ES2148206T3 - Procedimiento para preparar compuestos y productos intermedios antifolato basados en 4-hidroxipirrolo(2,3-d)pirimidina. - Google Patents

Procedimiento para preparar compuestos y productos intermedios antifolato basados en 4-hidroxipirrolo(2,3-d)pirimidina.

Info

Publication number
ES2148206T3
ES2148206T3 ES93307594T ES93307594T ES2148206T3 ES 2148206 T3 ES2148206 T3 ES 2148206T3 ES 93307594 T ES93307594 T ES 93307594T ES 93307594 T ES93307594 T ES 93307594T ES 2148206 T3 ES2148206 T3 ES 2148206T3
Authority
ES
Spain
Prior art keywords
reaction product
preparing
intermediate products
hydroxypyrol
pirimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93307594T
Other languages
English (en)
Inventor
Charles Jackson Barnett
Thomas Michael Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2148206T3 publication Critical patent/ES2148206T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCESO PARA PREPARAR UN 4-HIDROXIPIROLO [2,3-D] PIRIMIDINA SIN AISLAMIENTO O PURIFICACION DE PRODUCTOS INTERMEDIOS, DE FORMULA (I) EN LA QUE R NCH*H(COOR1)CH2CH2COOR1 O OR1; R1 ES H O UN GRUPO PROTECTOR CARBOXILO; LA CONFIGURACION ALREDEDOR DEL ATOMO DE CARBONO * ES L; N ES 0 O 1; Y A ES UN GRUPO ARILO QUE PUEDE SER SUSTITUIDO O UNA SAL DE ESTE, QUE COMPRENDE (A) LA HALOGENACION DE UN COMPUESTO DE LA FORMULA (II) EN LA QUE R, R1, A Y * SON COMO SE DEFINEN ARRIBA; J ES 0 O 1; (B) LA REACCION DE 2,4-DIAMINO-6-HIDROXIPIRIDINA, O UNA SAL DE ESTE, CON EL PRODUCTO DE REACCION DE LA ETAPA (A), EN PRESENCIA DE UN SOLVENTE POLAR; C HIDROLIZACION OPCIONAL DEL PRODUCTO DE REACCION DE ETAPA (B) CUANDO (R) DICHO PRODUCTO DE REACCION ES NCH*H(COOR1)CH2CH2COOR1 Y R1 ES UN GRUPO PROTECTOR CARBOXILO, Y (D) SALIFICACION OPCIONAL DEL PRODUCTO DE REACCION DEL PASO (B), CUANDO R DE DICHO PRODUCTO DE REACCION ES NCH*H(COOR1)CH2CH2COOR1 Y R1 ES H, O DE ETAPA (C).
ES93307594T 1992-09-25 1993-09-24 Procedimiento para preparar compuestos y productos intermedios antifolato basados en 4-hidroxipirrolo(2,3-d)pirimidina. Expired - Lifetime ES2148206T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/951,483 US5278307A (en) 1992-09-25 1992-09-25 Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates

Publications (1)

Publication Number Publication Date
ES2148206T3 true ES2148206T3 (es) 2000-10-16

Family

ID=25491731

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93307594T Expired - Lifetime ES2148206T3 (es) 1992-09-25 1993-09-24 Procedimiento para preparar compuestos y productos intermedios antifolato basados en 4-hidroxipirrolo(2,3-d)pirimidina.

Country Status (10)

Country Link
US (1) US5278307A (es)
EP (1) EP0595467B1 (es)
JP (1) JPH06211863A (es)
AT (1) ATE194840T1 (es)
CA (1) CA2106716A1 (es)
DE (1) DE69329052T2 (es)
DK (1) DK0595467T3 (es)
ES (1) ES2148206T3 (es)
GR (1) GR3034636T3 (es)
PT (1) PT595467E (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107041A (en) * 1992-09-25 2000-02-17 Lilly Co Eli Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids
CN101239991B (zh) * 2002-12-05 2011-08-31 武田药品工业株式会社 二膦化合物作为配体的过渡金属络合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424369A (en) * 1979-12-22 1984-01-03 Dynamit Nobel Ag Substituted pyran-2-ones
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
CA2031769A1 (en) * 1989-12-08 1991-06-09 Hiroshi Akimoto Pyrrolopyrimidine derivatives, their production and use
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use

Also Published As

Publication number Publication date
DE69329052D1 (de) 2000-08-24
CA2106716A1 (en) 1994-03-26
US5278307A (en) 1994-01-11
JPH06211863A (ja) 1994-08-02
EP0595467A2 (en) 1994-05-04
GR3034636T3 (en) 2001-01-31
ATE194840T1 (de) 2000-08-15
DK0595467T3 (da) 2000-09-18
EP0595467B1 (en) 2000-07-19
PT595467E (pt) 2000-12-29
EP0595467A3 (en) 1994-06-22
DE69329052T2 (de) 2001-03-22

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