ES2167453T3 - Composicion de suministro medicamentoso que contiene quitosano o derivado del mismo con un potencial z. definido. - Google Patents
Composicion de suministro medicamentoso que contiene quitosano o derivado del mismo con un potencial z. definido.Info
- Publication number
- ES2167453T3 ES2167453T3 ES95929164T ES95929164T ES2167453T3 ES 2167453 T3 ES2167453 T3 ES 2167453T3 ES 95929164 T ES95929164 T ES 95929164T ES 95929164 T ES95929164 T ES 95929164T ES 2167453 T3 ES2167453 T3 ES 2167453T3
- Authority
- ES
- Spain
- Prior art keywords
- chitosane
- derivative
- potential
- same
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
SE FACILITA UNA COMPOSICION DE SUMINISTRO MEDICAMENTOSO PARA LA ADMINISTRACION EN LA MUCOSA. LA COMPOSICION INCLUYE UN COMPUESTO Y PARTICULAS ACTIVAS FARMACOLOGICAMENTE, PREFERIBLEMENTE EN POLVO O MICROESFERAS, DE QUITOSANO O DERIVADO DE QUITOSANO O SAL EN LA QUE LAS PARTICULAS SE HALLAN BIEN SOLIDIFICADAS O PARCIALMENTE ENLAZADAS DE FORMA CRUZADA DE FORMA QUE TIENEN UN POTENCIAL-ZETA DE +0.5 A +50MV. LAS PARTICULAS SOLIDIFICADAS SE HACEN MEDIANTE EL TRATAMIENTO DE LAS PARTICULAS MEDIANTE UNA SAL DE QUITOSANO SOLUBLE EN AGUA CON UN AGENTE ALCALINO COMO EL HIDROXIDO DE SODIO EN AGUA QUE NO CONTIENE ACIDO PARA HACERLAS INSOLUBLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9416884A GB9416884D0 (en) | 1994-08-20 | 1994-08-20 | Drug delivery compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2167453T3 true ES2167453T3 (es) | 2002-05-16 |
Family
ID=10760170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95929164T Expired - Lifetime ES2167453T3 (es) | 1994-08-20 | 1995-08-21 | Composicion de suministro medicamentoso que contiene quitosano o derivado del mismo con un potencial z. definido. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5840341A (es) |
EP (1) | EP0776195B1 (es) |
JP (1) | JPH10508004A (es) |
AT (1) | ATE208193T1 (es) |
AU (1) | AU688566B2 (es) |
DE (1) | DE69523765T2 (es) |
DK (1) | DK0776195T3 (es) |
ES (1) | ES2167453T3 (es) |
FI (1) | FI970694A (es) |
GB (2) | GB9416884D0 (es) |
NO (1) | NO315636B1 (es) |
PT (1) | PT776195E (es) |
WO (1) | WO1996005810A1 (es) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3098401B2 (ja) * | 1995-07-12 | 2000-10-16 | 株式会社エルティーティー研究所 | 経鼻投与用製剤 |
CA2257408A1 (en) * | 1996-07-10 | 1998-01-15 | Lisbeth Illum | Compositions suitable for delivery of genes to epithelial cells |
US6649192B2 (en) * | 1996-07-29 | 2003-11-18 | Universidade De Santiago De Compostela | Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms |
ES2114502B1 (es) * | 1996-07-29 | 1999-07-01 | Univ Santiago Compostela | Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas. |
GB9700624D0 (en) | 1997-01-14 | 1997-03-05 | Danbiosyst Uk | Drug delivery composition |
DE19712978A1 (de) * | 1997-03-27 | 1998-10-01 | Henkel Kgaa | Chitosanmikrosphären |
EP1010435B1 (en) * | 1997-09-05 | 2010-11-03 | Maruho K.K. | Nanocapsule preparations for treating intraarticular diseases |
DE19756314C2 (de) * | 1997-12-12 | 2000-06-29 | Roland Bodmeier | Zubereitung mit verlängerter Verweildauer am Applikationsort |
JPH11246392A (ja) * | 1998-03-03 | 1999-09-14 | Makoto Otsuka | 経口用固形製剤 |
KR100306221B1 (ko) * | 1998-12-17 | 2002-03-21 | 김충섭 | 서방성키토산미세캡슐의제조방법 |
GB9905136D0 (en) | 1999-03-06 | 1999-04-28 | Danbiosyst Uk | Surface modification of lamellar particles |
PT1808438E (pt) | 1999-06-29 | 2015-01-14 | Mannkind Corp | Purificação e estabilização de péptidos e proteínas em agentes farmacêuticos |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
WO2001024795A1 (de) * | 1999-10-01 | 2001-04-12 | Skw Trostberg Aktiengesellschaft | α-LIPONSÄURE(-DERIVATE)ENTHALTENDE RETARDFORM |
GB9924797D0 (en) * | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
US20030206958A1 (en) * | 2000-12-22 | 2003-11-06 | Cattaneo Maurizio V. | Chitosan biopolymer for the topical delivery of active agents |
EP1278512A2 (en) * | 2000-05-03 | 2003-01-29 | MBT Munich Biotechnology AG | Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites |
US20040115133A1 (en) * | 2000-05-10 | 2004-06-17 | Wermeling Daniel P. | Intranasal opioid compositions |
GB2378383A (en) * | 2001-06-06 | 2003-02-12 | Gursharan Moonga | Nasal delivery of pharmaceutical compositions in powder form |
US20030134810A1 (en) * | 2001-10-09 | 2003-07-17 | Chris Springate | Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents |
US20030224000A1 (en) * | 2001-12-21 | 2003-12-04 | Kokai-Kun John Fitzgerald | Methods for blocking or alleviating staphylococcal nasal colonization by intranasal application of monoclonal antibodies |
AU2003207508A1 (en) * | 2002-01-10 | 2003-07-30 | Northeastern University | Hybrid immobilized catalytic system with controlled permeability |
ATE385193T1 (de) | 2002-03-20 | 2008-02-15 | Mannkind Corp | Inhalationsgerät |
AU2003270427A1 (en) * | 2002-09-06 | 2004-03-29 | University Of South Florida | Cellular delivery of natriuretic peptides |
AU2003268531A1 (en) * | 2002-09-06 | 2004-03-29 | University Of South Florida | Materials and methods for treatment of allergic diseases |
US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
GB0302738D0 (en) * | 2003-02-06 | 2003-03-12 | Advanced Biopolymers As | Composition |
JP2006525354A (ja) * | 2003-05-01 | 2006-11-09 | アルキメデス・ディヴェロップメント・リミテッド | Lh−rhアナログロイプロイドの経鼻投与 |
GB0315632D0 (en) | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
US20050147581A1 (en) * | 2003-11-19 | 2005-07-07 | The Board Of Trustees Of The University Of Illinois | Macromolecular drug complexes having improved stability and therapeutic use of the same |
US20050175679A1 (en) * | 2004-02-10 | 2005-08-11 | Michael Moshman | Controlled release formulations |
WO2005094420A2 (en) * | 2004-02-17 | 2005-10-13 | University Of South Florida | Materials and methods for treatment of inflammatory and cell proliferation disorders |
CA2565236A1 (en) * | 2004-05-06 | 2005-11-17 | Ivrea Pharmaceuticals, Inc. | Particles for the delivery of active agents |
CA2575692C (en) | 2004-08-20 | 2014-10-14 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
US7892414B1 (en) | 2004-11-19 | 2011-02-22 | The United States Of America As Represented By The Secretary Of Army | Electrochemical biosensors, applications and methods of making biosensors |
ES2277743B2 (es) * | 2005-06-02 | 2008-12-16 | Universidade De Santiago De Compostela | Nanoparticulas que comprenden quitosano y ciclodextrina. |
DK1937219T3 (en) | 2005-09-14 | 2016-02-15 | Mannkind Corp | A method for drug formulation based on increasing the affinity of the crystalline surfaces of the microparticle of active principles |
IN2015DN00888A (es) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
WO2008020318A2 (en) * | 2006-03-30 | 2008-02-21 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
EP2051585A4 (en) * | 2006-04-28 | 2010-06-02 | Univ South Florida | MATERIALS AND METHODS OF SUPPRESSING INFLAMMATION THROUGH INHIBITION OF THE VORHOF RECEPTOR FOR NATRIURETIC PEPTIDES |
PT2028937E (pt) * | 2006-05-22 | 2015-04-09 | Vanda Pharmaceuticals Inc | Tratamento por agonista de melatonina |
CN101148511B (zh) * | 2006-09-18 | 2010-10-20 | 中国科学院过程工程研究所 | 荧光壳聚糖微球的制备方法及其在示踪剂领域的应用 |
US20100028447A1 (en) | 2007-01-22 | 2010-02-04 | Targacept, Inc. | Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs |
ES2619181T3 (es) | 2007-08-28 | 2017-06-23 | Otago Innovation Limited | Hidrogel quirúrgico |
GB0716907D0 (en) | 2007-08-31 | 2007-10-10 | Archimedes Dev Ltd | Pharmaceutical powder compositions |
EP2057982A1 (en) | 2007-11-09 | 2009-05-13 | Archimedes Development Limited | Intranasal compositions |
AU2009240512B2 (en) * | 2008-04-24 | 2014-07-10 | Medtronic, Inc. | Protective gel based on chitosan and oxidized polysaccharide |
AU2009240509B2 (en) | 2008-04-24 | 2014-08-21 | Medtronic, Inc. | Rehydratable thiolated polysaccharide particles and sponge |
US8530632B2 (en) | 2008-04-24 | 2013-09-10 | Medtronic Xomed, Inc. | Chitosan-containing protective composition |
US8802652B2 (en) | 2008-04-24 | 2014-08-12 | Medtronic, Inc. | Rehydratable polysaccharide particles and sponge |
EP2123261A1 (en) * | 2008-05-20 | 2009-11-25 | Stallergenes S.A. | Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance |
KR101933816B1 (ko) | 2008-06-13 | 2019-03-29 | 맨카인드 코포레이션 | 건조 분말 흡입기 및 약물 투여 시스템 |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
EP2609954B1 (en) | 2008-06-20 | 2021-12-29 | MannKind Corporation | An interactive apparatus for real-time profiling of inhalation efforts |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
JP2009149675A (ja) * | 2009-02-24 | 2009-07-09 | Novadel Pharma Inc | 極性または非極性の、バッカルスプレーまたはカプセル |
US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
MY157166A (en) | 2009-06-12 | 2016-05-13 | Mankind Corp | Diketopiperazine microparticles with defined specific surface areas |
JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
US10184942B2 (en) | 2011-03-17 | 2019-01-22 | University Of South Florida | Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer |
JP6133270B2 (ja) | 2011-04-01 | 2017-05-24 | マンカインド コーポレイション | 薬剤カートリッジのためのブリスター包装 |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
KR102411809B1 (ko) | 2012-01-26 | 2022-06-22 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
ES2624294T3 (es) | 2012-07-12 | 2017-07-13 | Mannkind Corporation | Sistemas de suministro de fármacos en polvo seco |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
EP3767297A1 (en) | 2012-12-18 | 2021-01-20 | Vanda Pharmaceuticals Inc. | Method of determining tau and thereby determining whether a patient has a free-running circadian rhythm |
EP2970149B1 (en) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Microcrystalline diketopiperazine compositions and methods |
CA2908232A1 (en) * | 2013-03-26 | 2014-10-02 | Optinose As | Nasal administration of fluticasone and carbon dioxide |
US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
BR112016000937A8 (pt) | 2013-07-18 | 2021-06-22 | Mannkind Corp | formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco |
CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
JP6945614B2 (ja) * | 2014-03-26 | 2021-10-06 | オプティノーズ アズ | 経鼻投与 |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
CN106470724A (zh) * | 2014-06-25 | 2017-03-01 | 奥普蒂诺斯公司 | 鼻腔给药 |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
JOP20180128A1 (ar) * | 2018-12-24 | 2020-06-24 | Univ Of Petra | صيغة دوائية صلبة قابلة للتشتت في الفم |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4895724A (en) * | 1985-06-07 | 1990-01-23 | Pfizer Inc. | Chitosan compositions for controlled and prolonged release of macromolecules |
US5129877A (en) * | 1988-04-29 | 1992-07-14 | University Of Georgia Research Foundation, Inc. | Receptor-mediated delivery system |
GB8904370D0 (en) * | 1989-02-25 | 1989-04-12 | Cosmas Damian Ltd | Liquid delivery compositions |
GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
-
1994
- 1994-08-20 GB GB9416884A patent/GB9416884D0/en active Pending
-
1995
- 1995-08-21 JP JP8507876A patent/JPH10508004A/ja not_active Ceased
- 1995-08-21 DE DE69523765T patent/DE69523765T2/de not_active Expired - Lifetime
- 1995-08-21 WO PCT/GB1995/001980 patent/WO1996005810A1/en active IP Right Grant
- 1995-08-21 US US08/809,158 patent/US5840341A/en not_active Expired - Lifetime
- 1995-08-21 GB GB9702503A patent/GB2305124B/en not_active Expired - Lifetime
- 1995-08-21 AU AU32626/95A patent/AU688566B2/en not_active Ceased
- 1995-08-21 DK DK95929164T patent/DK0776195T3/da active
- 1995-08-21 ES ES95929164T patent/ES2167453T3/es not_active Expired - Lifetime
- 1995-08-21 PT PT95929164T patent/PT776195E/pt unknown
- 1995-08-21 AT AT95929164T patent/ATE208193T1/de active
- 1995-08-21 EP EP95929164A patent/EP0776195B1/en not_active Expired - Lifetime
-
1997
- 1997-02-05 NO NO19970507A patent/NO315636B1/no unknown
- 1997-02-19 FI FI970694A patent/FI970694A/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI970694A0 (fi) | 1997-02-19 |
PT776195E (pt) | 2002-04-29 |
GB9416884D0 (en) | 1994-10-12 |
FI970694A (fi) | 1997-02-19 |
NO970507L (no) | 1997-02-05 |
NO970507D0 (no) | 1997-02-05 |
GB2305124A (en) | 1997-04-02 |
ATE208193T1 (de) | 2001-11-15 |
GB2305124B (en) | 1998-11-18 |
DK0776195T3 (da) | 2001-12-27 |
AU3262695A (en) | 1996-03-14 |
JPH10508004A (ja) | 1998-08-04 |
EP0776195A1 (en) | 1997-06-04 |
WO1996005810A1 (en) | 1996-02-29 |
EP0776195B1 (en) | 2001-11-07 |
NO315636B1 (no) | 2003-10-06 |
DE69523765D1 (de) | 2001-12-13 |
GB9702503D0 (en) | 1997-03-26 |
US5840341A (en) | 1998-11-24 |
DE69523765T2 (de) | 2002-09-26 |
AU688566B2 (en) | 1998-03-12 |
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