DE69131199D1 - Verwendung von Polyisoprenyl pyrophosphate Analogen zur Hemmung des Proteinisoprenylations - Google Patents

Verwendung von Polyisoprenyl pyrophosphate Analogen zur Hemmung des Proteinisoprenylations

Info

Publication number
DE69131199D1
DE69131199D1 DE69131199T DE69131199T DE69131199D1 DE 69131199 D1 DE69131199 D1 DE 69131199D1 DE 69131199 T DE69131199 T DE 69131199T DE 69131199 T DE69131199 T DE 69131199T DE 69131199 D1 DE69131199 D1 DE 69131199D1
Authority
DE
Germany
Prior art keywords
independently represent
isoprenylation
polyisoprenyl
polyisoprenyl pyrophosphate
sulphur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131199T
Other languages
English (en)
Other versions
DE69131199T2 (de
Inventor
Louis H Cohen
Boom Jacobus H Van
Der Marel Gijsbert A Van
Adrianus P R M Valentijn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Universiteit Leiden
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Universiteit Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO, Universiteit Leiden filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Application granted granted Critical
Publication of DE69131199D1 publication Critical patent/DE69131199D1/de
Publication of DE69131199T2 publication Critical patent/DE69131199T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69131199T 1991-10-07 1991-10-07 Verwendung von Polyisoprenyl pyrophosphate Analogen zur Hemmung des Proteinisoprenylations Expired - Fee Related DE69131199T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91202616A EP0540782B1 (de) 1991-10-07 1991-10-07 Verwendung von Polyisoprenyl pyrophosphate Analogen zur Hemmung des Proteinisoprenylations

Publications (2)

Publication Number Publication Date
DE69131199D1 true DE69131199D1 (de) 1999-06-10
DE69131199T2 DE69131199T2 (de) 1999-08-26

Family

ID=8207934

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131199T Expired - Fee Related DE69131199T2 (de) 1991-10-07 1991-10-07 Verwendung von Polyisoprenyl pyrophosphate Analogen zur Hemmung des Proteinisoprenylations

Country Status (7)

Country Link
EP (1) EP0540782B1 (de)
JP (1) JP3518611B2 (de)
AT (1) ATE179607T1 (de)
DE (1) DE69131199T2 (de)
DK (1) DK0540782T3 (de)
ES (1) ES2133278T3 (de)
GR (1) GR3030795T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2267494B (en) * 1992-06-02 1995-09-20 Ciba Geigy Ag Trisamidodithionodiphosphates
US5883066A (en) * 1993-06-28 1999-03-16 The Procter & Gamble Company Liquid detergent compositions containing cellulase and amine
AU2122795A (en) * 1994-03-15 1995-10-03 Eisai Co. Ltd. Isoprenyl transferase inhibitors
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
EP1090909A1 (de) * 1999-09-28 2001-04-11 Rijksuniversiteit Leiden Hemmer für Enzyme, die Prenylpyrophosphate umsetzen
US6624147B1 (en) 1999-09-28 2003-09-23 Rijksuniversiteit Leiden Inhibitors of prenylated pyrophosphate consuming enzymes
US6353032B1 (en) * 1999-11-09 2002-03-05 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871721A (en) * 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
JP2714402B2 (ja) * 1988-07-13 1998-02-16 日清製粉株式会社 癌転移抑制剤
EP0356866A3 (de) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphor enthaltende Squalen-Synthetase-Inhibitoren und Verfahren
US5025003A (en) * 1989-09-18 1991-06-18 E. R. Squibb & Sons, Inc. Isoprenoid phosphinylformic acid squalene synthetase inhibitors

Also Published As

Publication number Publication date
EP0540782A1 (de) 1993-05-12
JPH07188028A (ja) 1995-07-25
GR3030795T3 (en) 1999-11-30
DK0540782T3 (da) 1999-11-01
JP3518611B2 (ja) 2004-04-12
ES2133278T3 (es) 1999-09-16
DE69131199T2 (de) 1999-08-26
EP0540782B1 (de) 1999-05-06
ATE179607T1 (de) 1999-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee