ES2156303T3 - Derivados de ester del acido carbapenem-3-carboxilico. - Google Patents

Derivados de ester del acido carbapenem-3-carboxilico.

Info

Publication number
ES2156303T3
ES2156303T3 ES96941156T ES96941156T ES2156303T3 ES 2156303 T3 ES2156303 T3 ES 2156303T3 ES 96941156 T ES96941156 T ES 96941156T ES 96941156 T ES96941156 T ES 96941156T ES 2156303 T3 ES2156303 T3 ES 2156303T3
Authority
ES
Spain
Prior art keywords
group
replaced
molecular weight
ester derivatives
carbapenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96941156T
Other languages
English (en)
Inventor
Takao Abe
Toshio Kumagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Japan Inc
Original Assignee
Wyeth Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Lederle Japan Ltd filed Critical Wyeth Lederle Japan Ltd
Application granted granted Critical
Publication of ES2156303T3 publication Critical patent/ES2156303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTER DERIVADOS DEL ACIDO (1R,5S,6S) ZOLIN TOMO DE HIDROGENO O UN GRUPO ALQUILO DE BAJO PESO MOLECULAR; R{SUP,2} ES UN GRUPO ALQUILO QUE PUEDE SER SUSTITUIDO POR UN GRUPO CICLOALQUILO DE 4 A 7 ATOMOS DE CARBONO QUE, A SU VEZ, PUEDE SER SUSTITUIDO POR UN GRUPO ALQUILO DE BAJO PESO MOLECULAR, O SE TRATA DE UN GRUPO CICLOALQUILO CON 4 A 7 CARBONOS QUE PUEDE SER SUSTITUIDO POR UN GRUPO ALQUILO DE BAJO PESO MOLECULAR; Y N ES 0 O 1. LOS COMPUESTOS SON ALTAMENTE ABSORBIBLES EN EL TRACTO DIGESTIVO Y SE CONVIERTEN RAPIDAMENTE EN EL COMPUESTO ACTIVO DENTRO DEL ORGANISMO MOSTRANDO UNA FUERTE ACTIVIDAD ANTIBACTERIANA.
ES96941156T 1995-12-08 1996-12-04 Derivados de ester del acido carbapenem-3-carboxilico. Expired - Lifetime ES2156303T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34507695 1995-12-08

Publications (1)

Publication Number Publication Date
ES2156303T3 true ES2156303T3 (es) 2001-06-16

Family

ID=18374125

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96941156T Expired - Lifetime ES2156303T3 (es) 1995-12-08 1996-12-04 Derivados de ester del acido carbapenem-3-carboxilico.

Country Status (14)

Country Link
US (1) US5886172A (es)
EP (1) EP0808315B1 (es)
JP (1) JP4667542B2 (es)
KR (1) KR19980702089A (es)
AT (1) ATE200289T1 (es)
AU (1) AU705408B2 (es)
CA (1) CA2211075A1 (es)
DE (1) DE69612374T2 (es)
ES (1) ES2156303T3 (es)
HU (1) HUP9801156A3 (es)
IL (1) IL121240A (es)
NO (1) NO973625D0 (es)
TW (1) TW420681B (es)
WO (1) WO1997021712A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100345468B1 (ko) * 2000-07-10 2002-07-26 한국과학기술연구원 신규 1-베타메틸카바페넴 유도체 및 그의 제조방법
KR100446432B1 (ko) * 2001-08-13 2004-08-30 한국화학연구원 2-벤조티아졸 카바페넴 유도체 및 그의 제조방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
AU2003301425A1 (en) * 2002-10-18 2004-05-04 Meiji Seika Kaisha, Ltd. Process for producing carbapenem derivative and intermediate for use in the production
KR100599876B1 (ko) * 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
WO2009066917A2 (en) * 2007-11-23 2009-05-28 Kukje Pharm. Ind. Co., Ltd. 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its salt, process for the preparation thereof and pharmaceutical composition comprising the same
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
CN102532139A (zh) * 2010-12-07 2012-07-04 重庆医药工业研究院有限责任公司 一种替比培南的制备方法
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN102757430B (zh) * 2011-04-29 2016-04-13 上海医药工业研究院 一种替比培南的制备方法
CN102775409B (zh) * 2011-05-10 2016-08-03 上海医药工业研究院 一种替比培南匹伏酯的中间体的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
SG11201506243XA (en) 2013-02-14 2015-09-29 Bristol Myers Squibb Co Tubulysin compounds, methods of making and use
US10077287B2 (en) 2014-11-10 2018-09-18 Bristol-Myers Squibb Company Tubulysin analogs and methods of making and use
BR112019015487A2 (pt) 2017-02-06 2020-03-31 Spero Therapeutics, Inc. Formas cristalinas de tebipenem pivoxil, composições incluindo as mesmas, métodos de fabricação e métodos de uso

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
ATE114654T1 (de) * 1988-04-01 1994-12-15 Sankyo Co 2-(heterocyclylthio)carbapenemderivate, deren herstellung und deren verwendung als antibiotika.
JPH06157532A (ja) * 1992-11-17 1994-06-03 Sankyo Co Ltd 結晶性カルバペネム化合物
AU682510B2 (en) * 1993-07-01 1997-10-09 Pfizer Japan Inc. 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives
JP3317604B2 (ja) * 1994-12-28 2002-08-26 日本ワイスレダリー株式会社 結晶形態のカルバペネム化合物

Also Published As

Publication number Publication date
DE69612374D1 (de) 2001-05-10
AU705408B2 (en) 1999-05-20
DE69612374T2 (de) 2001-07-12
EP0808315A1 (en) 1997-11-26
IL121240A (en) 2001-08-08
TW420681B (en) 2001-02-01
CA2211075A1 (en) 1997-06-19
IL121240A0 (en) 1998-01-04
NO973625L (no) 1997-08-06
WO1997021712A1 (en) 1997-06-19
NO973625D0 (no) 1997-08-06
JP4667542B2 (ja) 2011-04-13
US5886172A (en) 1999-03-23
HUP9801156A3 (en) 1999-03-01
ATE200289T1 (de) 2001-04-15
JPH11504039A (ja) 1999-04-06
HUP9801156A2 (hu) 1998-09-28
KR19980702089A (ko) 1998-07-15
AU1039997A (en) 1997-07-03
EP0808315B1 (en) 2001-04-04

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