ES2125679T3 - Sistema transdermico de administracion simultanea de varios principios activos. - Google Patents

Sistema transdermico de administracion simultanea de varios principios activos.

Info

Publication number
ES2125679T3
ES2125679T3 ES95943245T ES95943245T ES2125679T3 ES 2125679 T3 ES2125679 T3 ES 2125679T3 ES 95943245 T ES95943245 T ES 95943245T ES 95943245 T ES95943245 T ES 95943245T ES 2125679 T3 ES2125679 T3 ES 2125679T3
Authority
ES
Spain
Prior art keywords
active principles
administration
therapeutic dose
effective therapeutic
simultaneous administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95943245T
Other languages
English (en)
Inventor
Bruno Bevan
Cecile Aillaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires dHygiene et de Dietetique SA
Original Assignee
Laboratoires dHygiene et de Dietetique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires dHygiene et de Dietetique SA filed Critical Laboratoires dHygiene et de Dietetique SA
Application granted granted Critical
Publication of ES2125679T3 publication Critical patent/ES2125679T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Radiation-Therapy Devices (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO SISTEMA DE ADMINISTRACION POR VIA PERCUTANEA DE AL MENOS DOS PRINCIPIOS ACTIVOS, QUE ESTA CONSTITUIDO POR LA YUXTAPOSICION DE AL MENOS DOS DISPOSITIVOS. ESTE SISTEMA SE CARACTERIZA PORQUE COMPRENDE: (I) UN PRIMER DISPOSITIVO QUE CONTIENE UNA MEZCLA DEL CONJUNTO DE LOS PRINCIPIOS ACTIVOS EN LA QUE AL MENOS UN PRIMER PRINCIPIO ACTIVO (A) ESTA PRESENTE SEGUN UNA CANTIDAD QUE PERMITE ADMINISTRAR LA DOSIS TERAPEUTICA EFICAZ Y AL MENOS UN SEGUNDO PRINCIPIO ACTIVO (B) ESTA PRESENTE SEGUN UNA CANTIDAD INFERIOR A LA NECESARIA PARA LA ADMINISTRACION DE LA DOSIS TERAPEUTICA EFICAZ Y (II) UNO O VARIOS DISPOSITIVOS SUPLEMENTARIOS QUE CONTIENEN CADA UNO UN UNICO PRINCIPIO ACTIVO (B) ELEGIDO ENTRE LOS PRESENTES EN EL PRIMER DISPOSITIVO SEGUN UNA CANTIDAD INFERIOR A LA NECESARIA PARA LA ADMINISTRACION DE LA DOSIS TERAPEUTICA EFICAZ. EL/LOS DISPOSITIVO(S) SUPLEMENTARIO(S) COMPLETAN LA CANTIDAD DE CADA UNO DE LOS PRINCIPIOS ACTIVOS (B) PRESENTES EN EL SISTEMA HASTAOBTENER LA DOSIS TERAPEUTICA EFICAZ.
ES95943245T 1994-12-21 1995-12-19 Sistema transdermico de administracion simultanea de varios principios activos. Expired - Lifetime ES2125679T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415416A FR2728463A1 (fr) 1994-12-21 1994-12-21 Systeme transdermique d'administration simultanee de plusieurs principes actifs

Publications (1)

Publication Number Publication Date
ES2125679T3 true ES2125679T3 (es) 1999-03-01

Family

ID=9470067

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95943245T Expired - Lifetime ES2125679T3 (es) 1994-12-21 1995-12-19 Sistema transdermico de administracion simultanea de varios principios activos.

Country Status (23)

Country Link
US (1) US5919477A (es)
EP (1) EP0800386B1 (es)
JP (1) JPH10510823A (es)
KR (1) KR980700071A (es)
CN (1) CN1072929C (es)
AT (1) ATE173164T1 (es)
AU (1) AU692042B2 (es)
CA (1) CA2208374A1 (es)
CZ (1) CZ183297A3 (es)
DE (1) DE69506007T2 (es)
DK (1) DK0800386T3 (es)
ES (1) ES2125679T3 (es)
FI (1) FI972542A7 (es)
FR (1) FR2728463A1 (es)
HU (1) HUT77384A (es)
NO (1) NO972467L (es)
NZ (1) NZ298826A (es)
PL (1) PL182452B1 (es)
RU (1) RU2157193C2 (es)
SI (1) SI0800386T1 (es)
SK (1) SK280631B6 (es)
UA (1) UA42806C2 (es)
WO (1) WO1996019203A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US6214901B1 (en) 1998-04-27 2001-04-10 Surmodics, Inc. Bioactive agent release coating
DE10025970C2 (de) * 2000-05-25 2002-04-25 Lohmann Therapie Syst Lts Estrogenhaltiges Pflaster mit einem Wirkstoffreservoir auf der Basis von Ethylcellulose und einem Ethylen-Vinylacetat-Vinylpyrrolidon-Copolymer und seine Verwendung
US6682757B1 (en) 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
DE10141651B4 (de) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
US7097850B2 (en) 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US7243788B2 (en) * 2003-10-22 2007-07-17 Kimberly-Clark Worldwide, Inc. Package for segregating and mixing substances
EP1682061B1 (en) * 2003-10-28 2017-03-15 Noven Pharmaceuticals, Inc. Transdermal drug delivery device
US7541048B2 (en) 2004-04-06 2009-06-02 Surmodics, Inc. Coating compositions for bioactive agents
WO2008006083A2 (en) 2006-07-07 2008-01-10 Surmodics, Inc. Beaded wound spacer device
US20090202609A1 (en) * 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2014062839A1 (en) 2012-10-16 2014-04-24 Surmodics, Inc. Wound packing device and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
MX2016014281A (es) 2014-05-22 2017-02-22 Therapeuticsmd Inc Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US5023084A (en) * 1986-12-29 1991-06-11 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
US5538736A (en) * 1987-04-28 1996-07-23 Lts Lohmann Therapie-Systeme Gmbh Active substance-containing plaster for the controlled administration of active substances to the skin
DE3714140A1 (de) * 1987-04-28 1988-11-10 Lohmann Therapie Syst Lts Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut
DE3903794A1 (de) * 1989-02-09 1990-08-16 Lohmann Therapie Syst Lts Therapeutisches system zur transdermalen oder transmucosalen verabreichung von wirkstoffen und seine verwendung
US5788983A (en) * 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5350581A (en) * 1989-12-14 1994-09-27 Pharmetrix Corporation Method for manufacturing transdermal devices
US5064422A (en) * 1990-10-18 1991-11-12 Bertek, Inc. Twin patch applicator
DE4336557C2 (de) * 1993-05-06 1997-07-17 Lohmann Therapie Syst Lts Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung

Also Published As

Publication number Publication date
AU4450596A (en) 1996-07-10
SK79197A3 (en) 1997-12-10
HUT77384A (hu) 1998-04-28
FR2728463A1 (fr) 1996-06-28
KR980700071A (ko) 1998-03-30
EP0800386A1 (fr) 1997-10-15
PL320883A1 (en) 1997-11-10
CN1072929C (zh) 2001-10-17
NZ298826A (en) 1998-10-28
FI972542L (fi) 1997-06-16
FI972542A0 (fi) 1997-06-16
DE69506007D1 (de) 1998-12-17
NO972467L (no) 1997-06-17
US5919477A (en) 1999-07-06
ATE173164T1 (de) 1998-11-15
CZ183297A3 (en) 1997-10-15
FI972542A7 (fi) 1997-06-16
NO972467D0 (no) 1997-05-30
UA42806C2 (uk) 2001-11-15
HK1004375A1 (en) 1998-11-27
EP0800386B1 (fr) 1998-11-11
CA2208374A1 (en) 1996-06-27
DK0800386T3 (da) 1999-07-26
RU2157193C2 (ru) 2000-10-10
AU692042B2 (en) 1998-05-28
WO1996019203A1 (fr) 1996-06-27
PL182452B1 (pl) 2002-01-31
SI0800386T1 (en) 1999-04-30
CN1170359A (zh) 1998-01-14
DE69506007T2 (de) 1999-06-10
FR2728463B1 (es) 1997-02-21
MX9704527A (es) 1997-10-31
JPH10510823A (ja) 1998-10-20
SK280631B6 (sk) 2000-05-16

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