ES2145023T3 - Gel anti-inflamatorio y analgesico de diclofenac. - Google Patents
Gel anti-inflamatorio y analgesico de diclofenac.Info
- Publication number
- ES2145023T3 ES2145023T3 ES93119125T ES93119125T ES2145023T3 ES 2145023 T3 ES2145023 T3 ES 2145023T3 ES 93119125 T ES93119125 T ES 93119125T ES 93119125 T ES93119125 T ES 93119125T ES 2145023 T3 ES2145023 T3 ES 2145023T3
- Authority
- ES
- Spain
- Prior art keywords
- diclofenac
- cellulose
- molecular weight
- weight
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
UNA PREPARACION DE GEL ANALGESICO Y ANTIINFLAMATORIO QUE CONTIENE DICLOFENAC O SUS SALES, UN ESTER DE ACIDO DIBASICO, UN ALCOHOL INFERIOR, Y UN POLIMERO NO IONICO O UNA MEZCLA DE POLIMEROS NO IONICOS SELECCIONADOS DEL GRUPO COMPUESTO DE (A) 1,5-4% DE PESO DE HIDROXIPROPILO DE CELULOSA QUE TIENE UN PESO MOLECULAR DE 500.000 O MAYOR. (B) 2-4% DE PESO DE HIDROXIETILO DE CELULOSA QUE TIENE UN PESO MOLECULAR DE 1.250.000 O MAYOR, Y (C) 1,5-4% DE PESO DE UNA MEZCLA DE HIDROXIPROPILO DE CELULOSA QUE TIENE UN PESO MOLECULAR DE 500.000 O MAYOR E HIDROXIFENILO DE CELULOSA QUE TIENE UN PESO MOLECULAR DE 1.250.000 O MAYOR, Y QUE TIENE UNA VISCOSIDAD DE 5.000-35.000 CPS Y UN VALOR DE RENDIMIENTO DE 5 DYN CM (AL CUADRADO) O MAYOR. LA PREPARACION DE GEL ES EXCELENTE EN LA ABSORCION PERCUTANEA DE DICLOFENAC O SUS SALES Y PRODUCE BUENAS PROPIEDADES DE USO Y EFECTOS MEDICOS SUPERIORES AL DICLOFENAC O SUS SALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4325632A JP2523428B2 (ja) | 1992-12-04 | 1992-12-04 | 消炎鎮痛ゲル製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2145023T3 true ES2145023T3 (es) | 2000-07-01 |
Family
ID=18179022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93119125T Expired - Lifetime ES2145023T3 (es) | 1992-12-04 | 1993-11-26 | Gel anti-inflamatorio y analgesico de diclofenac. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5422102A (es) |
EP (1) | EP0600395B1 (es) |
JP (1) | JP2523428B2 (es) |
KR (1) | KR100245994B1 (es) |
CA (1) | CA2110119C (es) |
DE (1) | DE69328067T2 (es) |
ES (1) | ES2145023T3 (es) |
HK (1) | HK1012570A1 (es) |
SG (1) | SG47083A1 (es) |
WO (1) | WO1994013281A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
KR19990026792A (ko) * | 1997-09-26 | 1999-04-15 | 김윤 | 디클로페낙 디에틸암모늄염을 함유한 매트릭스형 패취제제 |
US6673808B1 (en) * | 1998-04-27 | 2004-01-06 | Fujisawa Pharmaceutical Co., Ltd. | Medicinal compositions |
WO1999055660A1 (en) * | 1998-04-28 | 1999-11-04 | Russinsky Limited | Process for the preparation of aceclofenac |
KR100348100B1 (ko) * | 1998-07-31 | 2002-11-07 | 하나제약 주식회사 | 2-[(2,6-디클로로페닐)아미노]페닐아세톡시아세트산의제조방법 |
US20030198616A1 (en) * | 2002-04-23 | 2003-10-23 | Combe Incorporated | Moisturizing skin gel and method |
JP4563642B2 (ja) * | 2002-05-31 | 2010-10-13 | ワトソン ラボラトリーズ、インコーポレイテッド | 医薬製剤 |
WO2005027977A2 (en) * | 2003-09-22 | 2005-03-31 | Agis Industries (1983) Ltd. | Diclofenac compositions for the treatment of skin disorders |
JP4820065B2 (ja) * | 2004-05-24 | 2011-11-24 | 同仁医薬化工株式会社 | 消炎鎮痛外用水性液剤 |
JP5432716B2 (ja) | 2006-10-17 | 2014-03-05 | ヌーボ リサーチ インコーポレイテッド | ジクロフェナクゲル |
US8618164B2 (en) | 2009-03-31 | 2013-12-31 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
US8697043B1 (en) * | 2013-01-08 | 2014-04-15 | Chattem, Inc. | Odor suppression of volatile organic analgesic compounds and method of use |
JP6676548B2 (ja) | 2015-01-30 | 2020-04-08 | 株式会社 メドレックス | 水性外用剤 |
CN112516081B (zh) * | 2020-12-16 | 2023-03-10 | 郑州百瑞动物药业有限公司 | 一种双氯芬酸注射液及其制备方法 |
WO2022249748A1 (ja) * | 2021-05-24 | 2022-12-01 | 住友精化株式会社 | ゲル状組成物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH643138A5 (de) * | 1983-08-29 | 1984-05-30 | Mepha Ag | Indomethacin enthaltende, gelartige salbe. |
JPS6160620A (ja) * | 1984-09-03 | 1986-03-28 | Teijin Ltd | ピログルタミン酸エステル類を含有する医薬品組成物 |
CH666621A5 (de) * | 1986-06-27 | 1988-08-15 | Ciba Geigy Ag | Topisch applizierbare pharmazeutische zusammensetzungen mit systemischer wirkung. |
JPS63222121A (ja) * | 1987-03-10 | 1988-09-16 | Nippon Soda Co Ltd | 徐放性ゲル製剤 |
JPH0696527B2 (ja) * | 1987-05-20 | 1994-11-30 | 佐藤製薬株式会社 | 消炎鎮痛ゲル剤 |
DK0450123T3 (da) * | 1990-04-05 | 1995-08-21 | Knoll Ag | Farmaceutisk præparat til topisk administration indeholdende dichlofenac-natrium |
CA2058975C (en) * | 1990-10-30 | 2000-06-06 | Shuichi Kasai | Antiinflammatory gel preparation |
JP3086290B2 (ja) * | 1991-07-26 | 2000-09-11 | エスエス製薬株式会社 | ジクロフェナクナトリウム貼付剤 |
-
1992
- 1992-12-04 JP JP4325632A patent/JP2523428B2/ja not_active Expired - Lifetime
- 1992-12-24 WO PCT/JP1992/001692 patent/WO1994013281A1/ja active Application Filing
-
1993
- 1993-08-20 US US08/109,257 patent/US5422102A/en not_active Expired - Lifetime
- 1993-11-26 SG SG1996005835A patent/SG47083A1/en unknown
- 1993-11-26 ES ES93119125T patent/ES2145023T3/es not_active Expired - Lifetime
- 1993-11-26 EP EP93119125A patent/EP0600395B1/en not_active Expired - Lifetime
- 1993-11-26 DE DE69328067T patent/DE69328067T2/de not_active Expired - Fee Related
- 1993-11-26 CA CA002110119A patent/CA2110119C/en not_active Expired - Lifetime
- 1993-11-29 KR KR1019930025660A patent/KR100245994B1/ko not_active IP Right Cessation
-
1998
- 1998-12-17 HK HK98113957A patent/HK1012570A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5422102A (en) | 1995-06-06 |
DE69328067T2 (de) | 2000-09-14 |
JPH07173058A (ja) | 1995-07-11 |
EP0600395A1 (en) | 1994-06-08 |
KR940013497A (ko) | 1994-07-15 |
KR100245994B1 (ko) | 2000-04-01 |
CA2110119C (en) | 2003-05-27 |
SG47083A1 (en) | 1998-03-20 |
JP2523428B2 (ja) | 1996-08-07 |
WO1994013281A1 (en) | 1994-06-23 |
CA2110119A1 (en) | 1994-06-05 |
EP0600395B1 (en) | 2000-03-15 |
HK1012570A1 (en) | 1999-08-06 |
DE69328067D1 (de) | 2000-04-20 |
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ONTENTS | reter al C-,.. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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