ES2154825T3 - Procedimiento para la hidrogenacion catalitica de nitro compuestos aromaticos. - Google Patents

Procedimiento para la hidrogenacion catalitica de nitro compuestos aromaticos.

Info

Publication number
ES2154825T3
ES2154825T3 ES96919685T ES96919685T ES2154825T3 ES 2154825 T3 ES2154825 T3 ES 2154825T3 ES 96919685 T ES96919685 T ES 96919685T ES 96919685 T ES96919685 T ES 96919685T ES 2154825 T3 ES2154825 T3 ES 2154825T3
Authority
ES
Spain
Prior art keywords
aromatic compounds
vanadium
catalytic hydrogenation
nitro aromatic
catalytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96919685T
Other languages
English (en)
Inventor
Martin Studer
Peter Baumeister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2154825T3 publication Critical patent/ES2154825T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
    • C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
    • C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
    • C07C209/365—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst by reduction with preservation of halogen-atoms in compounds containing nitro groups and halogen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN OBJETO DE LA INVENCION ES UN PROCESO PARA LA HIDROGENACION CATALITICA DE COMPUESTOS NITRO AROMATICOS EN DISOLUCION O FUNDIDOS EN PRESENCIA DE HIDROGENO Y POR LO MENOS UN CATALIZADOR DE METAL NOBLE, UN CATALIZADOR DE NIQUEL O UN CATALIZADOR DE COBALTO, Y EN CUYO PROCESO ESTA PRESENTE POR LO MENOS UNA CANTIDAD CATALITICA DE UN COMPUESTO DE VANADIO, EN EL QUE EL VANADIO TIENE EL ESTADO DE OXIDACION 0, II, IV O V. SE HA ENCONTRADO QUE EN LA HIDROGENACION CATALITICA DE COMPUESTOS NITRO AROMATICOS LA ACUMULACION DE HIDROXILAMINAS PUEDE SER EVITADA CASI POR COMPLETO CON LA ADICION DE CANTIDADES CATALITICAS DE COMPUESTOS DE VANADIO, LO QUE RESULTA USUALMENTE EN CONCENTRACIONES DE < 1 % DE HIDROXILAMINA. LOS PRODUCTOS HIDROGENADOS RESULTANTES SON MAS BLANCOS (MAS PUROS) QUE LOS QUE SE OBTIENEN SIN LA ADICION DEL COMPUESTO DE VANADIO YA QUE NO SE OBTIENEN APENAS COMPUESTOS AZO O AZOXI. LA HIDROGENACION, EN PARTICULAR LA FASE FINAL, TRANSCURRE MAS RAPIDO QUE SIN LA CITADA ADICION. EN CONSECUENCIA,SE OBTIENEN VENTAJAS SUSTANCIALES CON RESPECTO A LA CONSTANCIA EN LA CALIDAD Y LA ECONOMIA.
ES96919685T 1995-05-19 1996-05-07 Procedimiento para la hidrogenacion catalitica de nitro compuestos aromaticos. Expired - Lifetime ES2154825T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH149595 1995-05-19

Publications (1)

Publication Number Publication Date
ES2154825T3 true ES2154825T3 (es) 2001-04-16

Family

ID=4211795

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96919685T Expired - Lifetime ES2154825T3 (es) 1995-05-19 1996-05-07 Procedimiento para la hidrogenacion catalitica de nitro compuestos aromaticos.

Country Status (14)

Country Link
US (1) US6096924A (es)
EP (1) EP0825979B1 (es)
JP (1) JP4454044B2 (es)
KR (1) KR100400419B1 (es)
AT (1) ATE198471T1 (es)
AU (1) AU5814596A (es)
BR (1) BR9609083A (es)
CZ (1) CZ289721B6 (es)
DE (1) DE69611443T2 (es)
DK (1) DK0825979T3 (es)
ES (1) ES2154825T3 (es)
IL (1) IL118312A (es)
WO (1) WO1996036597A1 (es)
ZA (1) ZA963942B (es)

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US6087480A (en) * 1998-01-13 2000-07-11 Ciba Specialty Chemcals Corporation Process for preparing sparingly soluble aromatic amines
US6818720B2 (en) 2001-11-08 2004-11-16 Degussa Ag Supported hydrogenating catalyst in powder form
KR101053816B1 (ko) * 2003-02-20 2011-08-03 론자 아게 Ｎ-치환된 포름아미드의 제조 방법
US6861422B2 (en) 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
US20050124666A1 (en) * 2003-11-13 2005-06-09 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same
US7317124B2 (en) 2003-11-13 2008-01-08 Sanofi-Aventis Deutschland Gmbh Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
US7126026B2 (en) 2003-11-13 2006-10-24 Sanofi-Aventis Deutschland Gmbh Process for preparing 4-pentafluorosulfanylbenzoylguanidines
SE0401001D0 (sv) * 2004-03-31 2004-03-31 Astrazeneca Ab Chemical process
DE102004029784A1 (de) * 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de) 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US7728134B2 (en) 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060074088A1 (en) 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US7759485B2 (en) 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
EP2305631A1 (en) 2005-12-23 2011-04-06 Rolic AG Photocrosslinkable materials
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
US8022217B2 (en) * 2006-07-31 2011-09-20 Cadila Healthcare Limited Compounds suitable as modulators of HDL
CN101687763B (zh) 2007-05-25 2014-02-19 罗利克有限公司 包含脂环基的光可交联材料
US8329695B2 (en) * 2007-08-03 2012-12-11 Boehringer Ingelheim International Gmbh Crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide
WO2009090669A2 (en) 2007-10-12 2009-07-23 Dorf Ketal Chemicals (I) Private Limited A process for the preparation of 5-chloro-2(2,4-dichlorophenoxy) aniline
US20120203031A1 (en) * 2009-10-19 2012-08-09 Newreka Chemicals Private Limited Sustainable chemical process for reduction of nitro compounds (R-NO2) or nitroso compounds (R-NO) containing sulphonic or carboxylic group into corresponding amino compounds (R-NH2) with inherent recycle of all acidic streams generated in synthesis
IT1405996B1 (it) * 2010-07-23 2014-02-06 Alfa Parf Group Spa Procedimento per la preparazione di 2,5-diaminotoluolo
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
CN102675161B (zh) * 2011-03-10 2014-09-03 中国中化股份有限公司 一种制备dsd酸的方法
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
EP2705902B1 (de) 2012-09-06 2015-05-06 Allessa Chemie GmbH Verfahren zur Hydrierung von Nitroaromaten mit ausgewählten Platinkatalysatoren
CN103664641B (zh) * 2012-09-10 2016-01-20 中国石油化工股份有限公司 一种无溶剂催化加氢制备邻氯苯胺的方法
CN103962150B (zh) * 2013-02-06 2016-06-22 中国中化股份有限公司 一种用于制备氯代芳香胺的催化剂及其制备方法
CN103285856B (zh) * 2013-06-09 2016-02-24 南通市华峰化工有限责任公司 一种用于制备卤代苯胺的防脱卤钌基催化剂及其制备方法
EP3024464A1 (en) 2013-07-26 2016-06-01 Boehringer Ingelheim International GmbH Treatment of myelodysplastic syndrome
MX369174B (es) * 2013-08-22 2019-10-30 Genentech Inc Proceso para la preparación de un compuesto.
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CN104710316B (zh) * 2015-03-23 2016-10-05 西安凯立新材料股份有限公司 一种氟代硝基苯连续催化加氢制备氟代苯胺的方法
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CN115845919A (zh) * 2022-11-23 2023-03-28 浙江工业大学 氮掺杂酚醛树脂镶嵌镍多孔炭涂覆蜂窝陶瓷整体式催化剂

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Also Published As

Publication number Publication date
DK0825979T3 (da) 2001-05-07
AU5814596A (en) 1996-11-29
KR19990014908A (ko) 1999-02-25
JP4454044B2 (ja) 2010-04-21
CZ289721B6 (cs) 2002-03-13
IL118312A0 (en) 1996-09-12
ATE198471T1 (de) 2001-01-15
EP0825979B1 (en) 2001-01-03
US6096924A (en) 2000-08-01
WO1996036597A1 (en) 1996-11-21
ZA963942B (en) 1996-11-19
CZ364097A3 (cs) 1998-02-18
DE69611443D1 (de) 2001-02-08
DE69611443T2 (de) 2001-07-12
MX9708890A (es) 1998-03-31
EP0825979A1 (en) 1998-03-04
IL118312A (en) 2002-05-23
BR9609083A (pt) 1999-02-02
JPH11505537A (ja) 1999-05-21
KR100400419B1 (ko) 2003-12-18

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