ES2168319T3 - Procedimiento para la fabricacion de hemoglobinas hiperpolimericas molecularmente uniformes. - Google Patents

Procedimiento para la fabricacion de hemoglobinas hiperpolimericas molecularmente uniformes.

Info

Publication number
ES2168319T3
ES2168319T3 ES95107280T ES95107280T ES2168319T3 ES 2168319 T3 ES2168319 T3 ES 2168319T3 ES 95107280 T ES95107280 T ES 95107280T ES 95107280 T ES95107280 T ES 95107280T ES 2168319 T3 ES2168319 T3 ES 2168319T3
Authority
ES
Spain
Prior art keywords
hyperpolimeric
hemoglobins
procedure
manufacture
molecularly uniform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95107280T
Other languages
English (en)
Inventor
Wolfgang Prof Dr Dr Barnikol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANGUI BIOTECH AG
Original Assignee
SANGUI BIOTECH AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANGUI BIOTECH AG filed Critical SANGUI BIOTECH AG
Application granted granted Critical
Publication of ES2168319T3 publication Critical patent/ES2168319T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA ELABORACION DE HEMOGLOBINA HIPERPOLIMERA DE UNIFORMIDAD MOLECULAR, DONDE UNA HEMOGLOBINA HIPERPOLIMERA EN FORMA DE SOLUCION CONOCIDA CON PESO MOLECULAR DIFERENTE SE SOMETE AL MENOS A UN PROCESO DE FILTRACION Y AL MENOS A UN PROCESO DE PRECIPITACION FRACCIONADA Y/O AL MENOS UN PROCESO DE CROMATOGRAFIA Y/O AL MENOS UN PROCESO DE SOLUCION PARCIAL.
ES95107280T 1994-05-31 1995-05-13 Procedimiento para la fabricacion de hemoglobinas hiperpolimericas molecularmente uniformes. Expired - Lifetime ES2168319T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4418973A DE4418973A1 (de) 1994-05-31 1994-05-31 Verfahren zur Herstellung molekular-einheitlicher hyperpolymerer Hämoglobine
JP7159664A JPH0912472A (ja) 1994-05-31 1995-06-26 分子単一性の超高分子ヘモグロビンの製法

Publications (1)

Publication Number Publication Date
ES2168319T3 true ES2168319T3 (es) 2002-06-16

Family

ID=25937042

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95107280T Expired - Lifetime ES2168319T3 (es) 1994-05-31 1995-05-13 Procedimiento para la fabricacion de hemoglobinas hiperpolimericas molecularmente uniformes.

Country Status (6)

Country Link
EP (2) EP0685492B1 (es)
JP (1) JPH0912472A (es)
AT (1) ATE209217T1 (es)
DE (2) DE4418973A1 (es)
DK (1) DK0685492T3 (es)
ES (1) ES2168319T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0854151A1 (de) 1997-01-20 1998-07-22 SanguiBioTech AG Verfahren zur Gewinnung einheitlicher Fraktionen hyperpolymerer Hämoglobine
US5994509A (en) * 1998-04-08 1999-11-30 Sanguibiotech Ag Method for obtaining uniform fractions of hyperpolymeric hemoglobins
DE10031744A1 (de) 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
DE10352692A1 (de) 2003-11-12 2005-06-23 Sanguibiotech Gmbh Verwendung hypo-onkotischer Lösungen in das Blut addierbarer, hyperpolymerer Hämoglobine zur Behandlung eines Lungenödems
EP2614833A1 (en) 2012-01-13 2013-07-17 SastoMed GmbH Scarring reducing wound treatment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925344A (en) * 1973-04-11 1975-12-09 Community Blood Council Plasma protein substitute
DE2714252C2 (de) * 1977-03-31 1983-08-18 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines für die intravenöse Injektion geeigneten Hämoglobinpräparates mit erhöhter Sauerstoffabgabe gegenüber Erythrozyten
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
DE3320752A1 (de) * 1983-06-09 1984-12-13 Wolfgang Prof. Dr.Dr. 6500 Mainz Barnikol Lumineszierende schichten zur verwendung in vorrichtungen zur bestimmung der sauerstoffkonzentration in gasen und dergleichen durch messung der lumineszensverringerung
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
EP0277289B8 (en) * 1986-11-10 2003-05-21 Biopure Corporation Extra pure semi-synthetic blood substitute
DE3714351A1 (de) * 1987-04-29 1988-11-17 Barnikol Wolfgang Verfahren zur modifikation, insbesondere zur polymerisation von haemoglobin in vitro
DE3841105C2 (de) * 1988-12-07 1994-09-01 Wolfgang Karl Richard Barnikol Verfahren zur Aufreinigung und Modifikation von polymerisiertem Hämoglobin
NL8901174A (nl) * 1989-05-10 1990-12-03 Het Hoofd Van De Afdeling Mili Hemoglobine-preparaat en gebruik daarvan.
HUT64571A (en) * 1990-11-29 1994-01-28 Upjohn Co A method for producing hemoglobin preparatives containing imido ester cross bind
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation

Also Published As

Publication number Publication date
JPH0912472A (ja) 1997-01-14
EP0685492A3 (de) 1996-07-10
ATE209217T1 (de) 2001-12-15
DK0685492T3 (da) 2002-05-21
DE4418973A1 (de) 1995-12-14
EP0685492B1 (de) 2001-11-21
EP0685492A2 (de) 1995-12-06
DE59509857D1 (de) 2002-01-03
EP1097943A1 (de) 2001-05-09

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