ES2162897T3 - Mejoras en complejos de platino. - Google Patents

Mejoras en complejos de platino.

Info

Publication number
ES2162897T3
ES2162897T3 ES95302629T ES95302629T ES2162897T3 ES 2162897 T3 ES2162897 T3 ES 2162897T3 ES 95302629 T ES95302629 T ES 95302629T ES 95302629 T ES95302629 T ES 95302629T ES 2162897 T3 ES2162897 T3 ES 2162897T3
Authority
ES
Spain
Prior art keywords
platinum complexes
cycloalkyl
aryl
alkyl
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95302629T
Other languages
English (en)
Inventor
Christopher Francis Ja Barnard
Gerald Edward Bossard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson Matthey PLC
Original Assignee
Johnson Matthey PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey PLC filed Critical Johnson Matthey PLC
Application granted granted Critical
Publication of ES2162897T3 publication Critical patent/ES2162897T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Photolithography (AREA)

Abstract

COMPLEJOS PT(IV) DE FORMULA I, DONDE X ES HALURO, PSEUDOHALURO U OH, R{SUB, 1} Y R{SUB, 2} SON H, ALKILO C{SUB, 1} A C{SUB, 6}, CICLOALKILO, ARILO O R{SUB,1}NH{SUB,2} ES UN DONANTE DE HIDROGENO HETEROCICLICO, Y PUEDE SER EL MISMO O DIFERENTE, R{SUB, 3} Y R{SUB, 4} SON H, ALKILO C{SUB, 1} A C{SUB, 5}, CICLOALKILO O ARILO Y PUEDE SER EL MISMO O DIFERENTE, Y R{SUB, 5} ES H, ME O ET, TIENEN ACTIVIDAD IN VITRO E IN VIVO FRENTE A CELULAS CANCERIGENAS.
ES95302629T 1994-04-26 1995-04-20 Mejoras en complejos de platino. Expired - Lifetime ES2162897T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9408218A GB9408218D0 (en) 1994-04-26 1994-04-26 Improvements in platinum complexes

Publications (1)

Publication Number Publication Date
ES2162897T3 true ES2162897T3 (es) 2002-01-16

Family

ID=10754111

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95302629T Expired - Lifetime ES2162897T3 (es) 1994-04-26 1995-04-20 Mejoras en complejos de platino.

Country Status (12)

Country Link
US (1) US5519155A (es)
EP (1) EP0679656B1 (es)
JP (1) JPH0840892A (es)
AT (1) ATE205216T1 (es)
AU (1) AU692521B2 (es)
CA (1) CA2147567C (es)
DE (1) DE69522490T2 (es)
DK (1) DK0679656T3 (es)
ES (1) ES2162897T3 (es)
GB (1) GB9408218D0 (es)
GR (1) GR3036538T3 (es)
PT (1) PT679656E (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
DK1720540T3 (da) 2004-02-18 2008-10-06 Gpc Biotech Ag Satraplatin til behandling af resistente tumorer eller tumorer, der er vanskelige at behandle
WO2006002119A2 (en) 2004-06-18 2006-01-05 Gpc Biotech, Inc. Kinase inhibitors for treating cancers
EP1781230A1 (en) * 2004-07-14 2007-05-09 GPC Biotech AG Variable-dose packaging system
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
CN101809024A (zh) * 2007-07-16 2010-08-18 铂雅制药公司 吡铂的口服制剂
WO2009032172A2 (en) * 2007-08-31 2009-03-12 Massachusetts Institute Of Technology Platinum compositions as treatment for oct-related cancers
JP2011511071A (ja) * 2008-02-08 2011-04-07 ポニアード ファーマシューティカルズ， インコーポレイテッド 肺癌を治療するためのピコプラチンおよびアムルビシン
WO2010027428A1 (en) * 2008-08-26 2010-03-11 Massachusetts Institute Of Technology Platinum ( iv) complexes for use in dual mode pharmaceutical therapy
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
WO2011029639A2 (en) 2009-09-08 2011-03-17 Medexis S.A. Compounds and methods for treating neoplasia
US20130303500A1 (en) 2010-07-30 2013-11-14 Medexis S.A. Compounds and methods for treating neoplasia
WO2012177935A1 (en) 2011-06-21 2012-12-27 Massachusetts Inistitute Of Technology Compositions and methods for the treatment of cancer
US8729286B2 (en) 2012-05-10 2014-05-20 Massachusetts Institute Of Technology Platinum compounds as treatment for cancers, and related methods, kits, and compositions
WO2014160216A2 (en) 2013-03-13 2014-10-02 Massachusetts Institute Of Technology Dual targeting anticancer agents
US9593139B2 (en) 2013-04-05 2017-03-14 Massachusetts Institute Of Technology Compositions, methods, and kits comprising platinum compounds associated with a ligand comprising a targeting moiety

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE113054T1 (de) * 1988-02-02 1994-11-15 Johnson Matthey Inc Pt(iv) komplexe.

Also Published As

Publication number Publication date
US5519155A (en) 1996-05-21
AU1766195A (en) 1995-11-02
DE69522490D1 (de) 2001-10-11
CA2147567C (en) 2006-01-17
EP0679656A1 (en) 1995-11-02
CA2147567A1 (en) 1995-10-27
EP0679656B1 (en) 2001-09-05
GB9408218D0 (en) 1994-06-15
DE69522490T2 (de) 2002-05-16
AU692521B2 (en) 1998-06-11
PT679656E (pt) 2001-12-28
ATE205216T1 (de) 2001-09-15
JPH0840892A (ja) 1996-02-13
GR3036538T3 (en) 2001-12-31
DK0679656T3 (da) 2001-10-01

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