ES2119376T3 - Ensayo de enlace. - Google Patents
Ensayo de enlace.Info
- Publication number
- ES2119376T3 ES2119376T3 ES95904616T ES95904616T ES2119376T3 ES 2119376 T3 ES2119376 T3 ES 2119376T3 ES 95904616 T ES95904616 T ES 95904616T ES 95904616 T ES95904616 T ES 95904616T ES 2119376 T3 ES2119376 T3 ES 2119376T3
- Authority
- ES
- Spain
- Prior art keywords
- test
- agent
- signal
- liquid sample
- area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA UN METODO, DISPOSITIVO Y EQUIPO DE ENSAYO PARA DETERMINAR LA CONCENTRACION DE ANALITOS EN MUESTRAS LIQUIDAS, EN LAS QUE LA CANTIDAD DE AGENTE AGLOMERANTE CON LOCALIZACIONES DE UNION ESPECIFICAS PARA UN ANALITO DADO EN LA MUESTRA LIQUIDA, SE INMOVILIZA EN UNA ZONA DE ENSAYO SOBRE UN SOPORTE SOLIDO, ESTANDO EL AGENTE AGLOMERANTE DIVIDIDO EN UN CONJUNTO DE LOCALIZACIONES ESPACIALMENTE SEPARADAS EN LA ZONA DE ENSAYO. LA CONCENTRACION DEL ANALITO SE OBTIENE MEDIANTE LA RETRO-VALORACION DEL AGENTE DE UNION OCUPADO CON UN AGENTE DE DESARROLLO QUE TIENE UN MARCADOR, E INTEGRANDO LA SEÑAL DE CADA LOCALIZACION EN EL CONJUNTO. EL ENSAYO TIENE LA VENTAJA DE EVITAR LOS ERRORES ESTADISTICOS CRECIENTES AL REDUCIRSE EL AREA DE MICROLOCALIZACION DE TECNICAS ANTERIORES, MIENTRAS SE OPTIMIZA LA SEÑAL-A-RUIDO Y LA CINETICA DE LA REACCION ENTRE EL ANALITO Y EL AGENTE AGLOMERANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939326450A GB9326450D0 (en) | 1993-12-24 | 1993-12-24 | Binding assay |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2119376T3 true ES2119376T3 (es) | 1998-10-01 |
Family
ID=10747224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95904616T Expired - Lifetime ES2119376T3 (es) | 1993-12-24 | 1994-12-23 | Ensayo de enlace. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5837551A (es) |
EP (1) | EP0736176B1 (es) |
JP (1) | JP3391459B2 (es) |
AU (1) | AU1321895A (es) |
DE (1) | DE69410636T2 (es) |
ES (1) | ES2119376T3 (es) |
GB (1) | GB9326450D0 (es) |
WO (1) | WO1995018377A1 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7144119B2 (en) * | 1996-04-25 | 2006-12-05 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
ATE366418T1 (de) | 1996-04-25 | 2007-07-15 | Bioarray Solutions Ltd | Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen |
US6958245B2 (en) | 1996-04-25 | 2005-10-25 | Bioarray Solutions Ltd. | Array cytometry |
US6387707B1 (en) * | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
US7041510B2 (en) | 1996-04-25 | 2006-05-09 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
JPH10246725A (ja) * | 1997-03-03 | 1998-09-14 | Mikio Nakayama | 抗体又は抗原の検出方法 |
US20030027126A1 (en) | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
US7622294B2 (en) | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
DE19715484A1 (de) * | 1997-04-14 | 1998-10-15 | Boehringer Mannheim Gmbh | Verfahren zum Aufbringen von Reagenzspots |
JP4302780B2 (ja) * | 1997-05-23 | 2009-07-29 | バイオアレイ ソリューションズ エルエルシー | マトリックスで結合された化合物の色別コード化とインシトゥ探索 |
US7157234B2 (en) | 1997-10-24 | 2007-01-02 | Beckman Coulter, Inc. | Detection of very low quantities of analyte bound to a solid phase |
US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
US6242246B1 (en) | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
WO1999040434A1 (en) | 1998-02-04 | 1999-08-12 | Invitrogen Corporation | Microarrays and uses therefor |
US6271044B1 (en) * | 1998-05-06 | 2001-08-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method and kit for detecting an analyte |
GB9903555D0 (en) * | 1999-02-16 | 1999-04-07 | The Technology Partnership Plc | Chemical and biological assay method and apparatus |
US7708945B1 (en) | 1999-08-13 | 2010-05-04 | Bayer Technology Services Gmbh | Device and method for determining multiple analytes |
JP2004511753A (ja) | 2000-05-04 | 2004-04-15 | イエール ユニバーシティー | タンパク質活性のスクリーニング用タンパク質チップ |
US20030138208A1 (en) * | 2000-05-06 | 2003-07-24 | Michael Pawlak | Grating optical waveguide structure for multi-analyte determinations and the use thereof |
AU2001274068A1 (en) * | 2000-06-02 | 2001-12-11 | Zeptosens Ag | Kit and method for determining a plurality of analytes |
AU7299301A (en) | 2000-06-21 | 2002-01-02 | Bioarray Solutions Ltd | Multianalyte molecular analysis using application-specific random particle arrays |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
US7057704B2 (en) * | 2000-09-17 | 2006-06-06 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US20030045005A1 (en) * | 2000-10-17 | 2003-03-06 | Michael Seul | Light-controlled electrokinetic assembly of particles near surfaces |
US20040058385A1 (en) * | 2000-11-17 | 2004-03-25 | Abel Andreas Peter | Kit and method for determining multiple analytes, with provisions for refrencing the density of immobilised recognition elements |
US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
US20040253596A1 (en) * | 2001-08-27 | 2004-12-16 | Michael Pawlak | Bioanalytical recognition surface with optimized recognition element density |
JP4377689B2 (ja) | 2001-10-15 | 2009-12-02 | バイオアレイ ソリューションズ リミテッド | 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析 |
US7335153B2 (en) | 2001-12-28 | 2008-02-26 | Bio Array Solutions Ltd. | Arrays of microparticles and methods of preparation thereof |
JP2005517456A (ja) | 2002-02-15 | 2005-06-16 | ソマロジック・インコーポレーテッド | 核酸リガンドによる標的結合を検出する方法および試薬 |
WO2003096018A2 (de) * | 2002-05-13 | 2003-11-20 | Zeptosens Ag | Kit zur assay-entwicklung und für serien-analysen |
WO2004047007A1 (en) | 2002-11-15 | 2004-06-03 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US20040248323A1 (en) | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
EP1660858A4 (en) * | 2003-07-21 | 2007-10-24 | Amplified Proteomics Inc | MULTIPLEX analyte |
US7927796B2 (en) | 2003-09-18 | 2011-04-19 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
EP1664722B1 (en) | 2003-09-22 | 2011-11-02 | Bioarray Solutions Ltd | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
US7563569B2 (en) | 2003-10-28 | 2009-07-21 | Michael Seul | Optimization of gene expression analysis using immobilized capture probes |
JP2007509629A (ja) | 2003-10-29 | 2007-04-19 | バイオアレイ ソリューションズ リミテッド | 二本鎖dnaの切断による複合核酸分析 |
EP1682261B1 (en) * | 2003-11-12 | 2012-08-15 | BIO-RAD Haifa Ltd. | Method for carrying out multiple binding reactions in an array format |
US7887750B2 (en) * | 2004-05-05 | 2011-02-15 | Bayer Healthcare Llc | Analytical systems, devices, and cartridges therefor |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
GB0421838D0 (en) | 2004-09-30 | 2004-11-03 | Congenia S R L | Cancer markers |
DE102004052729A1 (de) | 2004-10-30 | 2006-05-04 | Roche Diagnostics Gmbh | Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten |
DE502005002994D1 (de) | 2005-04-04 | 2008-04-10 | Micronas Holding Gmbh | Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von mindestens zwei Liganden |
AU2006239534B2 (en) * | 2005-04-26 | 2012-05-31 | Bayer Intellectual Property Gmbh | Novel equipment and method for coating substrates for analyte detection by way of an affinity assay method |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US20110136099A1 (en) | 2007-01-16 | 2011-06-09 | Somalogic, Inc. | Multiplexed Analyses of Test Samples |
US7855054B2 (en) | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
US8906700B2 (en) | 2007-11-06 | 2014-12-09 | Ambergen, Inc. | Methods and compositions for phototransfer |
CN103025859A (zh) | 2010-05-25 | 2013-04-03 | 阿尔利克斯公司 | 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用 |
GB201016403D0 (en) | 2010-09-29 | 2010-11-10 | Bath Ventures | Novel interaction between staphylococcus aureus Sbi and C3d protiens |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0134215B1 (en) * | 1982-08-27 | 1989-10-25 | EKINS, Roger Philip | Measurement of analyte concentration |
US5096807A (en) * | 1985-03-06 | 1992-03-17 | Murex Corporation | Imaging immunoassay detection system with background compensation and its use |
AU614935B2 (en) * | 1986-08-06 | 1991-09-19 | Multilyte Limited | Determination of analyte concentration using two labelling markers |
GB8803000D0 (en) * | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
WO1993008472A1 (en) * | 1991-10-15 | 1993-04-29 | Multilyte Limited | Binding assay employing labelled reagent |
US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
US5508200A (en) * | 1992-10-19 | 1996-04-16 | Tiffany; Thomas | Method and apparatus for conducting multiple chemical assays |
US5552272A (en) * | 1993-06-10 | 1996-09-03 | Biostar, Inc. | Detection of an analyte by fluorescence using a thin film optical device |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
-
1993
- 1993-12-24 GB GB939326450A patent/GB9326450D0/en active Pending
-
1994
- 1994-12-23 JP JP51785595A patent/JP3391459B2/ja not_active Expired - Lifetime
- 1994-12-23 EP EP95904616A patent/EP0736176B1/en not_active Expired - Lifetime
- 1994-12-23 WO PCT/GB1994/002814 patent/WO1995018377A1/en active IP Right Grant
- 1994-12-23 DE DE69410636T patent/DE69410636T2/de not_active Expired - Lifetime
- 1994-12-23 US US08/663,176 patent/US5837551A/en not_active Expired - Lifetime
- 1994-12-23 AU AU13218/95A patent/AU1321895A/en not_active Abandoned
- 1994-12-23 ES ES95904616T patent/ES2119376T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69410636D1 (de) | 1998-07-02 |
DE69410636T2 (de) | 1998-11-26 |
EP0736176A1 (en) | 1996-10-09 |
EP0736176B1 (en) | 1998-05-27 |
WO1995018377A1 (en) | 1995-07-06 |
JP3391459B2 (ja) | 2003-03-31 |
AU1321895A (en) | 1995-07-17 |
GB9326450D0 (en) | 1994-02-23 |
US5837551A (en) | 1998-11-17 |
JPH09510539A (ja) | 1997-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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