ES2166021T3 - Procedimiento para la preparacion de 4-aril-3-hidroximetilpiperidinas. - Google Patents
Procedimiento para la preparacion de 4-aril-3-hidroximetilpiperidinas.Info
- Publication number
- ES2166021T3 ES2166021T3 ES97106096T ES97106096T ES2166021T3 ES 2166021 T3 ES2166021 T3 ES 2166021T3 ES 97106096 T ES97106096 T ES 97106096T ES 97106096 T ES97106096 T ES 97106096T ES 2166021 T3 ES2166021 T3 ES 2166021T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen atom
- hydroximethylpiperidins
- aril
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
UN PROCEDIMIENTO DE PRODUCCION DE UN PIPERIDINCARBINOL REPRESENTADO POR LA FORMULA GENERAL (2) QUE CONSISTE EN REDUCIR EL ISOMERO TRANS DE UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (1): DONDE R{SUP,1} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR O UN GRUPO ARALQUILO, R{SUP,2} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR, UN GRUPO ARILO O UN GRUPO ARALQUILO, Y X ES UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO, ARILO, ARALQUILO, ALCOXI, DIALQUILAMINO, ALQUILTIO, ARILTIO O C{SUB,M}F{SUB,2M+1 }, DONDE M ES UN ENTERO COMPRENDIDO ENTRE 1 Y 20.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP09279196A JP3446468B2 (ja) | 1996-04-15 | 1996-04-15 | ピペリジンカルビノール類の製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2166021T3 true ES2166021T3 (es) | 2002-04-01 |
Family
ID=14064248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97106096T Expired - Lifetime ES2166021T3 (es) | 1996-04-15 | 1997-04-14 | Procedimiento para la preparacion de 4-aril-3-hidroximetilpiperidinas. |
Country Status (9)
Country | Link |
---|---|
US (3) | US6197960B1 (es) |
EP (1) | EP0802185B1 (es) |
JP (1) | JP3446468B2 (es) |
AT (1) | ATE207055T1 (es) |
CA (1) | CA2202577C (es) |
DE (1) | DE69707341T2 (es) |
DK (1) | DK0802185T3 (es) |
ES (1) | ES2166021T3 (es) |
PT (1) | PT802185E (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0812827B1 (en) | 1996-06-13 | 2009-09-02 | Sumitomo Chemical Company, Limited | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation |
JP2002514222A (ja) * | 1997-05-29 | 2002-05-14 | スミスクライン・ビーチャム・コーポレイション | 新規方法 |
WO1998056787A1 (en) * | 1997-06-10 | 1998-12-17 | Synthon B.V. | 4-Phenylpiperidine compounds |
ES2137131B1 (es) * | 1998-02-06 | 2000-09-16 | Vita Invest Sa | Derivado de piperidinona procedimiento de obtencion y procedimiento para su utilizacion. |
ES2149687B1 (es) * | 1998-04-08 | 2001-05-16 | Medichem Sa | Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas. |
DE69910691T2 (de) | 1998-06-29 | 2004-07-08 | Sumika Fine Chemical Co. Ltd. | L-Tartrate von Trans-(-)-4-(4-Fluorphenyl)-3-Hydroxymethyl-Piperidin Verbindungen und Verfahren zu ihrer Herstellung |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
AU6360999A (en) * | 1998-11-02 | 2000-05-22 | Synthon B.V. | Process for producing 4-arylpiperidine-3-carbinols and related compounds |
EP1140832A4 (en) * | 1998-12-22 | 2004-11-03 | Pentech Pharmaceuticals Inc | PROCESS FOR THE PREPARATION OF INTERMEDIATES AND DERIVATIVES OF ARYLPIPERIDINE CARBINOL |
GB9915727D0 (en) * | 1999-07-03 | 1999-09-08 | Smithkline Beecham Plc | Novel compound and process |
EP1280775A1 (en) | 2000-05-12 | 2003-02-05 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
CA2464327A1 (en) | 2001-10-22 | 2003-05-30 | Synthon B.V. | N-formyl derivatives of paroxetine |
EP1954329B1 (en) * | 2005-12-01 | 2016-03-09 | SCA Hygiene Products AB | New absorbent article |
WO2015071831A1 (en) * | 2013-11-18 | 2015-05-21 | Piramal Enterprises Limited | An improved process for minimising the formation of dehalogenated byproducts |
CN115108968A (zh) * | 2021-03-23 | 2022-09-27 | 上药康丽(常州)药业有限公司 | 一种3-(4-溴苯基)-哌啶的生产方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
CH636858A5 (de) * | 1977-01-17 | 1983-06-30 | Ciba Geigy Ag | Verfahren zur herstellung neuer phenylazacycloalkane. |
US4593036A (en) | 1984-02-07 | 1986-06-03 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator |
EP0190496A3 (en) * | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Piperidine derivatives having a gastro-intestinal activity |
DE3680184D1 (de) | 1985-08-10 | 1991-08-14 | Beecham Group Plc | Verfahren zur herstellung von arylpiperidincarbinol. |
GB8520154D0 (en) | 1985-08-10 | 1985-09-18 | Beecham Group Plc | Chemical process |
US5227379A (en) | 1986-11-03 | 1993-07-13 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
IE66332B1 (en) | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
DK716088D0 (da) | 1988-12-22 | 1988-12-22 | Ferrosan As | Reduktion af piperidin-dion-derivater samt intermediat |
US5258517A (en) | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
JPH0696551A (ja) | 1992-09-11 | 1994-04-08 | Kao Corp | 磁気ディスクカートリッジ |
GB9305175D0 (en) | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
EP0812827B1 (en) | 1996-06-13 | 2009-09-02 | Sumitomo Chemical Company, Limited | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation |
US5672612A (en) | 1996-09-09 | 1997-09-30 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
-
1996
- 1996-04-15 JP JP09279196A patent/JP3446468B2/ja not_active Expired - Lifetime
-
1997
- 1997-04-11 US US08/835,646 patent/US6197960B1/en not_active Expired - Lifetime
- 1997-04-14 CA CA002202577A patent/CA2202577C/en not_active Expired - Fee Related
- 1997-04-14 ES ES97106096T patent/ES2166021T3/es not_active Expired - Lifetime
- 1997-04-14 AT AT97106096T patent/ATE207055T1/de active
- 1997-04-14 EP EP97106096A patent/EP0802185B1/en not_active Expired - Lifetime
- 1997-04-14 DE DE69707341T patent/DE69707341T2/de not_active Expired - Lifetime
- 1997-04-14 DK DK97106096T patent/DK0802185T3/da active
- 1997-04-14 PT PT97106096T patent/PT802185E/pt unknown
-
2000
- 2000-09-20 US US09/666,585 patent/US6476228B1/en not_active Expired - Lifetime
- 2000-11-27 US US09/721,762 patent/US6590102B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69707341D1 (de) | 2001-11-22 |
PT802185E (pt) | 2002-01-30 |
US6590102B1 (en) | 2003-07-08 |
JP3446468B2 (ja) | 2003-09-16 |
JPH09278754A (ja) | 1997-10-28 |
EP0802185B1 (en) | 2001-10-17 |
US6476228B1 (en) | 2002-11-05 |
CA2202577A1 (en) | 1997-10-15 |
CA2202577C (en) | 2006-05-30 |
DE69707341T2 (de) | 2002-07-25 |
EP0802185A1 (en) | 1997-10-22 |
ATE207055T1 (de) | 2001-11-15 |
US6197960B1 (en) | 2001-03-06 |
DK0802185T3 (da) | 2001-11-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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