ES2172829T3 - Derivados del nitrometiltiobenceno como inhibidores de la aldosa reductasa. - Google Patents
Derivados del nitrometiltiobenceno como inhibidores de la aldosa reductasa.Info
- Publication number
- ES2172829T3 ES2172829T3 ES97953797T ES97953797T ES2172829T3 ES 2172829 T3 ES2172829 T3 ES 2172829T3 ES 97953797 T ES97953797 T ES 97953797T ES 97953797 T ES97953797 T ES 97953797T ES 2172829 T3 ES2172829 T3 ES 2172829T3
- Authority
- ES
- Spain
- Prior art keywords
- aldosa
- reductasa
- compounds
- nitrometiltiobenceno
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/42—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS DE FORMULA GENERAL (1) EN LA CUAL: P, T1, T2 , X Y N SON TAL COMO SE DEFINEN EN LA REIVINDICACION 1, SUS FORMAS TAUTOMERICAS Y SUS SALES ADITIVAS CON BASES FARMACEUTICAMENTE ACEPTABLES. LA INVENCION SE REFIERE TAMBIEN A PROCEDIMIENTOS PARA PREPARAR ESTOS COMPUESTOS Y SUS APLICACIONES COMO MEDICINAS. ESTOS COMPUESTOS INHIBEN LA ENZIMA ALDOSA REDUCTASA Y PUEDEN UTILIZARSE EN EL TRATAMIENTO O LA PREVENCION DE LAS COMPLICACIONES DIABETICAS NEUROLOGICAS PERIFERICAS Y AUTONOMAS, RENALES Y OCULARES, TALES COMO LA CATARATA Y LA RETINOPATIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9615887A FR2757509B1 (fr) | 1996-12-23 | 1996-12-23 | Nouveaux derives de sulfonamides et sulfonylurees, leurs preparations et medicaments les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2172829T3 true ES2172829T3 (es) | 2002-10-01 |
Family
ID=9499031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97953797T Expired - Lifetime ES2172829T3 (es) | 1996-12-23 | 1997-12-12 | Derivados del nitrometiltiobenceno como inhibidores de la aldosa reductasa. |
Country Status (24)
Country | Link |
---|---|
US (2) | US6509499B1 (es) |
EP (1) | EP0946503B1 (es) |
JP (1) | JP2001507001A (es) |
KR (1) | KR20000069678A (es) |
CN (1) | CN1112356C (es) |
AT (1) | ATE215069T1 (es) |
AU (1) | AU728562B2 (es) |
BR (1) | BR9714069A (es) |
CA (1) | CA2275665A1 (es) |
CZ (1) | CZ227799A3 (es) |
DE (1) | DE69711429T2 (es) |
DK (1) | DK0946503T3 (es) |
ES (1) | ES2172829T3 (es) |
FR (1) | FR2757509B1 (es) |
HU (1) | HUP0002054A3 (es) |
ID (1) | ID22073A (es) |
NO (1) | NO313325B1 (es) |
PL (1) | PL334188A1 (es) |
PT (1) | PT946503E (es) |
RU (1) | RU2184110C2 (es) |
SK (1) | SK282820B6 (es) |
TR (1) | TR199901442T2 (es) |
UA (1) | UA56205C2 (es) |
WO (1) | WO1998028265A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2884820B1 (fr) * | 2005-04-25 | 2007-07-27 | Merck Sante Soc Par Actions Si | Nouveaux inhibiteurs specifiques de la caspase-10 |
US8158667B2 (en) | 2006-08-21 | 2012-04-17 | Kador Peter F | Topical treatment of cataracts in dogs |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8718619D0 (en) | 1987-08-06 | 1987-09-09 | Ici Plc | Pharmaceutical compositions |
IE63463B1 (en) * | 1989-02-06 | 1995-04-19 | Zeneca Ltd | Phenylsulphone derivatives |
GB9016978D0 (en) | 1990-08-02 | 1990-09-19 | Ici Plc | Acetamide derivatives |
US5250570A (en) | 1990-08-02 | 1993-10-05 | Imperial Chemical Industries Plc | Amidobenzene derivatives, compositions and use |
GB9016980D0 (en) * | 1990-08-02 | 1990-09-19 | Ici Plc | Amidobenzenes |
GB9016984D0 (en) * | 1990-08-02 | 1990-09-19 | Ici Plc | Aniline derivatives |
-
1996
- 1996-12-23 FR FR9615887A patent/FR2757509B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-12 KR KR1019997005722A patent/KR20000069678A/ko not_active Application Discontinuation
- 1997-12-12 CN CN97180948A patent/CN1112356C/zh not_active Expired - Fee Related
- 1997-12-12 ES ES97953797T patent/ES2172829T3/es not_active Expired - Lifetime
- 1997-12-12 TR TR1999/01442T patent/TR199901442T2/xx unknown
- 1997-12-12 HU HU0002054A patent/HUP0002054A3/hu unknown
- 1997-12-12 WO PCT/EP1997/006981 patent/WO1998028265A1/fr not_active Application Discontinuation
- 1997-12-12 DE DE69711429T patent/DE69711429T2/de not_active Expired - Fee Related
- 1997-12-12 JP JP52831998A patent/JP2001507001A/ja active Pending
- 1997-12-12 UA UA99074125A patent/UA56205C2/uk unknown
- 1997-12-12 DK DK97953797T patent/DK0946503T3/da active
- 1997-12-12 PT PT97953797T patent/PT946503E/pt unknown
- 1997-12-12 AT AT97953797T patent/ATE215069T1/de not_active IP Right Cessation
- 1997-12-12 CZ CZ992277A patent/CZ227799A3/cs unknown
- 1997-12-12 ID IDW990564A patent/ID22073A/id unknown
- 1997-12-12 CA CA002275665A patent/CA2275665A1/en not_active Abandoned
- 1997-12-12 RU RU99115476/04A patent/RU2184110C2/ru not_active IP Right Cessation
- 1997-12-12 US US09/331,662 patent/US6509499B1/en not_active Expired - Fee Related
- 1997-12-12 BR BR9714069-4A patent/BR9714069A/pt not_active IP Right Cessation
- 1997-12-12 PL PL97334188A patent/PL334188A1/xx unknown
- 1997-12-12 AU AU57571/98A patent/AU728562B2/en not_active Ceased
- 1997-12-12 EP EP97953797A patent/EP0946503B1/fr not_active Expired - Lifetime
- 1997-12-12 SK SK833-99A patent/SK282820B6/sk unknown
-
1999
- 1999-06-22 NO NO19993082A patent/NO313325B1/no not_active IP Right Cessation
-
2002
- 2002-11-12 US US10/291,677 patent/US20030203966A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK0946503T3 (da) | 2002-06-10 |
PL334188A1 (en) | 2000-02-14 |
DE69711429T2 (de) | 2002-10-31 |
CN1241997A (zh) | 2000-01-19 |
DE69711429D1 (en) | 2002-05-02 |
SK83399A3 (en) | 1999-12-10 |
EP0946503B1 (fr) | 2002-03-27 |
JP2001507001A (ja) | 2001-05-29 |
AU5757198A (en) | 1998-07-17 |
US6509499B1 (en) | 2003-01-21 |
CA2275665A1 (en) | 1998-07-02 |
FR2757509A1 (fr) | 1998-06-26 |
NO993082L (no) | 1999-08-20 |
CZ227799A3 (cs) | 1999-11-17 |
WO1998028265A1 (fr) | 1998-07-02 |
ATE215069T1 (de) | 2002-04-15 |
AU728562B2 (en) | 2001-01-11 |
UA56205C2 (uk) | 2003-05-15 |
TR199901442T2 (xx) | 1999-09-21 |
NO313325B1 (no) | 2002-09-16 |
US20030203966A1 (en) | 2003-10-30 |
ID22073A (id) | 1999-09-02 |
PT946503E (pt) | 2002-09-30 |
EP0946503A1 (fr) | 1999-10-06 |
NO993082D0 (no) | 1999-06-22 |
RU2184110C2 (ru) | 2002-06-27 |
CN1112356C (zh) | 2003-06-25 |
HUP0002054A3 (en) | 2002-09-30 |
FR2757509B1 (fr) | 1999-03-26 |
SK282820B6 (sk) | 2002-12-03 |
HUP0002054A2 (hu) | 2000-11-28 |
KR20000069678A (ko) | 2000-11-25 |
BR9714069A (pt) | 2000-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2177868T3 (es) | Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas. | |
UY27234A1 (es) | Inhibidores novedosos de tirosina cinasa | |
PA8501801A1 (es) | Inhibidores triciclicos de polimerasas (adp - polirribosas) | |
ES2161290T3 (es) | Derivados de quinazolina. | |
UY26782A1 (es) | Derivados del benzotiazol | |
UY27714A1 (es) | 2 - heteroaril - pirimidinas inhibidoras de cdk, su preparación y su uso como medicamentos. | |
AR018719A1 (es) | Inhibidores de renina. | |
AR025885A1 (es) | Derivados del acido indolil-3-glioxilico con valiosas propiedades terapeuticas | |
ES2157252T3 (es) | Aplicacion del riluzol en el tratamiento del neuro-sida. | |
MX9305248A (es) | Compuestos de diarilpiperazinoacetamida. | |
WO2022038365A3 (en) | Fumarate derivatives and their medical use | |
SE0301232D0 (sv) | Novel use | |
ES2101858T3 (es) | Derivados de geneserina como inhibidores de colinesterasa. | |
AR011094A1 (es) | Medicamento que contiene quinoxalinas en triple combinacion y el uso de quinoxalinas en triple combinacion con inhibidores de proteasas e inhibidoresde transcriptasa como medicamento para el tratamiento del sida y/o de infecciones por hiv | |
ES2174921T3 (es) | Inhibidores de la proteasa del vih. | |
UY26847A1 (es) | Derivados de la pirrolidina | |
AR019022A1 (es) | Utilizacion de un compuesto que posee una actividad inhibitoria en la produccion de oxido nitrico, y las composiciones que comprenden dicho compuesto. | |
UY26895A1 (es) | Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2 | |
ES2172829T3 (es) | Derivados del nitrometiltiobenceno como inhibidores de la aldosa reductasa. | |
ES2125356T3 (es) | Empleo de leflunomida para la inhibicion de interleuquina 8. | |
AR025379A1 (es) | 9a-azalidas con actividad antibacteriana. | |
PA8522301A1 (es) | Derivados de pirrolidina | |
ES2051954T3 (es) | 2-aminotiazoles substituidos. | |
ES2042741T3 (es) | Procedimiento para preparar nuevos derivados de tiazolidin-4-ona y sus sales por adicion de acido. | |
PA8522401A1 (es) | Derivados de pirrolidina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 946503 Country of ref document: ES |