DE69228751D1 - Zyklische harnstoffe mit antiarrhythmischer und antifibrillatorischer wirkung - Google Patents
Zyklische harnstoffe mit antiarrhythmischer und antifibrillatorischer wirkungInfo
- Publication number
- DE69228751D1 DE69228751D1 DE69228751T DE69228751T DE69228751D1 DE 69228751 D1 DE69228751 D1 DE 69228751D1 DE 69228751 T DE69228751 T DE 69228751T DE 69228751 T DE69228751 T DE 69228751T DE 69228751 D1 DE69228751 D1 DE 69228751D1
- Authority
- DE
- Germany
- Prior art keywords
- nil
- unsubstituted
- saturated
- substituted
- unsaturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74486491A | 1991-08-14 | 1991-08-14 | |
PCT/US1992/006683 WO1993004060A1 (en) | 1991-08-14 | 1992-08-10 | Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69228751D1 true DE69228751D1 (de) | 1999-04-29 |
DE69228751T2 DE69228751T2 (de) | 1999-10-07 |
Family
ID=24994265
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69228751T Expired - Fee Related DE69228751T2 (de) | 1991-08-14 | 1992-08-10 | Zyklische harnstoffe mit antiarrhythmischer und antifibrillatorischer wirkung |
DE69232825T Expired - Lifetime DE69232825D1 (de) | 1991-08-14 | 1992-08-10 | Zyklische Harnstoffe mit antiarrhythmischer und antifibrillatorischer Wirkung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232825T Expired - Lifetime DE69232825D1 (de) | 1991-08-14 | 1992-08-10 | Zyklische Harnstoffe mit antiarrhythmischer und antifibrillatorischer Wirkung |
Country Status (24)
Country | Link |
---|---|
US (1) | US5691369A (de) |
EP (2) | EP0891976B1 (de) |
JP (1) | JPH06509803A (de) |
AT (2) | ATE178063T1 (de) |
AU (1) | AU665209B2 (de) |
BR (1) | BR9206371A (de) |
CA (1) | CA2115426C (de) |
CZ (1) | CZ286265B6 (de) |
DE (2) | DE69228751T2 (de) |
DK (1) | DK0598046T3 (de) |
ES (1) | ES2132127T3 (de) |
FI (1) | FI940656A0 (de) |
GR (1) | GR3030579T3 (de) |
HU (1) | HUT70029A (de) |
IL (1) | IL102792A (de) |
MX (1) | MX9204735A (de) |
MY (1) | MY109528A (de) |
NO (1) | NO305285B1 (de) |
NZ (1) | NZ243937A (de) |
PL (1) | PL170960B1 (de) |
PT (1) | PT100776B (de) |
RU (1) | RU2142461C1 (de) |
SK (1) | SK279677B6 (de) |
WO (1) | WO1993004060A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2115427C (en) * | 1991-08-14 | 2000-05-02 | Stanford Salvatore Pelosi Jr. | Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents |
US6083945A (en) * | 1995-06-07 | 2000-07-04 | The Procter & Gamble Company | Cyclic ureas useful as antiarrhythmic and antifibrillatory agents |
KR100381213B1 (ko) * | 1998-03-26 | 2003-08-14 | 주식회사 엘지생명과학 | 파네실전이효소억제능을갖는사이클릭우레아유도체및그의제조방법 |
NZ510311A (en) * | 1998-09-08 | 2003-08-29 | Smithkline Beecham Corp | Lipstatin derivative - soluble fiber tablets |
US6288151B1 (en) * | 1999-10-14 | 2001-09-11 | Air Products And Chemicals, Inc. | Alkylated aminoalkyl cyclic urea surfactants |
US7129359B2 (en) | 2002-07-09 | 2006-10-31 | National Health Research Institutes | Imidazolidinone compounds |
US7259174B2 (en) | 2004-05-25 | 2007-08-21 | National Health Research Institutes | Imidazolidinone compounds |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2776979A (en) * | 1956-04-05 | 1957-01-08 | Norwich Pharma Co | 1-nitroso-2-imidazolidone and process |
NL257071A (de) * | 1959-10-23 | |||
US3254075A (en) * | 1963-08-28 | 1966-05-31 | Norwich Pharma Co | 1-(2-hydroxyethyl and 2-haloethyl-3-(5-nitrofurfurylideneamino)-2-imidazolidinones |
US3415821A (en) * | 1965-09-07 | 1968-12-10 | Norwich Pharma Co | 1-(5-substituted)furfurylideneamino hydantoins and imidazolidinones |
US3407195A (en) * | 1967-04-03 | 1968-10-22 | Norwich Pharma Co | 4-methyl-1-(5-nitrofurfurylideneamino)-2-imidazolidinone |
DE2335144A1 (de) * | 1973-07-07 | 1975-01-23 | Schering Ag | Basisch substituierte nitroimidazolmethylenamino-imidazolidinone |
US4775670A (en) * | 1980-09-29 | 1988-10-04 | E. R. Squibb & Sons, Inc. | 2-oxo-1-azetidinesulfonic acid salts |
US4393204A (en) * | 1982-05-21 | 1983-07-12 | Norwich Eaton Pharmaceuticals, Inc. | 3-[[5-(4-Chlorophenyl)furfurylidene]amino]-5-(substituted)-2-oxazolidinones |
US4543359A (en) * | 1982-10-01 | 1985-09-24 | Eaton Laboratories, Inc. | Treating cardiac arrhythmias with dantrolene sodium |
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
US4581370A (en) * | 1983-07-12 | 1986-04-08 | Schering A.G. | Antiarrhythmic imidazoliums |
US4720580A (en) * | 1984-09-21 | 1988-01-19 | American Home Products Corporation | N-(aminoalkylene)benzenesulfonamides |
US4707499A (en) * | 1985-12-02 | 1987-11-17 | G. D. Searle & Co. | 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia |
PH23283A (en) * | 1986-02-26 | 1989-06-30 | Eisai Co Ltd | Piperidine derivative, pharmaceutical composition containing the same and method of use thereof |
US4783443A (en) * | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
US4713832A (en) * | 1986-04-11 | 1987-12-15 | Ampex Corporation | Programmable divider up/down counter with anti-aliasing feature and asynchronous read/write |
US4870095A (en) * | 1988-06-13 | 1989-09-26 | Sterling Drug, Inc. | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use |
EP0347733A1 (de) * | 1988-06-20 | 1989-12-27 | Eisai Co., Ltd. | Optisch aktive Hydantoin-Derivate |
US5137905A (en) * | 1988-10-27 | 1992-08-11 | The Upjohn Company | Heterocyclic acetylenic amines having central nervous system activity |
US4966967A (en) * | 1989-09-15 | 1990-10-30 | Berlex Laboratories, Inc. | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents |
US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
US4963561A (en) * | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
FR2678272B1 (fr) * | 1991-06-27 | 1994-01-14 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
ES2141725T3 (es) * | 1991-08-14 | 2000-04-01 | Procter & Gamble Pharma | Derivados de oxazolidinona, utiles como agentes antiarritmicos y antifibriladores. |
-
1992
- 1992-08-10 EP EP98203050A patent/EP0891976B1/de not_active Expired - Lifetime
- 1992-08-10 CA CA002115426A patent/CA2115426C/en not_active Expired - Fee Related
- 1992-08-10 AT AT92917977T patent/ATE178063T1/de not_active IP Right Cessation
- 1992-08-10 AU AU24600/92A patent/AU665209B2/en not_active Ceased
- 1992-08-10 AT AT98203050T patent/ATE226202T1/de not_active IP Right Cessation
- 1992-08-10 PL PL92302376A patent/PL170960B1/pl unknown
- 1992-08-10 JP JP5504375A patent/JPH06509803A/ja active Pending
- 1992-08-10 EP EP92917977A patent/EP0598046B1/de not_active Expired - Lifetime
- 1992-08-10 WO PCT/US1992/006683 patent/WO1993004060A1/en active IP Right Grant
- 1992-08-10 DE DE69228751T patent/DE69228751T2/de not_active Expired - Fee Related
- 1992-08-10 BR BR9206371A patent/BR9206371A/pt not_active Application Discontinuation
- 1992-08-10 RU RU94018706A patent/RU2142461C1/ru active
- 1992-08-10 SK SK170-94A patent/SK279677B6/sk unknown
- 1992-08-10 DE DE69232825T patent/DE69232825D1/de not_active Expired - Lifetime
- 1992-08-10 CZ CZ1994305A patent/CZ286265B6/cs not_active IP Right Cessation
- 1992-08-10 DK DK92917977T patent/DK0598046T3/da active
- 1992-08-10 HU HU9400391A patent/HUT70029A/hu unknown
- 1992-08-10 ES ES92917977T patent/ES2132127T3/es not_active Expired - Lifetime
- 1992-08-12 IL IL10279292A patent/IL102792A/xx not_active IP Right Cessation
- 1992-08-13 NZ NZ243937A patent/NZ243937A/en unknown
- 1992-08-14 MY MYPI92001462A patent/MY109528A/en unknown
- 1992-08-14 PT PT100776A patent/PT100776B/pt not_active IP Right Cessation
- 1992-08-14 MX MX9204735A patent/MX9204735A/es unknown
-
1994
- 1994-02-11 FI FI940656A patent/FI940656A0/fi unknown
- 1994-02-14 NO NO940498A patent/NO305285B1/no unknown
-
1995
- 1995-06-07 US US08/479,256 patent/US5691369A/en not_active Expired - Fee Related
-
1999
- 1999-06-21 GR GR990401662T patent/GR3030579T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69232681T2 (de) | 4-oxozyklische harnstoffe mit antiarrhythmische und entfibrillatorische wirkung | |
DE69228751D1 (de) | Zyklische harnstoffe mit antiarrhythmischer und antifibrillatorischer wirkung | |
RU94015844A (ru) | 4-оксоциклические соединения мочевины, пригодные для использования в качестве антиаритмических и антифибрилляционных средств, фармацевтическая композиция, способ лечения | |
CA2115029A1 (en) | Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PROCTER & GAMBLE PHARMACEUTICALS, INC., NORWICH, N |
|
8339 | Ceased/non-payment of the annual fee |