ES2176237T3 - Derivados de taxano c2 y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de taxano c2 y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2176237T3
ES2176237T3 ES94907959T ES94907959T ES2176237T3 ES 2176237 T3 ES2176237 T3 ES 2176237T3 ES 94907959 T ES94907959 T ES 94907959T ES 94907959 T ES94907959 T ES 94907959T ES 2176237 T3 ES2176237 T3 ES 2176237T3
Authority
ES
Spain
Prior art keywords
derivatives
taxano
contain
pharmaceutical compositions
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94907959T
Other languages
English (en)
Inventor
Robert A Holton
Chunlin Tao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/010,798 external-priority patent/US5399726A/en
Application filed by Florida State University filed Critical Florida State University
Application granted granted Critical
Publication of ES2176237T3 publication Critical patent/ES2176237T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE TAXANO CON SUSTITUYENTE C2 ALTERNATIVO QUE ES -OCOR31, EN DONDE R31 ES FENILO SUSTITUIDO Y EL SUSTITUYENTE ES SELECCIONADO DE UN GRUPO QUE SE COMPONE DE ALCANOXIL, HIDROXIL PROTEGIDO, HALOGENO, ALKILO, ARILO, ALKENILO, ACILO, ACILOXILO, NITRO, AMINO Y AMIDO.
ES94907959T 1993-01-29 1994-01-28 Derivados de taxano c2 y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2176237T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/010,798 US5399726A (en) 1993-01-29 1993-01-29 Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US3485293A 1993-03-22 1993-03-22
US9471593A 1993-07-20 1993-07-20

Publications (1)

Publication Number Publication Date
ES2176237T3 true ES2176237T3 (es) 2002-12-01

Family

ID=27359309

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94907959T Expired - Lifetime ES2176237T3 (es) 1993-01-29 1994-01-28 Derivados de taxano c2 y composiciones farmaceuticas que los contienen.

Country Status (13)

Country Link
EP (2) EP0681573B1 (es)
JP (2) JP3452928B2 (es)
CN (1) CN1125061C (es)
AT (2) ATE220064T1 (es)
AU (2) AU685778B2 (es)
CA (2) CA2155013C (es)
DE (2) DE69430902T2 (es)
DK (1) DK0681573T3 (es)
ES (1) ES2176237T3 (es)
IL (1) IL108444A0 (es)
PT (1) PT681573E (es)
TW (2) TW360646B (es)
WO (2) WO1994017052A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
FR2702212B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
WO1998013359A1 (de) * 1996-09-24 1998-04-02 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
HUP0101457A3 (en) * 1997-12-31 2003-01-28 Bristol Myers Squibb Co Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
EP1747209A4 (en) * 2004-05-14 2007-12-12 Immunogen Inc A SIMPLE METHOD OF SYNTHESIZING BACCATINE III COMPOUNDS
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN104250235B (zh) * 2014-09-24 2016-10-05 江苏红豆杉药业有限公司 一种紫杉醇的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol

Also Published As

Publication number Publication date
JP3452928B2 (ja) 2003-10-06
EP0681575B1 (en) 2002-05-22
AU6132794A (en) 1994-08-15
WO1994017051A1 (en) 1994-08-04
JPH10502327A (ja) 1998-03-03
WO1994017052A1 (en) 1994-08-04
AU6234094A (en) 1994-08-15
CA2155013C (en) 2006-04-11
DE69430661T2 (de) 2002-10-24
CN1125061C (zh) 2003-10-22
DK0681573T3 (da) 2002-10-28
TW360646B (en) 1999-06-11
TW402598B (en) 2000-08-21
IL108444A0 (en) 1994-04-12
CA2155014C (en) 2007-06-26
DE69430902D1 (de) 2002-08-08
AU685778B2 (en) 1998-01-29
DE69430661D1 (de) 2002-06-27
PT681573E (pt) 2002-11-29
CA2155013A1 (en) 1994-08-04
CA2155014A1 (en) 1994-08-04
ATE217870T1 (de) 2002-06-15
EP0681573B1 (en) 2002-07-03
JPH08506326A (ja) 1996-07-09
ATE220064T1 (de) 2002-07-15
CN1101346A (zh) 1995-04-12
DE69430902T2 (de) 2002-10-24
AU684268B2 (en) 1997-12-11
EP0681575A4 (es) 1995-12-13
EP0681573A4 (es) 1995-12-06
JP3741715B2 (ja) 2006-02-01
EP0681573A1 (en) 1995-11-15
EP0681575A1 (en) 1995-11-15

Similar Documents

Publication Publication Date Title
NL350077I1 (nl) Cyprosulfamide
DE69430611T2 (de) Phosphonooxymethyl oder Methylthiomethylether von Taxanderivaten als Antitumormittel
MX9203576A (es) Derivados de 3-amido pirazol y composiciones farmaceuticas que los contienen.
MX9300498A (es) Derivados de n-sulfonil-2-oxo-indol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
YU40997A (sh) Novi oksadiazoli, postupci za njihovo pripremanje
NO955256L (no) Fenylheterosykluser som syklooksygenase-2-inhibitorer
ES2176237T3 (es) Derivados de taxano c2 y composiciones farmaceuticas que los contienen.
DE69317764T2 (de) Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
UA26427A (uk) Похідhі ксаhтиhу у вигляді суміші ізомерів або іhдивідуальhих ізомерів, що мають властивість аhтагоhіста адеhозиhу
MX9304756A (es) 9-[(glicilo substituido)amido]-6-desmetil-6-desoxitetraciclinas, metodo para su produccion y composiciones farmaceuticas que las contienen.
FI914723A0 (fi) 17b-substituerade 4-aza-5a-androstan -3-jon-derivat och foerfarande foer framstaellning av desamma.
BR9711586A (pt) Compostos e uso dos mesmo
DK0982992T3 (da) Anvendelse af thienopyrimidiner som fungicider
ES2122637T3 (es) Derivados de tiazolidina, su preparacion y los medicamentos que les contienen.
MX9306227A (es) Nuevos derivados de taxano, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2191029T3 (es) Derivados de taxano c7 y composiciones farmaceuticas que los contienen.
TR199800182T1 (xx) 2-oksazolidinon t�revlerinin bir kapta sentezi.
PT789590E (pt) Imunopotenciacao induzida por quitosano
MX9300628A (es) Nuevos derivados de taxano, procedimiento para su preparacion y composicion farmaceutica que los contiene.
SE9801494D0 (sv) Novel use
MX9203845A (es) Nuevos benzomorfanos, procedimieto para su preparacion y composiciones farmaceuticas que los contienen.
FI950842A (fi) Enkefalinaasin inhibiittoreina käyttökelpoisia uusia 2-substituoituja trisyklisiä indaani-2-merkaptoasetyyliamidijohdannaisia
UY24915A1 (es) Derivados de benzoxazindiona, aplicación de los mismos y medicamentos que los contienen
ES2164454T3 (es) Nuevos compuestos derivados de acido alquilendiamina di o tri-acetico, su procedimiento de preparacion, su utilizacion en composiciones cosmeticas y farmaceuticas y composiciones que los contienen.
MX9203383A (es) Nuevos derivados de piridobenzoindol y composiciones farmaceuticas que los contienen.