ES2064557T3 - Derivados de 1-fenilalquil-3-fenilurea. - Google Patents

Derivados de 1-fenilalquil-3-fenilurea.

Info

Publication number
ES2064557T3
ES2064557T3 ES90114966T ES90114966T ES2064557T3 ES 2064557 T3 ES2064557 T3 ES 2064557T3 ES 90114966 T ES90114966 T ES 90114966T ES 90114966 T ES90114966 T ES 90114966T ES 2064557 T3 ES2064557 T3 ES 2064557T3
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl group
fenilurea
fenilalquil
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90114966T
Other languages
English (en)
Inventor
Tetsuo Sekiya
Shinya Inoue
Chiaki Hyodo
Hiromi Okushima
Kohei Umezu
Kazuo A Mezon-Tsukushin Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP18584590A external-priority patent/JPH03294256A/ja
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Application granted granted Critical
Publication of ES2064557T3 publication Critical patent/ES2064557T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

SE PROVEEN NUEVOS DERIVADOS 1-FENILOALQUILO-3-FENILOUREA REPRESENTADOS POR LA SIGUIENTE FORMULA (I): EN DONDE R1 ES UN GRUPO ALQUILO DE 1 A 8 ATOMOS DE CARBONO, UN GRUPO ALCOXILO DE 1 A 5 ATOMOS DE CARBONO O UN ATOMO HALOGENO, R (AL CUADRADO) ES UN GRUPO ALQUILO DE 1 A 15 ATOMOS DE CARBONO, CADA UNO DE LOS R3 Y R4 SON INDEPENDIENTEMENTE UN GRUPO ALQUILO DE 1 A 5 ATOMOS DE CARBONO, M ES UN ENTERO DE 1 A 3, Y N ES 0 O 1. LOS COMPUESTOS SON POTENTES REDUCIENDO EL NIVEL DE COLESTEROL EN SUERO, Y SE USAN PARA TRATAR LA HIPERGLUCEMIA Y LA ARTERIOESCLEROSIS.
ES90114966T 1989-08-04 1990-08-03 Derivados de 1-fenilalquil-3-fenilurea. Expired - Lifetime ES2064557T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20242289 1989-08-04
JP5006590 1990-03-01
JP18584590A JPH03294256A (ja) 1989-08-04 1990-07-13 １―フェニルアルキル―３―フェニル尿素誘導体

Publications (1)

Publication Number Publication Date
ES2064557T3 true ES2064557T3 (es) 1995-02-01

Family

ID=27293825

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90114966T Expired - Lifetime ES2064557T3 (es) 1989-08-04 1990-08-03 Derivados de 1-fenilalquil-3-fenilurea.

Country Status (9)

Country Link
US (1) US5126483A (es)
EP (1) EP0415123B1 (es)
AT (1) ATE115121T1 (es)
AU (1) AU629376B2 (es)
CA (1) CA2022346A1 (es)
DE (1) DE69014775T2 (es)
DK (1) DK0415123T3 (es)
ES (1) ES2064557T3 (es)
GR (1) GR3015275T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05310678A (ja) * 1990-01-22 1993-11-22 Mitsubishi Kasei Corp １−フェニルアルキル−３−フェニル尿素誘導体
IL100915A (en) * 1991-02-19 1996-03-31 Erba Carlo Spa Double-transformed urea and theories, their preparation and pharmaceutical preparations containing them
FR2678938B1 (fr) * 1991-07-10 1993-10-08 Rhone Poulenc Rorer Sa Derives de pyrrolidine, leur preparation et les medicaments les contenant.
DE4126662A1 (de) * 1991-08-13 1993-02-18 Boehringer Mannheim Gmbh Neue 3,5-di-tert.butyl-4-hydroxyphenyl-derivate, verfahren zu ihrer herstellung und arzneimittel
KR950701621A (ko) * 1992-05-28 1995-04-28 알렌 제이. 스피겔 아실 조효소a : 콜레스테롤 아실 전이효소(acat)의 억제제로서 신규한 n- 아릴 및 n- 헤테로아릴우레아 유도체(new n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a : cholesterol acyl transferase(acat)
CA2107196A1 (en) * 1992-09-29 1994-03-30 Mitsubishi Chemical Corporation Carboxamide derivatives
US5441984A (en) * 1994-01-06 1995-08-15 Eli Lilly And Company Urea, thiourea and guanidine derivatives
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
CZ272296A3 (en) 1995-09-18 1997-04-16 Sankyo Co Novel derivatives of urea exhibiting acat inhibition activity, their preparation and therapeutic and prophylactic application
CA2398219A1 (en) 2000-02-02 2001-08-09 Warner-Lambert Company Dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders
JP5118120B2 (ja) * 2009-12-16 2013-01-16 エンパイア テクノロジー ディベロップメント エルエルシー コンデンサ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1471681A (es) * 1965-03-25 1967-05-25
US4623662A (en) * 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
IE61716B1 (en) * 1987-06-02 1994-11-30 Warner Lambert Co Antihyperlipidemic and antiatherosclerotic urea compounds
ATE61574T1 (de) * 1987-07-02 1991-03-15 Warner Lambert Co N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase.
JPH0678298B2 (ja) * 1988-03-30 1994-10-05 ワーナー‐ランバート・コンパニー Ｎ‐〔〔（２，６‐ジ置換）フエニル〕‐ｎ′‐アリールアルキル〕尿素
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions

Also Published As

Publication number Publication date
EP0415123A2 (en) 1991-03-06
AU6001390A (en) 1991-02-07
AU629376B2 (en) 1992-10-01
EP0415123B1 (en) 1994-12-07
EP0415123A3 (en) 1992-04-01
CA2022346A1 (en) 1991-02-05
ATE115121T1 (de) 1994-12-15
US5126483A (en) 1992-06-30
DK0415123T3 (da) 1995-02-13
GR3015275T3 (en) 1995-06-30
DE69014775D1 (de) 1995-01-19
DE69014775T2 (de) 1995-05-18

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