ES2133278T3 - Uso de analogos de pirofosfato de poliisoprenilo para inhibir la isoprenilacion de proteinas. - Google Patents

Uso de analogos de pirofosfato de poliisoprenilo para inhibir la isoprenilacion de proteinas.

Info

Publication number
ES2133278T3
ES2133278T3 ES91202616T ES91202616T ES2133278T3 ES 2133278 T3 ES2133278 T3 ES 2133278T3 ES 91202616 T ES91202616 T ES 91202616T ES 91202616 T ES91202616 T ES 91202616T ES 2133278 T3 ES2133278 T3 ES 2133278T3
Authority
ES
Spain
Prior art keywords
independently represent
isoprenylation
polyisoprenyl
polyisoprenyl pyrophosphate
sulphur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91202616T
Other languages
English (en)
Inventor
Louis H Cohen
Boom Jacobus H Van
Der Marel Gijsbert A Van
Adrianus P R M Valentijn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Universiteit Leiden
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Universiteit Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO, Universiteit Leiden filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Application granted granted Critical
Publication of ES2133278T3 publication Critical patent/ES2133278T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE AL USO DE UN ANALOGO DE UN PIROFOSFATO DE POLIISOPRENILO PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA PARA INHIBIR LA ISOPRENILACION DE PROTEINAS. EL ANALOGO DEL PIROFOSFATO DE POLIISOPRENILO PUEDE TENER LA FORMULA 1, EN DONDE: PREN REPRESENTA UN GRUPO TERPENOIDE C10 UN DERIVADO DEL MISMO; A1, A2, A3 Y A4 REPRESENTAN INDEPENDIENTE UN ENLACE DIRECTO O UN GRUPO ALQUILENO C1 O, OPCIONALMENTE SUSTITUIDO; X1, X2, X3 Y X4 REPRESENTAN INDEPENDIENTEMENTE UN ENLACE DIRECTO, OXIGENO, AZUFRE, IMINO O METILIMINO; Y1, Y2 E Y3 REPRESENTAN INDEPENDIENTEMENTE HIDROXI, ALCOXI, MERCAPTO, ALQUILTIO, AMINO, MONO O DIALQUILAMINO, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ARILO O ARILOALQUILO, CON LO QUE UNO DE LOS Y1, Y2 E Y3 PUEDE REPRESENTAR TAMBIEN UN GRUPO ALQUILO C7 NDIENTEMENTE OXIGENO O AZUFRE; Y N ES 0, 1 O 2, PREFERENTEMENTE 1; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. LA COMPOSICION FARMACEUTICA ES ADECUADA PARA LA PROFILAXIS Y/O TRATAMIENTO DE CARCINOMAS Y PARA LA INHIBICION DE LA ISOPRENILACION DE UNA PROTEINA RAS.
ES91202616T 1991-10-07 1991-10-07 Uso de analogos de pirofosfato de poliisoprenilo para inhibir la isoprenilacion de proteinas. Expired - Lifetime ES2133278T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91202616A EP0540782B1 (en) 1991-10-07 1991-10-07 Use of analogues of polyisoprenyl pyrophosphate for inhibiting protein isoprenylation

Publications (1)

Publication Number Publication Date
ES2133278T3 true ES2133278T3 (es) 1999-09-16

Family

ID=8207934

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91202616T Expired - Lifetime ES2133278T3 (es) 1991-10-07 1991-10-07 Uso de analogos de pirofosfato de poliisoprenilo para inhibir la isoprenilacion de proteinas.

Country Status (7)

Country Link
EP (1) EP0540782B1 (es)
JP (1) JP3518611B2 (es)
AT (1) ATE179607T1 (es)
DE (1) DE69131199T2 (es)
DK (1) DK0540782T3 (es)
ES (1) ES2133278T3 (es)
GR (1) GR3030795T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2267494B (en) * 1992-06-02 1995-09-20 Ciba Geigy Ag Trisamidodithionodiphosphates
US5883066A (en) * 1993-06-28 1999-03-16 The Procter & Gamble Company Liquid detergent compositions containing cellulase and amine
AU2122795A (en) * 1994-03-15 1995-10-03 Eisai Co. Ltd. Isoprenyl transferase inhibitors
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
JP2001158799A (ja) 1999-09-28 2001-06-12 Rijksuniv Leiden プレニル化ピロリン酸消費酵素の新規な阻害剤
EP1090909A1 (en) * 1999-09-28 2001-04-11 Rijksuniversiteit Leiden Novel inhibitors of prenylated pyrophosphate consuming enzymes
AU1226001A (en) * 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871721A (en) * 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
JP2714402B2 (ja) * 1988-07-13 1998-02-16 日清製粉株式会社 癌転移抑制剤
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method
US5025003A (en) * 1989-09-18 1991-06-18 E. R. Squibb & Sons, Inc. Isoprenoid phosphinylformic acid squalene synthetase inhibitors

Also Published As

Publication number Publication date
JP3518611B2 (ja) 2004-04-12
GR3030795T3 (en) 1999-11-30
EP0540782A1 (en) 1993-05-12
DE69131199T2 (de) 1999-08-26
DE69131199D1 (de) 1999-06-10
DK0540782T3 (da) 1999-11-01
JPH07188028A (ja) 1995-07-25
EP0540782B1 (en) 1999-05-06
ATE179607T1 (de) 1999-05-15

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