DE69232825D1 - Zyklische Harnstoffe mit antiarrhythmischer und antifibrillatorischer Wirkung - Google Patents

Zyklische Harnstoffe mit antiarrhythmischer und antifibrillatorischer Wirkung

Info

Publication number
DE69232825D1
DE69232825D1 DE69232825T DE69232825T DE69232825D1 DE 69232825 D1 DE69232825 D1 DE 69232825D1 DE 69232825 T DE69232825 T DE 69232825T DE 69232825 T DE69232825 T DE 69232825T DE 69232825 D1 DE69232825 D1 DE 69232825D1
Authority
DE
Germany
Prior art keywords
nil
unsubstituted
saturated
substituted
unsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232825T
Other languages
English (en)
Inventor
Pelosi, Jr
Chia-Nien Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Procter and Gamble Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Pharmaceuticals Inc filed Critical Procter and Gamble Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69232825D1 publication Critical patent/DE69232825D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69232825T 1991-08-14 1992-08-10 Zyklische Harnstoffe mit antiarrhythmischer und antifibrillatorischer Wirkung Expired - Lifetime DE69232825D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74486491A 1991-08-14 1991-08-14

Publications (1)

Publication Number Publication Date
DE69232825D1 true DE69232825D1 (de) 2002-11-21

Family

ID=24994265

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69232825T Expired - Lifetime DE69232825D1 (de) 1991-08-14 1992-08-10 Zyklische Harnstoffe mit antiarrhythmischer und antifibrillatorischer Wirkung
DE69228751T Expired - Fee Related DE69228751T2 (de) 1991-08-14 1992-08-10 Zyklische harnstoffe mit antiarrhythmischer und antifibrillatorischer wirkung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69228751T Expired - Fee Related DE69228751T2 (de) 1991-08-14 1992-08-10 Zyklische harnstoffe mit antiarrhythmischer und antifibrillatorischer wirkung

Country Status (24)

Country Link
US (1) US5691369A (de)
EP (2) EP0598046B1 (de)
JP (1) JPH06509803A (de)
AT (2) ATE226202T1 (de)
AU (1) AU665209B2 (de)
BR (1) BR9206371A (de)
CA (1) CA2115426C (de)
CZ (1) CZ286265B6 (de)
DE (2) DE69232825D1 (de)
DK (1) DK0598046T3 (de)
ES (1) ES2132127T3 (de)
FI (1) FI940656A0 (de)
GR (1) GR3030579T3 (de)
HU (1) HUT70029A (de)
IL (1) IL102792A (de)
MX (1) MX9204735A (de)
MY (1) MY109528A (de)
NO (1) NO305285B1 (de)
NZ (1) NZ243937A (de)
PL (1) PL170960B1 (de)
PT (1) PT100776B (de)
RU (1) RU2142461C1 (de)
SK (1) SK279677B6 (de)
WO (1) WO1993004060A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69232681T2 (de) * 1991-08-14 2003-02-13 Procter & Gamble Pharma 4-oxozyklische harnstoffe mit antiarrhythmische und entfibrillatorische wirkung
US6083945A (en) * 1995-06-07 2000-07-04 The Procter & Gamble Company Cyclic ureas useful as antiarrhythmic and antifibrillatory agents
KR100381213B1 (ko) * 1998-03-26 2003-08-14 주식회사 엘지생명과학 파네실전이효소억제능을갖는사이클릭우레아유도체및그의제조방법
JP2002524410A (ja) * 1998-09-08 2002-08-06 スミスクライン・ビーチャム・コーポレイション リプスタチン誘導体−可溶性繊維錠剤
US6288151B1 (en) * 1999-10-14 2001-09-11 Air Products And Chemicals, Inc. Alkylated aminoalkyl cyclic urea surfactants
US7129359B2 (en) 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
US7259174B2 (en) 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776979A (en) * 1956-04-05 1957-01-08 Norwich Pharma Co 1-nitroso-2-imidazolidone and process
NL257071A (de) * 1959-10-23
US3254075A (en) * 1963-08-28 1966-05-31 Norwich Pharma Co 1-(2-hydroxyethyl and 2-haloethyl-3-(5-nitrofurfurylideneamino)-2-imidazolidinones
US3415821A (en) * 1965-09-07 1968-12-10 Norwich Pharma Co 1-(5-substituted)furfurylideneamino hydantoins and imidazolidinones
US3407195A (en) * 1967-04-03 1968-10-22 Norwich Pharma Co 4-methyl-1-(5-nitrofurfurylideneamino)-2-imidazolidinone
DE2335144A1 (de) * 1973-07-07 1975-01-23 Schering Ag Basisch substituierte nitroimidazolmethylenamino-imidazolidinone
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
US4393204A (en) * 1982-05-21 1983-07-12 Norwich Eaton Pharmaceuticals, Inc. 3-[[5-(4-Chlorophenyl)furfurylidene]amino]-5-(substituted)-2-oxazolidinones
US4543359A (en) * 1982-10-01 1985-09-24 Eaton Laboratories, Inc. Treating cardiac arrhythmias with dantrolene sodium
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US4581370A (en) * 1983-07-12 1986-04-08 Schering A.G. Antiarrhythmic imidazoliums
US4720580A (en) * 1984-09-21 1988-01-19 American Home Products Corporation N-(aminoalkylene)benzenesulfonamides
US4707499A (en) * 1985-12-02 1987-11-17 G. D. Searle & Co. 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
US4783443A (en) * 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US4713832A (en) * 1986-04-11 1987-12-15 Ampex Corporation Programmable divider up/down counter with anti-aliasing feature and asynchronous read/write
US4870095A (en) * 1988-06-13 1989-09-26 Sterling Drug, Inc. 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use
JPH0276882A (ja) * 1988-06-20 1990-03-16 Eisai Co Ltd 光学活性ヒダントイン誘導体
US5137905A (en) * 1988-10-27 1992-08-11 The Upjohn Company Heterocyclic acetylenic amines having central nervous system activity
US4966967A (en) * 1989-09-15 1990-10-30 Berlex Laboratories, Inc. 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US4963561A (en) * 1990-02-28 1990-10-16 Sterling Drug Inc. Imidazopyridines, their preparation and use
FR2678272B1 (fr) * 1991-06-27 1994-01-14 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
SK16994A3 (en) * 1991-08-14 1995-03-08 Procter & Gamble Pharma Cyclic urethanes used as antiarrhythmic and antifibrillatory agents and pharmaceutical compounds containing these agents

Also Published As

Publication number Publication date
EP0598046A1 (de) 1994-05-25
US5691369A (en) 1997-11-25
DK0598046T3 (da) 1999-05-25
BR9206371A (pt) 1995-10-17
NZ243937A (en) 1996-10-28
IL102792A (en) 1997-01-10
SK279677B6 (sk) 1999-02-11
NO940498L (no) 1994-02-14
EP0891976A1 (de) 1999-01-20
WO1993004060A1 (en) 1993-03-04
FI940656A (fi) 1994-02-11
ATE178063T1 (de) 1999-04-15
CA2115426C (en) 2001-09-11
AU2460092A (en) 1993-03-16
CA2115426A1 (en) 1993-03-04
IL102792A0 (en) 1993-01-31
HU9400391D0 (en) 1994-05-30
SK17094A3 (en) 1995-02-08
CZ30594A3 (en) 1994-12-15
PT100776B (pt) 1999-07-30
PT100776A (pt) 1993-12-31
MY109528A (en) 1997-02-28
DE69228751T2 (de) 1999-10-07
FI940656A0 (fi) 1994-02-11
NO305285B1 (no) 1999-05-03
EP0598046B1 (de) 1999-03-24
ATE226202T1 (de) 2002-11-15
GR3030579T3 (en) 1999-10-29
RU2142461C1 (ru) 1999-12-10
NO940498D0 (no) 1994-02-14
EP0891976B1 (de) 2002-10-16
AU665209B2 (en) 1995-12-21
CZ286265B6 (cs) 2000-03-15
HUT70029A (en) 1995-09-28
JPH06509803A (ja) 1994-11-02
ES2132127T3 (es) 1999-08-16
DE69228751D1 (de) 1999-04-29
MX9204735A (es) 1994-03-31
PL170960B1 (pl) 1997-02-28

Similar Documents

Publication Publication Date Title
DE69232681T2 (de) 4-oxozyklische harnstoffe mit antiarrhythmische und entfibrillatorische wirkung
DE69232825D1 (de) Zyklische Harnstoffe mit antiarrhythmischer und antifibrillatorischer Wirkung
RU94015844A (ru) 4-оксоциклические соединения мочевины, пригодные для использования в качестве антиаритмических и антифибрилляционных средств, фармацевтическая композиция, способ лечения
CA2115029A1 (en) Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents

Legal Events

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8332 No legal effect for de