ES2123056T3 - Anticuerpo bnp e inmunoensayo que lo emplea. - Google Patents

Anticuerpo bnp e inmunoensayo que lo emplea.

Info

Publication number
ES2123056T3
ES2123056T3 ES93913278T ES93913278T ES2123056T3 ES 2123056 T3 ES2123056 T3 ES 2123056T3 ES 93913278 T ES93913278 T ES 93913278T ES 93913278 T ES93913278 T ES 93913278T ES 2123056 T3 ES2123056 T3 ES 2123056T3
Authority
ES
Spain
Prior art keywords
immuno assay
bnp antibody
bnp
forecast
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93913278T
Other languages
English (en)
Inventor
Christian Hall
Hanna Eva Dzieglewska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medinnova SF
Original Assignee
Medinnova SF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10716417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2123056(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medinnova SF filed Critical Medinnova SF
Application granted granted Critical
Publication of ES2123056T3 publication Critical patent/ES2123056T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/58Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EN LA PRESENTE INVENCION SE PRESENTAN ANTICUERPOS A UTILIZAR EN UN METODO DE INMUNOENSAYO EN DONDE LOS ANTICUERPOS SON ESPECIFICOS AL POLIPEPTIDO Y CONTIENEN LOS AMINOACIDOS 1-76 DEL FACTOR NATRIURETICO DEL CEREBRO N-TERMINAL BPN (1-76). TAMBIEN SE PRESENTAN LOS METODOS Y KITS PARA EL DIAGNOSTICO O PRONOSTICO DE ESTADOS EN QUE EL BNP (176) ES UN INDICADOR DE DIAGNOSTICO O PRONOSTICO DE, POR EJEMPLO, COLAPSOS O HIPERVOLEMIA.
ES93913278T 1992-06-03 1993-06-02 Anticuerpo bnp e inmunoensayo que lo emplea. Expired - Lifetime ES2123056T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929211686A GB9211686D0 (en) 1992-06-03 1992-06-03 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2123056T3 true ES2123056T3 (es) 1999-01-01

Family

ID=10716417

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93913278T Expired - Lifetime ES2123056T3 (es) 1992-06-03 1993-06-02 Anticuerpo bnp e inmunoensayo que lo emplea.

Country Status (11)

Country Link
US (1) US5786163A (es)
EP (1) EP0648228B8 (es)
JP (1) JP3375630B2 (es)
AT (1) ATE172989T1 (es)
AU (1) AU667223B2 (es)
CA (1) CA2136961C (es)
DE (1) DE69321955T2 (es)
DK (1) DK0648228T3 (es)
ES (1) ES2123056T3 (es)
GB (1) GB9211686D0 (es)
WO (1) WO1993024531A1 (es)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 hBNPのC端を認識するモノクロ−ナル抗体
PT2292662E (pt) 1996-03-04 2014-07-16 Scios Inc Ensaio e reagentes para a quantificação de hbnp
WO1999022235A1 (fr) 1997-10-24 1999-05-06 Shionogi & Co., Ltd. Procede d'inhibition de la decomposition de peptides natriuretiques et procede ameliore de dosage de peptides natriuretiques a l'aide desdits peptides
US7226729B1 (en) 1997-04-01 2007-06-05 Shionogi & Co., Ltd. Method for inhibiting degradation of brain natriuretic peptides
JP3516655B2 (ja) * 1997-09-11 2004-04-05 塩野義製薬株式会社 Bnpの免疫測定法
US6117644A (en) * 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
US6083700A (en) * 1998-06-26 2000-07-04 Incyte Pharmaceuticals, Inc. Human goose-type lysozyme
AT407674B (de) * 1998-09-29 2001-05-25 Biomedica Gmbh Verfahren zur bestimmung von atrialem natriuretischem peptid (anp)
GB9827348D0 (en) * 1998-12-12 1999-02-03 Univ Leicester Natriuretic peptide
ATE403158T1 (de) * 1999-01-29 2008-08-15 Roche Diagnostics Gmbh Verfahren zum nachweis von n-terminalem probnp
WO2002038794A2 (en) 2000-11-09 2002-05-16 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
US7632647B2 (en) * 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20040176914A1 (en) * 2001-04-13 2004-09-09 Biosite Incorporated Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
EP1666881B1 (en) * 2001-05-04 2010-02-17 Biosite Incorporated Diagnostic markers of acute coronary syndromes and methods of use thereof
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7608406B2 (en) * 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
CA2457775A1 (en) * 2001-08-20 2003-02-27 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US6461828B1 (en) 2001-09-04 2002-10-08 Syn X Pharma Conjunctive analysis of biological marker expression for diagnosing organ failure
PT3072978T (pt) 2002-05-09 2018-10-15 Brigham & Womens Hospital Inc 1l1rl-1 como um marcador de doença cardiovascular
MXPA03004105A (es) * 2002-05-14 2004-10-15 Hoffmann La Roche Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores.
FR2843396B1 (fr) * 2002-08-07 2005-04-15 Bio Rad Pasteur Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque
AU2003302087A1 (en) * 2002-11-18 2004-06-15 Syn X Pharma, Inc. Polyclonal-monoclonal elisa assay for detecting n-terminus probnp
US6960472B2 (en) * 2002-11-18 2005-11-01 Ottawa Heart Institute Research Corporation Monoclonal antibodies against N-Terminus proBNP
US20040096919A1 (en) 2002-11-18 2004-05-20 Michelle Davey Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP
US20050287613A1 (en) * 2002-11-18 2005-12-29 George Jackowski Polyclonal-polyclonal ELISA assay for detecting N-terminus-proBNP
US7977072B2 (en) * 2002-11-20 2011-07-12 B.R.A.H.M.S Gmbh Sandwich immunoassay for identifying partial proANP peptides
SG159387A1 (en) 2002-11-26 2010-03-30 Biocon Ltd In Modified natriuretic compounds, conjugates, and uses thereof
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
DE10316583A1 (de) * 2003-04-10 2004-10-28 B.R.A.H.M.S Aktiengesellschaft Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
CA2522709A1 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
US20060177870A1 (en) * 2003-04-28 2006-08-10 Ciphergen Biosystems, Inc Immunoassays
PL2256132T3 (pl) 2003-05-12 2016-08-31 Hoffmann La Roche Sposób wykrywania proBNP z zastosowaniem przeciwciała monoklonalnego
US20070037208A1 (en) * 2003-05-29 2007-02-15 Foote Robert S Method for detecting cardiac ischemia via changes in b-natriuretic peptide levels
GB2403533A (en) 2003-06-30 2005-01-05 Orion Corp Atrial natriuretic peptide and brain natriuretic peptide and assays and uses thereof
JP2007502991A (ja) * 2003-08-20 2007-02-15 バイオサイト インコーポレイテッド 生物活性ナトリウム利尿ペプチドを測定するための、およびその治療可能性を向上させるための方法および組成物
DE10351238A1 (de) * 2003-11-03 2005-06-02 Roche Diagnostics Gmbh Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern
DE10355731A1 (de) 2003-11-28 2005-06-30 Roche Diagnostics Gmbh Analytischer Sandwichtest zur Bestimmung von NT-proBNP
AT500800B1 (de) 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
WO2007028070A2 (en) * 2005-08-30 2007-03-08 Biosite, Inc. Use of soluble flt-1 and its fragments in cardiovascular conditions
EP1837659B1 (en) 2006-03-24 2010-06-09 F. Hoffman-la Roche AG Means and methods for the differentiation of acute and chronic myocardial necrosis in symptomatic patients
EP1845379A1 (en) 2006-04-13 2007-10-17 F. Hoffmann-La Roche AG Means and methods for the differentiation of cardiac and pulmonary causes of shortness of breath
ES2646142T3 (es) 2006-04-24 2017-12-12 Critical Care Diagnostics, Inc. Evaluación de la eficacia de un tratamiento en un sujeto en función de los niveles de ST2
WO2007143295A2 (en) * 2006-04-27 2007-12-13 Critical Care Diagnostics, Inc. Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease
DK2021796T3 (da) * 2006-05-01 2012-05-29 Critical Care Diagnostics Inc Diagnose af hjerte-kar-sygdom
DK2019965T3 (en) * 2006-05-02 2015-07-20 Critical Care Diagnostics Inc DIFFERENTIAL BETWEEN LUNG AND Cardiovascular Disease
US8147817B2 (en) * 2006-05-04 2012-04-03 The Brigham And Women's Hospital, Inc. IL-33 in the treatment and diagnosis of diseases and disorders
EP1882945A1 (en) 2006-07-28 2008-01-30 F.Hoffmann-La Roche Ag Means and methods for the differentiation of cardiac and pulmonary causes of acute shortness of breath
KR101245877B1 (ko) 2006-08-04 2013-03-20 메디치니쉐 호흐슐레 하노버 Gdf-15 를 바탕으로 한, 심장 중재의 위험도를 평가하는수단 및 방법
EP1890153A1 (en) 2006-08-16 2008-02-20 F. Hoffman-la Roche AG Cardiac troponin as an indicator of advanced coronary artery disease
ATE449966T1 (de) 2006-09-15 2009-12-15 Hoffmann La Roche Biochemische marker für akute lungenembolie
EP1925943A1 (en) 2006-11-21 2008-05-28 F. Hoffman-la Roche AG Means and methods for optimization of diagnostic and therapeutic approaches in chronic artery disease based on the detection of Troponin T and NT-proBNP.
EP2089719A2 (en) * 2006-11-21 2009-08-19 Roche Diagnostics GmbH Means and methods for optimization of diagnostic and therapeutic approaches in chronic artery disease based on troponin t and nt-probnp
ES2430290T3 (es) * 2007-03-06 2013-11-19 F. Hoffmann-La Roche Ag Utilización de péptidos de tipo PNC para predecir la necesidad de diálisis
AT504942B1 (de) 2007-03-07 2009-08-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
EP2031397A1 (en) 2007-08-30 2009-03-04 F. Hoffmann-La Roche AG Surfactant proteins B and D in differentiating the causes of shortness of breath
EP2210111A1 (en) 2007-10-10 2010-07-28 Roche Diagnostics GmbH Natriuretic peptide/troponin ratio for the assessment of preexisting myocardial dysfunction in patients with acute coronary syndrome
US9482677B2 (en) 2008-02-27 2016-11-01 Scios Inc. Method, composition and device for sampling natriuretic peptides in a biological fluid
SI2827152T1 (sl) 2008-04-18 2016-10-28 Critical Care Diagnostics,Inc. Napovedovanje tveganja večjih neželenih srčno-žilnih dogodkov
US20090286329A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratoires Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
US20090286256A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratories Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
EP2294424A1 (en) 2008-05-21 2011-03-16 F. Hoffmann-La Roche AG L-fabp, natriuretic peptides and cardiac troponin in individuals in need for a cardiac therapy
ES2644723T3 (es) 2008-07-23 2017-11-30 F. Hoffmann-La Roche Ag Identificación de sujetos susceptibles de tratamiento antiangiogénico
CA2732201A1 (en) 2008-08-13 2010-02-18 F. Hoffmann-La Roche Ag D-dimer, troponin, nt-probnp for pulmonary embolism
US20100297607A1 (en) 2009-05-20 2010-11-25 Jian Zheng Reagents For HCV Antigen-Antibody Combination Assays
KR101522078B1 (ko) 2009-09-17 2015-05-20 에프. 호프만-라 로슈 아게 좌심실 비대에 대한 멀티마커 패널
BR112012011230A2 (pt) * 2009-11-13 2016-04-05 Bg Medicine Inc fatores de risco e previsão de infarto do miocárdio
ES2647461T3 (es) 2009-12-18 2017-12-21 F. Hoffmann-La Roche Ag GDF-15 y/o troponina T para predecir insuficiencia renal en pacientes con cirugía cardíaca
WO2011098519A1 (en) 2010-02-12 2011-08-18 Synlab Medizinisches Versorgungszentrum Heidelberg Gmbh Homoarginine as a biomarker for the risk of mortality
EP2388594A1 (en) 2010-05-17 2011-11-23 Roche Diagnostics GmbH GDF-15 based means and methods for survival and recovery prediction in acute inflammation
EP2601531A1 (en) 2010-08-04 2013-06-12 IDEXX Laboratories, Inc. Detection of degradation products of canine nt-probnp
WO2012020045A1 (en) 2010-08-10 2012-02-16 Roche Diagnostics Gmbh Method for selecting patients with stable coronary artery disease for pci or medical treatment
EP2367006A1 (en) 2010-08-24 2011-09-21 Roche Diagnostics GmbH PLGF-based means and methods for diagnosing cardiac causes in acute inflammation
ES2627337T3 (es) 2010-08-26 2017-07-27 F. Hoffmann-La Roche Ag Uso de biomarcadores para controlar una medicación en un sujeto que padece insuficiencia cardíaca
EP2439535A1 (en) 2010-10-07 2012-04-11 F. Hoffmann-La Roche AG Diagnosis of diabetes related heart disease and GDF-15 and Troponin as predictors for the development of type 2 diabetes mellitus
EP2447720A1 (en) 2010-10-26 2012-05-02 Roche Diagnostics GmbH sFlt1 and pulmonary complications
EP2383579A1 (en) 2010-12-17 2011-11-02 F. Hoffmann-La Roche AG sFlt-1, cardiac troponins and natriuretic peptides in the recognition of therapy with HER-2 inhibitors
US8728742B2 (en) 2011-03-17 2014-05-20 Critical Care Diagnostics, Inc. Methods predicting risk of an adverse clinical outcome
EP2715353B1 (en) 2011-05-31 2016-08-24 IDEXX Laboratories, Inc. DETECTION OF DEGRADATION PRODUCTS OF FELINE NT-proBNP
EP2385373A1 (en) 2011-07-01 2011-11-09 F. Hoffmann-La Roche AG Natriuretic peptides in pregnancy
EP2581040A1 (en) 2011-10-10 2013-04-17 Roche Diagnostics GmbH TnT based cardiac hypertrophy risk related physiological training and guidance in athletes
BR122021026652B1 (pt) 2011-10-17 2022-08-23 F. Hoffmann-La Roche Ag Método in vitro para diagnosticar fibrilação atrial intermitente, uso de uma troponina cardíaca e dispositivo para diagnosticar fibrilação atrial intermitente
WO2013079567A2 (en) 2011-12-01 2013-06-06 Roche Diagnostics Gmbh Nt-proanp and nt-probnp for the diagnosis of stroke
ES2538226T3 (es) 2012-01-26 2015-06-18 F. Hoffmann-La Roche Ag Método para la diferenciación de la insuficiencia cardiaca anterógrada y retrógrada
EP2650684A1 (en) 2012-04-10 2013-10-16 Roche Diagniostics GmbH Pro SP-B and NT-proBNP based diagnosis in patients with pneumonia
EP2615459A1 (en) 2012-04-27 2013-07-17 Roche Diagniostics GmbH proSP-B based diagnosis of distal airway involvement in asthma
EP2600155A1 (en) 2012-06-18 2013-06-05 Roche Diagniostics GmbH sFlt-1 based diagnosis and monitoring of stroke patients
EP2597467A1 (en) 2012-06-26 2013-05-29 Roche Diagniostics GmbH Means and methods for proSP-B based diagnosis of pulmonary congestion in ACS patients
EP2597466A1 (en) 2012-06-26 2013-05-29 Roche Diagniostics GmbH Means and methods for proSP-B based diagnosis of alveolar damage in pulmonary hypertension patients
WO2014009418A1 (en) 2012-07-10 2014-01-16 Roche Diagnostics Gmbh TnT, NTproBNP, sFlt-1 for CURB65 IN PNEUMONIA
RU2015110054A (ru) 2012-08-21 2016-10-10 Критикал Кэа Дайэгностикс, Инк. Мультимаркерная стратификация риска
EP2895866B1 (en) 2012-09-12 2018-05-30 Roche Diagnostics GmbH Identification of patients with abnormal fractional shortening
US20140273273A1 (en) 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
EP2730923A1 (en) 2012-11-09 2014-05-14 Roche Diagniostics GmbH NTproBNP and cTnT based therapy guidance in heart failure
CN108120837B (zh) 2012-11-09 2021-06-22 霍夫曼-拉罗奇有限公司 阵发性心房纤颤的基于TnT的诊断
EP2929354B1 (en) 2012-12-04 2018-04-18 Roche Diagnostics GmbH Biomarkers in the selection of therapy of heart failure
US9862773B2 (en) * 2013-03-15 2018-01-09 The Translational Genomics Research Institute Hybridoma clones and monoclonal antibodies to CD9
JP6159010B2 (ja) * 2013-03-15 2017-07-05 ザ・トランスレーショナル・ジェノミクス・リサーチ・インスティチュート テトラスパニン8に対するハイブリドーマクローンおよびモノクローナル抗体
EP2866033A1 (en) 2013-10-23 2015-04-29 Roche Diagniostics GmbH Differential diagnosis of acute dyspnea based on C-terminal proSP-B, KL-6 and BNP-type peptides
AU2014343709B2 (en) 2013-11-04 2020-11-19 The Regents Of The University Of Michigan Biomarkers and methods for progression prediction for chronic kidney disease
ES2712201T3 (es) 2014-01-28 2019-05-09 Hoffmann La Roche Biomarcadores para la evaluación de riesgos y la monitorización del tratamiento en pacientes de insuficiencia cardíaca que han recibido terapia guiada por el péptido natriurético de tipo B
EP2916134B1 (en) 2014-03-05 2017-08-16 Roche Diagnostics GmbH Use of Seprase for differential diagnosis of acute dyspnea
ES2939018T3 (es) 2014-03-26 2023-04-18 Hoffmann La Roche IGFBP7 para diagnosticar una disfunción diastólica
EP3279665B1 (en) 2016-08-04 2020-07-08 Roche Diagniostics GmbH Circulating esm-1 (endocan) in the assessment of atrial fibrillation
WO2018069487A1 (en) 2016-10-14 2018-04-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of loss of renal function in patients with type 2 diabetes
WO2018127372A1 (en) 2016-12-13 2018-07-12 Witteman Johanna Cornelia Maria Detection of transient troponin peaks for diagnosis of subjects at high risk of cardiovascular disease
CN113167799A (zh) 2018-07-31 2021-07-23 豪夫迈·罗氏有限公司 循环DKK3(Dickkopf相关蛋白3)在心房颤动评定中的应用
KR20210044216A (ko) 2018-08-10 2021-04-22 에프. 호프만-라 로슈 아게 심방세동-관련 뇌졸중 평가를 위한 ces-2 (카르복실에스테라제-2)
JP2021535370A (ja) 2018-08-16 2021-12-16 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 心房細動および抗凝固療法の評価における循環tfpi−2(組織因子経路阻害剤2)
CN113260863A (zh) 2018-08-17 2021-08-13 豪夫迈·罗氏有限公司 用于心房纤颤的评价中的循环bmp10 (骨形态发生蛋白10)
EP3841381A1 (en) 2018-08-22 2021-06-30 Roche Diagnostics GmbH Circulating spon-1 (spondin-1) in the assessment of atrial fibrillation
WO2020039085A1 (en) 2018-08-24 2020-02-27 Roche Diagnostics Gmbh Circulating fgfbp-1 (fibroblast growth factor-binding protein 1) in the assessment of atrial fibrillation and for the prediction of stroke
WO2020064995A1 (en) 2018-09-28 2020-04-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of biomarkers representing cardiac, vascular and inflammatory pathways for the prediction of acute kidney injury in patients with type 2 diabetes
WO2020234451A1 (en) 2019-05-23 2020-11-26 Roche Diagnostics Gmbh IGFBP7 RATIO FOR HFpEF
CN115190886A (zh) 2020-02-20 2022-10-14 马斯特里赫特大学 循环bmp10(骨形态发生蛋白10)的检测方法
EP4365598A1 (en) 2022-11-07 2024-05-08 Hôpitaux Universitaires Saint-Louis-Lariboisière Rapid optimization of oral heart failure therapies helped by nt-probnp testing
WO2024100050A1 (en) 2022-11-07 2024-05-16 Hôpitaux Universitaires Saint-Louis-Lariboisière Rapid optimization of oral heart failure therapies helped by nt-probnp testing

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69020755T3 (de) * 1989-03-01 2000-03-02 Shionogi & Co Physiologisch aktives Polypeptid und DNA.
JP2676114B2 (ja) * 1990-04-16 1997-11-12 塩野義製薬株式会社 hBNPを認識するモノクローナル抗体および該抗体を用いるhBNPの免疫測定法
JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 hBNPのC端を認識するモノクロ−ナル抗体

Also Published As

Publication number Publication date
CA2136961A1 (en) 1993-12-09
WO1993024531A1 (en) 1993-12-09
EP0648228B1 (en) 1998-11-04
JP3375630B2 (ja) 2003-02-10
DK0648228T3 (da) 1999-07-19
AU4340593A (en) 1993-12-30
EP0648228B8 (en) 2004-04-21
DE69321955D1 (de) 1998-12-10
AU667223B2 (en) 1996-03-14
DE69321955T2 (de) 1999-06-10
US5786163A (en) 1998-07-28
CA2136961C (en) 2004-03-16
ATE172989T1 (de) 1998-11-15
GB9211686D0 (en) 1992-07-15
EP0648228A1 (en) 1995-04-19
JPH07507210A (ja) 1995-08-10

Similar Documents

Publication Publication Date Title
ES2123056T3 (es) Anticuerpo bnp e inmunoensayo que lo emplea.
ATE346858T1 (de) Antikörperreinigung durch hydrophobe wechselwirkungchromatografie bei niedrigem ph
ES2064316T3 (es) Composicion de peptido y procedimiento para la deteccion de anticuerpos frente al htlv-iii.
ES2089057T3 (es) Un reactivo sustituto de un analito para uso en metodos de ensayo de fijacion especifica, dispositivos y kits.
ES2162917T3 (es) Mejoras en o relativas al suministro de peptidos.
ES2128362T3 (es) Fragmentos de proteinas de prion.
NO901899L (no) Hiv-peptider, syntetiske hiv-antigener og immunoanalysekit
ATE142789T1 (de) Träger zur bindung von antiphospholipid- antikörpern, diese antikörper verwendender immunotest und kit dafür
ATE142646T1 (de) Verfahren zur immunologischen bestimmung des carboxyterminalen peptids von typ-i-prokollagen
ES2042461T3 (es) Producto y procedimiento para el teñido oxidativo del cabello.
ES2083387T3 (es) Peptidos sinteticos y sus mezclas para la deteccion de anticuerpos hiv.
ES2067518T3 (es) Composicion de sustrato para fosfatasa alcalina y metodo para un ensayo utilizando la misma.
ES2117784T3 (es) Metodo de inmunoensayo que utiliza potencial zeta.
ATE137864T1 (de) Immunobestimmung von menschlichem osteocalcin, reagenz und satz dafür
DE69629976D1 (de) Typ I Prokollagen aminoterminales Propeptid, dessen Antikörper und Testverfahren unter Verwendung davon
ES2061664T3 (es) Anticuerpos monoclonales que reconocen a alfa-hanp y correspondientes hibridomas, su preparacion y uso.
DE69229230T2 (de) Antikörpertest zur erkennung von alkoholikern und zur überwachung der alkoholaufnahme
PT87376A (pt) Monoklonaler antikoerper zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten
DK329789A (da) Monoklonalt antistof
NO904129L (no) Antistoffer mot hoeykonserverte aminosyresekvenser fra immunogene forbindelser, fremgangsmaate for fremstilling av antistoffer samt anvendelse derav i immunoanalyser.
AR014811A1 (es) Un peptido que enlaza anticuerpos con elevados niveles de pacientes esquizofrenicos, un ensayo para el diagnostico de la esquizofrenia y un equipopara el uso en el diagnostico de esquizofrenia
DE69312485D1 (de) Nachweis von maservirus-specifischer antikörpern durch gebrauch von rekombinanten maserproteinen
DE69333683D1 (de) Antikörper-testbesteck zur bestimmung von amylin
ATE389175T1 (de) Verfahren zur prüfung von antigenen, die mit durch mentalen stress bedingten erkrankungen assoziiert sind
ATE110470T1 (de) Immuntestverfahren von chondrocalcin.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 648228

Country of ref document: ES