AU3789595A - Novel sulfonamides - Google Patents

Novel sulfonamides

Info

Publication number
AU3789595A
AU3789595A AU37895/95A AU3789595A AU3789595A AU 3789595 A AU3789595 A AU 3789595A AU 37895/95 A AU37895/95 A AU 37895/95A AU 3789595 A AU3789595 A AU 3789595A AU 3789595 A AU3789595 A AU 3789595A
Authority
AU
Australia
Prior art keywords
alkyl
alkoxy
heterocyclyl
halo
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU37895/95A
Other versions
AU691353B2 (en
Inventor
Volker Breu
Kaspar Burri
Jean-Marie Cassal
Martine Clozel
Georges Hirth
Bernd-Michael Loffler
Marcel Muller
Werner Neidhart
Henri Ramuz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Speedel Pharma AG
Original Assignee
Speedel Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma AG filed Critical Speedel Pharma AG
Publication of AU3789595A publication Critical patent/AU3789595A/en
Application granted granted Critical
Publication of AU691353B2 publication Critical patent/AU691353B2/en
Assigned to SPEEDEL PHARMA AG reassignment SPEEDEL PHARMA AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Bipolar Transistors (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

4-sulphonylamino-5-phenoxy-pyrimidine derivs. of formula (I) are new: R1 = heterocyclyl; R2 = H, alkyl, alkoxy, alkylthio, alkoxyalkyl, alkylsulphonyl alkoxy, phenyl, alkylphenyl, alkoxyphenyl, alkylenedioxyphenyl, phenylalkyl, alkylphenylalkyl, alkoxyphenylalkyl, alkylenedioxyphenylalkyl, heterocyclyl or heterocyclylalkyl; R3 = alkyl (opt. substd. by halo, OH or amino), alkoxy, HCO, CH2OA-alkyl or (CH2)mO-(CRaRb)nX; X = OH, OR9, NH2 or B-R9; R4-R8 = H, alkoxy or halo; R9 = heterocyclyl, phenyl (opt. substd. by alkyl, alkoxy and/or halo) or alkyl; Ra, Rb = H or alkyl; A = ketalised 1,2-dihydroxyethylene; B = OCOO, OCONH, NHCONH or NHCOO; n = 2-4 m = 0-1.
AU37895/95A 1994-11-25 1995-11-16 Novel sulfonamides Ceased AU691353B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH355994 1994-11-25
CH3559/94 1994-11-25
CH284295 1995-10-09
CH2842/95 1995-10-09

Publications (2)

Publication Number Publication Date
AU3789595A true AU3789595A (en) 1996-05-30
AU691353B2 AU691353B2 (en) 1998-05-14

Family

ID=25691537

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37895/95A Ceased AU691353B2 (en) 1994-11-25 1995-11-16 Novel sulfonamides

Country Status (22)

Country Link
EP (1) EP0713875B1 (en)
JP (1) JP2755565B2 (en)
KR (1) KR100415030B1 (en)
AT (1) ATE199905T1 (en)
AU (1) AU691353B2 (en)
CA (1) CA2162630C (en)
CZ (1) CZ289920B6 (en)
DE (1) DE59509107D1 (en)
DK (1) DK0713875T3 (en)
ES (1) ES2156179T3 (en)
FI (1) FI117896B (en)
GR (1) GR3036065T3 (en)
HK (1) HK1012345A1 (en)
HU (1) HU225112B1 (en)
IL (1) IL116064A (en)
MA (1) MA23725A1 (en)
MY (1) MY119409A (en)
NO (1) NO307606B1 (en)
NZ (1) NZ280495A (en)
PT (1) PT713875E (en)
RU (1) RU2162084C2 (en)
TW (1) TW394763B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826674A4 (en) * 1995-04-03 1998-07-08 Sumitomo Pharma Novel pyrimidine derivatives efficacious as psychotropic drug and process for the production thereof
DK0897914T3 (en) * 1997-08-19 2004-09-27 Hoffmann La Roche Process for Preparation of 2,5-Disubstituted Pyridines
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
US6417360B1 (en) 1999-03-03 2002-07-09 Hoffmann-La Roche Inc. Heterocyclic sulfonamides
US6596719B1 (en) * 1999-09-03 2003-07-22 Actelio Pharmaceuticals Ltd. 6 alkoxy-4-pyrimidinyl bis-sulfonamides
WO2001046156A1 (en) * 1999-12-22 2001-06-28 Actelion Pharmaceuticals Ltd. Butyne diol derivatives
WO2001081338A1 (en) * 2000-04-25 2001-11-01 Actelion Pharmaceuticals Ltd Substituted sulfonylaminopyrimidines
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
DE60207890T2 (en) 2001-12-18 2006-08-10 Astrazeneca Ab NEW CONNECTIONS
TWI328007B (en) 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
EP1454625A1 (en) * 2003-03-06 2004-09-08 Speedel Development AG Pyridylsulfonamidyl-pyrimidines for the treatment of diabetic nephropathies
KR100822530B1 (en) * 2004-03-05 2008-04-16 에프. 호프만-라 로슈 아게 Diaminopyrimidines as p2x3 and p2x2/3 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (en) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity
TW287160B (en) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines

Also Published As

Publication number Publication date
EP0713875B1 (en) 2001-03-21
HK1012345A1 (en) 1999-07-30
DE59509107D1 (en) 2001-04-26
TW394763B (en) 2000-06-21
NO954718L (en) 1996-05-28
CZ289920B6 (en) 2002-04-17
KR100415030B1 (en) 2004-05-17
HU225112B1 (en) 2006-06-28
DK0713875T3 (en) 2001-06-11
FI117896B (en) 2007-04-13
GR3036065T3 (en) 2001-09-28
AU691353B2 (en) 1998-05-14
HUT75030A (en) 1997-03-28
CA2162630A1 (en) 1996-05-26
JPH08208625A (en) 1996-08-13
JP2755565B2 (en) 1998-05-20
NO307606B1 (en) 2000-05-02
PT713875E (en) 2001-09-28
MY119409A (en) 2005-05-31
CZ308895A3 (en) 1997-07-16
NZ280495A (en) 1996-12-20
MA23725A1 (en) 1996-07-01
ATE199905T1 (en) 2001-04-15
RU2162084C2 (en) 2001-01-20
FI955669A (en) 1996-05-26
FI955669A0 (en) 1995-11-24
KR960017644A (en) 1996-06-17
ES2156179T3 (en) 2001-06-16
CA2162630C (en) 2007-05-01
IL116064A (en) 2000-06-29
EP0713875A1 (en) 1996-05-29
IL116064A0 (en) 1996-01-31
NO954718D0 (en) 1995-11-22
HU9503311D0 (en) 1996-01-29

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