ATE173621T1 - Substituierte arginine und substituierte homoarginine und ihre verwendung - Google Patents

Substituierte arginine und substituierte homoarginine und ihre verwendung

Info

Publication number
ATE173621T1
ATE173621T1 AT93913866T AT93913866T ATE173621T1 AT E173621 T1 ATE173621 T1 AT E173621T1 AT 93913866 T AT93913866 T AT 93913866T AT 93913866 T AT93913866 T AT 93913866T AT E173621 T1 ATE173621 T1 AT E173621T1
Authority
AT
Austria
Prior art keywords
methyl
arginine
omega
alpha
nitric oxide
Prior art date
Application number
AT93913866T
Other languages
English (en)
Inventor
Owen W Griffith
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of ATE173621T1 publication Critical patent/ATE173621T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT93913866T 1992-05-28 1993-05-19 Substituierte arginine und substituierte homoarginine und ihre verwendung ATE173621T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/889,345 US5281627A (en) 1992-05-28 1992-05-28 Substituted arginines and substituted homoarginines and use thereof

Publications (1)

Publication Number Publication Date
ATE173621T1 true ATE173621T1 (de) 1998-12-15

Family

ID=25394938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93913866T ATE173621T1 (de) 1992-05-28 1993-05-19 Substituierte arginine und substituierte homoarginine und ihre verwendung

Country Status (7)

Country Link
US (2) US5281627A (de)
EP (1) EP0649303B1 (de)
JP (1) JPH07507306A (de)
AT (1) ATE173621T1 (de)
DE (1) DE69322272T2 (de)
ES (1) ES2123653T3 (de)
WO (1) WO1993024126A1 (de)

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US5877176A (en) * 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
BR9407515A (pt) * 1993-08-12 1997-01-07 Astra Ab Composto formulação farmaceutica uso do composto processos para o tratamento de desordens neurodegenerativas ou de enxaqueca ou para a prevenção e a reversão da tolerância aos opiatos e diazepinas ou para o tratamento do vicio das drogas e para a preparação do composto
US5821267A (en) * 1993-10-21 1998-10-13 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
EP0897912A1 (de) * 1993-10-21 1999-02-24 G.D. Searle & Co. Amidinoderivate als NO-Synthetase-Inhibitoren
US5364881A (en) * 1993-11-15 1994-11-15 The Medical College Of Wisconsin Research Foundation, Inc. S-alkyl-isothioureido-amino acids and use thereof
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
US5695761A (en) * 1993-12-23 1997-12-09 Rutgers University Suppression of nitric oxide production by osteopontin
ES2151055T3 (es) * 1994-03-10 2000-12-16 Searle & Co Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa.
DK0751930T3 (da) * 1994-03-24 2000-04-17 Searle & Co Amidinoderivater anvendelige som nitrogenoxid-synthase-inhibitorer
ATE182889T1 (de) * 1994-05-07 1999-08-15 Astra Ab Bicyclische amidinderivate als no-synthetase inhibitoren
FR2722507B1 (fr) * 1994-07-12 1996-08-14 Rhone Poulenc Rorer Sa Adenovirus comportant un gene codant pour une no synthase
US20030099945A1 (en) * 1994-09-20 2003-05-29 Invenux, Inc. Parallel selex
US5543430A (en) * 1994-10-05 1996-08-06 Kaesemeyer; W. H. Method and formulation of stimulating nitric oxide synthesis
US6239172B1 (en) * 1997-04-10 2001-05-29 Nitrosystems, Inc. Formulations for treating disease and methods of using same
US20110196039A9 (en) * 1994-10-05 2011-08-11 Kaesemeyer Wayne H Controlled release arginine formulations
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
FR2727111B1 (fr) * 1994-11-21 1997-01-17 Hoechst Lab Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments
FR2730930B1 (fr) * 1995-02-27 1997-04-04 Oreal Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives
BR9608012A (pt) * 1995-04-20 1999-01-05 Searle & Co Agentes de amidino cíclicos úteis como inbidores da sintase do óxido nítrico
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5908842A (en) * 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
US6620848B2 (en) 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
US6127420A (en) * 1997-08-22 2000-10-03 The Medical College Of Wisconsin Research Foundation, Inc. L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof
US20020031513A1 (en) * 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
CA2333691A1 (en) 1998-06-10 1999-12-16 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
EP1351674A4 (de) 2000-04-12 2004-12-22 Cornell Res Foundation Inc Pharmacotherapie für vaskuläre funktionsstörungen, die mit einer defizitären stickstoffmonoxid-bioaktivität assoziiert sind
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
WO2003051314A2 (en) * 2001-12-18 2003-06-26 Medallion Biomedical, Llc Antibiotic compounds
WO2003075832A2 (en) * 2002-03-06 2003-09-18 Duke University Methods and composition based on discovery of metabolism of nitroclycerin

Family Cites Families (19)

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US2663668A (en) * 1951-08-09 1953-12-22 Permanente Foundation Process for producing arginase
US2834713A (en) * 1952-11-22 1958-05-13 Armour & Co Preparation of enzyme extracts from liver
FR2093738A5 (de) * 1970-05-27 1972-01-28 Kyowa Hakko Kogyo Kk
US4061542A (en) * 1976-03-08 1977-12-06 Hoffmann-La Roche Inc. 2-Methyl-L-arginine produced by cultivating streptomyces strain
IT1127322B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
US4477428A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α,NG -diacyl derivatives of arginine
US4477429A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α -alkyl derivatives of arginine
US4499067A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -acyl derivatives of arginine
US4499068A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -alkyl derivatives of arginine
US4698442A (en) * 1982-12-21 1987-10-06 Syntex (U.S.A.) Inc. ω-Guanidino-substituted-α-amino acids
US4734438A (en) * 1983-04-26 1988-03-29 Macri Frank J Norepinephrine potentiated compositions and method of use
DE3838461A1 (de) * 1988-11-12 1990-05-23 Krebsoege Gmbh Sintermetall Pulvermetallurgischer werkstoff auf kupferbasis und dessen verwendung
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5216025A (en) * 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
CA2036770C (en) * 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
US5318992A (en) * 1990-02-26 1994-06-07 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof

Also Published As

Publication number Publication date
WO1993024126A1 (en) 1993-12-09
EP0649303B1 (de) 1998-11-25
US5281627A (en) 1994-01-25
DE69322272T2 (de) 1999-04-22
ES2123653T3 (es) 1999-01-16
EP0649303A1 (de) 1995-04-26
JPH07507306A (ja) 1995-08-10
US5453441A (en) 1995-09-26
DE69322272D1 (de) 1999-01-07
EP0649303A4 (de) 1995-07-05

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