NZ510071A - Aryl alkanol and heteroaryl alkanol derivatives, pharmaceuticals thereof, and their use in the modulation of inflammatory and allergic conditions - Google Patents
Aryl alkanol and heteroaryl alkanol derivatives, pharmaceuticals thereof, and their use in the modulation of inflammatory and allergic conditionsInfo
- Publication number
- NZ510071A NZ510071A NZ510071A NZ51007199A NZ510071A NZ 510071 A NZ510071 A NZ 510071A NZ 510071 A NZ510071 A NZ 510071A NZ 51007199 A NZ51007199 A NZ 51007199A NZ 510071 A NZ510071 A NZ 510071A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkanol
- inflammatory
- formula
- pharmaceuticals
- heteroaryl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/21—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/42—Y being a carbon atom of a six-membered aromatic ring
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- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
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- Health & Medical Sciences (AREA)
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Abstract
A compound of formula I, where: A is phenyl, pyridine, pyrimidine, thiazole, pyrrolidone, pyridazine or pyridone; R is halogen, nitro, alkyl, alkoxy, (CH2)pR3, NR4R5 or CONR4R5; n is 0, 1, 2 or 3; X is O, S or CH2; R1 and R2 are independently H, alkyl or cycloalkyl or R1 and R2 together with the carbon atom to which they are attached for a cycloalkyl group; Ar1 is optionally substituted biphenyl, naphthyl or tetrahydronaphthyl; Excluded are compounds where n is 0 and A is either pyridyl or pyrimidyl. Also described is a pharmaceutical composition comprising a compound of formula I in association with a pharmaceutically acceptable adjuvant, diluent or carrier. The compounds of formula I are useful for the treatment of allergic, inflammatory, auto-immune, proliferative or hyper-proliferative diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9803107A SE9803107D0 (en) | 1998-09-14 | 1998-09-14 | Novel Compunds |
PCT/SE1999/001600 WO2000015614A1 (en) | 1998-09-14 | 1999-09-13 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ510071A true NZ510071A (en) | 2003-06-30 |
Family
ID=20412583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ510071A NZ510071A (en) | 1998-09-14 | 1999-09-13 | Aryl alkanol and heteroaryl alkanol derivatives, pharmaceuticals thereof, and their use in the modulation of inflammatory and allergic conditions |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1114029A1 (en) |
JP (1) | JP2002524553A (en) |
CN (1) | CN1318054A (en) |
AU (1) | AU6236799A (en) |
BR (1) | BR9913601A (en) |
CA (1) | CA2341440A1 (en) |
HK (1) | HK1040994A1 (en) |
IL (1) | IL141504A0 (en) |
NO (1) | NO20011262L (en) |
NZ (1) | NZ510071A (en) |
SE (1) | SE9803107D0 (en) |
WO (1) | WO2000015614A1 (en) |
ZA (1) | ZA200101759B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376524B1 (en) | 2000-06-21 | 2002-04-23 | Sunesis Pharmaceuticals, Inc. | Triphenyl compounds as interleukin-4 antagonists |
CN105085347B (en) * | 2015-08-14 | 2016-09-14 | 天津小新医药科技有限公司 | MENTHOL class P2Y12 receptor antagonist of one class nitrile group-containing and application thereof |
CN105111118B (en) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | L-menthol P2Y12 receptor antagonists, preparation method thereof and use thereof |
CN105152996B (en) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | L-menthol type P2Y12 receptor antagonists and application thereof |
CN105111119B (en) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | Halogenobenzene L-menthol P2Y12 receptor antagonists and application thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US4609735A (en) * | 1974-10-25 | 1986-09-02 | A. H. Robins Company, Inc. | Certain aryloxy-4-chloro-2-butanol intermediates |
US4379167A (en) * | 1974-10-25 | 1983-04-05 | A. H. Robins Company, Inc. | 1-Aryloxy-4-amino-2-butanols and the pharmaceutical use thereof |
DE2507425A1 (en) * | 1975-02-21 | 1976-09-02 | Hoechst Ag | ANALOGS OF PROSTANIC ACIDS AND THE PROCESS FOR THEIR PRODUCTION |
JPS5931510B2 (en) * | 1979-09-03 | 1984-08-02 | 東レ株式会社 | 5,6,7-trinor-4,8-inter-m-phenylene PGI↓2 derivative |
WO1989012048A1 (en) * | 1988-06-01 | 1989-12-14 | Yoshitomi Pharmaceutical Industries, Ltd. | Cis-2,6-diazabicyclo[3.3.0]octane derivatives and their medicinal use |
AU711772B2 (en) * | 1995-12-06 | 1999-10-21 | Astra Pharmaceuticals Limited | Compounds |
-
1998
- 1998-09-14 SE SE9803107A patent/SE9803107D0/en unknown
-
1999
- 1999-09-13 AU AU62367/99A patent/AU6236799A/en not_active Abandoned
- 1999-09-13 CA CA002341440A patent/CA2341440A1/en not_active Abandoned
- 1999-09-13 CN CN99810885A patent/CN1318054A/en active Pending
- 1999-09-13 EP EP99949512A patent/EP1114029A1/en not_active Withdrawn
- 1999-09-13 NZ NZ510071A patent/NZ510071A/en unknown
- 1999-09-13 IL IL14150499A patent/IL141504A0/en unknown
- 1999-09-13 WO PCT/SE1999/001600 patent/WO2000015614A1/en not_active Application Discontinuation
- 1999-09-13 JP JP2000570154A patent/JP2002524553A/en active Pending
- 1999-09-13 BR BR9913601-5A patent/BR9913601A/en not_active IP Right Cessation
-
2001
- 2001-03-01 ZA ZA200101759A patent/ZA200101759B/en unknown
- 2001-03-13 NO NO20011262A patent/NO20011262L/en not_active Application Discontinuation
-
2002
- 2002-04-08 HK HK02102612.2A patent/HK1040994A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO20011262D0 (en) | 2001-03-13 |
EP1114029A1 (en) | 2001-07-11 |
NO20011262L (en) | 2001-05-14 |
BR9913601A (en) | 2001-05-22 |
AU6236799A (en) | 2000-04-03 |
CN1318054A (en) | 2001-10-17 |
WO2000015614A1 (en) | 2000-03-23 |
SE9803107D0 (en) | 1998-09-14 |
JP2002524553A (en) | 2002-08-06 |
HK1040994A1 (en) | 2002-06-28 |
IL141504A0 (en) | 2002-03-10 |
ZA200101759B (en) | 2002-06-03 |
CA2341440A1 (en) | 2000-03-23 |
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Legal Events
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RENW | Renewal (renewal fees accepted) | ||
PSEA | Patent sealed |