CA2162630A1 - Sulfonamides - Google Patents
SulfonamidesInfo
- Publication number
- CA2162630A1 CA2162630A1 CA002162630A CA2162630A CA2162630A1 CA 2162630 A1 CA2162630 A1 CA 2162630A1 CA 002162630 A CA002162630 A CA 002162630A CA 2162630 A CA2162630 A CA 2162630A CA 2162630 A1 CA2162630 A1 CA 2162630A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- alkoxy
- signifies
- phenyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Bipolar Transistors (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Lubricants (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compounds of the formula, (see formula I) wherein R1 signifies heterocyclyl; R2 signifies hydrogen, lower-alkyl, lower-alkoxy, lower-alkylthio, lower-alkoxy-lower-alkyl, lower-alkylsulphonyl-lower-alkoxy, phenyl, lower alkylphenyl, lower-alkoxy-phenyl, lower-alkylene-dioxyphenyl, phenyl-lower alkyl, lower alkyl-phenyl-lower alkyl, lower alkoxy-phenyl-lower alkyl, lower alkylenedioxyphenyl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl; R3 signifies lower-alkyl, lower-alkoxy, formyl, halo-lower-alkyl, hydroxy-lower-alkyl, amino-lower-alkyl or a residue -CH2O-A-lower-alkyl, -(CH2)m-O-(CR a R b)n OH, -(CH2)m-O-(CR a R b)n OR9, -(CH2)m-O-(CR a R b)n NH2 or -(CH2)m-O-(CR a R b)n-B-R9; R4-R8 signify hydrogen, lower-alkoxy or halogen; R9 signifies heterocyclyl; phenyl or phenyl substituted by lower-alkyl, lower-alkoxy and/or halogen, or lower-alkyl; R a and R b signify hydrogen or lower-alkyl; A signifies a ketalized 1,2-dihydroxy-ethylene group; B signifies -OC(O)O-, -O(C(O)NH-, -NH(C(O)NH- or -NHC(O)O-: n signifies 2, 3 or 4; and m signifies 0 or 1 are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH355994 | 1994-11-25 | ||
CH3559/94 | 1994-11-25 | ||
CH284295 | 1995-10-09 | ||
CH2842/95 | 1995-10-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2162630A1 true CA2162630A1 (en) | 1996-05-26 |
CA2162630C CA2162630C (en) | 2007-05-01 |
Family
ID=25691537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002162630A Expired - Lifetime CA2162630C (en) | 1994-11-25 | 1995-11-10 | Sulfonamides |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0713875B1 (en) |
JP (1) | JP2755565B2 (en) |
KR (1) | KR100415030B1 (en) |
AT (1) | ATE199905T1 (en) |
AU (1) | AU691353B2 (en) |
CA (1) | CA2162630C (en) |
CZ (1) | CZ289920B6 (en) |
DE (1) | DE59509107D1 (en) |
DK (1) | DK0713875T3 (en) |
ES (1) | ES2156179T3 (en) |
FI (1) | FI117896B (en) |
GR (1) | GR3036065T3 (en) |
HK (1) | HK1012345A1 (en) |
HU (1) | HU225112B1 (en) |
IL (1) | IL116064A (en) |
MA (1) | MA23725A1 (en) |
MY (1) | MY119409A (en) |
NO (1) | NO307606B1 (en) |
NZ (1) | NZ280495A (en) |
PT (1) | PT713875E (en) |
RU (1) | RU2162084C2 (en) |
TW (1) | TW394763B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2217034A1 (en) * | 1995-04-03 | 1996-10-10 | Sumitomo Pharmaceuticals Company, Limited | Novel pyrimidine derivatives effective as psychotropic drug and process for the production thereof |
DE69824090T2 (en) * | 1997-08-19 | 2005-07-07 | F. Hoffmann-La Roche Ag | Process for the preparation of 2,5-disubstituted pyridines |
TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
US6417360B1 (en) * | 1999-03-03 | 2002-07-09 | Hoffmann-La Roche Inc. | Heterocyclic sulfonamides |
CA2361402C (en) * | 1999-09-03 | 2009-05-12 | Actelion Pharmaceuticals Ltd | Bis-sulfonamides |
CN1407973A (en) * | 1999-12-22 | 2003-04-02 | 埃科特莱茵药品有限公司 | Butyne diol derivatives |
AU2001265871A1 (en) * | 2000-04-25 | 2001-11-07 | Actelion Pharmaceuticals Ltd | Substituted sulfonylaminopyrimidines |
US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
DE60207890T2 (en) * | 2001-12-18 | 2006-08-10 | Astrazeneca Ab | NEW CONNECTIONS |
TWI328007B (en) | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
EP1454625A1 (en) * | 2003-03-06 | 2004-09-08 | Speedel Development AG | Pyridylsulfonamidyl-pyrimidines for the treatment of diabetic nephropathies |
DK1725540T5 (en) * | 2004-03-05 | 2012-10-22 | Hoffmann La Roche | DIAMINOPYRIMIDINES AS P2X3 AND P2X2 / 3 ANTAGONISTS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (en) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity |
TW287160B (en) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
-
1995
- 1995-11-10 CA CA002162630A patent/CA2162630C/en not_active Expired - Lifetime
- 1995-11-13 ES ES95117833T patent/ES2156179T3/en not_active Expired - Lifetime
- 1995-11-13 EP EP95117833A patent/EP0713875B1/en not_active Expired - Lifetime
- 1995-11-13 DK DK95117833T patent/DK0713875T3/en active
- 1995-11-13 AT AT95117833T patent/ATE199905T1/en active
- 1995-11-13 DE DE59509107T patent/DE59509107D1/en not_active Expired - Lifetime
- 1995-11-13 PT PT95117833T patent/PT713875E/en unknown
- 1995-11-16 AU AU37895/95A patent/AU691353B2/en not_active Ceased
- 1995-11-20 JP JP7300933A patent/JP2755565B2/en not_active Expired - Lifetime
- 1995-11-20 HU HU9503311A patent/HU225112B1/en not_active IP Right Cessation
- 1995-11-20 NZ NZ280495A patent/NZ280495A/en not_active IP Right Cessation
- 1995-11-20 IL IL11606495A patent/IL116064A/en not_active IP Right Cessation
- 1995-11-21 MA MA24073A patent/MA23725A1/en unknown
- 1995-11-22 NO NO954718A patent/NO307606B1/en not_active IP Right Cessation
- 1995-11-22 KR KR1019950042804A patent/KR100415030B1/en not_active IP Right Cessation
- 1995-11-23 CZ CZ19953088A patent/CZ289920B6/en not_active IP Right Cessation
- 1995-11-23 MY MYPI95003579A patent/MY119409A/en unknown
- 1995-11-24 RU RU95120013/04A patent/RU2162084C2/en not_active IP Right Cessation
- 1995-11-24 TW TW084112546A patent/TW394763B/en not_active IP Right Cessation
- 1995-11-24 FI FI955669A patent/FI117896B/en not_active IP Right Cessation
-
1998
- 1998-12-15 HK HK98113451A patent/HK1012345A1/en not_active IP Right Cessation
-
2001
- 2001-06-18 GR GR20010400908T patent/GR3036065T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
CZ289920B6 (en) | 2002-04-17 |
EP0713875A1 (en) | 1996-05-29 |
NO307606B1 (en) | 2000-05-02 |
DK0713875T3 (en) | 2001-06-11 |
EP0713875B1 (en) | 2001-03-21 |
JP2755565B2 (en) | 1998-05-20 |
CA2162630C (en) | 2007-05-01 |
NO954718D0 (en) | 1995-11-22 |
NZ280495A (en) | 1996-12-20 |
PT713875E (en) | 2001-09-28 |
AU691353B2 (en) | 1998-05-14 |
MA23725A1 (en) | 1996-07-01 |
ATE199905T1 (en) | 2001-04-15 |
FI955669A (en) | 1996-05-26 |
JPH08208625A (en) | 1996-08-13 |
KR960017644A (en) | 1996-06-17 |
CZ308895A3 (en) | 1997-07-16 |
MY119409A (en) | 2005-05-31 |
NO954718L (en) | 1996-05-28 |
AU3789595A (en) | 1996-05-30 |
KR100415030B1 (en) | 2004-05-17 |
HK1012345A1 (en) | 1999-07-30 |
IL116064A (en) | 2000-06-29 |
GR3036065T3 (en) | 2001-09-28 |
TW394763B (en) | 2000-06-21 |
ES2156179T3 (en) | 2001-06-16 |
FI117896B (en) | 2007-04-13 |
HUT75030A (en) | 1997-03-28 |
IL116064A0 (en) | 1996-01-31 |
HU9503311D0 (en) | 1996-01-29 |
DE59509107D1 (en) | 2001-04-26 |
HU225112B1 (en) | 2006-06-28 |
FI955669A0 (en) | 1995-11-24 |
RU2162084C2 (en) | 2001-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20151110 |