ES2172749T3 - Derivados de amidas antibioticas de glicopeptido. - Google Patents

Derivados de amidas antibioticas de glicopeptido.

Info

Publication number
ES2172749T3
ES2172749T3 ES97304495T ES97304495T ES2172749T3 ES 2172749 T3 ES2172749 T3 ES 2172749T3 ES 97304495 T ES97304495 T ES 97304495T ES 97304495 T ES97304495 T ES 97304495T ES 2172749 T3 ES2172749 T3 ES 2172749T3
Authority
ES
Spain
Prior art keywords
antibiotic
derivatives
glicopeptide
amidas
control
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97304495T
Other languages
English (en)
Inventor
Robin David Grey Cooper
Michael John Rodriguez
Nancy June Snyder
Mark James Zweifel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2172749T3 publication Critical patent/ES2172749T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A AMIDAS DEL ANTIBIOTICO A82846B (TAMBIEN CONOCIDO COMO CLOROORIENTICINA A) Y DE DERIVADOS N{SUP,4} DEL A82846B. LOS PRESENTES COMPUESTOS AMIDA SON UTILES COMO ANTIBACTERIANOS, ESPECIALMENTE PARA EL CONTROL DE BACTERIAS GRAM POSITIVAS; LOS COMPUESTOS SON ESPECIALMENTE UTILES PARA EL CONTROL DE CEPAS BACTERIANAS RESISTENTES, TALES COMO LOS ESTEROCOCOS RESISTENTES A LA VANCOMICINA ("VRE").
ES97304495T 1996-06-28 1997-06-25 Derivados de amidas antibioticas de glicopeptido. Expired - Lifetime ES2172749T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2077496P 1996-06-28 1996-06-28
US08/847,069 US5919756A (en) 1996-06-28 1997-05-01 Amides

Publications (1)

Publication Number Publication Date
ES2172749T3 true ES2172749T3 (es) 2002-10-01

Family

ID=26693848

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97304495T Expired - Lifetime ES2172749T3 (es) 1996-06-28 1997-06-25 Derivados de amidas antibioticas de glicopeptido.

Country Status (12)

Country Link
US (1) US5919756A (es)
EP (1) EP0816378B1 (es)
JP (1) JP4086318B2 (es)
AT (1) ATE215965T1 (es)
AU (1) AU3411197A (es)
CA (1) CA2258906C (es)
DE (1) DE69711766T2 (es)
DK (1) DK0816378T3 (es)
ES (1) ES2172749T3 (es)
HK (1) HK1007884A1 (es)
PT (1) PT816378E (es)
WO (1) WO1998000153A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
ES2201825T3 (es) * 1998-12-23 2004-03-16 Theravance, Inc. Derivados del glicopeptidos y composiciones farmaceuticas que los contienen.
MY123217A (en) * 1998-12-23 2006-05-31 Theravance Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
WO2000042052A1 (en) * 1999-01-12 2000-07-20 Princeton University Substituted alpha-linked disaccharides
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
AU2001259298A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
ATE416791T1 (de) 2000-05-02 2008-12-15 Theravance Inc Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält
US6831150B2 (en) 2000-05-02 2004-12-14 Theravance, Inc. Reductive alkylation process
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
AU2001259303A1 (en) 2000-06-22 2002-01-02 Advanced Medicine, Inc. Glycopeptide carboxy-saccharide derivatives
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
GB0026924D0 (en) 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
US7144858B2 (en) * 2002-05-31 2006-12-05 The Trustees Of The University Of Pennsylvania Antibacterial compounds and methods for treating Gram positive bacterial infections
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US8445007B2 (en) 2005-09-22 2013-05-21 Medivas, Llc Bis-(α-amino)-diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
CN102250221A (zh) * 2010-05-19 2011-11-23 复旦大学 万古霉素类衍生物及其制备方法和用途
CN102838661A (zh) * 2011-06-21 2012-12-26 复旦大学 万古霉素或去甲万古霉素类似物及其药用用途
WO2014160250A2 (en) * 2013-03-13 2014-10-02 Yale University Site-selective functionalization of glycopeptide antibiotics
US20160303184A1 (en) 2013-09-23 2016-10-20 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
EP3532483A4 (en) * 2016-10-31 2020-09-02 The Scripps Research Institute PERIPHERAL MODIFICATIONS ON RECOGNIZED POCKET VANCOMYCIN ANALOGUES TO SYNERGICALLY IMPROVE ANTIMICROBIAL POWER AND DURABILITY

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
US4845194A (en) * 1987-02-27 1989-07-04 Eli Lilly And Company Glycopeptide recovery process
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
US5534420A (en) * 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
IL96603A (en) * 1989-12-13 1998-02-08 Lilly Co Eli Antibacterial glycopeptide derivativesProcess for their preparation and pharmaceutical preparations containing the same
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
NZ270387A (en) * 1994-01-28 1996-11-26 Lilly Co Eli Glycopeptide antibiotic, its production and compositions thereof

Also Published As

Publication number Publication date
HK1007884A1 (en) 1999-04-30
DE69711766T2 (de) 2002-11-07
JP2001524929A (ja) 2001-12-04
CA2258906A1 (en) 1998-01-08
AU3411197A (en) 1998-01-21
JP4086318B2 (ja) 2008-05-14
PT816378E (pt) 2002-08-30
CA2258906C (en) 2003-01-28
WO1998000153A1 (en) 1998-01-08
EP0816378A1 (en) 1998-01-07
EP0816378B1 (en) 2002-04-10
DE69711766D1 (de) 2002-05-16
DK0816378T3 (da) 2002-06-17
ATE215965T1 (de) 2002-04-15
US5919756A (en) 1999-07-06

Similar Documents

Publication Publication Date Title
ES2172749T3 (es) Derivados de amidas antibioticas de glicopeptido.
NZ217555A (en) Amides of teicoplanin compounds and pharmaceutical compositions
ES2136457T3 (es) Dimeros unidos covalentemente de antibioticos glucopeptidicos.
ES2140184T3 (es) Dimeros unidos covalentemente de antibioticos glicopeptidicos.
ES8705893A1 (es) Un procedimiento para preparar derivados monoamidicos basicos de actagardina
ATE244728T1 (de) Antibiotisch wirksame, alkylierte hexapeptide

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 816378

Country of ref document: ES