ES2121888T3 - Derivados iminicos ciclicos, procedimientos para su preparacion y medicamentos que contienen a estos compuestos. - Google Patents
Derivados iminicos ciclicos, procedimientos para su preparacion y medicamentos que contienen a estos compuestos.Info
- Publication number
- ES2121888T3 ES2121888T3 ES93106724T ES93106724T ES2121888T3 ES 2121888 T3 ES2121888 T3 ES 2121888T3 ES 93106724 T ES93106724 T ES 93106724T ES 93106724 T ES93106724 T ES 93106724T ES 2121888 T3 ES2121888 T3 ES 2121888T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- iminic
- cyclical
- procedures
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4213919A DE4213919A1 (de) | 1992-04-28 | 1992-04-28 | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2121888T3 true ES2121888T3 (es) | 1998-12-16 |
Family
ID=6457638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93106724T Expired - Lifetime ES2121888T3 (es) | 1992-04-28 | 1993-04-26 | Derivados iminicos ciclicos, procedimientos para su preparacion y medicamentos que contienen a estos compuestos. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5576444A (OSRAM) |
| EP (1) | EP0567966B1 (OSRAM) |
| JP (1) | JP3315463B2 (OSRAM) |
| KR (1) | KR940005569A (OSRAM) |
| AT (1) | ATE170509T1 (OSRAM) |
| AU (1) | AU662223B2 (OSRAM) |
| CA (1) | CA2095009A1 (OSRAM) |
| DE (2) | DE4213919A1 (OSRAM) |
| DK (1) | DK0567966T3 (OSRAM) |
| ES (1) | ES2121888T3 (OSRAM) |
| FI (1) | FI931880A7 (OSRAM) |
| HU (1) | HUT70039A (OSRAM) |
| IL (1) | IL105517A0 (OSRAM) |
| MX (1) | MX9302448A (OSRAM) |
| NO (1) | NO180045C (OSRAM) |
| NZ (1) | NZ247512A (OSRAM) |
| PL (1) | PL298717A1 (OSRAM) |
| TW (1) | TW232006B (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018058A1 (en) * | 1992-03-06 | 1993-09-16 | G.D. Searle & Co. | Peptides mimics useful as platelet aggregation inhibitors |
| DE4241632A1 (de) * | 1992-12-10 | 1994-06-16 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| EP0691953B1 (en) * | 1993-03-31 | 2000-08-02 | G.D. Searle & Co. | 1-amidinophenyl-pyrrolidones/ piperidinones as platelet aggregation inhibitors |
| DK0656348T3 (da) * | 1993-12-03 | 2000-09-11 | Hoffmann La Roche | Eddikesyrederivater som medikamenter |
| FI972646L (fi) * | 1994-12-23 | 1997-08-19 | Thomae Gmbh Dr K | Piperatsiinijohdannaiset, näitä yhdisteitä sisältävät lääkeaineet, niiden käyttö ja menetelmä niiden valmistamiseksi |
| EP0813525B9 (en) | 1995-03-10 | 2004-02-04 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
| US5691364A (en) * | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US5612363A (en) * | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
| US5849759A (en) * | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| AU1990197A (en) * | 1996-03-12 | 1997-10-01 | Bristol-Myers Squibb Company | Carbamyl guanidine and amidine prodrugs |
| US5693641A (en) * | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| US5753635A (en) * | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
| DK0929547T3 (da) | 1996-09-12 | 2003-03-10 | Schering Ag | Benzamidinderivater substitueret af cykliske aminosyrederivater eller cykliske hydroxysyrederivater og deres anvendelse som antikoagulantia |
| US6008234A (en) * | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| US7109326B2 (en) * | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| HUP0101172A3 (en) | 1997-12-19 | 2002-12-28 | Schering Ag | Ortho-anthranilamide derivatives and their use as anti-coagulants |
| AU2720199A (en) * | 1998-02-03 | 1999-08-23 | Boehringer Ingelheim Pharma Kg | Five-membered, benzo-condensed heterocycles used as antithrombotic agents |
| US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| DE19844787A1 (de) * | 1998-09-30 | 2000-04-13 | Boehringer Ingelheim Pharma | Disubstituierte Pyrrolidinone, diese Verbindung enthaltende Arzneimittel und deren Verwendung sowie ihre Herstellung |
| US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
| US6127376A (en) * | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
| US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| JP5440976B2 (ja) * | 2009-01-14 | 2014-03-12 | ホクト株式会社 | 血小板凝集抑制剤 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2123288A (en) * | 1982-07-16 | 1984-02-01 | Wellcome Found | Anti-thrombotic agent |
| EP0194548A3 (de) * | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| NO165341C (no) * | 1985-03-16 | 1991-01-30 | Wellcome Found | Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroksamsyrearylderivater. |
| DE3823299A1 (de) * | 1988-07-07 | 1990-01-11 | Schering Ag | Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln |
| JPH02247166A (ja) * | 1989-03-17 | 1990-10-02 | Taisho Pharmaceut Co Ltd | ３―ピロリン―２―オン誘導体 |
| DE3932403A1 (de) * | 1989-05-12 | 1991-04-11 | Thomae Gmbh Dr K | Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5026861A (en) * | 1989-07-17 | 1991-06-25 | Merrell Dow Pharmaceuticals | Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4107857A1 (de) * | 1991-03-12 | 1992-09-17 | Thomae Gmbh Dr K | Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4127404A1 (de) * | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
1992
- 1992-04-28 DE DE4213919A patent/DE4213919A1/de not_active Withdrawn
-
1993
- 1993-03-09 TW TW082101712A patent/TW232006B/zh active
- 1993-04-26 ES ES93106724T patent/ES2121888T3/es not_active Expired - Lifetime
- 1993-04-26 AT AT93106724T patent/ATE170509T1/de not_active IP Right Cessation
- 1993-04-26 US US08/053,037 patent/US5576444A/en not_active Expired - Lifetime
- 1993-04-26 DE DE59308940T patent/DE59308940D1/de not_active Expired - Fee Related
- 1993-04-26 DK DK93106724T patent/DK0567966T3/da active
- 1993-04-26 EP EP93106724A patent/EP0567966B1/de not_active Expired - Lifetime
- 1993-04-27 NZ NZ247512A patent/NZ247512A/en unknown
- 1993-04-27 PL PL29871793A patent/PL298717A1/xx unknown
- 1993-04-27 JP JP09993093A patent/JP3315463B2/ja not_active Expired - Fee Related
- 1993-04-27 IL IL105517A patent/IL105517A0/xx unknown
- 1993-04-27 MX MX9302448A patent/MX9302448A/es unknown
- 1993-04-27 NO NO931526A patent/NO180045C/no unknown
- 1993-04-27 CA CA002095009A patent/CA2095009A1/en not_active Abandoned
- 1993-04-27 KR KR1019930007059A patent/KR940005569A/ko not_active Withdrawn
- 1993-04-27 FI FI931880A patent/FI931880A7/fi not_active Application Discontinuation
- 1993-04-27 HU HU9301222A patent/HUT70039A/hu unknown
- 1993-04-28 AU AU38222/93A patent/AU662223B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NO180045C (no) | 1997-02-05 |
| HU9301222D0 (en) | 1993-07-28 |
| IL105517A0 (en) | 1993-08-18 |
| NZ247512A (en) | 1995-12-21 |
| CA2095009A1 (en) | 1993-10-29 |
| FI931880A0 (fi) | 1993-04-27 |
| JPH0673001A (ja) | 1994-03-15 |
| EP0567966A1 (de) | 1993-11-03 |
| EP0567966B1 (de) | 1998-09-02 |
| AU3822293A (en) | 1993-11-04 |
| HUT70039A (en) | 1995-09-28 |
| TW232006B (OSRAM) | 1994-10-11 |
| JP3315463B2 (ja) | 2002-08-19 |
| NO931526D0 (no) | 1993-04-27 |
| KR940005569A (ko) | 1994-03-21 |
| DE59308940D1 (de) | 1998-10-08 |
| DE4213919A1 (de) | 1993-11-04 |
| DK0567966T3 (da) | 1999-05-31 |
| ATE170509T1 (de) | 1998-09-15 |
| NO180045B (no) | 1996-10-28 |
| AU662223B2 (en) | 1995-08-24 |
| NO931526L (no) | 1993-10-29 |
| MX9302448A (es) | 1993-10-01 |
| FI931880L (fi) | 1993-10-29 |
| US5576444A (en) | 1996-11-19 |
| PL298717A1 (en) | 1994-01-24 |
| FI931880A7 (fi) | 1993-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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