ES2136743T3 - Parche de principios activos contenedor de substancias volatiles que puede ser elaborado sin disolventes. - Google Patents
Parche de principios activos contenedor de substancias volatiles que puede ser elaborado sin disolventes.Info
- Publication number
- ES2136743T3 ES2136743T3 ES94928368T ES94928368T ES2136743T3 ES 2136743 T3 ES2136743 T3 ES 2136743T3 ES 94928368 T ES94928368 T ES 94928368T ES 94928368 T ES94928368 T ES 94928368T ES 2136743 T3 ES2136743 T3 ES 2136743T3
- Authority
- ES
- Spain
- Prior art keywords
- active substance
- matrix
- readily volatile
- composite
- patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
LA INVENCION SE REFIERE A EMPLASTO, QUE CONTIENE SUSTANCIA ACTIVA CON UNA DISPOSICION DE FIJACION AUTOADHESIVA, CONTENIENDO AL MENOS UN INGREDIENTE ALTAMENTE VOLATIL Y CONSISTIENDO EN UNA CAPA POSTERIOR SUSTANCIALMENTE IMPERMEABLE A LA SUSTANCIA ACTIVA, AL MENOS DOS CAPAS DE MATRIZ CONTENIENDO SUSTANCIA ACTIVA Y UNA CAPA PROTECTORA DESMONTABLE. LA CAPA MATRIZ QUE CONTIENE LA SUSTANCIA ACTIVA ALTAMENTE VOLATIL ES LAMINADA SOBRE UN COMPOSITE PRODUCIDO DE FORMA SEPARADA, ELABORADO A PARTIR DE UNA O VARIAS CAPAS MATRIZ LIBRES DE OTRAS SUSTANCIAS ACTIVAS. EL EMPLASTO SE CARACTERIZA PORQUE LA PRIMERA CAPA MATRIZ CONTENIENDO SUSTANCIA ACTIVA CONSISTE EN UNA SOLUCION MOLECULAR DISPERSA DEL MATERIAL DE BASE MATRIZ DISPERSADO EN LOS INGREDIENTES ALTAMENTE VOLATILES COMO EL UNICO DISOLVENTE. DESPUES DE QUE EL INGREDIENTE ALTAMENTE VOLATIL EMIGRA DENTRO DE LA DISPOSICION DE COMPOSITE OBTENIDO DESPUES DE LA LAMINACION, EL COMPOSITE FORMA UNA MATRIZ DE SUSTANCIA ACTIVA QUE EN SU CONJUNTO ES RESISTENTE AEFECTO DE CORTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4332094A DE4332094C2 (de) | 1993-09-22 | 1993-09-22 | Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2136743T3 true ES2136743T3 (es) | 1999-12-01 |
Family
ID=6498227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94928368T Expired - Lifetime ES2136743T3 (es) | 1993-09-22 | 1994-09-16 | Parche de principios activos contenedor de substancias volatiles que puede ser elaborado sin disolventes. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5902601A (es) |
EP (1) | EP0720474B1 (es) |
JP (1) | JP3523259B2 (es) |
AT (1) | ATE182269T1 (es) |
CA (1) | CA2172402C (es) |
DE (2) | DE4332094C2 (es) |
DK (1) | DK0720474T3 (es) |
ES (1) | ES2136743T3 (es) |
GR (1) | GR3031626T3 (es) |
WO (1) | WO1995008324A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4433191A1 (de) * | 1994-09-17 | 1996-03-21 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster zur Abgabe von Wirkstoff an die Umgebung eines Trägers |
US5688523A (en) * | 1995-03-31 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Method of making a pressure sensitive skin adhesive sheet material |
DE19701059C2 (de) * | 1997-01-15 | 2000-12-21 | Lohmann Therapie Syst Lts | Acetylsalicylsäure enthaltendes transdermales therapeutisches System mit Resorptionsverstärkung |
DE19728516C2 (de) * | 1997-07-04 | 1999-11-11 | Sanol Arznei Schwarz Gmbh | TTS zur Verabreichung von Levonorgestrel und gegebenenfalls Estradiol |
DE19728517C2 (de) * | 1997-07-04 | 1999-11-11 | Sanol Arznei Schwarz Gmbh | TTS zur Verabreichung von Sexualsteroidhormonen und Verfahren zu seiner Herstellung |
DE19826592A1 (de) | 1998-06-15 | 1999-12-16 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung eines aus einzelnen Schichten bestehenden Laminats |
DE69916492T3 (de) † | 1998-12-07 | 2008-08-14 | J. Dev Ltd., Athlone | Pflaster zur transdermalen applikation von flüchtigen, flüssigen wirkstoffen |
DE19913732A1 (de) | 1999-03-26 | 2000-09-28 | Lohmann Therapie Syst Lts | Nikotin-TTS mit einem Zusatz von Monoterpenketonen |
DE19923427A1 (de) | 1999-05-21 | 2000-11-23 | Lohmann Therapie Syst Lts | Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen |
DE19949202A1 (de) * | 1999-10-13 | 2001-05-03 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Acetylsalicylsäure und/oder Salicylsäure |
DE10056011A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur insbesondere transdermalen Verabreichung ätherischer Öle |
DE10056010A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Pflaster mit hautpflegenden Substanzen |
DE10056009A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe |
DE10110391A1 (de) * | 2001-03-03 | 2002-09-26 | Lohmann Therapie Syst Lts | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
DE10121471A1 (de) * | 2001-05-02 | 2002-11-07 | Beiersdorf Ag | Oberflächendotierte wirkstoffhaltige Pflaster |
DE10338174A1 (de) * | 2003-08-20 | 2005-03-24 | Lts Lohmann Therapie-Systeme Ag | Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit |
UA84303C2 (ru) * | 2003-10-28 | 2008-10-10 | Новен Фармасьютикалз, Инк. | Система для трансдермальной доставки лечебного средства |
JP2006169160A (ja) * | 2004-12-15 | 2006-06-29 | Yuutoku Yakuhin Kogyo Kk | 外用貼付剤およびその製造方法 |
DE102005033543A1 (de) * | 2005-07-14 | 2007-01-18 | Grünenthal GmbH | Ein einen Duftstoff aufweisendes transdermales therapeutisches System |
JP4913738B2 (ja) * | 2005-08-19 | 2012-04-11 | ダイヤ製薬株式会社 | プラスターの製造方法及びその製造装置及びプラスター用ライナー |
DE102006026060B4 (de) * | 2006-01-12 | 2013-01-31 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme |
DE102006050558B4 (de) | 2006-10-26 | 2009-03-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System enthaltend Norelgestromin zur Kontrazeption und Hormonsubstitution |
DK2120896T3 (en) * | 2007-01-11 | 2017-09-11 | Drossapharm Ag | MEDICAL ACTIVE PLASTER |
JP5093545B1 (ja) * | 2012-02-28 | 2012-12-12 | ニチバン株式会社 | 貼付剤 |
DE102014000200A1 (de) | 2014-01-03 | 2015-07-09 | Michael Horstmann | Transdermales Therapeutisches System |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
GB2105990B (en) * | 1981-08-27 | 1985-06-19 | Nitto Electric Ind Co | Adhesive skin patches |
JPS61293911A (ja) * | 1985-06-24 | 1986-12-24 | Teisan Seiyaku Kk | 徐放化製剤 |
EP0249475A3 (en) * | 1986-06-13 | 1989-10-11 | Alza Corporation | Delayed percutaneous delivery |
DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
US5538736A (en) * | 1987-04-28 | 1996-07-23 | Lts Lohmann Therapie-Systeme Gmbh | Active substance-containing plaster for the controlled administration of active substances to the skin |
HU197519B (en) * | 1987-06-22 | 1989-04-28 | Biogal Gyogyszergyar | Process for producing medicine form capable for penetrating through epidermis and suitable for intaking the agent through epidermis by kinetics of zero-grade |
US5306502A (en) * | 1987-09-01 | 1994-04-26 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Apparatus for delivering nitroglycerin to the skin, processes for the production thereof and the use thereof |
DE3743946A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung |
DE3743945A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von stoffen, verfahren zu ihrer herstellung sowie ihre verwendung |
US4943435A (en) * | 1987-10-05 | 1990-07-24 | Pharmetrix Corporation | Prolonged activity nicotine patch |
FR2623718B1 (fr) * | 1987-11-27 | 1994-04-15 | Fabre Medicament Pierre | Dispositif therapeutique transdermique et son procede de preparation |
US4915950A (en) * | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
DE3843238C1 (es) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
US5164416A (en) * | 1989-02-03 | 1992-11-17 | Lintec Corporation | Transdermal therapeutic formulation containing a limonene |
DE69003632T2 (de) * | 1989-02-28 | 1994-02-17 | Teijin Ltd | Pflaster sowie dessen herstellung. |
DE4210165A1 (de) * | 1991-07-30 | 1993-02-04 | Schering Ag | Transdermale therapeutische systeme |
JP3182440B2 (ja) * | 1991-11-08 | 2001-07-03 | リンテック株式会社 | 経皮吸収型製剤の製造方法 |
US5323780A (en) * | 1992-08-07 | 1994-06-28 | University Of Florida Research Foundation, Inc. | Artifact-free imaging contrast agent |
US5462746A (en) * | 1992-11-02 | 1995-10-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
-
1993
- 1993-09-22 DE DE4332094A patent/DE4332094C2/de not_active Expired - Lifetime
-
1994
- 1994-09-16 DE DE59408524T patent/DE59408524D1/de not_active Expired - Lifetime
- 1994-09-16 DK DK94928368T patent/DK0720474T3/da active
- 1994-09-16 CA CA002172402A patent/CA2172402C/en not_active Expired - Lifetime
- 1994-09-16 AT AT94928368T patent/ATE182269T1/de active
- 1994-09-16 ES ES94928368T patent/ES2136743T3/es not_active Expired - Lifetime
- 1994-09-16 EP EP94928368A patent/EP0720474B1/de not_active Expired - Lifetime
- 1994-09-16 JP JP50954795A patent/JP3523259B2/ja not_active Expired - Lifetime
- 1994-09-16 WO PCT/EP1994/003107 patent/WO1995008324A1/de active IP Right Grant
-
1997
- 1997-10-24 US US08/959,541 patent/US5902601A/en not_active Expired - Lifetime
-
1999
- 1999-10-15 GR GR990402635T patent/GR3031626T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH09503756A (ja) | 1997-04-15 |
GR3031626T3 (en) | 2000-01-31 |
CA2172402A1 (en) | 1995-03-30 |
DE4332094C2 (de) | 1995-09-07 |
DK0720474T3 (da) | 2000-02-21 |
ATE182269T1 (de) | 1999-08-15 |
DE59408524D1 (de) | 1999-08-26 |
WO1995008324A1 (de) | 1995-03-30 |
JP3523259B2 (ja) | 2004-04-26 |
EP0720474A1 (de) | 1996-07-10 |
US5902601A (en) | 1999-05-11 |
EP0720474B1 (de) | 1999-07-21 |
CA2172402C (en) | 2005-08-23 |
DE4332094A1 (de) | 1995-03-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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