ES2078723T3 - 3-acilamino-2-pirrolidinonas como potenciadores de los procesos de aprendizaje y de la memoria y composiciones farmaceuticas que las contienen. - Google Patents

3-acilamino-2-pirrolidinonas como potenciadores de los procesos de aprendizaje y de la memoria y composiciones farmaceuticas que las contienen.

Info

Publication number
ES2078723T3
ES2078723T3 ES92830293T ES92830293T ES2078723T3 ES 2078723 T3 ES2078723 T3 ES 2078723T3 ES 92830293 T ES92830293 T ES 92830293T ES 92830293 T ES92830293 T ES 92830293T ES 2078723 T3 ES2078723 T3 ES 2078723T3
Authority
ES
Spain
Prior art keywords
pirrolidinonas
acilamino
contain
memory
enhancers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92830293T
Other languages
English (en)
Inventor
Fabio Giannessi
Orlando Ghirardi
Domenico Misiti
Maria Ornella Tinti
Roberto Cozzolino
Carlo Scolastico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2078723T3 publication Critical patent/ES2078723T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

3-ACILAMINO-2-PIRROLIDINONAS DE LA FORMULA GENERAL (I) EN DONDE R SE SELECCIONA DEL PIRROLIDIN-2-ONA-1-ACETILO, PMETOXIBENZOILO, N-BENCILOXICARBONIL-(S)-PROLILO, FENILBUTANOILO, 3-TRIFLUOROMETILBENZOILO, 3,4,5-TRIMETOXIBENZOILO, NICOTINOILO Y ACILO QUE TIENEN DE 1 A 5 ATOMOS DE CARBONO; Y R1 SE SELECCIONA DEL HIDROGENO, METOXICARBONILMETILO, AMINOCARBONILMETILO, 2HIDROXIMETILO Y FORMILMETILO, QUE SON UNOS INTENSIFICADORES POTENTES DE LOS PROCESOS DE APRENDIZADJE Y DE LA MEMORIA. LAS COMPOSICIONES ADMINISTRABLES ORAL O PARENTERALMENTE A MODO DE DOSIS UNITARIA CONTIENEN DE 100 A 500 MG APROXIMADAMENTE DE UN COMPUESTO DE LA FORMULA (I).
ES92830293T 1991-06-05 1992-06-04 3-acilamino-2-pirrolidinonas como potenciadores de los procesos de aprendizaje y de la memoria y composiciones farmaceuticas que las contienen. Expired - Lifetime ES2078723T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910391A IT1245870B (it) 1991-06-05 1991-06-05 3-acilammino-2-pirrolidinoni quali attivatori dei processi di appremdimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Publications (1)

Publication Number Publication Date
ES2078723T3 true ES2078723T3 (es) 1995-12-16

Family

ID=11400180

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92830293T Expired - Lifetime ES2078723T3 (es) 1991-06-05 1992-06-04 3-acilamino-2-pirrolidinonas como potenciadores de los procesos de aprendizaje y de la memoria y composiciones farmaceuticas que las contienen.

Country Status (7)

Country Link
EP (1) EP0519877B1 (es)
AT (1) ATE128461T1 (es)
DE (1) DE69205073T2 (es)
DK (1) DK0519877T3 (es)
ES (1) ES2078723T3 (es)
GR (1) GR3018173T3 (es)
IT (1) IT1245870B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
GB0512238D0 (en) 2005-06-15 2005-07-27 Univ Cambridge Tech Anti-inflammatory agents
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
CN106366031B (zh) * 2016-08-30 2018-11-06 山东默得森生物制药有限公司 一种(s)-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE27T1 (de) * 1978-05-08 1981-04-15 Ucb Sa Lactam-n-essigsaeuren und ihre amide, verfahren zu ihrer herstellung und heilmittel, die sie enthalten
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Also Published As

Publication number Publication date
DK0519877T3 (da) 1995-11-27
EP0519877B1 (en) 1995-09-27
ITRM910391A0 (it) 1991-06-05
ITRM910391A1 (it) 1992-12-05
EP0519877A1 (en) 1992-12-23
DE69205073T2 (de) 1996-03-07
DE69205073D1 (de) 1995-11-02
IT1245870B (it) 1994-10-25
ATE128461T1 (de) 1995-10-15
GR3018173T3 (en) 1996-02-29

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