DE69711766D1 - Derivate von Amiden glycopeptidischer Antibiotica - Google Patents

Derivate von Amiden glycopeptidischer Antibiotica

Info

Publication number
DE69711766D1
DE69711766D1 DE69711766T DE69711766T DE69711766D1 DE 69711766 D1 DE69711766 D1 DE 69711766D1 DE 69711766 T DE69711766 T DE 69711766T DE 69711766 T DE69711766 T DE 69711766T DE 69711766 D1 DE69711766 D1 DE 69711766D1
Authority
DE
Germany
Prior art keywords
amides
derivatives
glycopeptide antibiotics
control
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69711766T
Other languages
English (en)
Other versions
DE69711766T2 (de
Inventor
Robin David Grey Cooper
Michael John Rodriguez
Nancy June Snyder
Mark James Zweifel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69711766D1 publication Critical patent/DE69711766D1/de
Publication of DE69711766T2 publication Critical patent/DE69711766T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69711766T 1996-06-28 1997-06-25 Derivate von Amiden glycopeptidischer Antibiotica Expired - Fee Related DE69711766T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2077496P 1996-06-28 1996-06-28
US08/847,069 US5919756A (en) 1996-06-28 1997-05-01 Amides

Publications (2)

Publication Number Publication Date
DE69711766D1 true DE69711766D1 (de) 2002-05-16
DE69711766T2 DE69711766T2 (de) 2002-11-07

Family

ID=26693848

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69711766T Expired - Fee Related DE69711766T2 (de) 1996-06-28 1997-06-25 Derivate von Amiden glycopeptidischer Antibiotica

Country Status (12)

Country Link
US (1) US5919756A (de)
EP (1) EP0816378B1 (de)
JP (1) JP4086318B2 (de)
AT (1) ATE215965T1 (de)
AU (1) AU3411197A (de)
CA (1) CA2258906C (de)
DE (1) DE69711766T2 (de)
DK (1) DK0816378T3 (de)
ES (1) ES2172749T3 (de)
HK (1) HK1007884A1 (de)
PT (1) PT816378E (de)
WO (1) WO1998000153A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
CZ301184B6 (cs) 1998-12-23 2009-12-02 Theravance, Inc. Glykopeptidový derivát a farmaceutické prostredky, které jej obsahují
AR021964A1 (es) * 1998-12-23 2002-09-04 Theravance Inc Un compuesto glicopeptidico, composiciones farmaceuticas que los contienen y uso de dichos compuestos glicopeptidicos para la manufactura de un medicamento antibacteriano.
EP1147118A4 (de) * 1999-01-12 2004-01-28 Univ Princeton Substituierte alpha-verknüpfte disaccharide
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
EP1276759B1 (de) 2000-05-02 2008-07-30 Theravance, Inc. Verfahren zur reduktiven alkylierung von glykopeptiden
US6858584B2 (en) 2000-05-02 2005-02-22 Theravance, Inc. Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
US6770621B2 (en) * 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
WO2001098327A2 (en) 2000-06-22 2001-12-27 Theravance, Inc. Glycopeptide carboxy-saccharide derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
GB0026924D0 (en) * 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
WO2003101393A2 (en) * 2002-05-31 2003-12-11 The Trustees Of The University Of Pennsylvania Antibacterial compounds and methods for treating gram positive bacterial infections
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CN102083862A (zh) 2008-04-01 2011-06-01 康奈尔大学 有机-可溶性壳聚糖盐和由其制备的壳聚糖衍生生物材料
CN102250221A (zh) * 2010-05-19 2011-11-23 复旦大学 万古霉素类衍生物及其制备方法和用途
CN102838661A (zh) * 2011-06-21 2012-12-26 复旦大学 万古霉素或去甲万古霉素类似物及其药用用途
WO2014160250A2 (en) * 2013-03-13 2014-10-02 Yale University Site-selective functionalization of glycopeptide antibiotics
CA2925005A1 (en) 2013-09-23 2015-03-26 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
WO2018081797A1 (en) * 2016-10-31 2018-05-03 The Scripps Research Institute Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
US4845194A (en) * 1987-02-27 1989-07-04 Eli Lilly And Company Glycopeptide recovery process
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
US5534420A (en) * 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
CA2031803C (en) * 1989-12-13 2001-05-29 Ramakrishnan Nagarajan Improvements in or relating to glycopeptide deriveratives
AU703106B2 (en) * 1994-01-28 1999-03-18 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives

Also Published As

Publication number Publication date
ES2172749T3 (es) 2002-10-01
JP4086318B2 (ja) 2008-05-14
DE69711766T2 (de) 2002-11-07
JP2001524929A (ja) 2001-12-04
DK0816378T3 (da) 2002-06-17
EP0816378B1 (de) 2002-04-10
CA2258906A1 (en) 1998-01-08
AU3411197A (en) 1998-01-21
WO1998000153A1 (en) 1998-01-08
HK1007884A1 (en) 1999-04-30
EP0816378A1 (de) 1998-01-07
ATE215965T1 (de) 2002-04-15
PT816378E (pt) 2002-08-30
US5919756A (en) 1999-07-06
CA2258906C (en) 2003-01-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8339 Ceased/non-payment of the annual fee