DE69711766D1 - Derivate von Amiden glycopeptidischer Antibiotica - Google Patents

Derivate von Amiden glycopeptidischer Antibiotica

Info

Publication number
DE69711766D1
DE69711766D1 DE69711766T DE69711766T DE69711766D1 DE 69711766 D1 DE69711766 D1 DE 69711766D1 DE 69711766 T DE69711766 T DE 69711766T DE 69711766 T DE69711766 T DE 69711766T DE 69711766 D1 DE69711766 D1 DE 69711766D1
Authority
DE
Germany
Prior art keywords
amides
derivatives
glycopeptide antibiotics
control
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69711766T
Other languages
English (en)
Other versions
DE69711766T2 (de
Inventor
Robin David Grey Cooper
Michael John Rodriguez
Nancy June Snyder
Mark James Zweifel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69711766D1 publication Critical patent/DE69711766D1/de
Publication of DE69711766T2 publication Critical patent/DE69711766T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69711766T 1996-06-28 1997-06-25 Derivate von Amiden glycopeptidischer Antibiotica Expired - Fee Related DE69711766T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2077496P 1996-06-28 1996-06-28
US08/847,069 US5919756A (en) 1996-06-28 1997-05-01 Amides

Publications (2)

Publication Number Publication Date
DE69711766D1 true DE69711766D1 (de) 2002-05-16
DE69711766T2 DE69711766T2 (de) 2002-11-07

Family

ID=26693848

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69711766T Expired - Fee Related DE69711766T2 (de) 1996-06-28 1997-06-25 Derivate von Amiden glycopeptidischer Antibiotica

Country Status (12)

Country Link
US (1) US5919756A (de)
EP (1) EP0816378B1 (de)
JP (1) JP4086318B2 (de)
AT (1) ATE215965T1 (de)
AU (1) AU3411197A (de)
CA (1) CA2258906C (de)
DE (1) DE69711766T2 (de)
DK (1) DK0816378T3 (de)
ES (1) ES2172749T3 (de)
HK (1) HK1007884A1 (de)
PT (1) PT816378E (de)
WO (1) WO1998000153A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
AR021964A1 (es) * 1998-12-23 2002-09-04 Theravance Inc Un compuesto glicopeptidico, composiciones farmaceuticas que los contienen y uso de dichos compuestos glicopeptidicos para la manufactura de un medicamento antibacteriano.
AU768204B2 (en) 1998-12-23 2003-12-04 Cumberland Pharmaceuticals Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
WO2000042052A1 (en) * 1999-01-12 2000-07-20 Princeton University Substituted alpha-linked disaccharides
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
BR0110530A (pt) 2000-05-02 2003-04-08 Theravance Inc Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina
WO2001083520A2 (en) 2000-05-02 2001-11-08 Theravance,Inc Polyacid glycopeptide derivatives
EP1276759B1 (de) 2000-05-02 2008-07-30 Theravance, Inc. Verfahren zur reduktiven alkylierung von glykopeptiden
AU2001259816A1 (en) 2000-06-22 2002-01-02 Advanced Medecine, Inc. Polyhydroxy glycopeptide derivatives
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
ES2302733T3 (es) 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
GB0026924D0 (en) * 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
US7144858B2 (en) * 2002-05-31 2006-12-05 The Trustees Of The University Of Pennsylvania Antibacterial compounds and methods for treating Gram positive bacterial infections
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
EP1926780B1 (de) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-haltige poly(esteramid) und poly(esterurethan)-zusammensetzungen und verwendungsverfahren
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US8841440B2 (en) 2008-04-01 2014-09-23 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
CN102250221A (zh) * 2010-05-19 2011-11-23 复旦大学 万古霉素类衍生物及其制备方法和用途
CN102838661A (zh) * 2011-06-21 2012-12-26 复旦大学 万古霉素或去甲万古霉素类似物及其药用用途
WO2014160250A2 (en) * 2013-03-13 2014-10-02 Yale University Site-selective functionalization of glycopeptide antibiotics
AU2014322817A1 (en) 2013-09-23 2016-04-21 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
AU2017348434B2 (en) * 2016-10-31 2021-10-07 The Scripps Research Institute Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
US4845194A (en) * 1987-02-27 1989-07-04 Eli Lilly And Company Glycopeptide recovery process
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
US5534420A (en) * 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
NZ236393A (en) * 1989-12-13 1992-05-26 Lilly Co Eli N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
TW457248B (en) * 1994-01-28 2001-10-01 Lilly Co Eli Glycopeptide antibiotic derivatives

Also Published As

Publication number Publication date
DE69711766T2 (de) 2002-11-07
WO1998000153A1 (en) 1998-01-08
EP0816378B1 (de) 2002-04-10
CA2258906C (en) 2003-01-28
PT816378E (pt) 2002-08-30
DK0816378T3 (da) 2002-06-17
JP4086318B2 (ja) 2008-05-14
EP0816378A1 (de) 1998-01-07
JP2001524929A (ja) 2001-12-04
ES2172749T3 (es) 2002-10-01
CA2258906A1 (en) 1998-01-08
US5919756A (en) 1999-07-06
HK1007884A1 (en) 1999-04-30
AU3411197A (en) 1998-01-21
ATE215965T1 (de) 2002-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8339 Ceased/non-payment of the annual fee