ES2152932T3 - Particulas de apatita tratadas para tecnicas de imagen para diagnostico medico. - Google Patents
Particulas de apatita tratadas para tecnicas de imagen para diagnostico medico.Info
- Publication number
- ES2152932T3 ES2152932T3 ES92922461T ES92922461T ES2152932T3 ES 2152932 T3 ES2152932 T3 ES 2152932T3 ES 92922461 T ES92922461 T ES 92922461T ES 92922461 T ES92922461 T ES 92922461T ES 2152932 T3 ES2152932 T3 ES 2152932T3
- Authority
- ES
- Spain
- Prior art keywords
- diagnostic
- formation
- images
- particles
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000002245 particle Substances 0.000 title abstract 5
- 238000003745 diagnosis Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 6
- 230000005291 magnetic effect Effects 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 241000072692 Erica <spider> Species 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
- 238000004611 spectroscopical analysis Methods 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/183—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1842—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a phosphate or a phosphonate, not being a phospholipid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1878—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating
- A61K49/1881—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating wherein the coating consists of chelates, i.e. chelating group complexing a (super)(para)magnetic ion, bound to the surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/72—On an electrically conducting, semi-conducting, or semi-insulating substrate
- Y10S977/722—On a metal substrate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/88—Manufacture, treatment, or detection of nanostructure with arrangement, process, or apparatus for testing
- Y10S977/881—Microscopy or spectroscopy, e.g. sem, tem
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/908—Mechanical repair performed/surgical
- Y10S977/91—Strengthening cell or tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/928—X-ray agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/929—Ultrasound contrast agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/93—MRI contrast agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Ceramic Engineering (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Materials For Medical Uses (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
SE PRESENTAN PARTICULAS DE APATITA TRATADAS PARA MEJORAR LA FORMACION DE IMAGENES DE DIAGNOSTICO MEDICO TALES COMO LA INFORMACION DE IMAGENES POR RESONANCIA MAGNETICA (MRI), LA ESPECTROSCOPIA DE RESONANCIA MAGNETICA (MRS), LA FORMACION DE IMAGENES POR ESPECTROSCOPIA DE RESONANCIA MAGNETICA (MRSI), LA FORMACION DE IMAGENES DE DIAGNOSTICO MEDIANTE RAYOS X, Y LA FORMACION DE IMAGENES POR ULTRASONIDO. SE PRESENTAN NUEVOS REVESTIMIENTOS Y TECNICAS DE MANUFACTURACION PARA CONTROLAR EL TAMAÑO DE LAS PARTICULAS QUE DAN COMO RESULTADO COMPOSICIONES ESPECIFICAS PARA LA FORMACION DE IMAGENES DEL TRACTO GASTROINTESTINAL, DEL BAZO, DEL HIGADO O ESTADO DE ENFERMEDAD EN DIFERENTES TEJIDOS. DEPENDIENDO DE LA TECNICA DE FORMACION DE IMAGENES DE DIAGNOSTICO, SE TRATAN LAS PARTICULAS PARA QUE SEAN PARAMAGNETICAS, RADIOOPACAS, O ECOGENICAS. LAS PARTICULAS DE APATITA PUEDEN ESTAR TAMBIEN FLUORADAS PARA FORMAR COMPOSICIONES DE FLUOROPATITA ESTABLES UTILES PARA LA FORMACION DE IMAGENES 19F. TAMBIEN SE PRESENTAN COMPOSICIONES DE DIAGNOSTICO Y METODOS PARA REALIZAR PROCEDIMIENTOS MEDICOS DE DIAGNOSTICO QUE COMPRENDEN LA ADMINISTRACION A UN ANIMAL DE SANGRE CALIENTE DE UNA CANTIDAD EFECTIVA PARA SU DIAGNOSTICO DE LAS PARTICULAS DE APATITA ANTES DESCRITAS Y LA REALIZACION POSTERIOR DE UN PROCEDIMIENTO DE DIAGNOSTICO MEDICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78432591A | 1991-10-22 | 1991-10-22 | |
US07/948,540 US5344640A (en) | 1991-10-22 | 1992-09-22 | Preparation of apatite particles for medical diagnostic imaging |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2152932T3 true ES2152932T3 (es) | 2001-02-16 |
Family
ID=27120269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92922461T Expired - Lifetime ES2152932T3 (es) | 1991-10-22 | 1992-10-21 | Particulas de apatita tratadas para tecnicas de imagen para diagnostico medico. |
Country Status (9)
Country | Link |
---|---|
US (4) | US5344640A (es) |
EP (1) | EP0610333B1 (es) |
JP (1) | JPH07500823A (es) |
AT (1) | ATE198423T1 (es) |
AU (2) | AU674291B2 (es) |
CA (1) | CA2120130A1 (es) |
DE (1) | DE69231627T2 (es) |
ES (1) | ES2152932T3 (es) |
WO (1) | WO1993007905A2 (es) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
RU2114637C1 (ru) * | 1991-09-17 | 1998-07-10 | Сонус Фармасьютикалз, Инк. | Биосовместимая контрастная среда и способ получения ультразвукового изображения |
US5407659A (en) * | 1991-10-22 | 1995-04-18 | Mallinckrodt Medical, Inc. | Treated calcium/oxyanion-containing particles for medical diagnostic imaging |
US5560902A (en) * | 1991-10-22 | 1996-10-01 | Mallinckrodt Medical, Inc. | Microfluidization of radioactive calcium/oxyanion-containing particles |
US5401492A (en) * | 1992-12-17 | 1995-03-28 | Sterling Winthrop, Inc. | Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents |
US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
CZ191695A3 (en) * | 1993-01-25 | 1996-05-15 | Sonus Pharma Inc | Biologically compatible contrast agent, process of its preparation and representation method by ultrasound |
IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
JPH0797340A (ja) * | 1993-06-03 | 1995-04-11 | Terumo Corp | Mri造影剤組成物 |
JPH09511520A (ja) * | 1994-04-11 | 1997-11-18 | マリンクロッド・メディカル・インコーポレイテッド | カルシウム/オキシアニオン含有粒子の微流体化 |
DE19500665A1 (de) * | 1995-01-12 | 1996-07-18 | Axel Prof Dr Haase | Verfahren zur ortsauflösenden Abbildung eines Bereiches eines biologischen Objektes mit Hilfe elektromagnetischer Strahlen unter Applikation von Kontrastmittel |
US5520904A (en) * | 1995-01-27 | 1996-05-28 | Mallinckrodt Medical, Inc. | Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging |
CN1138825C (zh) * | 1995-07-12 | 2004-02-18 | 丸尾钙株式会社 | 合成树脂用添加剂及合成树脂组成物 |
ATE266426T1 (de) * | 1996-03-05 | 2004-05-15 | Acusphere Inc | Mikroverkapselte fluorierte gase zur anwendung als bilderzeugende mittel |
DE29608321U1 (de) * | 1996-05-08 | 1996-08-08 | Aesculap Ag, 78532 Tuttlingen | Markierungselement |
US20070092563A1 (en) | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US6106473A (en) * | 1996-11-06 | 2000-08-22 | Sts Biopolymers, Inc. | Echogenic coatings |
US7229413B2 (en) * | 1996-11-06 | 2007-06-12 | Angiotech Biocoatings Corp. | Echogenic coatings with overcoat |
EP0950686B1 (en) * | 1996-12-27 | 2004-09-22 | Maruo Calcium Company Limited | Synthetic resin composition |
US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
JP2002510656A (ja) * | 1998-04-03 | 2002-04-09 | デュポン ファーマシューティカルズ カンパニー | 放射性薬物デリバリーシステム用無機物質 |
US5921933A (en) * | 1998-08-17 | 1999-07-13 | Medtronic, Inc. | Medical devices with echogenic coatings |
US5980863A (en) * | 1998-11-02 | 1999-11-09 | Eagle Vision Pharmaceutical Corporation | Manganese compositions and methods for MRI |
US6203778B1 (en) | 1998-12-08 | 2001-03-20 | The Regents Of The University Of California | Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization |
US20090216118A1 (en) | 2007-07-26 | 2009-08-27 | Senorx, Inc. | Polysaccharide markers |
US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
US7983734B2 (en) | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
US7651505B2 (en) | 2002-06-17 | 2010-01-26 | Senorx, Inc. | Plugged tip delivery for marker placement |
US8498693B2 (en) * | 1999-02-02 | 2013-07-30 | Senorx, Inc. | Intracorporeal marker and marker delivery device |
US6575991B1 (en) | 1999-06-17 | 2003-06-10 | Inrad, Inc. | Apparatus for the percutaneous marking of a lesion |
CA2659484C (en) | 2000-11-20 | 2013-01-08 | Senorx, Inc. | Tissue site markers for in vivo imaging |
WO2002087629A1 (en) * | 2001-04-26 | 2002-11-07 | Analogic Corporation | Ct scanner for imaging a preselected portion of a patient |
US6975896B2 (en) | 2002-05-23 | 2005-12-13 | Koninklijke Philips Electronics N.V. | Fiducial markers for MRI |
US20060036158A1 (en) | 2003-11-17 | 2006-02-16 | Inrad, Inc. | Self-contained, self-piercing, side-expelling marking apparatus |
AU2003299565A1 (en) * | 2002-11-27 | 2004-06-23 | Board Of Regents, The University Of Texas System | Radiopharmaceuticals and radioactive microspheres for locoregional ablation of abnormal tissues |
US20040170692A1 (en) * | 2003-02-12 | 2004-09-02 | The Curators Of The University Of Missouri | Calcium phosphate bodies and a process for making calcium phosphate bodies |
US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
US7081366B2 (en) * | 2003-06-02 | 2006-07-25 | Northrop Grumman Corporation | Uniform bead dosing from a stable dispersion |
US20050273002A1 (en) | 2004-06-04 | 2005-12-08 | Goosen Ryan L | Multi-mode imaging marker |
US8142758B2 (en) * | 2004-02-20 | 2012-03-27 | Algeta As | Alpha-emitting hydroxyapatite particles |
CN100427142C (zh) * | 2005-01-10 | 2008-10-22 | 重庆海扶(Hifu)技术有限公司 | 一种高强度聚焦超声治疗用助剂及其筛选方法 |
CN100574810C (zh) * | 2005-01-10 | 2009-12-30 | 重庆海扶(Hifu)技术有限公司 | 一种高强度聚焦超声治疗用质粒类助剂及其应用 |
US20100041983A9 (en) * | 2005-04-04 | 2010-02-18 | Elisha Rabinovitz | Device and method for pathology detection |
US10357328B2 (en) | 2005-04-20 | 2019-07-23 | Bard Peripheral Vascular, Inc. and Bard Shannon Limited | Marking device with retractable cannula |
US20060293581A1 (en) * | 2005-05-12 | 2006-12-28 | Sunnybrook And Women's College Health Sciences Centre | Marker device for X-ray, ultrasound and MR imaging |
CA2562580C (en) | 2005-10-07 | 2014-04-29 | Inrad, Inc. | Drug-eluting tissue marker |
US11241296B2 (en) | 2005-11-17 | 2022-02-08 | Breast-Med, Inc. | Imaging fiducial markers and methods |
US7702378B2 (en) | 2005-11-17 | 2010-04-20 | Breast-Med, Inc. | Tissue marker for multimodality radiographic imaging |
CA2638833A1 (en) * | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
US20070258903A1 (en) * | 2006-05-02 | 2007-11-08 | Kleiner Lothar W | Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers |
GB2442000A (en) | 2006-06-07 | 2008-03-26 | Apatech Ltd | Biomedical materials containing gadolinium |
US20080038190A1 (en) * | 2006-08-11 | 2008-02-14 | Simpson Thomas J | Composition apparatus and method for use in imaging |
WO2008073965A2 (en) | 2006-12-12 | 2008-06-19 | C.R. Bard Inc. | Multiple imaging mode tissue marker |
WO2008076973A2 (en) | 2006-12-18 | 2008-06-26 | C.R.Bard Inc. | Biopsy marker with in situ-generated imaging properties |
JP5074803B2 (ja) * | 2007-03-30 | 2012-11-14 | ニプロ株式会社 | エコー造影可能な金属針 |
FR2922454B1 (fr) * | 2007-10-22 | 2010-01-01 | Biomatlante | Substitut osseux comprenant un agent de contraste, son procede de preparation et ses utilisations |
US9327061B2 (en) | 2008-09-23 | 2016-05-03 | Senorx, Inc. | Porous bioabsorbable implant |
JP5458231B2 (ja) * | 2008-09-30 | 2014-04-02 | HOYA Technosurgical株式会社 | フッ素アパタイト粉体の製造方法、フッ素アパタイト粉体および吸着装置 |
US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US20110190662A1 (en) * | 2008-10-01 | 2011-08-04 | Beacon Endoscopic Corporation | Rapid exchange fna biopsy device with diagnostic and therapeutic capabilities |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
CA2742765C (en) | 2008-12-30 | 2016-04-12 | C.R. Bard Inc. | Marker delivery device for tissue marker placement |
US20100204570A1 (en) * | 2009-02-06 | 2010-08-12 | Paul Lubock | Anchor markers |
US8894958B2 (en) * | 2009-03-03 | 2014-11-25 | Centre National De La Recherche Scientifique (C.N.R.S.) | Galliated calcium phosphate biomaterials |
EP2228079A1 (en) * | 2009-03-03 | 2010-09-15 | Graftys | Gallium-doped phosphocalcic compounds |
EP2228080A1 (en) * | 2009-03-03 | 2010-09-15 | Graftys | Galliated calcium phosphate biomaterials |
US8623311B2 (en) | 2009-03-03 | 2014-01-07 | Graftys | Gallium-doped phosphocalcic compounds |
US9039784B2 (en) * | 2009-07-28 | 2015-05-26 | Southwest Research Institute | Micro-structure particles for load bearing bone growth |
EP2488100A1 (en) * | 2009-10-15 | 2012-08-22 | Koninklijke Philips Electronics N.V. | Spectral magnetic particle imaging |
US20130017155A1 (en) * | 2010-04-01 | 2013-01-17 | Kevin Bennett | Dual ct/mri nanoparticle contrast agent |
IT1401487B1 (it) * | 2010-07-29 | 2013-07-26 | Consiglio Nazionale Ricerche | Idrossiapatite intrinsecamente magnetica |
US9849200B2 (en) | 2010-09-16 | 2017-12-26 | Mo-Sci Corporation | Strontium phosphate microparticle for radiological imaging and therapy |
US8865123B1 (en) | 2010-09-16 | 2014-10-21 | Mo-Sci Corporation | Strontium phosphate microparticle for radiological imaging and therapy |
US9119887B2 (en) | 2010-09-16 | 2015-09-01 | Mo-Sci Corporation | Low-density magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging |
WO2014141288A1 (en) | 2013-03-12 | 2014-09-18 | Amrita Vishwa Vidyapeetham University | The art, method, manner, process and system of a nano-biomineral for multi-modal contrast imaging and drug delivery |
WO2014141287A1 (en) | 2013-03-12 | 2014-09-18 | Amrita Vishwa Vidyapeetham University | The art, method, manner, process and system of multifunctional nanobiomaterial for molecular imaging and drug- delivery |
USD716450S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD715942S1 (en) | 2013-09-24 | 2014-10-21 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716451S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD715442S1 (en) | 2013-09-24 | 2014-10-14 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
US9795455B2 (en) | 2014-08-22 | 2017-10-24 | Breast-Med, Inc. | Tissue marker for multimodality radiographic imaging |
US11369681B2 (en) | 2015-12-03 | 2022-06-28 | Amrita Vishwa Vidyapeetham | Radio-wave responsive doped nanoparticles for image-guided therapeutics |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3505239A (en) * | 1966-07-26 | 1970-04-07 | Westinghouse Electric Corp | Crystal laser material |
US4079124A (en) * | 1976-04-21 | 1978-03-14 | Medi-Physics, Inc. | Method of preparing X-ray contrast media containing ores of hafnium, tantalum and tungsten |
DE2724814C3 (de) * | 1977-06-02 | 1980-03-27 | Kulzer & Co Gmbh, 6380 Bad Homburg | Vorprodukt fur die Zubereitung von Knochenzement |
US4243652A (en) * | 1978-07-14 | 1981-01-06 | The Procter & Gamble Company | Gastrointestinal scanning agent |
US4681119A (en) * | 1980-11-17 | 1987-07-21 | Schering Aktiengesellschaft | Method of production and use of microbubble precursors |
FR2509611B1 (fr) * | 1981-07-20 | 1986-07-18 | Fabre Sa Pierre | Nouvel agent anti-acide et composition pharmaceutique le contenant |
CA1193087A (en) * | 1982-04-20 | 1985-09-10 | Thomas E. Peters | Ce-mn coactivated fluoroapatite phosphors as the yellow emitting component for high efficacy lamp blends, process for producing same, and a fluorescent lamp containing same |
CA1222947A (en) * | 1982-04-23 | 1987-06-16 | Finn N. Christensen | Composition and method for investigating alimentary functions |
US4635643A (en) * | 1982-09-28 | 1987-01-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Assay method for the in vivo quantitative determination of mineral content in bone |
US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
SE463651B (sv) * | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
FR2568238B1 (fr) * | 1984-07-24 | 1988-06-24 | Centre Nat Rech Scient | Apatite de terres rares, procedes de preparation et applications |
US4680171A (en) * | 1985-03-15 | 1987-07-14 | William Shell | Visualization of a bloodstream circulation with biodegradable microspheres |
US5186922A (en) * | 1985-03-15 | 1993-02-16 | See/Shell Biotechnology, Inc. | Use of biodegradable microspheres labeled with imaging energy constrast materials |
GB8518300D0 (en) * | 1985-07-19 | 1985-08-29 | Amersham Int Plc | Contrast agent |
GB8522535D0 (en) * | 1985-09-11 | 1985-10-16 | Amersham Int Plc | Contrast agent |
US4709703A (en) * | 1985-11-12 | 1987-12-01 | Mayo Foundation | Imaging system and method using radiopaque microspheres for evaluation of organ tissue perfusion |
DE3542972A1 (de) * | 1985-12-05 | 1987-06-11 | Merck Patent Gmbh | Pharmakadepot |
US4888248A (en) * | 1986-07-01 | 1989-12-19 | Hidefumi Hirai | Colloidal metal dispersion, and a colloidal metal complex |
GB8701054D0 (en) * | 1987-01-16 | 1987-02-18 | Amersham Int Plc | Contrast agent for nmr scanning |
DE3709851A1 (de) * | 1987-03-24 | 1988-10-06 | Silica Gel Gmbh Adsorptions Te | Nmr-diagnostische fluessigkeitszusammensetzungen |
US5047031A (en) * | 1988-04-20 | 1991-09-10 | Norian Corporation | In situ calcium phosphate minerals method |
ATE117829T1 (de) * | 1988-05-24 | 1995-02-15 | Anagen Uk Ltd | Magnetisch anziehbare teilchen und herstellungsverfahren. |
JPH0288059A (ja) * | 1988-09-26 | 1990-03-28 | Univ Kyoto | 温熱療法用セラミックス発熱体及びその製造方法 |
US5009898A (en) * | 1988-09-29 | 1991-04-23 | Kabushiki Kaisha Sangi | Antimicrobial hydroxyapatite powders and methods for preparing them |
EP0376331A3 (en) * | 1988-12-29 | 1991-03-13 | Asahi Kogaku Kogyo Kabushiki Kaisha | Slow release drug delivery granules and process for production thereof |
US5081997A (en) * | 1989-03-09 | 1992-01-21 | Vance Products Incorporated | Echogenic devices, material and method |
DD291982A5 (de) * | 1990-02-12 | 1991-07-18 | ���������`��������`����@����k�� | Apatitglaskeramik, vorzugsweise fuer dentale glasionomerzemente |
US5236693A (en) * | 1990-11-14 | 1993-08-17 | Brigham And Women's Hospital | Medical ultrasound contrast agent and method of using same |
US5122363A (en) * | 1990-12-07 | 1992-06-16 | Board Of Regents, The University Of Texas System | Zeolite-enclosed transistion and rare earth metal ions as contrast agents for the gastrointestinal tract |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5179955A (en) * | 1991-02-22 | 1993-01-19 | Molecular Biosystems, Inc. | Method of abdominal ultrasound imaging |
US5330742A (en) * | 1991-08-05 | 1994-07-19 | Mallinckrodt Medical, Inc. | Methods and compositions for magnetic resonance imaging |
US5342609A (en) * | 1991-10-22 | 1994-08-30 | Mallinckrodt Medical, Inc. | Microfluidization of calcium/oxyanion-containing particles |
US5407659A (en) * | 1991-10-22 | 1995-04-18 | Mallinckrodt Medical, Inc. | Treated calcium/oxyanion-containing particles for medical diagnostic imaging |
-
1992
- 1992-09-22 US US07/948,540 patent/US5344640A/en not_active Expired - Fee Related
- 1992-10-21 CA CA002120130A patent/CA2120130A1/en not_active Abandoned
- 1992-10-21 ES ES92922461T patent/ES2152932T3/es not_active Expired - Lifetime
- 1992-10-21 DE DE69231627T patent/DE69231627T2/de not_active Expired - Fee Related
- 1992-10-21 EP EP92922461A patent/EP0610333B1/en not_active Expired - Lifetime
- 1992-10-21 WO PCT/US1992/009032 patent/WO1993007905A2/en active IP Right Grant
- 1992-10-21 AT AT92922461T patent/ATE198423T1/de not_active IP Right Cessation
- 1992-10-21 JP JP5507914A patent/JPH07500823A/ja not_active Ceased
- 1992-10-21 AU AU28864/92A patent/AU674291B2/en not_active Ceased
-
1994
- 1994-07-06 US US08/271,921 patent/US5468465A/en not_active Expired - Fee Related
-
1995
- 1995-08-22 US US08/518,124 patent/US5609850A/en not_active Expired - Fee Related
- 1995-11-13 US US08/557,759 patent/US5690908A/en not_active Expired - Fee Related
-
1996
- 1996-10-22 AU AU70345/96A patent/AU686523B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2120130A1 (en) | 1993-04-29 |
WO1993007905A3 (en) | 1993-08-05 |
DE69231627T2 (de) | 2001-04-26 |
JPH07500823A (ja) | 1995-01-26 |
EP0610333A1 (en) | 1994-08-17 |
US5609850A (en) | 1997-03-11 |
AU686523B2 (en) | 1998-02-05 |
AU7034596A (en) | 1997-01-23 |
US5690908A (en) | 1997-11-25 |
ATE198423T1 (de) | 2001-01-15 |
WO1993007905A2 (en) | 1993-04-29 |
US5468465A (en) | 1995-11-21 |
AU674291B2 (en) | 1996-12-19 |
EP0610333B1 (en) | 2001-01-03 |
DE69231627D1 (de) | 2001-02-08 |
US5344640A (en) | 1994-09-06 |
AU2886492A (en) | 1993-05-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2152932T3 (es) | Particulas de apatita tratadas para tecnicas de imagen para diagnostico medico. | |
Feng et al. | Biologically Excretable Aggregation‐Induced Emission Dots for Visualizing through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine | |
Rizzo et al. | Diagnosis of occult fractures about the hip. Magnetic resonance imaging compared with bone-scanning. | |
NO970665L (no) | Blod billeddannende sammensetninger, anvendelse og fremgangsmåte | |
Montenegro et al. | Neuroimaging of acute cerebellitis | |
Tournissac et al. | Cranial window for longitudinal and multimodal imaging of the whole mouse cortex | |
Komatsu et al. | A novel model of ischemia in rats with middle cerebral artery occlusion using a microcatheter and zirconia ball under fluoroscopy | |
Hecht-Leavitt et al. | MR of brain radiation injury: experimental studies in cats. | |
Inui et al. | Activation of efferents from the basolateral amygdala during the retrieval of conditioned taste aversion | |
Carlson et al. | Treatment of dysphasia with rTMS and language therapy after childhood stroke: multimodal imaging of plastic change | |
Das et al. | Real-time fluorescence imaging in thoracic surgery | |
Wayman et al. | Gadolinium‐DTPA‐Enhanced magnetic resonance scanning in cerebellopontine angle tumors | |
CN108335338A (zh) | 实验动物体多模融合成像系统及使用方法 | |
Tang et al. | From light to sound: photoacoustic and ultrasound imaging in fundamental research of Alzheimer’s disease | |
Tokue et al. | Phosphoglyceride crystal deposition disease mimicking a malignant tumor | |
Feng et al. | Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine | |
Sridharan et al. | Translational research in pediatric contrast-enhanced ultrasound | |
Zagzoog et al. | Perspective review on applications of optics in skull base surgery | |
Thomas | Arterial spin labelling perfusion imaging of the brain: Sree Chitra experience | |
Garborg | Understanding the nature and drivers of brain motion in a behaving mouse model | |
Rajendran | Advancing photoacoustic tomography using deep learning | |
Choi et al. | Magnetic Resonance Imaging Meets Fiber Optics: a Brief Investigation of Multimodal Studies on Fiber Optics-Based Diagnostic/Therapeutic Techniques and Magnetic Resonance Imaging | |
Smith | Update on advanced imaging techniques applicable for lesions within long bones in equines | |
Nye et al. | Mammographic appearance of calcinosis in dermatomyositis. | |
Airewele et al. | Lesion regression |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 610333 Country of ref document: ES |