ES2064557T3 - Derivados de 1-fenilalquil-3-fenilurea. - Google Patents
Derivados de 1-fenilalquil-3-fenilurea.Info
- Publication number
- ES2064557T3 ES2064557T3 ES90114966T ES90114966T ES2064557T3 ES 2064557 T3 ES2064557 T3 ES 2064557T3 ES 90114966 T ES90114966 T ES 90114966T ES 90114966 T ES90114966 T ES 90114966T ES 2064557 T3 ES2064557 T3 ES 2064557T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl group
- fenilurea
- fenilalquil
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
SE PROVEEN NUEVOS DERIVADOS 1-FENILOALQUILO-3-FENILOUREA REPRESENTADOS POR LA SIGUIENTE FORMULA (I): EN DONDE R1 ES UN GRUPO ALQUILO DE 1 A 8 ATOMOS DE CARBONO, UN GRUPO ALCOXILO DE 1 A 5 ATOMOS DE CARBONO O UN ATOMO HALOGENO, R (AL CUADRADO) ES UN GRUPO ALQUILO DE 1 A 15 ATOMOS DE CARBONO, CADA UNO DE LOS R3 Y R4 SON INDEPENDIENTEMENTE UN GRUPO ALQUILO DE 1 A 5 ATOMOS DE CARBONO, M ES UN ENTERO DE 1 A 3, Y N ES 0 O 1. LOS COMPUESTOS SON POTENTES REDUCIENDO EL NIVEL DE COLESTEROL EN SUERO, Y SE USAN PARA TRATAR LA HIPERGLUCEMIA Y LA ARTERIOESCLEROSIS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20242289 | 1989-08-04 | ||
JP5006590 | 1990-03-01 | ||
JP18584590A JPH03294256A (ja) | 1989-08-04 | 1990-07-13 | 1―フェニルアルキル―3―フェニル尿素誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064557T3 true ES2064557T3 (es) | 1995-02-01 |
Family
ID=27293825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90114966T Expired - Lifetime ES2064557T3 (es) | 1989-08-04 | 1990-08-03 | Derivados de 1-fenilalquil-3-fenilurea. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5126483A (es) |
EP (1) | EP0415123B1 (es) |
AT (1) | ATE115121T1 (es) |
AU (1) | AU629376B2 (es) |
CA (1) | CA2022346A1 (es) |
DE (1) | DE69014775T2 (es) |
DK (1) | DK0415123T3 (es) |
ES (1) | ES2064557T3 (es) |
GR (1) | GR3015275T3 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05310678A (ja) * | 1990-01-22 | 1993-11-22 | Mitsubishi Kasei Corp | 1−フェニルアルキル−3−フェニル尿素誘導体 |
IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Double-transformed urea and theories, their preparation and pharmaceutical preparations containing them |
FR2678938B1 (fr) * | 1991-07-10 | 1993-10-08 | Rhone Poulenc Rorer Sa | Derives de pyrrolidine, leur preparation et les medicaments les contenant. |
DE4126662A1 (de) * | 1991-08-13 | 1993-02-18 | Boehringer Mannheim Gmbh | Neue 3,5-di-tert.butyl-4-hydroxyphenyl-derivate, verfahren zu ihrer herstellung und arzneimittel |
JPH07503737A (ja) * | 1992-05-28 | 1995-04-20 | フアイザー・インコーポレイテツド | アシル補酵素a:コレステロールアシルトランスフェラーゼ(acat)の阻害剤としての新規なn−アリールおよびn−ヘテロアリール尿素誘導体 |
CA2107196A1 (en) * | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
US5441984A (en) * | 1994-01-06 | 1995-08-15 | Eli Lilly And Company | Urea, thiourea and guanidine derivatives |
US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
AU712467B2 (en) * | 1995-09-18 | 1999-11-04 | Sankyo Company Limited | New urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use |
KR20020073574A (ko) | 2000-02-02 | 2002-09-27 | 워너-램버트 캄파니 | 피지선 장애 치료용 콜레스테롤 에스테르 및 왁스에스테르 합성 이중 억제제 |
JP5118120B2 (ja) * | 2009-12-16 | 2013-01-16 | エンパイア テクノロジー ディベロップメント エルエルシー | コンデンサ |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1471681A (es) * | 1965-03-25 | 1967-05-25 | ||
US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
IE61716B1 (en) * | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
JPH0193569A (ja) * | 1987-07-02 | 1989-04-12 | Warner Lambert Co | アシル‐CoA:コレステロールアシルトランスフエラーゼのN‐〔(2,6‐ジ置換)フエニル〕尿素およびカルバメート阻害剤 |
US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
DE68911203T2 (de) * | 1988-03-30 | 1994-04-14 | Warner Lambert Co | N-[[(2,6-disubstituierte)phenyl]N'- arylalkyl] Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel. |
US4868210A (en) * | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
-
1990
- 1990-07-31 CA CA002022346A patent/CA2022346A1/en not_active Abandoned
- 1990-07-31 AU AU60013/90A patent/AU629376B2/en not_active Ceased
- 1990-08-03 AT AT90114966T patent/ATE115121T1/de not_active IP Right Cessation
- 1990-08-03 DK DK90114966.6T patent/DK0415123T3/da active
- 1990-08-03 DE DE69014775T patent/DE69014775T2/de not_active Expired - Fee Related
- 1990-08-03 ES ES90114966T patent/ES2064557T3/es not_active Expired - Lifetime
- 1990-08-03 EP EP90114966A patent/EP0415123B1/en not_active Expired - Lifetime
- 1990-08-03 US US07/562,337 patent/US5126483A/en not_active Expired - Fee Related
-
1995
- 1995-03-03 GR GR940404117T patent/GR3015275T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU6001390A (en) | 1991-02-07 |
DK0415123T3 (da) | 1995-02-13 |
EP0415123B1 (en) | 1994-12-07 |
CA2022346A1 (en) | 1991-02-05 |
DE69014775D1 (de) | 1995-01-19 |
GR3015275T3 (en) | 1995-06-30 |
AU629376B2 (en) | 1992-10-01 |
DE69014775T2 (de) | 1995-05-18 |
ATE115121T1 (de) | 1994-12-15 |
US5126483A (en) | 1992-06-30 |
EP0415123A2 (en) | 1991-03-06 |
EP0415123A3 (en) | 1992-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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