ATE174602T1 - Verfahren zur herstellung von kristallen des wachstumshormones und die so erhaltenen kristalle - Google Patents
Verfahren zur herstellung von kristallen des wachstumshormones und die so erhaltenen kristalleInfo
- Publication number
- ATE174602T1 ATE174602T1 AT93924266T AT93924266T ATE174602T1 AT E174602 T1 ATE174602 T1 AT E174602T1 AT 93924266 T AT93924266 T AT 93924266T AT 93924266 T AT93924266 T AT 93924266T AT E174602 T1 ATE174602 T1 AT E174602T1
- Authority
- AT
- Austria
- Prior art keywords
- crystals
- pct
- growth hormone
- date
- alkyl
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 5
- 102000018997 Growth Hormone Human genes 0.000 title abstract 4
- 108010051696 Growth Hormone Proteins 0.000 title abstract 4
- 239000000122 growth hormone Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000001624 naphthyl group Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9203175A SE9203175D0 (sv) | 1992-10-28 | 1992-10-28 | Growth hormone |
| SE19939302278A SE9302278D0 (sv) | 1992-10-28 | 1993-07-02 | Growth hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174602T1 true ATE174602T1 (de) | 1999-01-15 |
Family
ID=26661557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93924266T ATE174602T1 (de) | 1992-10-28 | 1993-10-27 | Verfahren zur herstellung von kristallen des wachstumshormones und die so erhaltenen kristalle |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5734026A (de) |
| EP (1) | EP0669934B1 (de) |
| JP (1) | JP3470135B2 (de) |
| AT (1) | ATE174602T1 (de) |
| AU (1) | AU679012B2 (de) |
| CA (1) | CA2147482C (de) |
| DE (1) | DE69322654T2 (de) |
| DK (1) | DK0669934T3 (de) |
| ES (1) | ES2126660T3 (de) |
| FI (1) | FI110609B (de) |
| HK (1) | HK1013299A1 (de) |
| NO (1) | NO320171B1 (de) |
| SE (1) | SE9302278D0 (de) |
| WO (1) | WO1994010192A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9302278D0 (sv) * | 1992-10-28 | 1993-07-02 | Kabi Pharmacia Ab | Growth hormone |
| ES2306477T3 (es) * | 1997-09-05 | 2008-11-01 | Altus Pharmaceuticals Inc. | Cristales de glicoproteina reticulados por carbohidratos. |
| US6500933B1 (en) | 1997-09-05 | 2002-12-31 | Altus Biologics Inc. | Methods of preparing carbohydrate crosslinked glycoprotein crystals |
| US6380357B2 (en) * | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
| US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
| BR0307727A (pt) * | 2002-02-20 | 2005-01-25 | Lilly Co Eli | Fomulação |
| SE0202719D0 (sv) * | 2002-09-13 | 2002-09-13 | Pharmacia Ab | Process for mfg crystals of growth hormone |
| JP4686361B2 (ja) | 2002-12-31 | 2011-05-25 | アルタス ファーマシューティカルズ インコーポレイテッド | ヒト成長ホルモンの結晶およびその調製方法 |
| US20060286129A1 (en) * | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| US7444197B2 (en) | 2004-05-06 | 2008-10-28 | Smp Logic Systems Llc | Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes |
| US7799273B2 (en) | 2004-05-06 | 2010-09-21 | Smp Logic Systems Llc | Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes |
| WO2007076131A2 (en) * | 2005-12-23 | 2007-07-05 | Altus Pharmaceuticals Inc. | Compositions comprising polycation-complexed protein crystals and methods of treatment using them |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991018927A1 (en) * | 1990-06-04 | 1991-12-12 | Schering Corporation | Method for preparing interferon alpha-2 crystals |
| CN1033034C (zh) * | 1990-06-15 | 1996-10-16 | 先灵公司 | 产生结晶白细胞介素－4的方法 |
| DK168790D0 (de) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
| US5015627A (en) * | 1990-07-20 | 1991-05-14 | Smithkline Beecham Corporation | Stabilized somatotropin for parenteral administration |
| SE9302278D0 (sv) * | 1992-10-28 | 1993-07-02 | Kabi Pharmacia Ab | Growth hormone |
-
1993
- 1993-07-02 SE SE19939302278A patent/SE9302278D0/xx unknown
- 1993-10-27 ES ES93924266T patent/ES2126660T3/es not_active Expired - Lifetime
- 1993-10-27 DE DE69322654T patent/DE69322654T2/de not_active Expired - Fee Related
- 1993-10-27 JP JP51096494A patent/JP3470135B2/ja not_active Expired - Fee Related
- 1993-10-27 CA CA002147482A patent/CA2147482C/en not_active Expired - Fee Related
- 1993-10-27 AU AU54011/94A patent/AU679012B2/en not_active Ceased
- 1993-10-27 US US08/424,450 patent/US5734026A/en not_active Expired - Fee Related
- 1993-10-27 WO PCT/SE1993/000885 patent/WO1994010192A1/en active IP Right Grant
- 1993-10-27 AT AT93924266T patent/ATE174602T1/de not_active IP Right Cessation
- 1993-10-27 EP EP93924266A patent/EP0669934B1/de not_active Expired - Lifetime
- 1993-10-27 DK DK93924266T patent/DK0669934T3/da active
-
1995
- 1995-04-24 NO NO19951547A patent/NO320171B1/no unknown
- 1995-04-27 FI FI952021A patent/FI110609B/fi active
-
1998
- 1998-12-22 HK HK98114660A patent/HK1013299A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2126660T3 (es) | 1999-04-01 |
| FI952021A0 (fi) | 1995-04-27 |
| DE69322654D1 (de) | 1999-01-28 |
| NO320171B1 (no) | 2005-11-07 |
| FI952021A (fi) | 1995-04-27 |
| DK0669934T3 (da) | 1999-08-23 |
| FI110609B (fi) | 2003-02-28 |
| SE9302278D0 (sv) | 1993-07-02 |
| AU679012B2 (en) | 1997-06-19 |
| AU5401194A (en) | 1994-05-24 |
| NO951547L (no) | 1995-04-24 |
| EP0669934B1 (de) | 1998-12-16 |
| NO951547D0 (no) | 1995-04-24 |
| DE69322654T2 (de) | 1999-06-17 |
| WO1994010192A1 (en) | 1994-05-11 |
| JPH08505127A (ja) | 1996-06-04 |
| JP3470135B2 (ja) | 2003-11-25 |
| HK1013299A1 (en) | 1999-08-20 |
| CA2147482C (en) | 2003-09-23 |
| EP0669934A1 (de) | 1995-09-06 |
| CA2147482A1 (en) | 1994-05-11 |
| US5734026A (en) | 1998-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |