ES2169419T3 - Particulas esfericas de hidroxiapatita y procedimiento para la produccion de las mismas. - Google Patents

Particulas esfericas de hidroxiapatita y procedimiento para la produccion de las mismas.

Info

Publication number
ES2169419T3
ES2169419T3 ES97941008T ES97941008T ES2169419T3 ES 2169419 T3 ES2169419 T3 ES 2169419T3 ES 97941008 T ES97941008 T ES 97941008T ES 97941008 T ES97941008 T ES 97941008T ES 2169419 T3 ES2169419 T3 ES 2169419T3
Authority
ES
Spain
Prior art keywords
particles
exceed
microns
hydoxyapatite
density
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97941008T
Other languages
English (en)
Inventor
Lawrence A Shimp
Peter J Renkema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osteotech Inc
Original Assignee
Osteotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteotech Inc filed Critical Osteotech Inc
Application granted granted Critical
Publication of ES2169419T3 publication Critical patent/ES2169419T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/15—Compositions characterised by their physical properties
    • A61K6/17—Particle size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/74—Fillers comprising phosphorus-containing compounds
    • A61K6/75—Apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/322—Preparation by neutralisation of orthophosphoric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Dental Preparations (AREA)
  • Powder Metallurgy (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PRODUCCION DE PARTICULAS DE HIDROXIAPATITA ESFERICAS, NO POROSAS, CON UN TAMAÑO NO SUPERIOR A 250 MICRONES Y UNA DENSIDAD DE AL MENOS 3,00 G/CC. DICHO PROCEDIMIENTO CONSISTE EN AGLOMERAR EN PRESENCIA DE AGUA COMO UNICO ADITIVO, UNA CARGA DE ALIMENTACION DE HIDROXIAPATITA EN POLVO, CON UNA PUREZA DE AL MENOS EL 97 %, Y CON IMPUREZAS METALICAS QUE SUPEREN LAS 500 PPM, PARA FORMAR PARTICULAS DE HIDROXIAPATITA CON UN TAMAÑO NO SUPERIOR A 350 MICRONES. A CONTINUACION, DICHAS PARTICULAS SE SECAN Y SINTERIZAN A UNA TEMPERATURA COMPRENDIDA ENTRE APROX. 1.100 Y 1,200 °C, PRODUCIENDO PARTICULAS DE HIDROXIAPATITA ESFERICAS, NO POROSAS, DE TAMAÑO NO SUPERIOR A 250 MICRONES Y DE DENSIDAD AL MENOS 3,00 G/CC. DICHAS PARTICULAS PRESENTAN DIVERSOS USOS MEDICOS, INCLUYENDO EL REEMPLAZAMIENTO DE HUESOS, REVESTIMIENTOS DE IMPLANTES Y APLICACIONES DENTALES, COMO EL AUMENTO DEL REBORDE ALVEOLAR, OBTURACIONES DE CAVIDADES TRAS LA EXTRACCION DE RAICES DENTALES, RESTAURACION DE LESIONES OSEAS PERIODONTALES Y AUMENTO DE LOS TEJIDOS BLANDOS.
ES97941008T 1996-07-10 1997-06-20 Particulas esfericas de hidroxiapatita y procedimiento para la produccion de las mismas. Expired - Lifetime ES2169419T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/679,611 US5702677A (en) 1996-07-10 1996-07-10 Spherical hydroxyapatite particles and process for the production thereof

Publications (1)

Publication Number Publication Date
ES2169419T3 true ES2169419T3 (es) 2002-07-01

Family

ID=24727604

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97941008T Expired - Lifetime ES2169419T3 (es) 1996-07-10 1997-06-20 Particulas esfericas de hidroxiapatita y procedimiento para la produccion de las mismas.

Country Status (11)

Country Link
US (1) US5702677A (es)
EP (1) EP0910546B1 (es)
JP (1) JP2000514390A (es)
KR (1) KR20000022475A (es)
AT (1) ATE210071T1 (es)
CA (1) CA2257290A1 (es)
DE (1) DE69708870T2 (es)
EA (1) EA001032B1 (es)
ES (1) ES2169419T3 (es)
HK (1) HK1019581A1 (es)
WO (1) WO1998001388A1 (es)

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US7060287B1 (en) * 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
US7968110B2 (en) * 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
EP0838494B1 (en) * 1995-07-12 2003-05-28 Maruo Calcium Company Limited Additive for synthethic resins and synthetic resin compositions
JP3986564B2 (ja) * 1996-12-27 2007-10-03 丸尾カルシウム株式会社 合成樹脂組成物
US6013591A (en) 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US6919070B1 (en) * 1997-10-17 2005-07-19 Zakrytoe Aktsionernoe Obschestvo “OSTIM” Stomatic composition
JP3974276B2 (ja) * 1998-11-30 2007-09-12 ペンタックス株式会社 セラミックス複合体の製造方法およびセラミックス複合体
DE19930335A1 (de) * 1999-07-02 2001-01-18 Henkel Kgaa Kompositmaterialien aus Calciumverbindungen und Proteinkomponenten
CA2380932A1 (en) * 1999-08-13 2001-02-22 Bioform Inc. Tissue augmentation material and methods
US6426114B1 (en) 2000-05-02 2002-07-30 The University Of British Columbia Sol-gel calcium phosphate ceramic coatings and method of making same
US20040028676A1 (en) * 2002-08-06 2004-02-12 Klein Dean A. Swallowing system tissue modifier
FR2850282B1 (fr) * 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US20040170692A1 (en) * 2003-02-12 2004-09-02 The Curators Of The University Of Missouri Calcium phosphate bodies and a process for making calcium phosphate bodies
WO2005065079A2 (en) * 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
US7390335B2 (en) * 2004-04-06 2008-06-24 American Dental Association Foundation Nanostructured bioactive materials prepared by spray drying techniques
US7670579B2 (en) * 2004-04-06 2010-03-02 American Dental Association Foundation Nanostructured bioactive materials prepared by dual nozzle spray drying techniques
US7244270B2 (en) 2004-09-16 2007-07-17 Evera Medical Systems and devices for soft tissue augmentation
US7641688B2 (en) 2004-09-16 2010-01-05 Evera Medical, Inc. Tissue augmentation device
DE102004049140B4 (de) * 2004-10-07 2011-05-05 Leonora Ivanusch Werkstück und Verfahren zur Herstellung eines chirurgischen Implantats oder eines künstlichen Zahnmaterials
EP1893174A2 (en) * 2005-05-10 2008-03-05 Cytophil, Inc. Injectable hydrogels and methods of making and using same
US7651701B2 (en) * 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
DE102006009793A1 (de) * 2005-10-31 2007-09-06 Sus Tech Gmbh & Co. Kg Verwendung von schwer wasserlöslichen Calciumsalzen und/oder deren Kompositen
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US20070184087A1 (en) * 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
DE102006009799A1 (de) * 2006-03-01 2007-09-06 Henkel Kgaa Vorwiegend plättchenförmige schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien, umfassend diese
US20080221688A1 (en) * 2007-03-09 2008-09-11 Warsaw Orthopedic, Inc. Method of Maintaining Fatigue Performance In A Bone-Engaging Implant
US20080221681A1 (en) * 2007-03-09 2008-09-11 Warsaw Orthopedic, Inc. Methods for Improving Fatigue Performance of Implants With Osteointegrating Coatings
US9138509B2 (en) * 2007-09-14 2015-09-22 Musculoskeletal Transplant Foundation Composition for filling bone defects
US20090198329A1 (en) 2008-02-01 2009-08-06 Kesten Randy J Breast implant with internal flow dampening
JP5960051B2 (ja) 2009-08-04 2016-08-02 プシロクス・エービーＰｓｉｌｏｘ ＡＢ イオン置換リン酸カルシウム粒子
GB201317105D0 (en) * 2013-09-26 2013-11-06 Glaxo Group Ltd Novel Composition
JP2014177399A (ja) * 2014-04-28 2014-09-25 Asahi Kasei Chemicals Corp 回収リン
WO2016187413A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
AU2016293656B2 (en) * 2015-07-13 2018-11-29 Kabushiki Kaisha Sangi Tooth-surface-membrane-forming powder containing sintered apatite
CN110078038B (zh) * 2019-05-27 2022-12-06 淄博新维陶瓷科技有限公司 一种羟基磷灰石及其制备方法与应用

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US5034352A (en) * 1985-06-25 1991-07-23 Lifecore Biomedical, Inc. Calcium phosphate materials
US5217699A (en) * 1985-09-23 1993-06-08 Toa Nenryo Kogyo Kabushiki Kaisha Calcium-phosphate type hydroxyapatite
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US5205928A (en) * 1988-03-11 1993-04-27 Kanto Kagaku Kabushiki Kaisha Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite
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Also Published As

Publication number Publication date
US5702677A (en) 1997-12-30
CA2257290A1 (en) 1998-01-15
EP0910546B1 (en) 2001-12-05
EA001032B1 (ru) 2000-08-28
EP0910546A1 (en) 1999-04-28
DE69708870T2 (de) 2002-06-06
ATE210071T1 (de) 2001-12-15
EA199900055A1 (ru) 1999-08-26
JP2000514390A (ja) 2000-10-31
WO1998001388A1 (en) 1998-01-15
KR20000022475A (ko) 2000-04-25
DE69708870D1 (de) 2002-01-17
HK1019581A1 (en) 2000-02-18
EP0910546A4 (en) 1999-08-11

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