ATE215965T1 - Derivate von amiden glycopeptidischer antibiotica - Google Patents

Derivate von amiden glycopeptidischer antibiotica

Info

Publication number
ATE215965T1
ATE215965T1 AT97304495T AT97304495T ATE215965T1 AT E215965 T1 ATE215965 T1 AT E215965T1 AT 97304495 T AT97304495 T AT 97304495T AT 97304495 T AT97304495 T AT 97304495T AT E215965 T1 ATE215965 T1 AT E215965T1
Authority
AT
Austria
Prior art keywords
derivatives
amids
glycopeptide antibiotics
control
resistant
Prior art date
Application number
AT97304495T
Other languages
English (en)
Inventor
Robin David Grey Cooper
Michael John Rodriguez
Nancy June Snyder
Mark James Zweifel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE215965T1 publication Critical patent/ATE215965T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97304495T 1996-06-28 1997-06-25 Derivate von amiden glycopeptidischer antibiotica ATE215965T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2077496P 1996-06-28 1996-06-28
US08/847,069 US5919756A (en) 1996-06-28 1997-05-01 Amides

Publications (1)

Publication Number Publication Date
ATE215965T1 true ATE215965T1 (de) 2002-04-15

Family

ID=26693848

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97304495T ATE215965T1 (de) 1996-06-28 1997-06-25 Derivate von amiden glycopeptidischer antibiotica

Country Status (12)

Country Link
US (1) US5919756A (de)
EP (1) EP0816378B1 (de)
JP (1) JP4086318B2 (de)
AT (1) ATE215965T1 (de)
AU (1) AU3411197A (de)
CA (1) CA2258906C (de)
DE (1) DE69711766T2 (de)
DK (1) DK0816378T3 (de)
ES (1) ES2172749T3 (de)
HK (1) HK1007884A1 (de)
PT (1) PT816378E (de)
WO (1) WO1998000153A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
SG87877A1 (en) * 1998-12-23 2002-04-16 Advanced Medicine Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
CN1249081C (zh) 1998-12-23 2006-04-05 施万制药 糖肽衍生物或含有它们的药物组合物
EP1147118A4 (de) * 1999-01-12 2004-01-28 Univ Princeton Substituierte alpha-verknüpfte disaccharide
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
CA2726789A1 (en) 2000-02-05 2001-11-08 Theravance, Inc. Cyclodextrin containing glycopeptide antibiotic compositions
AU2001259298A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
CA2407994C (en) 2000-05-02 2010-02-02 Advanced Medecine Inc. Reductive alkylation process
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
AU2001259303A1 (en) 2000-06-22 2002-01-02 Advanced Medicine, Inc. Glycopeptide carboxy-saccharide derivatives
US6828299B2 (en) 2000-06-22 2004-12-07 Theravance, Inc. Polyhydroxy glycopeptide derivatives
GB0026924D0 (en) 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
US7144858B2 (en) * 2002-05-31 2006-12-05 The Trustees Of The University Of Pennsylvania Antibacterial compounds and methods for treating Gram positive bacterial infections
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
EP1926780B1 (de) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-haltige poly(esteramid) und poly(esterurethan)-zusammensetzungen und verwendungsverfahren
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US8841440B2 (en) 2008-04-01 2014-09-23 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
CN102250221A (zh) * 2010-05-19 2011-11-23 复旦大学 万古霉素类衍生物及其制备方法和用途
CN102838661A (zh) * 2011-06-21 2012-12-26 复旦大学 万古霉素或去甲万古霉素类似物及其药用用途
US10294275B2 (en) * 2013-03-13 2019-05-21 Yale University Site-selective functionalization of glycopeptide antibiotics
AU2014322817A1 (en) 2013-09-23 2016-04-21 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
WO2018081797A1 (en) * 2016-10-31 2018-05-03 The Scripps Research Institute Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
US4845194A (en) * 1987-02-27 1989-07-04 Eli Lilly And Company Glycopeptide recovery process
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
US5534420A (en) * 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
IL96603A (en) * 1989-12-13 1998-02-08 Lilly Co Eli Antibacterial glycopeptide derivativesProcess for their preparation and pharmaceutical preparations containing the same
MY128335A (en) * 1994-01-28 2007-01-31 Lilly Co Eli Glycopeptide antibiotic derivatives
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives

Also Published As

Publication number Publication date
DE69711766T2 (de) 2002-11-07
US5919756A (en) 1999-07-06
JP2001524929A (ja) 2001-12-04
EP0816378A1 (de) 1998-01-07
DK0816378T3 (da) 2002-06-17
JP4086318B2 (ja) 2008-05-14
ES2172749T3 (es) 2002-10-01
HK1007884A1 (en) 1999-04-30
CA2258906C (en) 2003-01-28
PT816378E (pt) 2002-08-30
CA2258906A1 (en) 1998-01-08
AU3411197A (en) 1998-01-21
DE69711766D1 (de) 2002-05-16
EP0816378B1 (de) 2002-04-10
WO1998000153A1 (en) 1998-01-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee