ES2144355A1 - Compuestos derivados del cromeno. - Google Patents

Compuestos derivados del cromeno.

Info

Publication number
ES2144355A1
ES2144355A1 ES009702718A ES9702718A ES2144355A1 ES 2144355 A1 ES2144355 A1 ES 2144355A1 ES 009702718 A ES009702718 A ES 009702718A ES 9702718 A ES9702718 A ES 9702718A ES 2144355 A1 ES2144355 A1 ES 2144355A1
Authority
ES
Spain
Prior art keywords
hydrogen
chromen
piperidin
propoxy
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009702718A
Other languages
English (en)
Other versions
ES2144355B1 (es
Inventor
Ambros Rafael Foguet
Gener Jordi Bolos
Munoz Aurelio Sacristan
Barenys Josep Castello
Hernandez Jose A Ortiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Priority to ES009702718A priority Critical patent/ES2144355B1/es
Priority to TW087119931A priority patent/TW464650B/zh
Priority to ZA9811217A priority patent/ZA9811217B/xx
Priority to PA19988464301A priority patent/PA8464301A1/es
Priority to BR9807276-5A priority patent/BR9807276A/pt
Priority to NZ337260A priority patent/NZ337260A/xx
Priority to US09/380,092 priority patent/US6187793B1/en
Priority to EP98966856A priority patent/EP0970076A1/en
Priority to RU99120682/04A priority patent/RU2179556C2/ru
Priority to IL13157298A priority patent/IL131572A0/xx
Priority to ARP980106728A priority patent/AR017968A1/es
Priority to KR1019997007915A priority patent/KR20000075840A/ko
Priority to JP53563099A priority patent/JP2001515517A/ja
Priority to AU25143/99A priority patent/AU2514399A/en
Priority to CA002282596A priority patent/CA2282596A1/en
Priority to PCT/EP1998/008497 priority patent/WO1999035144A1/en
Priority to PL98335463A priority patent/PL335463A1/xx
Priority to NO994161A priority patent/NO994161L/no
Publication of ES2144355A1 publication Critical patent/ES2144355A1/es
Application granted granted Critical
Publication of ES2144355B1 publication Critical patent/ES2144355B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos derivados del cromeno de fórmula general (I) donde R significa hidrógeno, CHO, CH sub,2 OR sub,2 , o COOH; R sub,1 significa hidrógeno o CH sub,2 OH; y R sub,2 significa alquilo cuyo número de carbonos está comprendido entre 1 y 4, ambos inclusive, con la condición de que un sustituyente elegido entre R y R sub,1 debe ser hidrógeno, así como sus sales farmacéuticamente aceptables. Se describe también el procedimiento para su obtención y las composiciones farmacéuticas que los contienen. Estos compuestos son nuevos y tienen aplicación en el tratamiento de la psicosis, la esquizofrenia y la alergia.
ES009702718A 1997-12-30 1997-12-30 Compuestos derivados del cromeno. Expired - Lifetime ES2144355B1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ES009702718A ES2144355B1 (es) 1997-12-30 1997-12-30 Compuestos derivados del cromeno.
TW087119931A TW464650B (en) 1997-12-30 1998-11-30 7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and allergy
ZA9811217A ZA9811217B (en) 1997-12-30 1998-12-08 7-[3-[4(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and allergy.
PA19988464301A PA8464301A1 (es) 1997-12-30 1998-12-10 Compuestos derivados del cromeno
AU25143/99A AU2514399A (en) 1997-12-30 1998-12-29 7-((piperidin-1-yl)-propoxy)-chromen-4-one derivatives, their preparation and their pharmaceutical use
US09/380,092 US6187793B1 (en) 1997-12-30 1998-12-29 7-[(Piperidin-1-YL)-Propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use
EP98966856A EP0970076A1 (en) 1997-12-30 1998-12-29 7-[(piperidin-1-yl)- propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use
RU99120682/04A RU2179556C2 (ru) 1997-12-30 1998-12-29 Производные 7-[3-[4-(6-фторбензо[d]изоксазол-3-ил)пиперидин-1-ил]пропокси]-хромен-4-она, способ их получения, фармацевтическая композиция для ингибирования d2-,5-ht2a- и h1-рецепторов и способ ингибирования d2-,5-ht2a- и h1-рецепторов при лечении психоза и шизофрении
IL13157298A IL131572A0 (en) 1997-12-30 1998-12-29 7-[(Piperidin-1-yl)- propoxy]- chromen -4-one derivatives their preparation and their pharmaceutical use
ARP980106728A AR017968A1 (es) 1997-12-30 1998-12-29 Compuesto derivado del cromeno, procedimiento de obtencion de dicho compuesto y composicion farmaceutica para el tratamiento de la psicosis, laesquizofrenia y la alergia
BR9807276-5A BR9807276A (pt) 1997-12-30 1998-12-29 Derivados de 7-[3-[4-(6-fluorobenzo[d] isoxazol 3-il ) piperidin-1-il] propóxi]- cromen-4-ona, sua preparação e seu uso no tratamento de psicose, esquizofrenia a alegria
JP53563099A JP2001515517A (ja) 1997-12-30 1998-12-29 ７−〔（ピペリジン−１−イル）−プロポキシ〕−クロメン−４−オン誘導体、それらの製造およびそれらの医薬としての使用
NZ337260A NZ337260A (en) 1997-12-30 1998-12-29 7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl) piperidin-1-yl]-propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use
CA002282596A CA2282596A1 (en) 1997-12-30 1998-12-29 7-[(piperidin-1-yl)-propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use
PCT/EP1998/008497 WO1999035144A1 (en) 1997-12-30 1998-12-29 7-[(piperidin-1-yl)-propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use
PL98335463A PL335463A1 (en) 1997-12-30 1998-12-29 Derivatives of 7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen-4-one, their production and application in treating psychosis, schisophrenia and allergy
KR1019997007915A KR20000075840A (ko) 1997-12-30 1998-12-29 7-[(피페리딘-1-와이엘)프로폭시]-크로멘-4-원 유도체, 그 제조및 그 약학적 이용
NO994161A NO994161L (no) 1997-12-30 1999-08-27 7-[(piperidin-1-yl)-propoksy]-kromen-4-onderivater, deres fremstilling og deres farmasöytiske anvendelse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009702718A ES2144355B1 (es) 1997-12-30 1997-12-30 Compuestos derivados del cromeno.

Publications (2)

Publication Number Publication Date
ES2144355A1 true ES2144355A1 (es) 2000-06-01
ES2144355B1 ES2144355B1 (es) 2001-01-01

Family

ID=8301662

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009702718A Expired - Lifetime ES2144355B1 (es) 1997-12-30 1997-12-30 Compuestos derivados del cromeno.

Country Status (18)

Country Link
US (1) US6187793B1 (es)
EP (1) EP0970076A1 (es)
JP (1) JP2001515517A (es)
KR (1) KR20000075840A (es)
AR (1) AR017968A1 (es)
AU (1) AU2514399A (es)
BR (1) BR9807276A (es)
CA (1) CA2282596A1 (es)
ES (1) ES2144355B1 (es)
IL (1) IL131572A0 (es)
NO (1) NO994161L (es)
NZ (1) NZ337260A (es)
PA (1) PA8464301A1 (es)
PL (1) PL335463A1 (es)
RU (1) RU2179556C2 (es)
TW (1) TW464650B (es)
WO (1) WO1999035144A1 (es)
ZA (1) ZA9811217B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2359735T3 (es) 2005-11-03 2011-05-26 F. Hoffmann-La Roche Ag Arilsulfonilcromanos como inhibidores de 5-ht6.
CN102206214B (zh) * 2011-04-07 2014-03-12 华中科技大学 苯并吡喃酮类衍生物及其应用
CN103702995B (zh) * 2011-05-18 2016-04-13 拉夸里亚创药株式会社 4-{[4-({[4-(2,2,2-三氟乙氧基)-1,2-苯并异噁唑-3-基]氧}甲基)哌啶-1-基]甲基}-四氢-2h-吡喃-4-羧酸的多晶型形式
CN103694233B (zh) * 2013-12-10 2016-08-17 沈阳药科大学 苯并异噁唑类化合物及其应用
CN105153246B (zh) * 2015-08-05 2018-05-25 广州嘉德乐生化科技有限公司 一种蔗糖脂肪酸酯的制备方法及其乳饮料组合物
CN111320619A (zh) * 2018-12-17 2020-06-23 江苏恩华药业股份有限公司 一种类酰胺类衍生物的杂质及用途

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064255A1 (de) * 1981-05-02 1982-11-10 Roche Diagnostics GmbH Benzopyranylether, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel und Zwischenprodukte
EP0190015A1 (en) * 1985-01-30 1986-08-06 Warner-Lambert Company Novel 4H-1-benzopyran-4-ones and their sulphur containing analogs
EP0228893A2 (en) * 1985-12-20 1987-07-15 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
EP0402644A1 (en) * 1989-05-19 1990-12-19 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments
EP0428437A1 (fr) * 1989-11-07 1991-05-22 Adir Et Compagnie Dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
EP0613897A1 (en) * 1993-03-05 1994-09-07 Kowa Co. Ltd. Piperidine derivatives with antihistaminic and antileukotriene activity
ES2074966A1 (es) * 1994-02-11 1995-09-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluo-ruro-benzo(d)isoxazol-3-il)-piperidin-1-il)-etil)-2-metil-6, 7,8,9-tetrahidro-4h-pirido-(1,2-a) pirimidin-4-ona.
WO1995025733A1 (en) * 1994-03-18 1995-09-28 Ferrer Internacional, S.A. 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis and schizophrenia
WO1996032389A1 (en) * 1995-04-12 1996-10-17 Ferrer Internacional, S.A. 4-(6-fluoro-1,2-benzisoxazolyl)-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and anxiety

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064255A1 (de) * 1981-05-02 1982-11-10 Roche Diagnostics GmbH Benzopyranylether, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel und Zwischenprodukte
EP0190015A1 (en) * 1985-01-30 1986-08-06 Warner-Lambert Company Novel 4H-1-benzopyran-4-ones and their sulphur containing analogs
EP0228893A2 (en) * 1985-12-20 1987-07-15 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
EP0402644A1 (en) * 1989-05-19 1990-12-19 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments
EP0428437A1 (fr) * 1989-11-07 1991-05-22 Adir Et Compagnie Dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
EP0613897A1 (en) * 1993-03-05 1994-09-07 Kowa Co. Ltd. Piperidine derivatives with antihistaminic and antileukotriene activity
ES2074966A1 (es) * 1994-02-11 1995-09-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluo-ruro-benzo(d)isoxazol-3-il)-piperidin-1-il)-etil)-2-metil-6, 7,8,9-tetrahidro-4h-pirido-(1,2-a) pirimidin-4-ona.
WO1995025733A1 (en) * 1994-03-18 1995-09-28 Ferrer Internacional, S.A. 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis and schizophrenia
WO1996032389A1 (en) * 1995-04-12 1996-10-17 Ferrer Internacional, S.A. 4-(6-fluoro-1,2-benzisoxazolyl)-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and anxiety

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal Medicinal Chemistry, Vol. 34, paginas 248-256, 1991. J.C. JAÉN et al. "Dopamine Antoreceptor Agonists as Potential Antipsychotics. (Aminoalcoxy)-4H-1-benzopyran-4-ones". *
Journal Medicinal Chemistry, Vol. 39, paginas 2962-2970, 1996. J. BOLOS et al. "7-[3-(1-Piperidinyl)propoxy]chromenones as Potential Atypical Antipsychotics" *

Also Published As

Publication number Publication date
TW464650B (en) 2001-11-21
NO994161D0 (no) 1999-08-27
PA8464301A1 (es) 2000-09-29
US6187793B1 (en) 2001-02-13
AU2514399A (en) 1999-07-26
WO1999035144A1 (en) 1999-07-15
RU2179556C2 (ru) 2002-02-20
ES2144355B1 (es) 2001-01-01
EP0970076A1 (en) 2000-01-12
AR017968A1 (es) 2001-10-24
NZ337260A (en) 2000-09-29
JP2001515517A (ja) 2001-09-18
PL335463A1 (en) 2000-04-25
NO994161L (no) 1999-10-25
CA2282596A1 (en) 1999-07-15
ZA9811217B (en) 1999-07-14
IL131572A0 (en) 2001-01-28
BR9807276A (pt) 2000-05-02
KR20000075840A (ko) 2000-12-26

Similar Documents

Publication Publication Date Title
HK1073460A1 (en) Substituted 1, 3-oxathiolanes with antiviral properties
NZ514873A (en) 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
ATE115581T1 (de) 1-azabicyclo(3.2.2>nonan-3-aminderivate.
HUP0204085A2 (hu) Kardiális aritmiák kezelésében alkalmazható új oxa-biszpidin-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0203422A2 (hu) Foszfodiészteráz VII inhibitor hatású imidazolszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0401235A2 (hu) 5-HT6 receptor affinitással rendelkező arilszulfonil-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
FR2613365B1 (fr) Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
MA23639A1 (fr) Derives pyrrocarbazole, leur preparation, les compositions pharmaceutiques les contenant, leur utilisation dans le traitement des tumeurs malignes.
HUP0004020A2 (hu) Triciklusos triazolo-benzazepin-származékok, eljárás a vegyületek előállítására és alkalmazásuk antiallergiás szerként
ES2144355A1 (es) Compuestos derivados del cromeno.
AU2636988A (en) New 2-(piperazinyl)-2-substituted flavonoid derivatives, processes for preparing them and pharmaceutical compositions containing them
HUT57694A (en) Process for producing new beta-diketones and pharmaceutical compositions comprising same
ES2000125A6 (es) Procedimiento para la obtencion de derivados de 6-aminopirimidina 5-sustiuidos
HUP9903526A2 (hu) Pirimidinszármazékok és az ezeket tartalmazó gyógyszerkészítmények
IL117646A (en) 7-¬3-¬4-(6-fluoro-1,2-benzisoxazole-3-YL)piperidin-1-YL¾propoxy¾3-alkyl-chromen-4-ones their preparation their uses and pharmaceutical compositions comprising them
NZ216110A (en) 4-(z)-6-((2,4,5-cis -2-alkyl-4-(2-hydroxyphenyl)-1,3- dioxan-5-yl) hexenoic acid derivatives and pharmaceutical compositions
HUP0000854A2 (hu) 4-[6-Fluor-(1H)-indol-3-il]-1,2,3,6-tetrahidropiridin-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás mindezek előállítására
IL147307A0 (en) Indolocarbazole alkaloid derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
TW288015B (en) New chromene derivatives
ES8702889A1 (es) Un procedimiento para la preparacion de acidos pirrilidinpropanoicos.
ES8502972A1 (es) Procedimiento para la preparacion de esteres piridincarboxilicos de dipamina y de sus derivados n-alquilicos.
ES8601145A1 (es) Procedimiento para la preparacion de nuevos derivados de 1-fenilimidazolidin-2-ona

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20000601

Kind code of ref document: A1

Effective date: 20000601