DK0595467T3 - Fremgangsmåde ttil fremstilling af antifolate 4-hydroxypyrrolo[2,3-d]pyrimidinderivater - Google Patents

Fremgangsmåde ttil fremstilling af antifolate 4-hydroxypyrrolo[2,3-d]pyrimidinderivater

Info

Publication number
DK0595467T3
DK0595467T3 DK93307594T DK93307594T DK0595467T3 DK 0595467 T3 DK0595467 T3 DK 0595467T3 DK 93307594 T DK93307594 T DK 93307594T DK 93307594 T DK93307594 T DK 93307594T DK 0595467 T3 DK0595467 T3 DK 0595467T3
Authority
DK
Denmark
Prior art keywords
reaction product
hydroxypyrrolo
ch2ch2coor
nhc
coor
Prior art date
Application number
DK93307594T
Other languages
English (en)
Inventor
Charles Jackson Barnett
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0595467T3 publication Critical patent/DK0595467T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK93307594T 1992-09-25 1993-09-24 Fremgangsmåde ttil fremstilling af antifolate 4-hydroxypyrrolo[2,3-d]pyrimidinderivater DK0595467T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/951,483 US5278307A (en) 1992-09-25 1992-09-25 Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates

Publications (1)

Publication Number Publication Date
DK0595467T3 true DK0595467T3 (da) 2000-09-18

Family

ID=25491731

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93307594T DK0595467T3 (da) 1992-09-25 1993-09-24 Fremgangsmåde ttil fremstilling af antifolate 4-hydroxypyrrolo[2,3-d]pyrimidinderivater

Country Status (10)

Country Link
US (1) US5278307A (da)
EP (1) EP0595467B1 (da)
JP (1) JPH06211863A (da)
AT (1) ATE194840T1 (da)
CA (1) CA2106716A1 (da)
DE (1) DE69329052T2 (da)
DK (1) DK0595467T3 (da)
ES (1) ES2148206T3 (da)
GR (1) GR3034636T3 (da)
PT (1) PT595467E (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
CN101239992B (zh) * 2002-12-05 2011-09-28 武田药品工业株式会社 二膦化合物作为配体的过渡金属络合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424369A (en) * 1979-12-22 1984-01-03 Dynamit Nobel Ag Substituted pyran-2-ones
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
CA2031769A1 (en) * 1989-12-08 1991-06-09 Hiroshi Akimoto Pyrrolopyrimidine derivatives, their production and use
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use

Also Published As

Publication number Publication date
DE69329052T2 (de) 2001-03-22
EP0595467B1 (en) 2000-07-19
EP0595467A2 (en) 1994-05-04
US5278307A (en) 1994-01-11
PT595467E (pt) 2000-12-29
ES2148206T3 (es) 2000-10-16
ATE194840T1 (de) 2000-08-15
DE69329052D1 (de) 2000-08-24
EP0595467A3 (en) 1994-06-22
JPH06211863A (ja) 1994-08-02
CA2106716A1 (en) 1994-03-26
GR3034636T3 (en) 2001-01-31

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