ES2123653T3 - Argininas sustituidas y homoargininas sustituidas y uso de las mismas. - Google Patents

Argininas sustituidas y homoargininas sustituidas y uso de las mismas.

Info

Publication number
ES2123653T3
ES2123653T3 ES93913866T ES93913866T ES2123653T3 ES 2123653 T3 ES2123653 T3 ES 2123653T3 ES 93913866 T ES93913866 T ES 93913866T ES 93913866 T ES93913866 T ES 93913866T ES 2123653 T3 ES2123653 T3 ES 2123653T3
Authority
ES
Spain
Prior art keywords
substituted
compound
homoarginins
arginins
ych3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93913866T
Other languages
English (en)
Inventor
Owen W Griffith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Application granted granted Critical
Publication of ES2123653T3 publication Critical patent/ES2123653T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

ARGININAS U HOMOARGININAS SUSTITUIDAS DE GUANIDINA, BASADAS EN ORNITINAS O LISINAS SUSTITUIDAS DE CARBONO MONOALQUILO, TENIENDO LA FORMULA (I), EN LA QUE R (CH2)YCH3, O H, R'' ES CH2 O C(H)(CH2)YCH3, Y R" ES CH2 O C(H)(CH2)YCH3 CON, Y ENTRE 0 A 5, Y X ES 0 O 1 Y Q ES UN GRUPO ALQUILO, CONTENIENDO DE 1 A 6 ATOMOS DE CARBONO, O NH2 O NO2, Y SOLAMENTE UNO DE R, R'' Y R" PROPORCIONANDO UN SUSTITUYENTE ALQUILO SOBRE LA ORNITINA O EL MEDIO DE LISINA. UNA COMPOSICION INCLUYE EL CITADO COMPUESTO, JUNTAMENTE CON UN PORTADOR FARMACEUTICAMENTE ACEPTABLE. METODOS DE USO SE ENCAMINAN A LA ENTREGA DEL CITADO COMPUESTO PARA LA SINTESIS DEL OXIDO NITRICO INDUCIBLE PARA INHIBIR LA FACULTAD DE LA ENZIMA DE CATALIZAR LA CONVERSION DE ARGININA A OXIDO NITRICO, PARA ADMINISTRAR EL CITADO COMPUESTO Y PARA PODER INHIBIR LA SUPERPRODUCCION PATOLOGICA DE OXIDO NITRICO DE LA ARGININA, Y A ADMINISTRAR EL CITADO COMPUESTO A UNA PERSONA QUE TENGA HIPOTENSION SISTEMATICA, DEBIDO A LA SUPERPRODUCCION PATOLOGICA DE OXIDO NITRICO Y UN 1, AGONISTA ADRENERGICO PARA AUMENTAR LA PRESION SANGUINEA EN LA PERSONA HASTA UN NIVEL CLINICAMETE ACEPTABLE.
ES93913866T 1992-05-28 1993-05-19 Argininas sustituidas y homoargininas sustituidas y uso de las mismas. Expired - Lifetime ES2123653T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/889,345 US5281627A (en) 1992-05-28 1992-05-28 Substituted arginines and substituted homoarginines and use thereof

Publications (1)

Publication Number Publication Date
ES2123653T3 true ES2123653T3 (es) 1999-01-16

Family

ID=25394938

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93913866T Expired - Lifetime ES2123653T3 (es) 1992-05-28 1993-05-19 Argininas sustituidas y homoargininas sustituidas y uso de las mismas.

Country Status (7)

Country Link
US (2) US5281627A (es)
EP (1) EP0649303B1 (es)
JP (1) JPH07507306A (es)
AT (1) ATE173621T1 (es)
DE (1) DE69322272T2 (es)
ES (1) ES2123653T3 (es)
WO (1) WO1993024126A1 (es)

Families Citing this family (41)

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Publication number Priority date Publication date Assignee Title
US5877176A (en) * 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
CZ29996A3 (en) * 1993-08-12 1996-09-11 Astra Ab Amidine derivatives with activities of nitrogen oxide sythetase
ATE222100T1 (de) * 1993-10-21 2002-08-15 Searle & Co Amidino-derivate nützlich als no synthase-hemmer
CN1077886C (zh) * 1993-10-21 2002-01-16 G·D·瑟尔公司 用作一氧化一氮合酶抑制剂的脒基衍生物
US5364881A (en) * 1993-11-15 1994-11-15 The Medical College Of Wisconsin Research Foundation, Inc. S-alkyl-isothioureido-amino acids and use thereof
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
US5695761A (en) * 1993-12-23 1997-12-09 Rutgers University Suppression of nitric oxide production by osteopontin
ATE195933T1 (de) * 1994-03-10 2000-09-15 Searle & Co L-n6-(1-iminoethyl)lysin - derivate und ihre verwendung als no-synthase - inhibitoren
WO1995025717A1 (en) * 1994-03-24 1995-09-28 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
ATE182889T1 (de) * 1994-05-07 1999-08-15 Astra Ab Bicyclische amidinderivate als no-synthetase inhibitoren
FR2722507B1 (fr) * 1994-07-12 1996-08-14 Rhone Poulenc Rorer Sa Adenovirus comportant un gene codant pour une no synthase
US20030099945A1 (en) * 1994-09-20 2003-05-29 Invenux, Inc. Parallel selex
US6239172B1 (en) * 1997-04-10 2001-05-29 Nitrosystems, Inc. Formulations for treating disease and methods of using same
US5543430A (en) * 1994-10-05 1996-08-06 Kaesemeyer; W. H. Method and formulation of stimulating nitric oxide synthesis
US20110196039A9 (en) * 1994-10-05 2011-08-11 Kaesemeyer Wayne H Controlled release arginine formulations
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
FR2727111B1 (fr) * 1994-11-21 1997-01-17 Hoechst Lab Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments
FR2730930B1 (fr) * 1995-02-27 1997-04-04 Oreal Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives
US6011028A (en) * 1995-04-20 2000-01-04 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5908842A (en) * 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
US6620848B2 (en) 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
US6127420A (en) * 1997-08-22 2000-10-03 The Medical College Of Wisconsin Research Foundation, Inc. L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof
US20020031513A1 (en) * 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
EP1086108A1 (en) 1998-06-10 2001-03-28 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
WO2001078717A1 (en) 2000-04-12 2001-10-25 Cornell Research Foundation, Inc. Pharmacotherapy for vascular dysfunction associated with deficient nitric oxide bioactivity
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
AR031608A1 (es) 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
WO2003051314A2 (en) * 2001-12-18 2003-06-26 Medallion Biomedical, Llc Antibiotic compounds
AU2003210808A1 (en) * 2002-03-06 2003-09-22 Duke University Methods and composition based on discovery of metabolism of nitroclycerin

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2663668A (en) * 1951-08-09 1953-12-22 Permanente Foundation Process for producing arginase
US2834713A (en) * 1952-11-22 1958-05-13 Armour & Co Preparation of enzyme extracts from liver
CA974910A (en) * 1970-05-27 1975-09-23 Kyowa Hakko Kogyo Kabushiki Kaisha Process for preparing l-arginase
US4061542A (en) * 1976-03-08 1977-12-06 Hoffmann-La Roche Inc. 2-Methyl-L-arginine produced by cultivating streptomyces strain
IT1127322B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
US4499067A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -acyl derivatives of arginine
US4477428A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α,NG -diacyl derivatives of arginine
US4499068A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -alkyl derivatives of arginine
US4477429A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α -alkyl derivatives of arginine
US4698442A (en) * 1982-12-21 1987-10-06 Syntex (U.S.A.) Inc. ω-Guanidino-substituted-α-amino acids
US4734438A (en) * 1983-04-26 1988-03-29 Macri Frank J Norepinephrine potentiated compositions and method of use
DE3838461A1 (de) * 1988-11-12 1990-05-23 Krebsoege Gmbh Sintermetall Pulvermetallurgischer werkstoff auf kupferbasis und dessen verwendung
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5216025A (en) * 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
US5318992A (en) * 1990-02-26 1994-06-07 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
CA2036770C (en) * 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof

Also Published As

Publication number Publication date
DE69322272D1 (de) 1999-01-07
US5453441A (en) 1995-09-26
DE69322272T2 (de) 1999-04-22
ATE173621T1 (de) 1998-12-15
EP0649303A4 (en) 1995-07-05
WO1993024126A1 (en) 1993-12-09
EP0649303A1 (en) 1995-04-26
JPH07507306A (ja) 1995-08-10
EP0649303B1 (en) 1998-11-25
US5281627A (en) 1994-01-25

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