ES2132450T3 - Sintesis de acidos nucleicos de peptidos o poliamidas (pna) utilizando un grupo protector de amino inestable frente a acidos debiles. - Google Patents

Sintesis de acidos nucleicos de peptidos o poliamidas (pna) utilizando un grupo protector de amino inestable frente a acidos debiles.

Info

Publication number
ES2132450T3
ES2132450T3 ES95103318T ES95103318T ES2132450T3 ES 2132450 T3 ES2132450 T3 ES 2132450T3 ES 95103318 T ES95103318 T ES 95103318T ES 95103318 T ES95103318 T ES 95103318T ES 2132450 T3 ES2132450 T3 ES 2132450T3
Authority
ES
Spain
Prior art keywords
pna
polyamides
peptides
synthesis
protective group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95103318T
Other languages
English (en)
Inventor
Gerhard Dr Breipohl
Eugen Dr Uhlmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2132450T3 publication Critical patent/ES2132450T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBE PROCESO PARA ELABORACION DE OLIGOMEROS PNA DE LA FORMULA DONDE B/X ESTAN DEFINIDOS COMO EN LA DESCRIPCION, R0 SIGNIFICA HIDROGENO, ALCANOIL, ALCOXICARBONIL, CICLOALCANOIL, AROIL, HETEROAROIL O UN GRUPO, QUE ES FAVORABLE PARA LA RECEPCION INTRACELULAR DE OLIGOMEROS, A Y Q REPRESENTAN RESPECTIVAMENTE UN RESTO DE AMINOACIDO; K Y L SON RESPECTIVAMENTE UNA CIFRA COMPLETA DESDE 0 HASTA 10, B ES UNA NUCLEOBASE NATURAL HABITUAL EN LA QUIMICA DE NUCLEOTIDOS O NUCLEOBASE NATURAL O SUS FORMAS DE MEDICAMENTO, O TAMBIEN UN COMPUESTO DE SUSTITUCION DE BASE, Q0 ES HIDROXI O NH2 EVENTUALMENTE SUSTITUIDO Y N ES UNA CIFRA COMPLETA DESDE 1 HASTA 50. CON ELLO SE DESCRIBEN LOS RESTOS DE AMINOACIDO Y LOS COMPONENTES DONDE PG ES UN GRUPO DE PROTECCION AMINO INESTABLE CONTRA ACIDOS DEBILES Y B'' ES UNA NUCLEOBASE PROTEGIDA EN SU FUNCION HIDROXI O AMINO EXOCICLICA, HABIENDOSE PREVISTO DE FORMA ESCALONADA SEGUN EL METODO DE FASE SOLIDA SOBRE UN SOPORTE POLIMERO, QUE ESTA EQUIPADO CON UN GRUPO DE ANCLAJE,ACOPLADO Y DESPUES DE LA CONSTITUCION TERMINADA SE OBTIENEN LOS COMPUESTOS OBJETIVOS POR MEDIO DE UNA REACCION DE DESDOBLAMIENTO A PARTIR DE LOS SOPORTES POLIMEROS. SE DESCRIBEN ADEMAS PRODUCTOS INTERMEDIOS DEL OLIGOMERO PNA ASI COMO PROCESO PARA SU ELABORACION.
ES95103318T 1994-03-14 1995-03-08 Sintesis de acidos nucleicos de peptidos o poliamidas (pna) utilizando un grupo protector de amino inestable frente a acidos debiles. Expired - Lifetime ES2132450T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4408531A DE4408531A1 (de) 1994-03-14 1994-03-14 PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe

Publications (1)

Publication Number Publication Date
ES2132450T3 true ES2132450T3 (es) 1999-08-16

Family

ID=6512696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95103318T Expired - Lifetime ES2132450T3 (es) 1994-03-14 1995-03-08 Sintesis de acidos nucleicos de peptidos o poliamidas (pna) utilizando un grupo protector de amino inestable frente a acidos debiles.

Country Status (12)

Country Link
US (1) US6046306A (es)
EP (1) EP0672700B1 (es)
JP (1) JP4098837B2 (es)
AT (1) ATE180805T1 (es)
AU (1) AU695931B2 (es)
CA (1) CA2144477C (es)
DE (2) DE4408531A1 (es)
DK (1) DK0672700T3 (es)
ES (1) ES2132450T3 (es)
FI (1) FI120261B (es)
GR (1) GR3030883T3 (es)
NO (1) NO321034B1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7825215B1 (en) 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
DE4438918A1 (de) * 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
JP2001518054A (ja) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド Ｐｎａ−ｄｎａキメラと、このキメラ合成用のｐｎａシントン
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US20040171030A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
US20050032068A1 (en) * 2002-11-05 2005-02-10 Prakash Thazha P. Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation
US20050118605A9 (en) * 1996-06-06 2005-06-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20050042647A1 (en) * 1996-06-06 2005-02-24 Baker Brenda F. Phosphorous-linked oligomeric compounds and their use in gene modulation
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US6331618B1 (en) * 1999-05-13 2001-12-18 Pe Corporation (Ny) Compositions of solvents and high concentrations of nucleic acid analogs
DE10019136A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019135A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
EP1562971B1 (en) * 2002-11-05 2014-02-12 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US9150606B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
AU2003290598A1 (en) * 2002-11-05 2004-06-03 Isis Pharmaceuticals, Inc. Modified oligonucleotides for use in rna interference
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
JP2008501694A (ja) * 2004-06-03 2008-01-24 アイシス ファーマシューティカルズ、インク． 遺伝子調節の使用のために個別に修飾された鎖を有する二本鎖組成物
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
AU2006332945C1 (en) 2005-12-23 2013-02-28 Wyeth Modified lysine-mimetic compounds
EP2074087A2 (en) 2006-12-21 2009-07-01 Wyeth Synthesis of pyrrolidine compounds
DK3618847T3 (da) 2017-05-05 2021-05-25 Boston Medical Ct Corp GAP-junction-modulatorer af intercellulær kommunikation og deres anvendelse til behandling af diabetisk øjensygdom

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
US5367066A (en) * 1984-10-16 1994-11-22 Chiron Corporation Oligonucleotides with selectably cleavable and/or abasic sites
DE4016596A1 (de) * 1990-05-23 1991-11-28 Hoechst Ag Ein neues kupplungsreagenz fuer die peptidsynthese
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene

Also Published As

Publication number Publication date
GR3030883T3 (en) 1999-11-30
JPH07285989A (ja) 1995-10-31
NO321034B1 (no) 2006-03-06
CA2144477A1 (en) 1995-09-15
JP4098837B2 (ja) 2008-06-11
FI951130A (fi) 1995-09-15
EP0672700A1 (de) 1995-09-20
EP0672700B1 (de) 1999-06-02
US6046306A (en) 2000-04-04
AU695931B2 (en) 1998-08-27
ATE180805T1 (de) 1999-06-15
FI120261B (fi) 2009-08-31
DE4408531A1 (de) 1995-09-28
DE59506063D1 (de) 1999-07-08
FI951130A0 (fi) 1995-03-10
NO950957D0 (no) 1995-03-13
CA2144477C (en) 2007-09-18
AU1480195A (en) 1995-09-21
DK0672700T3 (da) 1999-11-29
NO950957L (no) 1995-09-15

Similar Documents

Publication Publication Date Title
ES2132450T3 (es) Sintesis de acidos nucleicos de peptidos o poliamidas (pna) utilizando un grupo protector de amino inestable frente a acidos debiles.
ES2608848T3 (es) Procedimiento de preparación de derivados 4''-sustituidos de 9-desoxo-9a-aza-9a-homoeritromicina A
BR0114630A (pt) Secretagogos de hormÈnio do crescimento
CO4810375A1 (es) Derivados de 9-amino-3-ceto eritromicina
GT199800197A (es) Proceso para la sintesis de 1,3-dioles.
PA8539401A1 (es) Quinazolinas como inhibidores de mmp-13
SV2001000188A (es) Aminoacidos biciclicos como agentes farmaceuticos
ES2159738T3 (es) Derivados de benzamida y su uso como antagonistas de vasopresina.
BR9810953A (pt) "processo para produzir policarbonatos ramificados"
DE60044367D1 (de) Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendung
AR028948A1 (es) Compuestos novedosos
BR0305203A (pt) Preparação de poliissocianatos contendo grupos uretdiona
BR9913072A (pt) Sistemas de anel azacìclico, composição farmacêutica, e, processo para induzir a analgesia
Guillaumie et al. Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle
CA2210031A1 (en) Solid phase synthesis of oligonucleotides
BR0103969A (pt) Aparelho e processo para a preparação de fundidos de sal e seus usos
BRPI0412843A (pt) lactamas substituìdas e uso das mesmas como agentes anticáncer
ES2169886T3 (es) Derivados condensados de la piperidina como inhibidor de sintesis de monoxido de nitrogeno.
BR9911250A (pt) Processo para preparação de compostos
BR9807988A (pt) Processo para a preparação de um composto, e, composto.
AR028947A1 (es) Compuestos novedosos
BR9811821A (pt) 2-acilaminopropanaminas como antagonistas de receptores de taquicinina
ES2129384T3 (es) Un procedimiento para la preparacion de derivados del acido 5-amino-2,4,6-triyodo-1,3-bencenocarboxilico.
ES2110726T3 (es) Tttr como grupo protector en la sintesis de nucleotidos.
CA2144473A1 (en) Pna synthesis using a base-labile amino protecting group

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 672700

Country of ref document: ES