ES2136094T3 - Peptidos capaces de unirse a las moleculas cd8 sobre los precursores de ctl. - Google Patents

Peptidos capaces de unirse a las moleculas cd8 sobre los precursores de ctl.

Info

Publication number
ES2136094T3
ES2136094T3 ES92924245T ES92924245T ES2136094T3 ES 2136094 T3 ES2136094 T3 ES 2136094T3 ES 92924245 T ES92924245 T ES 92924245T ES 92924245 T ES92924245 T ES 92924245T ES 2136094 T3 ES2136094 T3 ES 2136094T3
Authority
ES
Spain
Prior art keywords
peptides
sequence
ctl
join
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92924245T
Other languages
English (en)
Inventor
Carol Clayberger
Alan M Krensky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2136094T3 publication Critical patent/ES2136094T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

EL PRESENTE INVENTO PROPORCIONA COMPOSICIONES QUE CONSTAN DE UN PEPTIDO QUE TIENE ENTRE APROXIMADAMENTE 7 Y 20 RESIDUOS DE AMINOACIDO, SIENDO CAPAZ EL PEPTIDO DE ENLAZAR UNA MOLECULA CD8 EN UN PRECURSOR DE LINFOCITO T CITOLITICO (CTL) Y DE INHIBIR LA DIFERENCIACION DE PRECURSOR DE CTL A CTL MADURO. LOS PEPTIDOS TIENEN SECUENCIAS AMINOACIDAS SUBSTANCIALMENTE HOMOLOGAS A UNA SECUENCIA EN UN DOMINIO ALFA3 DE UNA MOLECULA DE MHC DE CLASE I HUMANA. LA SECUENCIA DEL DOMINIO ALFA3 ESTA PREFERIBLEMENTE ENTRE RESIDUO (220) Y RESIDUO (225). LOS PEPTIDOS TIPICAMENTE COMPRENDEN LA SECUENCIA DQTQDTE (SEQ. ID NO. 1) O EDQTQDTELVETRP (SEQ. ID NO. 2).
ES92924245T 1991-11-08 1992-11-03 Peptidos capaces de unirse a las moleculas cd8 sobre los precursores de ctl. Expired - Lifetime ES2136094T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79192591A 1991-11-08 1991-11-08

Publications (1)

Publication Number Publication Date
ES2136094T3 true ES2136094T3 (es) 1999-11-16

Family

ID=25155235

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92924245T Expired - Lifetime ES2136094T3 (es) 1991-11-08 1992-11-03 Peptidos capaces de unirse a las moleculas cd8 sobre los precursores de ctl.

Country Status (11)

Country Link
US (1) US5620956A (es)
EP (1) EP0661985B1 (es)
JP (1) JP3345419B2 (es)
AT (1) ATE181836T1 (es)
AU (1) AU673985B2 (es)
CA (1) CA2122266A1 (es)
DE (1) DE69229562T2 (es)
DK (1) DK0661985T3 (es)
ES (1) ES2136094T3 (es)
GR (1) GR3031169T3 (es)
WO (1) WO1993008817A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6908094A (en) * 1993-05-05 1994-11-21 Mark L. Tykocinski Compositions and methods for immunotherapy with the alpha-3 domain of a class i major histocompatibility molecule
US6162434A (en) 1995-05-03 2000-12-19 Sangstat Medical Corporation Cytomodulating peptide for inhibiting lymphocyte activity
US6103239A (en) * 1996-08-09 2000-08-15 Cel-Sci Corporation Modified HGP-30 heteroconjugates, compositions and methods of use
US6696545B1 (en) 1997-04-11 2004-02-24 Sangstat Medical Corporation Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation
ATE352556T1 (de) 1997-04-11 2007-02-15 Sangstat Medical Corp Zytomodulierende lipophile peptide zur modulation der immunsystemaktivität und hemmung von entzündungen
EP1525216A4 (en) 2002-01-24 2009-07-08 Sangstat Medical Corp COMBINATION THERAPY FOR THE TREATMENT OF HIV INFECTION
JP5191235B2 (ja) 2005-10-21 2013-05-08 中外製薬株式会社 心疾患治療剤
AR057582A1 (es) * 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
CN101495146B (zh) 2006-04-07 2012-10-17 国立大学法人大阪大学 肌肉再生促进剂
GB0609121D0 (en) * 2006-05-09 2006-06-21 Univ Birmingham Peptide Therapy
MX2009007830A (es) 2007-01-23 2009-10-07 Univ Shinshu Inhibidor de rechazo cronico.
WO2008139163A1 (en) * 2007-05-09 2008-11-20 Circassia Limited Prognostic assay for determining t cell response to hla antigens and use thereof in field of tissue transplantation
CN102256623A (zh) 2008-06-05 2011-11-23 独立行政法人国立癌症研究中心 神经浸润抑制剂
US8340782B2 (en) 2009-07-08 2012-12-25 Boston Scientific Neuromodulation Corporation Systems and methods of making and using support elements for elongated members of implantable electric stimulation systems
DK2578231T3 (da) 2010-05-28 2022-12-12 Chugai Pharmaceutical Co Ltd Antitumor-t-celle-reaktionsforstærker
ES2755129T3 (es) * 2013-12-06 2020-04-21 Dana Farber Cancer Inst Inc Péptidos terapéuticos
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
EP3984554A4 (en) * 2019-06-11 2023-11-08 ONO Pharmaceutical Co., Ltd. IMMUNOSUPPRESSION AGENT

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0365525B1 (en) * 1987-01-30 1995-08-09 The Board Of Trustees Of The Leland Stanford Junior University Lymphocyte inhibition by hla peptides

Also Published As

Publication number Publication date
JP3345419B2 (ja) 2002-11-18
EP0661985A1 (en) 1995-07-12
ATE181836T1 (de) 1999-07-15
EP0661985B1 (en) 1999-07-07
AU3062892A (en) 1993-06-07
DE69229562D1 (de) 1999-08-12
US5620956A (en) 1997-04-15
JPH07505609A (ja) 1995-06-22
DE69229562T2 (de) 1999-11-25
EP0661985A4 (en) 1996-07-03
GR3031169T3 (en) 1999-12-31
AU673985B2 (en) 1996-12-05
WO1993008817A1 (en) 1993-05-13
DK0661985T3 (da) 2000-01-31
CA2122266A1 (en) 1993-05-13

Similar Documents

Publication Publication Date Title
ES2136094T3 (es) Peptidos capaces de unirse a las moleculas cd8 sobre los precursores de ctl.
ES2539812T3 (es) Péptidos derivados de PRAME y composiciones inmunogénicas que comprenden los mismos
DK0728148T3 (da) Forbedrede immunogene sammensætninger mod humant gastrin 17
DK1137400T3 (da) Præparater indeholdende et peptid og polymælkesyre-glycolsyre egnet til fremstilling af subkutane implantater med en forlænget frigivelsesperiode
AR073099A2 (es) Analogos de ghrelina
PT1196184E (pt) Composicoes para tratamento de disfuncao sexual
DE69131014T2 (de) Rekombinante avirulente salmonella antifruchtbarkeitsimpfstoffe
DK0883687T3 (da) C-C CKR-5, CC-chemokinreceptor, derivater deraf og anvendelse deraf
ES2721172T3 (es) Una nueva clase de moléculas terapéuticas a base de proteínas
HUP9901186A2 (hu) Peptid-és adjuvánsalapú gyógyszerkészítmény immunmodulációra
IT1242149B (it) Sequenza di nucleotidi codificante per una proteina umana con proprieta' regolative dell'angiogenesi
MX2010002001A (es) Peptido cdca1 y agente farmaceutico que comprende elmismo.
ES2190653T3 (es) Productos de reaccion del acido hialuronico y de aminoacidos naturales y su utilizacion en composiciones cosmeticas y farmaceuticas.
ES2173284T3 (es) Agentes endoparasicitidas.
MX2010002018A (es) Peptido de cdh3 y agente medicinal que comprende al mismo.
MX9300787A (es) Peptido para diagnosticar e inmunizar contra la infeccion por t. cruzi.
ATE210149T1 (de) Entzündungshemmende zusammensetzung und methode, in welchen des-tyr dynorphin und analoge benutzt werden
DE68925660D1 (de) Peptidfragmente von HIV
ES2127217T3 (es) Epitopos de porina hibridos de recombinacion.
DE69313647D1 (de) Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien
ES2051714T3 (es) Un procedimiento para la preparacion de un fragmento de interferon inmune recombinante homogeneo.
AR057639A2 (es) Analogos del peptido 1- similar al glucagon uso de los mismos par ala manufactura de un medicamento y composiciones farmaceuticas que los contienen
IT1249684B (it) Epitopi della proteina env del virus dell'epatite c.
HUP0003396A1 (hu) Szomatosztatin antagonista peptidek
DE69127974T2 (de) Peptide und deren verwendung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 661985

Country of ref document: ES