ES2132127T3 - Ureas ciclicas, utiles como agentes antiarritmicos y antifibriladores. - Google Patents

Ureas ciclicas, utiles como agentes antiarritmicos y antifibriladores.

Info

Publication number
ES2132127T3
ES2132127T3 ES92917977T ES92917977T ES2132127T3 ES 2132127 T3 ES2132127 T3 ES 2132127T3 ES 92917977 T ES92917977 T ES 92917977T ES 92917977 T ES92917977 T ES 92917977T ES 2132127 T3 ES2132127 T3 ES 2132127T3
Authority
ES
Spain
Prior art keywords
nil
unsubstituted
saturated
substituted
unsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92917977T
Other languages
English (en)
Inventor
Stanford Salvatore Pelosi Jr
Chia-Nien Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Procter and Gamble Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Pharmaceuticals Inc filed Critical Procter and Gamble Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2132127T3 publication Critical patent/ES2132127T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LAS NUEVAS UREAS CICLICAS DE LA PRESENTE INVENCION SON UTILES COMO AGENTES ANTIARRITMICOS Y ANTIFIBRILATORIOS, Y TIENEN ESTRUCTURA GENERAL (I) EN LA QUE (A) X ES UN CARBOCICLO O HETEROCICLO DE 5, 6 O 7 MIEMBROS, SATURADO O NO SATURADO; (B) R SE SELECCIONA DE UN GRUPO FORMADO POR ENLACE COVALENTE, NULO, HETEROATOMO, CARBONILO, ANILLO HETEROCICLICO, ANILLO CARBOCICLICO, ALQUILO, ALQUENILO, ALCOXI, ALQUILAMINO, ARIALQUILO, ARILOXI, ACILO, ACILOXI Y ACILAMINO; (C) Y ES UN ANILLO CARBOCICLICO O ANILLO HETEROCICLICO, DE 5, 6 O 7 MIEMBROS, SATURADO O NO SATURADO, SUSTITUIDO O NO SUSTITUIDO, O ES NULO; Y DONDE, CUANDO R ES NULO, X E Y SON SISTEMAS DE ANILLO CONDENSADO; Y CUANDO R ES UN ENLACE COVALENTE, X E Y SON SISTEMAS DE ANILLO, UNIDOS A TRAVES DE UN ENLACE COVALENTE; Y CUANDO Y ES NULO, R ES UN ENLACE COVALENTE Y X ESTA UNIDO A L A TRAVES DE R; (D) R1, R2 Y R3 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO FORMADO POR NINGUNO, CL, F, BR, NH2, CF3, OH, SO3H, CH3SO2NH, COOH, ALCOXI, ALQUILO, ALCOXICARBONILO, HIDROXIALQUILO, CARBOXIALQUILO, AMINOALQUILO, ACILAMINO Y ACILOXI; (E) L SE SELECCIONA DEL GRUPO FORMADO POR ALQUILAMINO, ALQUENILAMINO, ALQUILIMINO, ALQUENILIMINO Y ACILAMINO, DONDE EL ATOMO DE NITROGENO DEL MISMO SE UNE AL ATOMO DE NITROGENO, EN LA POSICION 1 DE LA MITAD DE UREA CICLICA; (F) R4 SE SELECCIONA DEL GRUPO FORMADO POR ALQUILO, ALQUENILO, ALQUINILO, ALQUILACILO Y HETEROALQUILO; (G) A ES UN HETEROALQUILO C1 ATURADO, SUSTITUIDO O NO SUSTITUIDO, O UN HETEROCICLO SATURADO O NO SATURADO, SUSTITUIDO O NO SUSTITUIDO, QUE TIENE 5, 6 O 7 MIEMBROS; Y TIENE UN ATOMO DE NITROGENO, QUE ESTA ADYACENTE A R4: Y (H) R5 ES UN ALQUILO C1 O C2, SUSTITUIDO O NO SUSTITUIDO; Y LAS SALES Y ESTERES DE LOS MISMOS, FARMACEUTICAMENTE ACEPTABLES.
ES92917977T 1991-08-14 1992-08-10 Ureas ciclicas, utiles como agentes antiarritmicos y antifibriladores. Expired - Lifetime ES2132127T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74486491A 1991-08-14 1991-08-14

Publications (1)

Publication Number Publication Date
ES2132127T3 true ES2132127T3 (es) 1999-08-16

Family

ID=24994265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92917977T Expired - Lifetime ES2132127T3 (es) 1991-08-14 1992-08-10 Ureas ciclicas, utiles como agentes antiarritmicos y antifibriladores.

Country Status (24)

Country Link
US (1) US5691369A (es)
EP (2) EP0891976B1 (es)
JP (1) JPH06509803A (es)
AT (2) ATE178063T1 (es)
AU (1) AU665209B2 (es)
BR (1) BR9206371A (es)
CA (1) CA2115426C (es)
CZ (1) CZ286265B6 (es)
DE (2) DE69228751T2 (es)
DK (1) DK0598046T3 (es)
ES (1) ES2132127T3 (es)
FI (1) FI940656A0 (es)
GR (1) GR3030579T3 (es)
HU (1) HUT70029A (es)
IL (1) IL102792A (es)
MX (1) MX9204735A (es)
MY (1) MY109528A (es)
NO (1) NO305285B1 (es)
NZ (1) NZ243937A (es)
PL (1) PL170960B1 (es)
PT (1) PT100776B (es)
RU (1) RU2142461C1 (es)
SK (1) SK279677B6 (es)
WO (1) WO1993004060A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0598061B1 (en) * 1991-08-14 2002-07-17 Procter & Gamble Pharmaceuticals Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
US6083945A (en) * 1995-06-07 2000-07-04 The Procter & Gamble Company Cyclic ureas useful as antiarrhythmic and antifibrillatory agents
KR100381213B1 (ko) * 1998-03-26 2003-08-14 주식회사 엘지생명과학 파네실전이효소억제능을갖는사이클릭우레아유도체및그의제조방법
NZ510311A (en) * 1998-09-08 2003-08-29 Smithkline Beecham Corp Lipstatin derivative - soluble fiber tablets
US6288151B1 (en) * 1999-10-14 2001-09-11 Air Products And Chemicals, Inc. Alkylated aminoalkyl cyclic urea surfactants
US7129359B2 (en) 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
US7259174B2 (en) 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776979A (en) * 1956-04-05 1957-01-08 Norwich Pharma Co 1-nitroso-2-imidazolidone and process
NL257071A (es) * 1959-10-23
US3254075A (en) * 1963-08-28 1966-05-31 Norwich Pharma Co 1-(2-hydroxyethyl and 2-haloethyl-3-(5-nitrofurfurylideneamino)-2-imidazolidinones
US3415821A (en) * 1965-09-07 1968-12-10 Norwich Pharma Co 1-(5-substituted)furfurylideneamino hydantoins and imidazolidinones
US3407195A (en) * 1967-04-03 1968-10-22 Norwich Pharma Co 4-methyl-1-(5-nitrofurfurylideneamino)-2-imidazolidinone
DE2335144A1 (de) * 1973-07-07 1975-01-23 Schering Ag Basisch substituierte nitroimidazolmethylenamino-imidazolidinone
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
US4393204A (en) * 1982-05-21 1983-07-12 Norwich Eaton Pharmaceuticals, Inc. 3-[[5-(4-Chlorophenyl)furfurylidene]amino]-5-(substituted)-2-oxazolidinones
US4543359A (en) * 1982-10-01 1985-09-24 Eaton Laboratories, Inc. Treating cardiac arrhythmias with dantrolene sodium
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US4581370A (en) * 1983-07-12 1986-04-08 Schering A.G. Antiarrhythmic imidazoliums
US4720580A (en) * 1984-09-21 1988-01-19 American Home Products Corporation N-(aminoalkylene)benzenesulfonamides
US4707499A (en) * 1985-12-02 1987-11-17 G. D. Searle & Co. 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
US4783443A (en) * 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US4713832A (en) * 1986-04-11 1987-12-15 Ampex Corporation Programmable divider up/down counter with anti-aliasing feature and asynchronous read/write
US4870095A (en) * 1988-06-13 1989-09-26 Sterling Drug, Inc. 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use
EP0347733A1 (en) * 1988-06-20 1989-12-27 Eisai Co., Ltd. Optically active hydantoin derivatives
US5137905A (en) * 1988-10-27 1992-08-11 The Upjohn Company Heterocyclic acetylenic amines having central nervous system activity
US4966967A (en) * 1989-09-15 1990-10-30 Berlex Laboratories, Inc. 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US4963561A (en) * 1990-02-28 1990-10-16 Sterling Drug Inc. Imidazopyridines, their preparation and use
FR2678272B1 (fr) * 1991-06-27 1994-01-14 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
BR9206353A (pt) * 1991-08-14 1995-11-07 Procter & Gamble Pharma Uretanos cíclicos utilizáveis como agentes antiarrítmicos e antifibrilatórios

Also Published As

Publication number Publication date
IL102792A (en) 1997-01-10
ATE178063T1 (de) 1999-04-15
CZ30594A3 (en) 1994-12-15
NO940498D0 (no) 1994-02-14
RU2142461C1 (ru) 1999-12-10
MX9204735A (es) 1994-03-31
AU665209B2 (en) 1995-12-21
DE69228751D1 (de) 1999-04-29
FI940656A (fi) 1994-02-11
EP0891976B1 (en) 2002-10-16
EP0598046B1 (en) 1999-03-24
JPH06509803A (ja) 1994-11-02
AU2460092A (en) 1993-03-16
HU9400391D0 (en) 1994-05-30
NZ243937A (en) 1996-10-28
GR3030579T3 (en) 1999-10-29
EP0598046A1 (en) 1994-05-25
NO305285B1 (no) 1999-05-03
MY109528A (en) 1997-02-28
CA2115426A1 (en) 1993-03-04
SK17094A3 (en) 1995-02-08
NO940498L (no) 1994-02-14
IL102792A0 (en) 1993-01-31
CZ286265B6 (cs) 2000-03-15
PT100776B (pt) 1999-07-30
EP0891976A1 (en) 1999-01-20
SK279677B6 (sk) 1999-02-11
BR9206371A (pt) 1995-10-17
ATE226202T1 (de) 2002-11-15
DK0598046T3 (da) 1999-05-25
PT100776A (pt) 1993-12-31
WO1993004060A1 (en) 1993-03-04
CA2115426C (en) 2001-09-11
PL170960B1 (pl) 1997-02-28
HUT70029A (en) 1995-09-28
DE69228751T2 (de) 1999-10-07
FI940656A0 (fi) 1994-02-11
US5691369A (en) 1997-11-25
DE69232825D1 (de) 2002-11-21

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