ES2154561A1 - Derivados de 2-fenilpiran-4-ona. - Google Patents
Derivados de 2-fenilpiran-4-ona.Info
- Publication number
- ES2154561A1 ES2154561A1 ES009802011A ES9802011A ES2154561A1 ES 2154561 A1 ES2154561 A1 ES 2154561A1 ES 009802011 A ES009802011 A ES 009802011A ES 9802011 A ES9802011 A ES 9802011A ES 2154561 A1 ES2154561 A1 ES 2154561A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- phenylpyran
- derivatives
- cyclooxygenase
- cox
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de 2-fenilpiran-4-ona de fórmula (1): **formula 1** en donde: R{sup,1} representa un grupo alquilo o -NR{sup,4}R{sup,5} donde R{sup,4} y R{sup,5} cada uno independientemente representa un átomo de hidrógeno o un grupo alquilo; R{sup,2} representa un grupo alquilo, C{sub,3}-C{sub,7} cicloalquilo, piridilo, tienilo, nautilo, tetrahidronaftilo o indanilo, o un grupo fenilo el cual puede estar no sustituido o sustituido por uno o más átomo de halógeno o un grupo alquilo, trifluorometilo, hodroxi.alcoxi, metiltio, amino, mono- o dialquilamino, hidroalquilo o hidroxicarbonilo; R{sup,3} representa un grupo metilo, hidroximetilo, alcoximetilo, C{sub,3}-C{sub,7} cicloalcoximetilo, benziloximetilo, hidroxicarbonilo, nitrilo, trifuorometilo o difluorometilo o un grupo Ch{sub,2}-R{sup,6} representa un grupo alquilo; y X representa un enlace sencillo, un átomo de oxígeno o azufre, o un grupo metileno; o sus sales farmacéuticamente aceptables, procedimientos para su producción, composiciones farmacéuticas que los contienen y su uso en tratamiento médico.
Priority Applications (36)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9802011A ES2154561B1 (es) | 1998-09-25 | 1998-09-25 | Derivados de 2-fenilpiran-4-ona. |
TW088115924A TW587079B (en) | 1998-09-25 | 1999-09-15 | 2-phenylpyran-4-one derivatives |
DK99947372T DK1115716T3 (da) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-on-derivater |
CA002345069A CA2345069C (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives |
IDW20010685D ID28624A (id) | 1998-09-25 | 1999-09-16 | Turunan 2-fenilpiran-4-on |
EEP200100173A EE04812B1 (et) | 1998-09-25 | 1999-09-16 | 2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioon |
CNB998125709A CN1202104C (zh) | 1998-09-25 | 1999-09-16 | 2-苯基吡喃-4-酮衍生物 |
ES99947372T ES2190252T3 (es) | 1998-09-25 | 1999-09-16 | Derivados de 2-fenilpiran-4-ona. |
IL14208799A IL142087A0 (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives |
DE69904738T DE69904738T2 (de) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivate |
CZ20011058A CZ300357B6 (cs) | 1998-09-25 | 1999-09-16 | Deriváty 2-fenylpyran-4-onu |
PCT/EP1999/006873 WO2000018753A1 (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives |
BR9913939-1A BR9913939A (pt) | 1998-09-25 | 1999-09-16 | Composto, processo para a preparação do mesmo, uso do mesmo, composição farmacêutica, e, método para o tratamento da dor, febre ou inflamação |
EP99947372A EP1115716B1 (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives |
SI9930232T SI1115716T1 (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives |
RU2001111323/04A RU2232158C2 (ru) | 1998-09-25 | 1999-09-16 | Производные 2-фенилпиран-4-она, фармацевтическая композиция на их основе и способ лечения |
AU60847/99A AU765653B2 (en) | 1998-09-25 | 1999-09-16 | 2-Phenylpyran-4-one derivatives |
AT99947372T ATE230405T1 (de) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivate |
HU0104620A HUP0104620A3 (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives, process for their preparation and medicaments containing them |
PL99346895A PL346895A1 (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives |
NZ510625A NZ510625A (en) | 1998-09-25 | 1999-09-16 | 2-Phenylpyran-4-one derivatives |
MXPA01003069A MXPA01003069A (es) | 1998-09-25 | 1999-09-16 | Derivados de 2-fenilpiran-4-cetona. |
SK370-2001A SK286471B6 (sk) | 1998-09-25 | 1999-09-16 | Deriváty 2-fenylpyran-4-ónu, spôsob ich prípravy,farmaceutické kompozície s ich obsahom a ich použitie |
KR1020017003835A KR100806684B1 (ko) | 1998-09-25 | 1999-09-16 | 2-페닐피란-4-온 유도체 |
TR2001/00852T TR200100852T2 (tr) | 1998-09-25 | 1999-09-16 | 2-Fenilpiran-4-on türevleri |
JP2000572213A JP4717211B2 (ja) | 1998-09-25 | 1999-09-16 | 2−フェニルピラン−4−オン誘導体 |
MYPI99004101A MY121793A (en) | 1998-09-25 | 1999-09-21 | 2-phenylpyran-4-one derivatives |
CO99060536A CO5140127A1 (es) | 1998-09-25 | 1999-09-23 | Derivados de 2-fenilpiran-4-ona |
PE1999000966A PE20001067A1 (es) | 1998-09-25 | 1999-09-23 | Derivados de 2-fenilpiran-4-ona |
ARP990104836A AR021826A1 (es) | 1998-09-25 | 1999-09-24 | COMPUESTOS DE 2- FENILPIRAN-4-ONA, PROCESOS PARA PREPARARLOS, USO DE UN COMPUESTO INTERMEDIARIO EN DICHOS, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE Y USO DE DICHOS COMPUESTOS Y DICHA COMPOSICIoN PARA LA FABRICACIoN DE UN MEDICAMENTO |
EG118999A EG23802A (en) | 1998-09-25 | 1999-09-25 | 2-Phenylpyran-4-one derivatives |
US09/809,645 US6518303B2 (en) | 1998-09-25 | 2001-03-16 | 2-phenylpyran-4-one derivatives |
ZA200102393A ZA200102393B (en) | 1998-09-25 | 2001-03-22 | 2-phenylpyran-4-one derivatives. |
BG105373A BG65308B1 (bg) | 1998-09-25 | 2001-03-22 | 2-фенилпиран-4-онови производни |
NO20011512A NO327987B1 (no) | 1998-09-25 | 2001-03-23 | 2-Fenylpyran-4-on derivater |
HK01105498A HK1034961A1 (en) | 1998-09-25 | 2001-08-08 | 2-phenylpyran-4-one derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9802011A ES2154561B1 (es) | 1998-09-25 | 1998-09-25 | Derivados de 2-fenilpiran-4-ona. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2154561A1 true ES2154561A1 (es) | 2001-04-01 |
ES2154561B1 ES2154561B1 (es) | 2001-12-01 |
Family
ID=8305270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9802011A Expired - Lifetime ES2154561B1 (es) | 1998-09-25 | 1998-09-25 | Derivados de 2-fenilpiran-4-ona. |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2154561B1 (es) |
ZA (1) | ZA200102393B (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6768008B2 (en) | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US7582676B2 (en) | 2003-02-13 | 2009-09-01 | Laboratorios Almirall, S.A. | 2-phenylpyran-4-one derivatives as selective COX-2 inhibitors |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995014014A2 (en) * | 1993-11-19 | 1995-05-26 | Parke, Davis & Company | Pyrone derivatives as protease inhibitors and antiviral agents |
WO1997034882A1 (en) * | 1996-03-21 | 1997-09-25 | Almirall Prodesfarma, S.A. | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
-
1998
- 1998-09-25 ES ES9802011A patent/ES2154561B1/es not_active Expired - Lifetime
-
2001
- 2001-03-22 ZA ZA200102393A patent/ZA200102393B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995014014A2 (en) * | 1993-11-19 | 1995-05-26 | Parke, Davis & Company | Pyrone derivatives as protease inhibitors and antiviral agents |
WO1997034882A1 (en) * | 1996-03-21 | 1997-09-25 | Almirall Prodesfarma, S.A. | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6768008B2 (en) | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US7582676B2 (en) | 2003-02-13 | 2009-09-01 | Laboratorios Almirall, S.A. | 2-phenylpyran-4-one derivatives as selective COX-2 inhibitors |
Also Published As
Publication number | Publication date |
---|---|
ZA200102393B (en) | 2002-06-24 |
ES2154561B1 (es) | 2001-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20010401 Kind code of ref document: A1 Effective date: 20010401 |