ES2126660T3 - Proceso para la preparacion de cristales de hormona del crecimiento y los cristales asi obtenidos. - Google Patents
Proceso para la preparacion de cristales de hormona del crecimiento y los cristales asi obtenidos.Info
- Publication number
- ES2126660T3 ES2126660T3 ES93924266T ES93924266T ES2126660T3 ES 2126660 T3 ES2126660 T3 ES 2126660T3 ES 93924266 T ES93924266 T ES 93924266T ES 93924266 T ES93924266 T ES 93924266T ES 2126660 T3 ES2126660 T3 ES 2126660T3
- Authority
- ES
- Spain
- Prior art keywords
- crystals
- pct
- date
- alkyl
- growth hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013078 crystal Substances 0.000 title abstract 5
- 102000018997 Growth Hormone Human genes 0.000 title abstract 4
- 108010051696 Growth Hormone Proteins 0.000 title abstract 4
- 239000000122 growth hormone Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 125000001624 naphthyl group Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
EL INVENTO SE REFIERE A UN PROCESO PARA FABRICAR CRISTALES DE HORMONA DEL CRECIMIENTO (GH) O DERIVADOS FUNCIONALES DE LA MISMA CARACTERIZADO POR LOS PASOS DE: (I) MEZCLAR GH O DERIVADOS FUNCIONALES DE LA MISMA CON UNA SOLUCION ACUOSA QUE COMPRENDE UN AMORTIGUADOR Y UN COMPUESTO QUIMICO CON LA FORMULA GENERAL (I): AR - [ - CR1R2 - ]N - [ - CR3R4 - ]M - CR5R6 - OH EN LA QUE AR ES FENILO, FENILO SUBSTITUIDO ALQUILO, NAFTILO, NAFTILO SUBSTITUIDO ALQUILO, R1 A R6 ES H, OH O ALQUIL Y N Y M SON 0 O 1; (II) INCUBAR LA MEZCLA; (III) AISLAR LOS CRISTALES POR METODOS CONOCIDOS. TAMBIEN SE REFIERE AL EMPLEO DEL COMPUESTO QUIMICO CON LA FORMULA GENERAL (I) EN LA PREPARACION DE CRISTALES DE GH A PARTIR DE UNA SOLUCION AMORTIGUADORA, CRISTALES DE HORMONA DEL CRECIMIENTO O CUALQUIER ANALOGO FUNCIONAL DE LOS MISMOS EN FORMA DE AGUJAS, FORMAS TETRAGONALES, CUBOS O PARALELEPIPEDOS CON UNA LONGITUD DE AL MENOS 20 MICRONES, Y SUSPENSIONES PARA LA INYECCION, FORMULACIONES DE DEPOSITO Y FORMULACIONES EN SECO QUECONTIENEN LOS CRISTALES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9203175A SE9203175D0 (sv) | 1992-10-28 | 1992-10-28 | Growth hormone |
SE19939302278A SE9302278D0 (sv) | 1992-10-28 | 1993-07-02 | Growth hormone |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2126660T3 true ES2126660T3 (es) | 1999-04-01 |
Family
ID=26661557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93924266T Expired - Lifetime ES2126660T3 (es) | 1992-10-28 | 1993-10-27 | Proceso para la preparacion de cristales de hormona del crecimiento y los cristales asi obtenidos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5734026A (es) |
EP (1) | EP0669934B1 (es) |
JP (1) | JP3470135B2 (es) |
AT (1) | ATE174602T1 (es) |
AU (1) | AU679012B2 (es) |
CA (1) | CA2147482C (es) |
DE (1) | DE69322654T2 (es) |
DK (1) | DK0669934T3 (es) |
ES (1) | ES2126660T3 (es) |
FI (1) | FI110609B (es) |
HK (1) | HK1013299A1 (es) |
NO (1) | NO320171B1 (es) |
SE (1) | SE9302278D0 (es) |
WO (1) | WO1994010192A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9302278D0 (sv) * | 1992-10-28 | 1993-07-02 | Kabi Pharmacia Ab | Growth hormone |
US6500933B1 (en) | 1997-09-05 | 2002-12-31 | Altus Biologics Inc. | Methods of preparing carbohydrate crosslinked glycoprotein crystals |
DE69839563D1 (de) | 1997-09-05 | 2008-07-10 | Altus Pharmaceuticals Inc | Kohlenhydrat-vernetzte glykoproteinkristalle |
US6380357B2 (en) * | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
KR20040085205A (ko) * | 2002-02-20 | 2004-10-07 | 일라이 릴리 앤드 캄파니 | Glp-1 분자의 투여 방법 |
SE0202719D0 (sv) * | 2002-09-13 | 2002-09-13 | Pharmacia Ab | Process for mfg crystals of growth hormone |
RU2357750C2 (ru) | 2002-12-31 | 2009-06-10 | Элтус Фармасьютикалз Инк. | Кристаллы человеческого гормона роста и способы их получения |
US20060286129A1 (en) * | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
US7444197B2 (en) | 2004-05-06 | 2008-10-28 | Smp Logic Systems Llc | Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes |
US7799273B2 (en) | 2004-05-06 | 2010-09-21 | Smp Logic Systems Llc | Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes |
AU2006330833A1 (en) * | 2005-12-23 | 2007-07-05 | Altus Pharmaceuticals Inc. | Compositions comprising polycation-complexed protein crystals and methods of treatment using them |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69125035T2 (de) * | 1990-06-04 | 1997-07-10 | Schering Corp | Verfahren zur herstellung von interferon-alpha-2 kristallen |
IL98484A0 (en) * | 1990-06-15 | 1992-07-15 | Schering Corp | Crystalline interleukin-4 |
DK168790D0 (es) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
US5015627A (en) * | 1990-07-20 | 1991-05-14 | Smithkline Beecham Corporation | Stabilized somatotropin for parenteral administration |
SE9302278D0 (sv) * | 1992-10-28 | 1993-07-02 | Kabi Pharmacia Ab | Growth hormone |
-
1993
- 1993-07-02 SE SE19939302278A patent/SE9302278D0/xx unknown
- 1993-10-27 AT AT93924266T patent/ATE174602T1/de not_active IP Right Cessation
- 1993-10-27 DE DE69322654T patent/DE69322654T2/de not_active Expired - Fee Related
- 1993-10-27 EP EP93924266A patent/EP0669934B1/en not_active Expired - Lifetime
- 1993-10-27 DK DK93924266T patent/DK0669934T3/da active
- 1993-10-27 ES ES93924266T patent/ES2126660T3/es not_active Expired - Lifetime
- 1993-10-27 US US08/424,450 patent/US5734026A/en not_active Expired - Fee Related
- 1993-10-27 CA CA002147482A patent/CA2147482C/en not_active Expired - Fee Related
- 1993-10-27 WO PCT/SE1993/000885 patent/WO1994010192A1/en active IP Right Grant
- 1993-10-27 JP JP51096494A patent/JP3470135B2/ja not_active Expired - Fee Related
- 1993-10-27 AU AU54011/94A patent/AU679012B2/en not_active Ceased
-
1995
- 1995-04-24 NO NO19951547A patent/NO320171B1/no unknown
- 1995-04-27 FI FI952021A patent/FI110609B/fi active
-
1998
- 1998-12-22 HK HK98114660A patent/HK1013299A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69322654D1 (de) | 1999-01-28 |
FI952021A (fi) | 1995-04-27 |
ATE174602T1 (de) | 1999-01-15 |
SE9302278D0 (sv) | 1993-07-02 |
NO320171B1 (no) | 2005-11-07 |
CA2147482C (en) | 2003-09-23 |
DK0669934T3 (da) | 1999-08-23 |
CA2147482A1 (en) | 1994-05-11 |
NO951547D0 (no) | 1995-04-24 |
HK1013299A1 (en) | 1999-08-20 |
JP3470135B2 (ja) | 2003-11-25 |
WO1994010192A1 (en) | 1994-05-11 |
US5734026A (en) | 1998-03-31 |
AU5401194A (en) | 1994-05-24 |
DE69322654T2 (de) | 1999-06-17 |
AU679012B2 (en) | 1997-06-19 |
EP0669934B1 (en) | 1998-12-16 |
JPH08505127A (ja) | 1996-06-04 |
EP0669934A1 (en) | 1995-09-06 |
FI952021A0 (fi) | 1995-04-27 |
FI110609B (fi) | 2003-02-28 |
NO951547L (no) | 1995-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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