de tionucleosido y metodos para producir estos intermediarios.
WO2014197578A1 (en) * 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
EP3109245B1 (en) 2014-02-18 2018-01-03 FUJIFILM Corporation Method for producting thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
US10662214B2 (en) 2015-04-03 2020-05-26 Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
EP3508205B1 (en) * 2016-08-31 2022-05-18 FUJIFILM Corporation Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
EP3560944A4 (en) 2016-12-22 2020-08-26 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. SOLID FORM OF 4'-THIO-2'-FLUORONUCLEOSIDE PHOSPHAMIDE COMPOUND, PROCESS FOR PREPARATION AND USE
WO2019042226A1 (zh) * 2017-09-01 2019-03-07 四川科伦博泰生物医药股份有限公司 用于肿瘤治疗或预防的药物组合物、方法及其用途
WO2019146129A1 (ja) * 2018-01-29 2019-08-01 富士フイルム株式会社 イソクエン酸デヒドロゲナーゼ変異を有する腫瘍に対する医薬組成物および抗腫瘍剤ならびにその利用
TW201932119A (zh) * 2018-01-29 2019-08-16 日商富士軟片股份有限公司 膽道癌用抗腫瘤劑和膽道癌的處理方法
WO2019164010A1 (ja) * 2018-02-26 2019-08-29 富士フイルム株式会社 膀胱がん用抗腫瘍剤および膀胱がんの処置方法
CN111836628B (zh) * 2018-03-13 2025-01-07 富士胶片株式会社 抗肿瘤剂、抗肿瘤效果增强剂及抗肿瘤用试剂盒
EP3856754A1 (en) * 2018-09-25 2021-08-04 The United States of America, as represented by the Secretary, Department of Health and Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
CN112770731A (zh) * 2018-11-28 2021-05-07 四川科伦博泰生物医药股份有限公司 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
US20220281910A1 (en) * 2019-07-30 2022-09-08 Pinotbio, Inc. Dinucleotide compounds for treating cancers and medical uses thereof
KR20240028451A (ko) 2021-07-29 2024-03-05 후지필름 가부시키가이샤 Bap1 및 pbrm1 중 적어도 하나의 기능 저하를 갖는 종양에 대한 의약 조성물 및 항종양제

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
EP0841344A1 (en) 1998-05-13
ATE224909T1 (de) 2002-10-15
DK0841344T3 (da) 2002-12-23
DE69715774D1 (de) 2002-10-31
EP0841344A4 (OSRAM) 1998-05-13
CA2224155C (en) 2004-10-26
WO1997038001A1 (en) 1997-10-16
EP0841344B1 (en) 2002-09-25
CA2224155A1 (en) 1997-10-16
PT841344E (pt) 2003-02-28
DE69715774T2 (de) 2003-05-15
US6147058A (en) 2000-11-14
JP3657008B2 (ja) 2005-06-08

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