ES2133334T3 - Procedimiento para la preparacion del hemiheptahidrato de sal disodica de ceftriaxona. - Google Patents

Procedimiento para la preparacion del hemiheptahidrato de sal disodica de ceftriaxona.

Info

Publication number
ES2133334T3
ES2133334T3 ES93101216T ES93101216T ES2133334T3 ES 2133334 T3 ES2133334 T3 ES 2133334T3 ES 93101216 T ES93101216 T ES 93101216T ES 93101216 T ES93101216 T ES 93101216T ES 2133334 T3 ES2133334 T3 ES 2133334T3
Authority
ES
Spain
Prior art keywords
ceftriaxone
procedure
preparation
ceftriaxon
salt hemiheptahydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93101216T
Other languages
English (en)
Inventor
Natasa Dipl-Ing Hafner-Milac
Igor Dipl-Ing Langof
Boris Dipl-Ing Rusjakovski
Sandi Borisek
Darja Jereb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Application granted granted Critical
Publication of ES2133334T3 publication Critical patent/ES2133334T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO NUEVO MEJORADO PARA LA FABRICACION DE HEMIHEPTAHIDRATO DE SAL DISODICA CEFTRIAXON DE LA FORMULA I DONDE SE TRANSFORMA EL 7 DIHIDRO IL)TIO]METIL 3 CON UN REACTIVO DERIVADO 2 YN ESTER EN UNA SOLUCION ACUOSA Y EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE APROPIADO COMO ACETONA, EN UNA TEMPERATURA ENTRE 0 ONTINUACION LOS COMPUESTOS DESEADOS SON AISLADOS EN FORMA MUY PURA Y EN RENDIMIENTO COMPLETO MAS ALTO. CEFTRIAXON ES UN ANTIBIOTICO CEFALOSPORIN DE LA TERCERA GENERACION PARA UTILIZACION PARENTERAL Y UN MEDIO COMPLETO PARA EL TRATAMIENTO DE INFECCIONES GRAVES.
ES93101216T 1992-01-28 1993-01-27 Procedimiento para la preparacion del hemiheptahidrato de sal disodica de ceftriaxona. Expired - Lifetime ES2133334T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0013292A AT398764B (de) 1992-01-28 1992-01-28 Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat

Publications (1)

Publication Number Publication Date
ES2133334T3 true ES2133334T3 (es) 1999-09-16

Family

ID=3482382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93101216T Expired - Lifetime ES2133334T3 (es) 1992-01-28 1993-01-27 Procedimiento para la preparacion del hemiheptahidrato de sal disodica de ceftriaxona.

Country Status (13)

Country Link
US (1) US5527906A (es)
EP (1) EP0553792B1 (es)
KR (1) KR960002911B1 (es)
AT (1) AT398764B (es)
CA (1) CA2088173A1 (es)
CZ (1) CZ282447B6 (es)
DE (1) DE59309598D1 (es)
DK (1) DK0553792T3 (es)
ES (1) ES2133334T3 (es)
PL (1) PL172486B1 (es)
RU (1) RU2081120C1 (es)
SI (1) SI9300042A (es)
SK (1) SK279280B6 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
IN184690B (es) * 1996-03-18 2000-09-23 Ranbaxy Lab Ltd
KR100361829B1 (ko) * 1997-04-16 2005-08-17 주식회사 엘지생명과학 반응성 유기산 유도체로 부터 세프트리악손을 제조하는 방법
RU2504548C1 (ru) * 2012-09-28 2014-01-20 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) ПРОИЗВОДНОЕ β-ЛАКТАМНОГО АНТИБИОТИКА ЦЕФТРИАКСОНА

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1240314A (en) * 1974-06-21 1988-08-09 Marc Montavon Acyl derivatives
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
CH641468A5 (de) * 1978-05-30 1984-02-29 Hoffmann La Roche Cephemderivate.
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
FI67385C (fi) * 1979-11-21 1985-03-11 Hoffmann La Roche Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat
DE3165922D1 (en) * 1980-03-28 1984-10-18 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
ES8302007A1 (es) * 1982-03-10 1983-01-16 Servicios Y Suministros Farmac Procedimiento para la obtencion de la sal disodica del acido 7-(2-(2-amino-4-tiazolil)-2-metoxiimino-acetamido)-3-((2,5-dihidro-6-hidroxi-2-metil-5-oxo-as-triazin-3-il)tio)metil)-8-oxo-5-tia-1-azabiciclo (4.2.0)oct-2-ene-2-carboxilico
KR870001332B1 (ko) * 1984-09-27 1987-07-18 한미약품공업 주식회사 세펨 유도체의 간단한 제조방법
KR890002107B1 (ko) * 1986-06-25 1989-06-19 재단법인 한국화학연구소 세팔로스포린 유도체의 제조방법
DE3911322A1 (de) * 1989-04-07 1990-10-11 Hoechst Ag Verfahren zur herstellung von cefodizim-dinatrium
IT1234385B (it) * 1989-05-23 1992-05-18 Sbd Synthetic And Biolog Devel Procedimento migliorato per la produzione di una sostanza antibiotica appartenente al gruppo delle cefalosporine

Also Published As

Publication number Publication date
AT398764B (de) 1995-01-25
PL297535A1 (en) 1993-10-04
SK279280B6 (sk) 1998-09-09
SK4193A3 (en) 1993-09-09
US5527906A (en) 1996-06-18
ATA13292A (de) 1994-06-15
EP0553792B1 (de) 1999-05-26
CA2088173A1 (en) 1993-07-29
SI9300042A (en) 1993-09-30
RU2081120C1 (ru) 1997-06-10
CZ282447B6 (cs) 1997-07-16
DE59309598D1 (de) 1999-07-01
EP0553792A2 (de) 1993-08-04
EP0553792A3 (en) 1993-12-29
CZ9193A3 (en) 1993-12-15
PL172486B1 (pl) 1997-09-30
DK0553792T3 (da) 1999-11-08
KR930016427A (ko) 1993-08-26
KR960002911B1 (ko) 1996-02-28

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