ES2144355A1 - Compuestos derivados del cromeno. - Google Patents
Compuestos derivados del cromeno.Info
- Publication number
- ES2144355A1 ES2144355A1 ES009702718A ES9702718A ES2144355A1 ES 2144355 A1 ES2144355 A1 ES 2144355A1 ES 009702718 A ES009702718 A ES 009702718A ES 9702718 A ES9702718 A ES 9702718A ES 2144355 A1 ES2144355 A1 ES 2144355A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- chromen
- piperidin
- propoxy
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados del cromeno de fórmula general (I) donde R significa hidrógeno, CHO, CH sub,2 OR sub,2 , o COOH; R sub,1 significa hidrógeno o CH sub,2 OH; y R sub,2 significa alquilo cuyo número de carbonos está comprendido entre 1 y 4, ambos inclusive, con la condición de que un sustituyente elegido entre R y R sub,1 debe ser hidrógeno, así como sus sales farmacéuticamente aceptables. Se describe también el procedimiento para su obtención y las composiciones farmacéuticas que los contienen. Estos compuestos son nuevos y tienen aplicación en el tratamiento de la psicosis, la esquizofrenia y la alergia.
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009702718A ES2144355B1 (es) | 1997-12-30 | 1997-12-30 | Compuestos derivados del cromeno. |
TW087119931A TW464650B (en) | 1997-12-30 | 1998-11-30 | 7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and allergy |
ZA9811217A ZA9811217B (en) | 1997-12-30 | 1998-12-08 | 7-[3-[4(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and allergy. |
PA19988464301A PA8464301A1 (es) | 1997-12-30 | 1998-12-10 | Compuestos derivados del cromeno |
IL13157298A IL131572A0 (en) | 1997-12-30 | 1998-12-29 | 7-[(Piperidin-1-yl)- propoxy]- chromen -4-one derivatives their preparation and their pharmaceutical use |
NZ337260A NZ337260A (en) | 1997-12-30 | 1998-12-29 | 7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl) piperidin-1-yl]-propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use |
PL98335463A PL335463A1 (en) | 1997-12-30 | 1998-12-29 | Derivatives of 7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen-4-one, their production and application in treating psychosis, schisophrenia and allergy |
EP98966856A EP0970076A1 (en) | 1997-12-30 | 1998-12-29 | 7-[(piperidin-1-yl)- propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use |
ARP980106728A AR017968A1 (es) | 1997-12-30 | 1998-12-29 | Compuesto derivado del cromeno, procedimiento de obtencion de dicho compuesto y composicion farmaceutica para el tratamiento de la psicosis, laesquizofrenia y la alergia |
KR1019997007915A KR20000075840A (ko) | 1997-12-30 | 1998-12-29 | 7-[(피페리딘-1-와이엘)프로폭시]-크로멘-4-원 유도체, 그 제조및 그 약학적 이용 |
PCT/EP1998/008497 WO1999035144A1 (en) | 1997-12-30 | 1998-12-29 | 7-[(piperidin-1-yl)-propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use |
US09/380,092 US6187793B1 (en) | 1997-12-30 | 1998-12-29 | 7-[(Piperidin-1-YL)-Propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use |
CA002282596A CA2282596A1 (en) | 1997-12-30 | 1998-12-29 | 7-[(piperidin-1-yl)-propoxy]-chromen-4-one derivatives, their preparation and their pharmaceutical use |
RU99120682/04A RU2179556C2 (ru) | 1997-12-30 | 1998-12-29 | Производные 7-[3-[4-(6-фторбензо[d]изоксазол-3-ил)пиперидин-1-ил]пропокси]-хромен-4-она, способ их получения, фармацевтическая композиция для ингибирования d2-,5-ht2a- и h1-рецепторов и способ ингибирования d2-,5-ht2a- и h1-рецепторов при лечении психоза и шизофрении |
BR9807276-5A BR9807276A (pt) | 1997-12-30 | 1998-12-29 | Derivados de 7-[3-[4-(6-fluorobenzo[d] isoxazol 3-il ) piperidin-1-il] propóxi]- cromen-4-ona, sua preparação e seu uso no tratamento de psicose, esquizofrenia a alegria |
JP53563099A JP2001515517A (ja) | 1997-12-30 | 1998-12-29 | 7−〔(ピペリジン−1−イル)−プロポキシ〕−クロメン−4−オン誘導体、それらの製造およびそれらの医薬としての使用 |
AU25143/99A AU2514399A (en) | 1997-12-30 | 1998-12-29 | 7-((piperidin-1-yl)-propoxy)-chromen-4-one derivatives, their preparation and their pharmaceutical use |
NO994161A NO994161L (no) | 1997-12-30 | 1999-08-27 | 7-[(piperidin-1-yl)-propoksy]-kromen-4-onderivater, deres fremstilling og deres farmasöytiske anvendelse |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009702718A ES2144355B1 (es) | 1997-12-30 | 1997-12-30 | Compuestos derivados del cromeno. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2144355A1 true ES2144355A1 (es) | 2000-06-01 |
ES2144355B1 ES2144355B1 (es) | 2001-01-01 |
Family
ID=8301662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009702718A Expired - Lifetime ES2144355B1 (es) | 1997-12-30 | 1997-12-30 | Compuestos derivados del cromeno. |
Country Status (18)
Country | Link |
---|---|
US (1) | US6187793B1 (es) |
EP (1) | EP0970076A1 (es) |
JP (1) | JP2001515517A (es) |
KR (1) | KR20000075840A (es) |
AR (1) | AR017968A1 (es) |
AU (1) | AU2514399A (es) |
BR (1) | BR9807276A (es) |
CA (1) | CA2282596A1 (es) |
ES (1) | ES2144355B1 (es) |
IL (1) | IL131572A0 (es) |
NO (1) | NO994161L (es) |
NZ (1) | NZ337260A (es) |
PA (1) | PA8464301A1 (es) |
PL (1) | PL335463A1 (es) |
RU (1) | RU2179556C2 (es) |
TW (1) | TW464650B (es) |
WO (1) | WO1999035144A1 (es) |
ZA (1) | ZA9811217B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006310612A1 (en) | 2005-11-03 | 2007-05-10 | F. Hoffmann-La Roche Ag | Arylsulfonylchromans as 5-HT6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors |
CN102206214B (zh) * | 2011-04-07 | 2014-03-12 | 华中科技大学 | 苯并吡喃酮类衍生物及其应用 |
US9187463B2 (en) * | 2011-05-18 | 2015-11-17 | Raqualia Pharma Inc. | Polymorph form of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylic acid |
CN103694233B (zh) * | 2013-12-10 | 2016-08-17 | 沈阳药科大学 | 苯并异噁唑类化合物及其应用 |
CN105153246B (zh) * | 2015-08-05 | 2018-05-25 | 广州嘉德乐生化科技有限公司 | 一种蔗糖脂肪酸酯的制备方法及其乳饮料组合物 |
CN111320619A (zh) * | 2018-12-17 | 2020-06-23 | 江苏恩华药业股份有限公司 | 一种类酰胺类衍生物的杂质及用途 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0064255A1 (de) * | 1981-05-02 | 1982-11-10 | Roche Diagnostics GmbH | Benzopyranylether, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel und Zwischenprodukte |
EP0190015A1 (en) * | 1985-01-30 | 1986-08-06 | Warner-Lambert Company | Novel 4H-1-benzopyran-4-ones and their sulphur containing analogs |
EP0228893A2 (en) * | 1985-12-20 | 1987-07-15 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment |
EP0402644A1 (en) * | 1989-05-19 | 1990-12-19 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments |
EP0428437A1 (fr) * | 1989-11-07 | 1991-05-22 | Adir Et Compagnie | Dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent |
EP0613897A1 (en) * | 1993-03-05 | 1994-09-07 | Kowa Co. Ltd. | Piperidine derivatives with antihistaminic and antileukotriene activity |
ES2074966A1 (es) * | 1994-02-11 | 1995-09-16 | Vita Invest Sa | Procedimiento para la obtencion de 3-(2-(4-(6-fluo-ruro-benzo(d)isoxazol-3-il)-piperidin-1-il)-etil)-2-metil-6, 7,8,9-tetrahidro-4h-pirido-(1,2-a) pirimidin-4-ona. |
WO1995025733A1 (en) * | 1994-03-18 | 1995-09-28 | Ferrer Internacional, S.A. | 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis and schizophrenia |
WO1996032389A1 (en) * | 1995-04-12 | 1996-10-17 | Ferrer Internacional, S.A. | 4-(6-fluoro-1,2-benzisoxazolyl)-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and anxiety |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
-
1997
- 1997-12-30 ES ES009702718A patent/ES2144355B1/es not_active Expired - Lifetime
-
1998
- 1998-11-30 TW TW087119931A patent/TW464650B/zh active
- 1998-12-08 ZA ZA9811217A patent/ZA9811217B/xx unknown
- 1998-12-10 PA PA19988464301A patent/PA8464301A1/es unknown
- 1998-12-29 EP EP98966856A patent/EP0970076A1/en not_active Withdrawn
- 1998-12-29 KR KR1019997007915A patent/KR20000075840A/ko not_active Application Discontinuation
- 1998-12-29 NZ NZ337260A patent/NZ337260A/xx unknown
- 1998-12-29 WO PCT/EP1998/008497 patent/WO1999035144A1/en not_active Application Discontinuation
- 1998-12-29 US US09/380,092 patent/US6187793B1/en not_active Expired - Fee Related
- 1998-12-29 BR BR9807276-5A patent/BR9807276A/pt not_active IP Right Cessation
- 1998-12-29 CA CA002282596A patent/CA2282596A1/en not_active Abandoned
- 1998-12-29 AU AU25143/99A patent/AU2514399A/en not_active Abandoned
- 1998-12-29 RU RU99120682/04A patent/RU2179556C2/ru active
- 1998-12-29 PL PL98335463A patent/PL335463A1/xx unknown
- 1998-12-29 JP JP53563099A patent/JP2001515517A/ja active Pending
- 1998-12-29 AR ARP980106728A patent/AR017968A1/es not_active Application Discontinuation
- 1998-12-29 IL IL13157298A patent/IL131572A0/xx unknown
-
1999
- 1999-08-27 NO NO994161A patent/NO994161L/no not_active Application Discontinuation
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0064255A1 (de) * | 1981-05-02 | 1982-11-10 | Roche Diagnostics GmbH | Benzopyranylether, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel und Zwischenprodukte |
EP0190015A1 (en) * | 1985-01-30 | 1986-08-06 | Warner-Lambert Company | Novel 4H-1-benzopyran-4-ones and their sulphur containing analogs |
EP0228893A2 (en) * | 1985-12-20 | 1987-07-15 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment |
EP0402644A1 (en) * | 1989-05-19 | 1990-12-19 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments |
EP0428437A1 (fr) * | 1989-11-07 | 1991-05-22 | Adir Et Compagnie | Dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent |
EP0613897A1 (en) * | 1993-03-05 | 1994-09-07 | Kowa Co. Ltd. | Piperidine derivatives with antihistaminic and antileukotriene activity |
ES2074966A1 (es) * | 1994-02-11 | 1995-09-16 | Vita Invest Sa | Procedimiento para la obtencion de 3-(2-(4-(6-fluo-ruro-benzo(d)isoxazol-3-il)-piperidin-1-il)-etil)-2-metil-6, 7,8,9-tetrahidro-4h-pirido-(1,2-a) pirimidin-4-ona. |
WO1995025733A1 (en) * | 1994-03-18 | 1995-09-28 | Ferrer Internacional, S.A. | 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis and schizophrenia |
WO1996032389A1 (en) * | 1995-04-12 | 1996-10-17 | Ferrer Internacional, S.A. | 4-(6-fluoro-1,2-benzisoxazolyl)-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and anxiety |
Non-Patent Citations (2)
Title |
---|
Journal Medicinal Chemistry, Vol. 34, paginas 248-256, 1991. J.C. JAÉN et al. "Dopamine Antoreceptor Agonists as Potential Antipsychotics. (Aminoalcoxy)-4H-1-benzopyran-4-ones". * |
Journal Medicinal Chemistry, Vol. 39, paginas 2962-2970, 1996. J. BOLOS et al. "7-[3-(1-Piperidinyl)propoxy]chromenones as Potential Atypical Antipsychotics" * |
Also Published As
Publication number | Publication date |
---|---|
NO994161L (no) | 1999-10-25 |
AU2514399A (en) | 1999-07-26 |
BR9807276A (pt) | 2000-05-02 |
NZ337260A (en) | 2000-09-29 |
PL335463A1 (en) | 2000-04-25 |
ZA9811217B (en) | 1999-07-14 |
KR20000075840A (ko) | 2000-12-26 |
EP0970076A1 (en) | 2000-01-12 |
RU2179556C2 (ru) | 2002-02-20 |
ES2144355B1 (es) | 2001-01-01 |
IL131572A0 (en) | 2001-01-28 |
JP2001515517A (ja) | 2001-09-18 |
NO994161D0 (no) | 1999-08-27 |
AR017968A1 (es) | 2001-10-24 |
CA2282596A1 (en) | 1999-07-15 |
WO1999035144A1 (en) | 1999-07-15 |
TW464650B (en) | 2001-11-21 |
PA8464301A1 (es) | 2000-09-29 |
US6187793B1 (en) | 2001-02-13 |
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