ES2173230T3 - Procedimiento para la preparacion de derivados de n-etil-glicina sustituidos. - Google Patents

Procedimiento para la preparacion de derivados de n-etil-glicina sustituidos.

Info

Publication number
ES2173230T3
ES2173230T3 ES96113530T ES96113530T ES2173230T3 ES 2173230 T3 ES2173230 T3 ES 2173230T3 ES 96113530 T ES96113530 T ES 96113530T ES 96113530 T ES96113530 T ES 96113530T ES 2173230 T3 ES2173230 T3 ES 2173230T3
Authority
ES
Spain
Prior art keywords
acid
formula
protecting
labile
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96113530T
Other languages
English (en)
Inventor
Gerhard Breipohl
Eugen Uhlmann
David William Will
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2173230T3 publication Critical patent/ES2173230T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN PROCEDIMIENTOS PARA LA OBTENCION DE DERIVADOS DE N-ETIL-GLICINA DE FORMULA EN DONDE PG ES UN GRUPO LABIL DE PROTECCION DE AMINO CONTRA ACIDOS DEBILES DEL TIPO DE URETANO O DEL TIPO DEL TRITILO, X ES NH O O, Y B{SUP,''} SON BASES USUALES EN LA QUIMICA DE LOS NUCLEOTIDOS, CUYOS GRUPOS AMINO O HIDROXILO EXOCICLICOS ESTAN PROTEGIDOS POR GRUPOS PROTECTORES CONOCIDOS Y APROPIADOS; ASI COMO SUS SALES. EL PROCEDIMIENTO SE CARACTERIZA PORQUE SE HACE REACCIONAR UN COMPUESTO DE FORMULA EN DONDE R ES HIDROGENO, O SI X = NH, ES UN GRUPO LABIL DE PROTECCION DE ACIDOS Y R{SUP,1} ES UN GRUPO DE PROTECCION LABIL CONTRA ACIDOS Y ESTABLE CONTRA AMINAS, Y X ESTA DEFINIDO COM ANTES, CON UN COMPUESTO DE FORMULA A 0 - 45 C EN UN DISOLVENTE APROPIADO UTILIZANDO UN REACTIVO DE UNION USUAL EN LA QUIMICA DE LOS PEPTIDOS PARA DAR UN COMPUESTO DE FORMULA A CONTINUACION POR DESPRENDIMIENTO DEL GRUPO DE PROTECCION DE ESTER R{SUP,1} LABIL A LOS ACIDOS, O PARA X = NH POR DESPRENDIMIENTO SIMULTANEO DEL GRUPO DEPROTECCION R LABIL A LOS ACIDOS BAJO CONDICIONES ACIDAS APROPIADAS Y EN UN DISOLVENTE APROPIADO OPCIONALMENTE CON ADICION DE CAPTADORES DE CATIONES, SE TRANSFORMA EN UN COMPUESTO DE FORMULA, Y ESTE SE TRANSFORMA CON UN REACTIVO APROPIADO EN UN DISOLVENTE APROPIADO Y UTILIZANDO UNA BASE AUXILIAR EN EL COMPUESTO DEL TITULO, Y A CONTINUACION OPCIONALMENTE EN SUS SALES.
ES96113530T 1995-09-04 1996-08-22 Procedimiento para la preparacion de derivados de n-etil-glicina sustituidos. Expired - Lifetime ES2173230T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19532553A DE19532553A1 (de) 1995-09-04 1995-09-04 Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate

Publications (1)

Publication Number Publication Date
ES2173230T3 true ES2173230T3 (es) 2002-10-16

Family

ID=7771182

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96113530T Expired - Lifetime ES2173230T3 (es) 1995-09-04 1996-08-22 Procedimiento para la preparacion de derivados de n-etil-glicina sustituidos.

Country Status (11)

Country Link
US (1) US5817811A (es)
EP (1) EP0761681B1 (es)
JP (1) JP3934708B2 (es)
AT (1) ATE214398T1 (es)
AU (1) AU708034B2 (es)
CA (1) CA2184681C (es)
DE (2) DE19532553A1 (es)
DK (1) DK0761681T3 (es)
ES (1) ES2173230T3 (es)
NO (1) NO313833B1 (es)
PT (1) PT761681E (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710164B1 (en) 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
CA2241331C (en) * 1995-12-22 2003-06-17 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
US6043353A (en) * 1995-12-22 2000-03-28 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
CA2261566A1 (en) * 1996-07-24 1998-01-29 Buchardt, Dorte Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US6977244B2 (en) * 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
DE19640974A1 (de) * 1996-10-04 1998-04-16 Bayer Ag Bausteine für DNA/PNA-Cooligomere
CZ299816B6 (cs) * 1997-05-14 2008-12-03 Morphochem Ag Isonitrilové slouceniny pro výrobu polymeru, které obsahují nukleové báze jako postranní skupiny
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7135564B1 (en) * 1998-07-02 2006-11-14 University Technologies International Inc. Reusable solid support for oligonucleotide synthesis
WO2000002899A1 (en) * 1998-07-09 2000-01-20 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
HUP0203338A2 (hu) * 1999-04-13 2003-03-28 Abbott Gmbh & Co. Kg Integrin receptor ligandumok
ATE346950T1 (de) * 2001-03-09 2006-12-15 Boston Probes Inc Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
US6541626B2 (en) * 2001-04-17 2003-04-01 Isis Pharmaceuticals, Inc. Process for selective N-acylation of purine nucleosides
KR20030084444A (ko) * 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
EP1576188B1 (en) * 2002-11-21 2008-10-15 Epicentre Technologies Methods for using riboprimers for strand displacement replication of target sequences
KR101354692B1 (ko) * 2010-11-26 2014-02-06 서울대학교산학협력단 올리고머 및 그 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0840741B1 (en) * 1995-06-07 2004-04-28 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation

Also Published As

Publication number Publication date
ATE214398T1 (de) 2002-03-15
JPH09124572A (ja) 1997-05-13
NO963677D0 (no) 1996-09-03
EP0761681B1 (de) 2002-03-13
DE59608867D1 (de) 2002-04-18
NO313833B1 (no) 2002-12-09
JP3934708B2 (ja) 2007-06-20
PT761681E (pt) 2002-08-30
NO963677L (no) 1997-03-05
AU6440896A (en) 1997-03-06
AU708034B2 (en) 1999-07-29
DE19532553A1 (de) 1997-03-06
CA2184681C (en) 2010-01-05
CA2184681A1 (en) 1997-03-05
EP0761681A2 (de) 1997-03-12
EP0761681A3 (de) 1997-07-09
DK0761681T3 (da) 2002-07-08
US5817811A (en) 1998-10-06

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