ES2151880T3 - Antagonistas de proteina de coagulacion de la sangre y sus utilizaciones. - Google Patents
Antagonistas de proteina de coagulacion de la sangre y sus utilizaciones.Info
- Publication number
- ES2151880T3 ES2151880T3 ES91920567T ES91920567T ES2151880T3 ES 2151880 T3 ES2151880 T3 ES 2151880T3 ES 91920567 T ES91920567 T ES 91920567T ES 91920567 T ES91920567 T ES 91920567T ES 2151880 T3 ES2151880 T3 ES 2151880T3
- Authority
- ES
- Spain
- Prior art keywords
- viia
- factors vii
- factor
- complex
- tissue factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 title 1
- 102000002262 Thromboplastin Human genes 0.000 abstract 3
- 108010000499 Thromboplastin Proteins 0.000 abstract 3
- 108010054265 Factor VIIa Proteins 0.000 abstract 2
- 229940012414 factor viia Drugs 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940076372 protein antagonist Drugs 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60145490A | 1990-10-22 | 1990-10-22 | |
| US07/759,443 US5506134A (en) | 1990-10-22 | 1991-09-13 | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2151880T3 true ES2151880T3 (es) | 2001-01-16 |
Family
ID=27083860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91920567T Expired - Lifetime ES2151880T3 (es) | 1990-10-22 | 1991-10-17 | Antagonistas de proteina de coagulacion de la sangre y sus utilizaciones. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5506134A (OSRAM) |
| EP (1) | EP0554383B1 (OSRAM) |
| JP (1) | JP2680192B2 (OSRAM) |
| AT (1) | ATE195149T1 (OSRAM) |
| AU (1) | AU654311B2 (OSRAM) |
| CA (1) | CA2094372A1 (OSRAM) |
| DE (1) | DE69132352T2 (OSRAM) |
| ES (1) | ES2151880T3 (OSRAM) |
| WO (1) | WO1992006711A1 (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843442A (en) * | 1990-10-22 | 1998-12-01 | Corvas International, Inc. | Blood coagulation protein antagonists and uses therefor |
| CA2180140A1 (en) * | 1993-12-27 | 1995-07-06 | Jeffrey I. Weitz | Methods and compositions for inhibiting thrombogenesis |
| US5683899A (en) * | 1994-02-03 | 1997-11-04 | University Of Hawaii | Methods and compositions for combinatorial-based discovery of new multimeric molecules |
| DE19802139C1 (de) * | 1998-01-22 | 1999-09-23 | Centeon Pharma Gmbh | Monoklonaler Antikörper spezifisch für aktivierten Gerinnungsfaktor VII und seine Verwendung |
| EP0987274A1 (en) | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Factor VIIa Inhibitors |
| WO2000030677A1 (en) * | 1998-11-20 | 2000-06-02 | Eli Lilly And Company | Method of treating viral hemorrhagic fever |
| EP1059302A1 (en) | 1999-06-08 | 2000-12-13 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitors |
| EP1095933A1 (en) | 1999-10-30 | 2001-05-02 | Aventis Pharma Deutschland GmbH | Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them |
| US6677473B1 (en) | 1999-11-19 | 2004-01-13 | Corvas International Inc | Plasminogen activator inhibitor antagonists |
| EP1162194A1 (en) | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
| RU2003120070A (ru) | 2000-12-06 | 2004-12-27 | Авентис Фармаа Дойчланд Гмбх (De) | Производные гуанидина и амидина в качестве ингибиторов фактора ха |
| US20040063685A1 (en) * | 2000-12-08 | 2004-04-01 | Juji Ilzawa | Combination Drugs |
| WO2002059268A2 (en) * | 2001-01-23 | 2002-08-01 | Saint Louis University | Factor ixa: factor viiia interaction and methods therefor |
| EP1260817A3 (en) | 2001-05-08 | 2002-12-18 | Warner-Lambert Company | Method for direct measurement of coagulation factor VIIa activity in plasma |
| EP1270551A1 (en) | 2001-06-26 | 2003-01-02 | Aventis Pharma Deutschland GmbH | Urea derivatives with antiproteolytic activity |
| EP1409713B1 (en) * | 2001-07-03 | 2013-03-20 | Oklahoma Medical Research Foundation | Assay for measuring factor viia-antithrombin complexes |
| PL372138A1 (en) | 2001-10-15 | 2005-07-11 | Chiron Corporation | Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi) |
| JP2005510515A (ja) * | 2001-11-09 | 2005-04-21 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Ｖｉｉ因子ポリペプチドおよびプロテインｃ阻害剤を含む薬学的組成物 |
| EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| US20040126856A1 (en) * | 2002-01-23 | 2004-07-01 | Bajaj Paul S. | Factor ixa: factor Vllla interaction and methods therefor |
| IL163605A0 (en) * | 2002-02-22 | 2005-12-18 | Prophy Med Ab | Use of an inhibitor or antagonist against tissue factor |
| US6706068B2 (en) | 2002-04-23 | 2004-03-16 | Bret A. Ferree | Artificial disc replacements with natural kinematics |
| US7579000B2 (en) * | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| NZ536242A (en) * | 2002-05-01 | 2006-04-28 | Schering Ag | Anticoagulant fusion proteins that bind tissue factor (TF) or the FVIIa/TF complex thereby localizing thrombomodulin to the injury site and thus preventing thrombus formation |
| US20040110929A1 (en) * | 2002-07-12 | 2004-06-10 | Bjorn Soren E. | TF binding compound |
| US7358268B2 (en) | 2002-12-04 | 2008-04-15 | Sanofi-Aventis Deutschland Gmbh | Imidazole derivatives as factor Xa inhibitors |
| US7429581B2 (en) | 2002-12-23 | 2008-09-30 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
| US7425328B2 (en) * | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
| US7741341B2 (en) | 2003-05-19 | 2010-06-22 | Sanofi-Aventis Deutschland Gmbh | Benzimidazole-derivatives as factor Xa inhibitors |
| EP1479675A1 (en) | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Indazole-derivatives as factor Xa inhibitors |
| US7317027B2 (en) | 2003-05-19 | 2008-01-08 | Sanofi-Aventis Deutschland Gmbh | Azaindole-derivatives as factor Xa inhibitors |
| EP1479677A1 (en) | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | New indole derivatives as factor xa inhibitors |
| US7223780B2 (en) | 2003-05-19 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors |
| PL1641914T3 (pl) | 2003-06-27 | 2017-01-31 | DePuy Synthes Products, Inc. | Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek |
| DE10333508A1 (de) * | 2003-07-18 | 2005-02-17 | Technische Universität Dresden | Gegen Prothrombin gerichtete Erkennungsmoleküle und die Verwendung dieser |
| EP1568698A1 (en) | 2004-02-27 | 2005-08-31 | Aventis Pharma Deutschland GmbH | Pyrrole-derivatives as factor Xa inhibitors |
| AU2005287449A1 (en) * | 2004-04-16 | 2006-03-30 | The Scripps Research Institute | Method of modulating vascularization |
| ES2621847T3 (es) | 2004-12-23 | 2017-07-05 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas |
| PL2297207T3 (pl) * | 2008-06-19 | 2019-03-29 | Prothix Bv | Zastosowanie przeciwciał przeciw czynnikowi XI do zapobiegania lub leczenia tworzenia skrzepliny |
| SMT201700547T1 (it) | 2010-06-15 | 2018-01-11 | Genmab As | Coniugati di farmaco anticorpo umano contro il fattore tissutale |
| MX347454B (es) | 2011-07-22 | 2017-04-27 | Csl Ltd | Anticuerpos monoclonales inhibidores anti-factor xii-xiia. |
| SG11201501741YA (en) | 2012-09-13 | 2015-04-29 | Bristol Myers Squibb Co | Fibronectin based scaffold domain proteins that bind to myostatin |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| JP7460608B2 (ja) | 2018-05-07 | 2024-04-02 | ジェンマブ エー／エス | 抗ｐｄ－１抗体と抗組織因子抗体－薬物コンジュゲートとの組み合わせを用いるがんの治療方法 |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| AU2020259982A1 (en) | 2019-04-17 | 2021-10-28 | Novo Nordisk A/S | Bispecific antibodies |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4382083A (en) * | 1981-06-25 | 1983-05-03 | Baxter Travenol Laboratories, Inc. | Therapeutic method for treating blood-clotting defects with factor VIIa |
| GB2148299B (en) * | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
| SE461315B (sv) * | 1988-06-16 | 1990-02-05 | Jan Niels Faergemann | Anvaendning av en komposition innehaallande aluminiumacetotartrat och en diol foer att minska hudirritationer orsakade av urin eller avfoering, samt bloeja impregnerad med kompositionen |
| US5190919A (en) * | 1989-11-13 | 1993-03-02 | Board Of Regents, The University Of Texas System | Antihemostatic factor vii peptides |
-
1991
- 1991-09-13 US US07/759,443 patent/US5506134A/en not_active Expired - Lifetime
- 1991-10-17 WO PCT/US1991/007811 patent/WO1992006711A1/en not_active Ceased
- 1991-10-17 ES ES91920567T patent/ES2151880T3/es not_active Expired - Lifetime
- 1991-10-17 EP EP91920567A patent/EP0554383B1/en not_active Expired - Lifetime
- 1991-10-17 JP JP3518610A patent/JP2680192B2/ja not_active Expired - Fee Related
- 1991-10-17 CA CA002094372A patent/CA2094372A1/en not_active Abandoned
- 1991-10-17 AU AU90298/91A patent/AU654311B2/en not_active Ceased
- 1991-10-17 AT AT91920567T patent/ATE195149T1/de not_active IP Right Cessation
- 1991-10-17 DE DE69132352T patent/DE69132352T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992006711A1 (en) | 1992-04-30 |
| JPH06502307A (ja) | 1994-03-17 |
| US5506134A (en) | 1996-04-09 |
| AU9029891A (en) | 1992-05-20 |
| EP0554383A1 (en) | 1993-08-11 |
| JP2680192B2 (ja) | 1997-11-19 |
| DE69132352T2 (de) | 2001-03-15 |
| EP0554383A4 (OSRAM) | 1994-04-27 |
| DE69132352D1 (de) | 2000-09-07 |
| AU654311B2 (en) | 1994-11-03 |
| CA2094372A1 (en) | 1992-04-23 |
| EP0554383B1 (en) | 2000-08-02 |
| ATE195149T1 (de) | 2000-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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