ES2156179T3 - Nuevas sulfonamidas. - Google Patents

Nuevas sulfonamidas.

Info

Publication number
ES2156179T3
ES2156179T3 ES95117833T ES95117833T ES2156179T3 ES 2156179 T3 ES2156179 T3 ES 2156179T3 ES 95117833 T ES95117833 T ES 95117833T ES 95117833 T ES95117833 T ES 95117833T ES 2156179 T3 ES2156179 T3 ES 2156179T3
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
heterocyclyl
halo
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95117833T
Other languages
English (en)
Inventor
Volker Breu
Kaspar Burri
Jean-Marie Cassal
Martine Clozel
Georges Hirth
Bernd-Michael Loffler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2156179T3 publication Critical patent/ES2156179T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Bipolar Transistors (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)

Abstract

COMPUESTOS DE LA FORMULA DONDE R 1 ES HETEROCICLILO; R{SUP,2} ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, ALQUILTIO INFERIOR, ALCOXI INFERIOR ALQUILO INFERIOR, ALQUILSULFONILO INFERIOR - ALCOXI INFERIOR, FENILO, ALQUIL FENILO INFERIOR, ALCOXI INFERIOR FENILO INFERIOR, ALQUILENDIOXIFENILO INFERIOR, FENIL - ALQUILO INFERIOR, ALQUILFENIL - ALQUILO INFERIOR, ALCOXI - FENIL - ALQUILO INFERIOR, ALQUILENDIOXIFENILO INFERIOR ALQUILO INFERIOR, HETEROCICLILO O HETEROCICLILO - ALQUILO INFERIOR; R{SUP,3} ES ALQUILO INFERIOR, ALCOXI INFERIOR, FORMILO, HALOGENO - ALQUILO INFERIOR, HIDROXI - ALQUILO INFERIOR, AMINO - ALQUILO INFERIOR O UN RESTO - CH{SUB,2}O - A - ALQUILO INFERIOR, (CH{SUP,2}){SUB,M} - O - (CR{SUP,AR{SUP,B}){SUB,N}OH, (CH{SUB,2}){SUB,M} - O - (CR{SUP,2}R{SUP,B}){SUB,N}OR{SUP,9}, (CH{SUB,2}){SUB,M} - O - (CR{SUB,A}R{SUP,B}){SUB,N}NH{SUB,2} O (CH{SUB,2}){SUB,M} - O - (CR{SUP,A}R{SUP,B}){SUB,N} - B R{SUP,9}; R{SUP,4}R{SUP,8} SON HIDROGENO, ALCOXI INFERIOR O HALOGENO; R{SUP,9} ES HETEROCICLILO; FENILO O FENILO SUSTITUIDO POR ALQUILO INFERIOR, ALCOXI INFERIOR Y/O HALOGENO, ALQUILO INFERIOR; R{SUP,A} Y R{SUP,B} SON HIDROGENO O ALQUILO INFERIOR; A ES UN GRUPO 1,2 - DIHIDROXI - ETILENO CETALIZADO; B ES - OC(O)O -, O(C)O (NH) -, - NH(C)O(NH) - O - NHC(O) -, N ES 2,3 O 4; Y M ES 0 O 1 SIENDO SUSTANCIAS INHIBIDORAS PARA RECEPTORES ENDOTELINA. PUEDEN SER UTILIZADOS POR ELLO PARA TRATAMIENTO DE ENFERMEDADES, QUE ESTAN ASOCIADAS A ACTIVADOS ENDOTELINA, EN PARTICULAR ENFERMEDADES CIRCULATORIAS, TALES COMO HIPERTONIA, ISQUEMIA, ESPASMOS Y ANGINA DE PECHO.
ES95117833T 1994-11-25 1995-11-13 Nuevas sulfonamidas. Expired - Lifetime ES2156179T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH355994 1994-11-25
CH284295 1995-10-09

Publications (1)

Publication Number Publication Date
ES2156179T3 true ES2156179T3 (es) 2001-06-16

Family

ID=25691537

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95117833T Expired - Lifetime ES2156179T3 (es) 1994-11-25 1995-11-13 Nuevas sulfonamidas.

Country Status (22)

Country Link
EP (1) EP0713875B1 (es)
JP (1) JP2755565B2 (es)
KR (1) KR100415030B1 (es)
AT (1) ATE199905T1 (es)
AU (1) AU691353B2 (es)
CA (1) CA2162630C (es)
CZ (1) CZ289920B6 (es)
DE (1) DE59509107D1 (es)
DK (1) DK0713875T3 (es)
ES (1) ES2156179T3 (es)
FI (1) FI117896B (es)
GR (1) GR3036065T3 (es)
HK (1) HK1012345A1 (es)
HU (1) HU225112B1 (es)
IL (1) IL116064A (es)
MA (1) MA23725A1 (es)
MY (1) MY119409A (es)
NO (1) NO307606B1 (es)
NZ (1) NZ280495A (es)
PT (1) PT713875E (es)
RU (1) RU2162084C2 (es)
TW (1) TW394763B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2217034A1 (en) * 1995-04-03 1996-10-10 Sumitomo Pharmaceuticals Company, Limited Novel pyrimidine derivatives effective as psychotropic drug and process for the production thereof
DK0897914T3 (da) * 1997-08-19 2004-09-27 Hoffmann La Roche Fremgangsmåde til fremstilling af 2,5-disubstituerede pyridiner
TWI284642B (en) 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
US6417360B1 (en) 1999-03-03 2002-07-09 Hoffmann-La Roche Inc. Heterocyclic sulfonamides
HUP0201402A3 (en) * 1999-09-03 2003-12-29 Actelion Pharmaceuticals Ltd Bis-sulfonamides, process for their preparation and pharmaceutical compositions containing them
BR0016241A (pt) * 1999-12-22 2002-11-12 Actelion Pharmaceuticals Ltd Compostos, composições farmacêuticas, uso de um ou mais compostos, e, processo para a fabricação de composições farmacêuticas
AU2001265871A1 (en) * 2000-04-25 2001-11-07 Actelion Pharmaceuticals Ltd Substituted sulfonylaminopyrimidines
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
EP1458715B1 (en) * 2001-12-18 2005-12-07 AstraZeneca AB Novel compounds
TWI328007B (en) 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
EP1454625A1 (en) * 2003-03-06 2004-09-08 Speedel Development AG Pyridylsulfonamidyl-pyrimidines for the treatment of diabetic nephropathies
AU2005229331B2 (en) * 2004-03-05 2011-10-13 F. Hoffmann-La Roche Ag Diaminopyrimidines as P2X3 and P2X2/3 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW287160B (es) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines

Also Published As

Publication number Publication date
KR100415030B1 (ko) 2004-05-17
IL116064A0 (en) 1996-01-31
MY119409A (en) 2005-05-31
RU2162084C2 (ru) 2001-01-20
NO954718L (no) 1996-05-28
AU691353B2 (en) 1998-05-14
CA2162630A1 (en) 1996-05-26
EP0713875B1 (de) 2001-03-21
DE59509107D1 (de) 2001-04-26
KR960017644A (ko) 1996-06-17
ATE199905T1 (de) 2001-04-15
CZ289920B6 (cs) 2002-04-17
CZ308895A3 (en) 1997-07-16
FI117896B (fi) 2007-04-13
JPH08208625A (ja) 1996-08-13
DK0713875T3 (da) 2001-06-11
FI955669A (fi) 1996-05-26
PT713875E (pt) 2001-09-28
NZ280495A (en) 1996-12-20
EP0713875A1 (de) 1996-05-29
GR3036065T3 (en) 2001-09-28
CA2162630C (en) 2007-05-01
AU3789595A (en) 1996-05-30
FI955669A0 (fi) 1995-11-24
HUT75030A (en) 1997-03-28
NO954718D0 (no) 1995-11-22
JP2755565B2 (ja) 1998-05-20
HU225112B1 (en) 2006-06-28
MA23725A1 (fr) 1996-07-01
HU9503311D0 (en) 1996-01-29
HK1012345A1 (en) 1999-07-30
TW394763B (en) 2000-06-21
IL116064A (en) 2000-06-29
NO307606B1 (no) 2000-05-02

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