ES2180784T3 - Composiciones para formacion de imagen de un fondo de sangre, utilizacion y metodo. - Google Patents
Composiciones para formacion de imagen de un fondo de sangre, utilizacion y metodo.Info
- Publication number
- ES2180784T3 ES2180784T3 ES96919971T ES96919971T ES2180784T3 ES 2180784 T3 ES2180784 T3 ES 2180784T3 ES 96919971 T ES96919971 T ES 96919971T ES 96919971 T ES96919971 T ES 96919971T ES 2180784 T3 ES2180784 T3 ES 2180784T3
- Authority
- ES
- Spain
- Prior art keywords
- compositions
- circulation
- mixed micelles
- blood
- mri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
LA INVENCION SE REFIERE A COMPOSICIONES DE CONTRASTE DE FORMACION DE IMAGENES POR NMR QUE CONTIENEN ESPECIES QUE RESPONDEN MAGNETICAMENTE UNIDAS A MATERIALES DE BASE ORGANICOS ANFIPATICOS FISIOLOGICAMENTE ACEPTABLES A MODO DE MICELAS MIXTAS SUSPENDIDAS O DISPERSADAS EN UN SOPORTE LIQUIDO ACUOSO FISIOLOGICAMENTE ACEPTABLE. LAS COMPOSICIONES SON PARTICULARMENTE UTILES PARA INVESTIGACIONES DE DIAGNOSTICO DE BOLSAS DE SANGRE. LA INVENCION TAMBIEN SE REFIERE A LA PREPARACION DE LAS MICELAS MIXTAS, ASI COMO A COMPOSICIONES INYECTABLES QUE CONTIENEN LAS MICELAS MIXTAS COMO AGENTES DE CONTRASTE PARA MRI. UNA VEZ INYECTADAS, LAS MICELAS MIXTAS DE LAS COMPOSICIONES SE COMPORTAN COMO INTENSIFICADORES DEL CONTRASTE PARA LA FORMACION DE IMAGENES, EJ. MEJORARAN LA CALIDAD Y LA RESOLUCION DE LAS IMAGENES PROCESADAS ELECTRONICAMENTE OBTENIDAS DURANTE EXAMENES POR MRI DE LA CIRCULACION Y/O DE LOS ORGANOS DE LA CIRCULACION SELECCIONADOS. LAS COMPOSICIONES SE FORMULAN PARA PROTEGER A LAS PARTICULAS DE LOS AGENTES DE CONTRASTE CONTRA UNA RETIRADA ANTICIPADA POR PARTE DEL SISTEMA RETICULOENDOTELIAL (RES) DEL HIGADO Y DEL BAZO, DE MODO QUE PERMANEZCAN EN CIRCULACION DURANTE UN PERIODO DE TIEMPO SUFICIENTE COMO PARA PODER TOMAR UNA IMAGEN CORRECTA DE LOS VASOS SANGUINEOS Y SEAN TRANSPORTADOS A LOS ORGANOS SELECCIONADOS. LA FORMACION DE IMAGENES POR MRI DE LA CIRCULACION Y DE LOS ORGANOS SELECCIONADOS PUEDE AYUDAR EN GRAN MEDIDA EN EL DIAGNOSTICO DE POSIBLES SUFRIMIENTOS DE PACIENTES HUMANOS Y ANIMALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95810403 | 1995-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180784T3 true ES2180784T3 (es) | 2003-02-16 |
Family
ID=8221760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96919971T Expired - Lifetime ES2180784T3 (es) | 1995-06-15 | 1996-06-14 | Composiciones para formacion de imagen de un fondo de sangre, utilizacion y metodo. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5833948A (es) |
EP (1) | EP0804251B1 (es) |
JP (1) | JP4335976B2 (es) |
KR (1) | KR100399712B1 (es) |
AT (1) | ATE224737T1 (es) |
AU (1) | AU708328B2 (es) |
CA (1) | CA2195633C (es) |
DE (1) | DE69623929T2 (es) |
ES (1) | ES2180784T3 (es) |
NO (1) | NO314127B1 (es) |
PT (1) | PT804251E (es) |
WO (1) | WO1997000087A1 (es) |
ZA (1) | ZA965101B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1297034B1 (it) * | 1997-12-30 | 1999-08-03 | Bracco Spa | Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
IT1297035B1 (it) * | 1997-12-30 | 1999-08-03 | Bracco Spa | Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
US6342598B1 (en) | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
EP1289565B1 (en) | 2000-06-02 | 2015-04-22 | Bracco Suisse SA | Compounds for targeting endothelial cells |
US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
US20060073197A1 (en) * | 2004-05-20 | 2006-04-06 | Ramaekers Joseph C | Encapsulated transfer factor compositions and methods of use |
US20070128253A1 (en) * | 2005-04-13 | 2007-06-07 | Ramaekers Joseph C | Encapsulated transfer factor compositions and methods of use |
US6506413B1 (en) * | 2001-04-30 | 2003-01-14 | Joseph C. Ramaekers | Compositions for treating animal diseases and syndromes |
US6803046B2 (en) | 2002-08-16 | 2004-10-12 | Bracco International B.V. | Sincalide formulations |
US20050130892A1 (en) * | 2003-03-07 | 2005-06-16 | Xencor, Inc. | BAFF variants and methods thereof |
US7553930B2 (en) * | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
US20060014248A1 (en) * | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity |
US20050221443A1 (en) * | 2003-01-06 | 2005-10-06 | Xencor, Inc. | Tumor necrosis factor super family agonists |
ES2352087T3 (es) | 2003-02-04 | 2011-02-15 | Bracco Suisse Sa | Agentes de contraste para ultrasonido y procedimiento para la preparación de los mismos. |
CA2542353A1 (en) | 2003-10-10 | 2005-04-21 | Xencor, Inc. | Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders |
JP5513708B2 (ja) | 2003-12-22 | 2014-06-04 | ブラッコ・シュイス・ソシエテ・アノニム | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
WO2005063304A2 (en) * | 2003-12-24 | 2005-07-14 | Board Of Regents, The University Of Texas_System | Poly (l-glutamic acid) paramagnetic material complex and use as a biodegradable mri contrast agent |
JP4773430B2 (ja) * | 2004-06-03 | 2011-09-14 | ブラッコ・リサーチ・ソシエテ・アノニム | 治療および/または診断用途のためのリポソーム集合体 |
JP4837663B2 (ja) | 2004-08-18 | 2011-12-14 | ブラッコ・シュイス・ソシエテ・アノニム | 造影画像化のためのガス充填微小胞組成物 |
FR2883562B1 (fr) | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
CN101203249A (zh) * | 2005-04-01 | 2008-06-18 | 德克萨斯大学体系董事会 | 多(肽)作为螯合剂:制造方法和用途 |
US20090130018A1 (en) * | 2005-05-31 | 2009-05-21 | Accardo Antonella | Supramolecular aggregates containing chelating agents and bioactive peptides as effective and selective delivery tools for drugs and contrast agents in mri or nuclear medicine |
US20090053197A1 (en) * | 2006-06-14 | 2009-02-26 | Ramaekers Joseph C | Transfer Factor Compositions and Methods |
US9125874B2 (en) | 2007-11-30 | 2015-09-08 | The Ramaekers Family Trust | Administration of transfer factor for improving reproductive health |
DE602007006968D1 (de) | 2006-09-05 | 2010-07-15 | Bracco Research Sa | Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden |
GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
WO2009039256A1 (en) * | 2007-09-18 | 2009-03-26 | Ramaekers Nutrition, Llc | Growth factor fraction compositions and methods |
KR101401217B1 (ko) * | 2007-11-07 | 2014-05-28 | 충남대학교산학협력단 | Pe-dtpa의 새로운 용도 |
MX338336B (es) | 2007-11-20 | 2016-04-07 | Ambrx Inc | Polipeptidos de insulina modificados y sus usos. |
EP2278984A4 (en) * | 2007-11-30 | 2013-02-27 | Ramaekers Family Trust | COMPOSITIONS AND METHODS FOR ENHANCING FERTILITY |
SG10201906494PA (en) | 2008-01-30 | 2019-09-27 | Histogen Inc | Extracellular matrix compositions |
EP2398503B1 (en) * | 2009-02-13 | 2018-10-31 | University Of Washington | Gadolinium expressed lipid nanoparticles for magnetic resonance imaging |
WO2010139003A1 (en) * | 2009-06-01 | 2010-12-09 | Commonwealth Scientific And Industrial Research Organisation | Chelating amphiphiles |
PL2605789T3 (pl) | 2010-08-17 | 2019-11-29 | Ambrx Inc | Zmodyfikowane polipeptydy relaksyny i ich zastosowania |
EP2639227A1 (en) | 2012-03-14 | 2013-09-18 | Bracco Imaging S.p.A | A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents |
JP6251744B2 (ja) | 2012-09-07 | 2017-12-20 | ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. | MRI用の両親媒性錯体を含む常磁性固体脂質ナノ粒子(pSLN) |
EP3738605A1 (en) | 2012-09-10 | 2020-11-18 | Xencor, Inc. | Methods of treating neurological diseases |
JP6313329B2 (ja) | 2012-12-21 | 2018-04-18 | ブラッコ・スイス・ソシエテ・アノニムBracco Suisse SA | ガス封入マイクロベシクル |
WO2015119642A1 (en) | 2014-02-10 | 2015-08-13 | The Johns Hopkins University | Low oxygen tension enhances endothelial fate of human pluripotent stem cells |
EP3307253A4 (en) | 2015-06-12 | 2018-11-21 | Georgia State University Research Foundation, Inc. | Compositions and methods for treating opioid tolerance |
US11110063B2 (en) | 2017-08-25 | 2021-09-07 | MAIA Pharmaceuticals, Inc. | Storage stable sincalide formulations |
US12077780B2 (en) | 2020-02-14 | 2024-09-03 | Allergan Sales, Llc | Conditioned medium from cells cultured under hypoxic conditions and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5387410A (en) * | 1983-03-18 | 1995-02-07 | Mallinckrodt, Inc. | Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes |
US4728575A (en) * | 1984-04-27 | 1988-03-01 | Vestar, Inc. | Contrast agents for NMR imaging |
US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
EP0594640A4 (en) * | 1991-05-23 | 1998-06-03 | Evan C Unger | Liposoluble compounds for magnetic resonance imaging |
US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
US5534241A (en) * | 1993-07-23 | 1996-07-09 | Torchilin; Vladimir P. | Amphipathic polychelating compounds and methods of use |
US5567410A (en) * | 1994-06-24 | 1996-10-22 | The General Hospital Corporation | Composotions and methods for radiographic imaging |
-
1996
- 1996-06-13 US US08/663,545 patent/US5833948A/en not_active Expired - Lifetime
- 1996-06-14 WO PCT/IB1996/000577 patent/WO1997000087A1/en active IP Right Grant
- 1996-06-14 ES ES96919971T patent/ES2180784T3/es not_active Expired - Lifetime
- 1996-06-14 AT AT96919971T patent/ATE224737T1/de not_active IP Right Cessation
- 1996-06-14 DE DE69623929T patent/DE69623929T2/de not_active Expired - Lifetime
- 1996-06-14 KR KR1019970700923A patent/KR100399712B1/ko not_active IP Right Cessation
- 1996-06-14 PT PT96919971T patent/PT804251E/pt unknown
- 1996-06-14 AU AU58431/96A patent/AU708328B2/en not_active Ceased
- 1996-06-14 ZA ZA965101A patent/ZA965101B/xx unknown
- 1996-06-14 JP JP50285697A patent/JP4335976B2/ja not_active Expired - Fee Related
- 1996-06-14 CA CA002195633A patent/CA2195633C/en not_active Expired - Fee Related
- 1996-06-14 EP EP96919971A patent/EP0804251B1/en not_active Expired - Lifetime
-
1997
- 1997-02-13 NO NO19970665A patent/NO314127B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP4335976B2 (ja) | 2009-09-30 |
ZA965101B (en) | 1997-01-22 |
PT804251E (pt) | 2003-01-31 |
CA2195633A1 (en) | 1997-01-03 |
CA2195633C (en) | 2008-09-16 |
KR100399712B1 (ko) | 2004-02-18 |
DE69623929D1 (de) | 2002-10-31 |
NO314127B1 (no) | 2003-02-03 |
AU708328B2 (en) | 1999-08-05 |
EP0804251B1 (en) | 2002-09-25 |
WO1997000087A1 (en) | 1997-01-03 |
KR970704477A (ko) | 1997-09-06 |
NO970665L (no) | 1997-04-03 |
EP0804251A1 (en) | 1997-11-05 |
US5833948A (en) | 1998-11-10 |
NO970665D0 (no) | 1997-02-13 |
ATE224737T1 (de) | 2002-10-15 |
JPH10504044A (ja) | 1998-04-14 |
DE69623929T2 (de) | 2003-05-15 |
AU5843196A (en) | 1997-01-15 |
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