ES2169770T3 - Dispositivos mesoescalares de amplificacion de polinucleotidos. - Google Patents

Dispositivos mesoescalares de amplificacion de polinucleotidos.

Info

Publication number
ES2169770T3
ES2169770T3 ES95941393T ES95941393T ES2169770T3 ES 2169770 T3 ES2169770 T3 ES 2169770T3 ES 95941393 T ES95941393 T ES 95941393T ES 95941393 T ES95941393 T ES 95941393T ES 2169770 T3 ES2169770 T3 ES 2169770T3
Authority
ES
Spain
Prior art keywords
reaction
camera
amplification
polinucleotide
devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95941393T
Other languages
English (en)
Inventor
Peter Wilding
Larry J Kricka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/338,369 external-priority patent/US5726026A/en
Priority claimed from US08/338,380 external-priority patent/US5744366A/en
Priority claimed from US08/338,728 external-priority patent/US5587128A/en
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Application granted granted Critical
Publication of ES2169770T3 publication Critical patent/ES2169770T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0213—Silicon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0215—Silicon carbide; Silicon nitride; Silicon oxycarbide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00826—Quartz
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PRESENTAN DISPOSITIVOS PARA AMPLIFICAR UN POLINUCLEOTIDO PRESELECCIONADO EN UNA MUESTRA REALIZANDO UNA REACCION DE AMPLIFICACION DEL POLINUCLEOTIDO. LOS DISPOSITIVOS ESTAN PROVISTOS DE UN SUBSTRATO MICROFABRICADO PARA INCLUIR UNA CAMARA DE REACCION DE AMPLIFICACION DE POLINUCLEOTIDO, QUE TIENE AL MENOS UNA DIMENSION DE SECCION DE CORTE DE ENTRE 0.1 Y 1000 {MI}M. EL DISPOSITIVO TAMBIEN INCLUYE AL MENOS UN PUERTO EN COMUNICACION FLUIDA CON LA CAMARA DE REACCION, PARA INTRODUCIR UNA MUESTRA EN LA CAMARA, PARA AIREAR LA CAMARA CUANDO FUERA NECESARIO, Y OPCIONALMENTE, PARA ELIMINAR PRODUCTOS O MATERIAL DE DESECHO DEL DISPOSITIVO. LA CAMARA DE REACCION PUEDE ESTAR PROVISTA DE LOS REAGENTES REQUERIDOS PARA LA AMPLIFICACION DEL POLINUCLEOTIDO PRESELECCIONADO. EL DISPOSITIVO PUEDE TAMBIEN INCLUIR MEDIOS PARA REGULAR TERMICAMENTE LOS CONTENIDOS DE LA CAMARA DE REACCION, PARA AMPLIFICAR UN POLINUCLEOTIDO PRESELECCIONADO. PREFERIBLEMENTE, LA CAMARA DE REACCION ESTA FABRICADA CON UNA ALTA PROPORCIONDE SUPERFICIE:VOLUMEN, PARA FACILITAR LA REGULACION TERMICA. LA CAMARA DE REACCION DE AMPLIFICACION TAMBIEN PUEDE ESTAR PROVISTA DE UNA COMPOSICION QUE DISMINUYA LA INHIBICION DE LA REACCION DE AMPLIFICACION POR EL MATERIAL QUE COMPRENDE UNA PARED DE LA CAMARA DE REACCION, CUANDO EL TRATAMIENTO SEA REQUERIDO.
ES95941393T 1994-11-14 1995-11-13 Dispositivos mesoescalares de amplificacion de polinucleotidos. Expired - Lifetime ES2169770T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/338,369 US5726026A (en) 1992-05-01 1994-11-14 Mesoscale sample preparation device and systems for determination and processing of analytes
US08/338,380 US5744366A (en) 1992-05-01 1994-11-14 Mesoscale devices and methods for analysis of motile cells
US08/338,728 US5587128A (en) 1992-05-01 1994-11-14 Mesoscale polynucleotide amplification devices
PCT/US1995/014823 WO1996015269A2 (en) 1994-11-14 1995-11-13 Mesoscale polynucleotide amplification devices

Publications (1)

Publication Number Publication Date
ES2169770T3 true ES2169770T3 (es) 2002-07-16

Family

ID=46332642

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95941393T Expired - Lifetime ES2169770T3 (es) 1994-11-14 1995-11-13 Dispositivos mesoescalares de amplificacion de polinucleotidos.

Country Status (9)

Country Link
EP (1) EP0739423B1 (es)
JP (2) JP3909859B2 (es)
CN (1) CN1145704C (es)
AT (1) ATE212064T1 (es)
CA (1) CA2181189C (es)
DE (1) DE69525036T2 (es)
DK (1) DK0739423T3 (es)
ES (1) ES2169770T3 (es)
WO (1) WO1996015269A2 (es)

Cited By (1)

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ES2220227A1 (es) * 2003-05-30 2004-12-01 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" Metodo y aparato para la deteccion de sustancias o analitos a partir del analisis de una o varias muestras.

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US6245227B1 (en) 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
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JP5305361B2 (ja) 2007-05-04 2013-10-02 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニー 流体コネクタおよびマイクロ流体システム
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2220227A1 (es) * 2003-05-30 2004-12-01 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" Metodo y aparato para la deteccion de sustancias o analitos a partir del analisis de una o varias muestras.
WO2004106922A1 (es) * 2003-05-30 2004-12-09 Instituto Nacional De Tecnica Aeroespacial 'esteban Terradas' Método y aparato para la detección de sustancias o analitos a partir del análisis de una o varias muestras
US8097209B2 (en) 2003-05-30 2012-01-17 Instituto Nacional de Technica Aerospacial “Easteban Terradas” Method and apparatus for detecting substances or analytes from the analysis of one or more samples

Also Published As

Publication number Publication date
CA2181189C (en) 1999-09-21
WO1996015269A2 (en) 1996-05-23
ATE212064T1 (de) 2002-02-15
EP0739423A1 (en) 1996-10-30
CA2181189A1 (en) 1996-05-23
JP2007050008A (ja) 2007-03-01
JPH09511407A (ja) 1997-11-18
CN1145704C (zh) 2004-04-14
EP0739423B1 (en) 2002-01-16
JP3909859B2 (ja) 2007-04-25
WO1996015269A3 (en) 1996-11-21
AU698213B2 (en) 1998-10-29
DE69525036D1 (de) 2002-02-21
DK0739423T3 (da) 2002-05-06
CN1157639A (zh) 1997-08-20
DE69525036T2 (de) 2002-08-01
JP4176124B2 (ja) 2008-11-05
MX9602775A (es) 1997-07-31
AU4282896A (en) 1996-06-06

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