DE69027440D1 - Bizyklische pyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung - Google Patents
Bizyklische pyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungInfo
- Publication number
- DE69027440D1 DE69027440D1 DE69027440T DE69027440T DE69027440D1 DE 69027440 D1 DE69027440 D1 DE 69027440D1 DE 69027440 T DE69027440 T DE 69027440T DE 69027440 T DE69027440 T DE 69027440T DE 69027440 D1 DE69027440 D1 DE 69027440D1
- Authority
- DE
- Germany
- Prior art keywords
- bizyclic
- production
- pharmaceutical composition
- composition containing
- pyrimidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26476389 | 1989-10-11 | ||
PCT/JP1990/001313 WO1991005784A1 (fr) | 1989-10-11 | 1990-10-11 | Derive de pyrimidine bicyclique, procede de production et preparation pharmaceutique le contenant en tant qu'ingredient actif |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69027440D1 true DE69027440D1 (de) | 1996-07-18 |
DE69027440T2 DE69027440T2 (de) | 1997-02-06 |
Family
ID=17407851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69027440T Expired - Fee Related DE69027440T2 (de) | 1989-10-11 | 1990-10-11 | Bizyklische pyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung |
Country Status (11)
Country | Link |
---|---|
US (1) | US5378700A (de) |
EP (1) | EP0495982B1 (de) |
JP (1) | JP2541702B2 (de) |
KR (1) | KR0155955B1 (de) |
AT (1) | ATE139232T1 (de) |
AU (1) | AU645504B2 (de) |
CA (1) | CA2067221C (de) |
DE (1) | DE69027440T2 (de) |
DK (1) | DK0495982T3 (de) |
ES (1) | ES2087916T3 (de) |
WO (1) | WO1991005784A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU641183B2 (en) * | 1989-09-19 | 1993-09-16 | Teijin Limited | Pyrrolo(2,3-d)pyrimidine derivative, process for preparing the same, and pharmaceutical preparation comprising the derivative as active ingredient |
US5254716A (en) * | 1992-10-15 | 1993-10-19 | Eli Lilly And Company | Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines |
FR2699176B1 (fr) * | 1992-12-11 | 1995-03-03 | Adir | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
JPH10501532A (ja) * | 1994-06-09 | 1998-02-10 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗物質 |
EP0770080B1 (de) | 1995-05-12 | 1999-07-14 | Neurogen Corporation | Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden |
US6395733B1 (en) | 1995-06-07 | 2002-05-28 | Pfizer Inc | Heterocyclic ring-fused pyrimidine derivatives |
CA2223081C (en) * | 1995-06-07 | 2001-03-06 | Pfizer Inc. | Heterocyclic ring-fused pyrimidine derivatives |
AU6344396A (en) * | 1996-06-28 | 1998-01-21 | James E. Dowling | 5,6,7,8-tetrahydropyrimido{4,5-b}azepine derivatives |
US6339089B2 (en) * | 1997-08-13 | 2002-01-15 | Fujirebio Inc. | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same |
EP1012151B1 (de) * | 1997-09-02 | 2002-08-07 | Bristol-Myers Squibb Pharma Company | Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress |
US6472402B1 (en) | 1998-04-02 | 2002-10-29 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives |
JP2002510686A (ja) | 1998-04-02 | 2002-04-09 | ニューロゲン コーポレイション | アミノアルキルで置換された5,6,7,8−テトラヒドロ−9H−ピリジノ[2,3−b]インドール及び5,6,7,8−テトラヒドロ−9Hピリミジノ[4,5−B]インドール誘導体:CRF1特異的配位子 |
WO1999064422A1 (en) | 1998-06-09 | 1999-12-16 | Neurogen Corporation | Pyrido[2,3-b]indolizine derivatives and aza analogues thereof; crf1 specific ligands |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
US20070021429A1 (en) * | 2003-04-09 | 2007-01-25 | Yves St-Denis | Condensed n-heterocyclic compounds and their use as crf receptor antagonists |
GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
ES2612196T3 (es) | 2005-12-13 | 2017-05-12 | Incyte Holdings Corporation | Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas Janus |
PL2050749T3 (pl) * | 2006-08-08 | 2018-03-30 | Chugai Seiyaku Kabushiki Kaisha | Pochodna pirymidyny jako inhibitor pi3k i jej zastosowanie |
MX342814B (es) | 2007-06-13 | 2016-10-13 | Incyte Holdings Corp | Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo. |
WO2009094123A1 (en) * | 2008-01-22 | 2009-07-30 | Merck Serono S.A. | Protein kinase inhibitors and use thereof |
TW200938201A (en) * | 2008-02-07 | 2009-09-16 | Chugai Pharmaceutical Co Ltd | Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof |
WO2009107767A1 (ja) * | 2008-02-29 | 2009-09-03 | 大日本住友製薬株式会社 | H4受容体アンタゴニスト作用を有する新規2環性ピリミジン誘導体 |
KR20120030447A (ko) | 2009-05-22 | 2012-03-28 | 인사이트 코포레이션 | Jak 저해물질로서 3-[4-(7h-피롤로[2,3-d]피리미딘-4-일)-1h-피라졸-1-일]옥탄- 또는 헵탄-니트릴 |
TW201113285A (en) * | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
RS60680B1 (sr) | 2010-03-10 | 2020-09-30 | Incyte Holdings Corp | Piperidin-4-il azetidin derivati kao inhibitori jak1 |
SG10201503983QA (en) | 2010-05-21 | 2015-06-29 | Incyte Corp | Topical Formulation for a JAK Inhibitor |
TW201249845A (en) | 2010-11-19 | 2012-12-16 | Incyte Corp | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
EP2640725B1 (de) | 2010-11-19 | 2015-01-07 | Incyte Corporation | Heterocyclensubstituierte pyrrolopyridine und pyrrolopyrimidine als jak-inhibitoren |
CA2819333A1 (en) | 2010-11-29 | 2012-06-07 | Galleon Pharmaceuticals, Inc. | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
US20120295911A1 (en) | 2010-11-29 | 2012-11-22 | Galleon Pharmaceuticals, Inc. | Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases |
MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
RS62329B1 (sr) | 2012-11-15 | 2021-10-29 | Incyte Holdings Corp | Dozni oblici ruksolitiniba sa produženim vremenom oslobađanja |
ES2900492T3 (es) | 2013-03-06 | 2022-03-17 | Incyte Holdings Corp | Procesos y productos intermedios para elaborar un inhibidor de JAK |
EA201690357A1 (ru) | 2013-08-07 | 2016-07-29 | Инсайт Корпорейшн | Лекарственные формы с замедленным высвобождением для ингибитора jak1 |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
CA3033752C (en) * | 2016-08-15 | 2022-05-31 | Purdue Research Foundation | 4-substituted aminoisoquinoline derivatives |
AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
SG11202007164UA (en) | 2018-01-30 | 2020-08-28 | Incyte Corp | Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
DK3773593T3 (da) | 2018-03-30 | 2024-05-27 | Incyte Corp | Behandling af hidradenitis suppurativa under anvendelse af JAK-inhibitorer |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3631045A (en) * | 1969-11-04 | 1971-12-28 | American Home Prod | 4 5-diamino-7h-pyrrolo(2 3-d)pyrimidine derivatives |
AU641183B2 (en) * | 1989-09-19 | 1993-09-16 | Teijin Limited | Pyrrolo(2,3-d)pyrimidine derivative, process for preparing the same, and pharmaceutical preparation comprising the derivative as active ingredient |
-
1990
- 1990-10-11 JP JP2513974A patent/JP2541702B2/ja not_active Expired - Fee Related
- 1990-10-11 CA CA002067221A patent/CA2067221C/en not_active Expired - Fee Related
- 1990-10-11 AT AT90914955T patent/ATE139232T1/de not_active IP Right Cessation
- 1990-10-11 AU AU65220/90A patent/AU645504B2/en not_active Ceased
- 1990-10-11 DE DE69027440T patent/DE69027440T2/de not_active Expired - Fee Related
- 1990-10-11 KR KR1019920700846A patent/KR0155955B1/ko not_active IP Right Cessation
- 1990-10-11 ES ES90914955T patent/ES2087916T3/es not_active Expired - Lifetime
- 1990-10-11 US US07/839,769 patent/US5378700A/en not_active Expired - Fee Related
- 1990-10-11 EP EP90914955A patent/EP0495982B1/de not_active Expired - Lifetime
- 1990-10-11 WO PCT/JP1990/001313 patent/WO1991005784A1/ja active IP Right Grant
- 1990-10-11 DK DK90914955.1T patent/DK0495982T3/da active
Also Published As
Publication number | Publication date |
---|---|
DK0495982T3 (da) | 1996-07-01 |
KR0155955B1 (ko) | 1998-11-16 |
ATE139232T1 (de) | 1996-06-15 |
CA2067221C (en) | 1997-04-15 |
WO1991005784A1 (fr) | 1991-05-02 |
EP0495982B1 (de) | 1996-06-12 |
AU645504B2 (en) | 1994-01-20 |
JP2541702B2 (ja) | 1996-10-09 |
ES2087916T3 (es) | 1996-08-01 |
AU6522090A (en) | 1991-05-16 |
EP0495982A4 (en) | 1994-07-20 |
CA2067221A1 (en) | 1991-04-12 |
US5378700A (en) | 1995-01-03 |
EP0495982A1 (de) | 1992-07-29 |
DE69027440T2 (de) | 1997-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |