ES2149548T3 - Derivado de hidroquinona y uso farmaceutico del mismo. - Google Patents
Derivado de hidroquinona y uso farmaceutico del mismo.Info
- Publication number
- ES2149548T3 ES2149548T3 ES97250280T ES97250280T ES2149548T3 ES 2149548 T3 ES2149548 T3 ES 2149548T3 ES 97250280 T ES97250280 T ES 97250280T ES 97250280 T ES97250280 T ES 97250280T ES 2149548 T3 ES2149548 T3 ES 2149548T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- sup
- hydrogen atom
- sub
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCUBRE UN DERIVADO DE HIDROQUINONA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, ESTANDO REPRESENTADO EL DERIVADO DE HIDROQUINONA POR LA FORMULA (I): EN LA QUE R SUP,1} ES UN GRUPO FENILO QUE NO ESTA SUSTITUIDO O ESTA SUSTITUIDO CON UN SUSTITUYENTE O SUSTITUYENTES CADA UNO SELECCIONADO INDEPENDIENTEMENTE DEL GRUPO CONSISTENTE EN UN ATOMO DE HALOGENO, UN GRUPO ALQUILO C1-4 Y UN GRUPO ALCOXI C1-4; R SUP,2} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; CADA UNO DE R SUP,3} Y R SUP,4} ES INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; R SUP,5} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; CADA UNO DE R SUP,6}, R SUP,7} Y R SUP,8} ES INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; P ES UN GRUPO HIDROXILO; Q ES UN GRUPO HIDROXILO, UN GRUPO ALCOXI C1-4, UN GRUPO ACILOXI C1-18 O UN GRUPO OXO; P PUEDE FORMAR JUNTO CON Q UN ENLACE ETER; R ES UN GRUPO HIDROXILO, UN GRUPO ALCOXI C1-4, UN GRUPO ACILOXI C1-18 O UN GRUPO OXO, CON LA CONDICION DE QUE CUANDO UNO DE DICHO Q Y DICHO R ES UN GRUPO OXO, EL OTRO ES TAMBIEN UN GRUPO OXO; X ES UN ENLACE SENCILLO, UN GRUPO -NR SUB,10} O UN GRUPO CH SUB,2}-NR SUB,10} EN EL QUE R SUB,10} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; Y ES UN GRUPO METILENO O UN GRUPO CARBONILO; Y LAS LINEAS PUNTEADAS EN UN ANILLO DE SEIS MIEMBROS REPRESENTAN QUE DICHO ANILLO DE SEIS MIEMBROS TIENE EL MAXIMO NUMERO DE DOBLES ENLACES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24827296 | 1996-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2149548T3 true ES2149548T3 (es) | 2000-11-01 |
Family
ID=17175664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97250280T Expired - Lifetime ES2149548T3 (es) | 1996-09-19 | 1997-09-17 | Derivado de hidroquinona y uso farmaceutico del mismo. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5821247A (es) |
| EP (1) | EP0831092B1 (es) |
| AT (1) | ATE194838T1 (es) |
| AU (1) | AU716992B2 (es) |
| CA (1) | CA2216288C (es) |
| DE (1) | DE69702580T2 (es) |
| DK (1) | DK0831092T3 (es) |
| ES (1) | ES2149548T3 (es) |
| GR (1) | GR3034418T3 (es) |
| NO (1) | NO313413B1 (es) |
| NZ (1) | NZ328769A (es) |
| PT (1) | PT831092E (es) |
| ZA (1) | ZA978413B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ519781A (en) * | 1999-12-23 | 2004-04-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| JPWO2004026842A1 (ja) * | 2002-09-20 | 2006-01-12 | 住友製薬株式会社 | 新規ウラシル誘導体及びその医薬用途 |
| CA2704473C (en) | 2007-11-06 | 2016-10-04 | Edison Pharmaceuticals, Inc. | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| ES2912585T3 (es) | 2014-12-16 | 2022-05-26 | Ptc Therapeutics Inc | Formas polimórficas y amorfas de la (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida |
| WO2017060432A1 (en) * | 2015-10-08 | 2017-04-13 | Khondrion Ip B.V. | Novel compounds for treating mitochondrial disease |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5661153A (en) * | 1994-07-19 | 1997-08-26 | Japan Energy Corporation | 1-arylpyrimidine derivatives and pharmaceutical use thereof |
-
1997
- 1997-09-16 US US08/933,208 patent/US5821247A/en not_active Expired - Fee Related
- 1997-09-16 AU AU37601/97A patent/AU716992B2/en not_active Ceased
- 1997-09-17 PT PT97250280T patent/PT831092E/pt unknown
- 1997-09-17 DE DE69702580T patent/DE69702580T2/de not_active Expired - Fee Related
- 1997-09-17 AT AT97250280T patent/ATE194838T1/de not_active IP Right Cessation
- 1997-09-17 DK DK97250280T patent/DK0831092T3/da active
- 1997-09-17 ES ES97250280T patent/ES2149548T3/es not_active Expired - Lifetime
- 1997-09-17 EP EP97250280A patent/EP0831092B1/en not_active Expired - Lifetime
- 1997-09-18 ZA ZA9708413A patent/ZA978413B/xx unknown
- 1997-09-18 NO NO19974313A patent/NO313413B1/no unknown
- 1997-09-18 NZ NZ328769A patent/NZ328769A/en unknown
- 1997-09-19 CA CA002216288A patent/CA2216288C/en not_active Expired - Fee Related
-
1998
- 1998-07-10 US US09/113,826 patent/US5877318A/en not_active Expired - Fee Related
-
2000
- 2000-09-18 GR GR20000402106T patent/GR3034418T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0831092B1 (en) | 2000-07-19 |
| NZ328769A (en) | 1998-07-28 |
| DK0831092T3 (da) | 2000-10-16 |
| NO313413B1 (no) | 2002-09-30 |
| DE69702580T2 (de) | 2001-03-08 |
| NO974313D0 (no) | 1997-09-18 |
| ZA978413B (en) | 1998-03-26 |
| NO974313L (no) | 1998-03-20 |
| CA2216288A1 (en) | 1998-03-19 |
| AU3760197A (en) | 1998-03-26 |
| CA2216288C (en) | 2006-02-07 |
| US5821247A (en) | 1998-10-13 |
| US5877318A (en) | 1999-03-02 |
| EP0831092A2 (en) | 1998-03-25 |
| DE69702580D1 (de) | 2000-08-24 |
| AU716992B2 (en) | 2000-03-16 |
| PT831092E (pt) | 2000-10-31 |
| GR3034418T3 (en) | 2000-12-29 |
| ATE194838T1 (de) | 2000-08-15 |
| EP0831092A3 (en) | 1998-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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